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01.07.2011 | Original Paper

Antioxidant and antiglycating activities of Salvia sahendica and its protective effect against oxidative stress in neuron-like PC12 cells

verfasst von: Fatemeh Shaerzadeh, Abolhassan Ahmadiani, Mohammad Ali Esmaeili, Niloufar Ansari, Sareh Asadi, Solaleh Khoramian Tusi, Ali Sonboli, Mina Ghahremanzamaneh, Fariba Khodagholi

Erschienen in: Journal of Natural Medicines | Ausgabe 3-4/2011

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Abstract

Increased oxidative stress is widely accepted to be a factor in the development and progression of Alzheimer’s disease (AD). Here we introduced Salvia sahendica as a protective agent in differentiated PC12 cells, which are commonly considered to be a reliable model of neuronal cells. Our results demonstrated that S. sahendica has antioxidant and antiglycating properties in in vitro system and these properties are expanded into H₂O₂-induced model. S. sahendica inhibited H₂O₂-induced cell death in PC12 cells. We further showed that this plant exerts its protective effect by increasing superoxide dismutase and catalase levels, reducing lipid peroxidation and upregulating hemoxygenase-1 and glutamylcysteine synthetase proteins. This study raises the possibility of developing S. sahendica as a potential neuroprotective agent.

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Titel: Antioxidant and antiglycating activities of Salvia sahendica and its protective effect against oxidative stress in neuron-like PC12 cells
verfasst von: Fatemeh Shaerzadeh
Abolhassan Ahmadiani
Mohammad Ali Esmaeili
Niloufar Ansari
Sareh Asadi
Solaleh Khoramian Tusi
Ali Sonboli
Mina Ghahremanzamaneh
Fariba Khodagholi
Publikationsdatum: 01.07.2011
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 3-4/2011
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-011-0519-9

Springer Medizin

Abstract

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