Kazakhstan belongs to countries with a high level of brucellosis among humans and farm animals. Although antibiotic therapy is the main way to treat acute brucellosis in humans there is still little information on a circulation of the antibiotic-resistant Brucella strains in the Central Eurasia. In this article we describe an occurrence of the drug resistance of Brucella melitensis isolates in Kazakhstan which is among the largest countries of the region.
Susceptibilities to tetracyclin, gentamycin, doxycyclin, streptomycin and rifampicin were investigated in 329 clinical isolates of Brucella melitensis using E-test method.
All isolates were susceptible to streptomycin, tetracycline and doxycycline. 97.3% of the Brucella isolates were susceptible to gentamycin, although only 37.4% of isolates were susceptible to rifampicin. 21.9% of isolates had intermediate resistance, and 26.4% of isolates were resistant to this antibacterial drug.
Isolates of Brucella melitensis circulating in Kazakhstan are susceptible to streptomycin, doxicyclin, tetracyclin and gentamycin. At the same time the resistance to rifampicin is widespread, almost half of the isolates were rifampicin-resistant (including the intermediate resistance).
Nicoletti P. Brucellosis: past, present and future. Prilozi. 2010;31(1):21–32. PubMed
Scholz HC, Revilla-Fernandez S, Al Dahouk S, Hammerl JA, Zygmunt MS, Cloeckaert A, Koylass M, Whatmore AM, Blom J, Vergnaud G, et al. Brucella vulpis sp. nov., isolated from mandibular lymph nodes of red foxes (Vulpes Vulpes). Int J Syst Evol Microbiol. 2016;66(5):2090–8. PubMed
Galinska EM, Zagorski J. Brucellosis in humans - etiology, diagnostics, clinical forms. Ann Agr Env Med. 2013;20(2):233–8.
Yousefi-Nooraie R, Mortaz-Hejri S, Mehrani M, Sadeghipour P. Antibiotics for treating human brucellosis. Cochrane Database Syst Rev. 2012;10:CD007179. PubMed
Saltoglu N, Tasova Y, Inal AS, Seki T, Aksu HS. Efficacy of rifampicin plus doxycycline versus rifampicin plus quinolone in the treatment of brucellosis. Saudi Med J. 2002;23(8):921–4. PubMed
Geyik MF, Gur A, Nas K, Cevik R, Sarac J, Dikici B, Ayaz C. Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases. Swiss Med Wkly. 2002;132(7-8):98–105. PubMed
Corbel MJ. Brucellosis in humans and animals. Geneva: World Health Organization; 2006.
Lopez-Goni I, Garcia-Yoldi D, Marin CM, de Miguel MJ, Munoz PM, Blasco JM, Jacques I, Grayon M, Cloeckaert A, Ferreira AC, et al. Evaluation of a multiplex PCR assay (Bruce-ladder) for molecular typing of all Brucella species, including the vaccine strains. J Clin Microbiol. 2008;46(10):3484–7. CrossRefPubMedPubMedCentral
Jorgensen JH, Hindler JA, Bernard K. Methods of antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria.Approved guidelines - second edition, vol. 30. Wayne, PA: Clinical and Laboratory Standard Institute; 2010.
CLSI. Performance standard for antimicrobial susceptibility testing: twenty-fourth informational supplement.CLSI document M100-S24, vol. 34. Wayne, PA: Clinical and Laboratory Standard Institute; 2014.
Organization WH. Global tuberculosis report 2013. Geneva: World Health Organization; 2013.
Barbosa Pauletti R, Reinato Stynen AP, Pinto da Silva Mol J, Seles Dorneles EM, Alves TM, de Sousa Moura Souto M, Minharro S, Heinemann MB, Lage AP. Reduced susceptibility to Rifampicin and resistance to multiple antimicrobial agents among Brucella abortus isolates from cattle in Brazil. PLoS One. 2015;10(7):e0132532. CrossRefPubMedPubMedCentral
Denk A, Demirdag K, Kalkan A, Ozden M, Cetinkaya B, Kilic SS. In vitro activity of Brucella melitensis isolates to various antimicrobials in Turkey. Infect Dis (Lond). 2015;47(6):364–9. CrossRef
- Antimicrobial susceptibility of Brucella melitensis in Kazakhstan
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