Skip to main content

01.02.2010

Antiretroviral Adherence Interventions: Translating Research Findings to the Real World Clinic

Erschienen in: Current HIV/AIDS Reports | Ausgabe 1/2010

Einloggen, um Zugang zu erhalten

Abstract

The success of potent combination antiretroviral therapy (ART) for HIV infection is compromised primarily by failure to maintain optimal levels of adherence over the long term. Recent reviews suggest behavioral interventions to promote ART adherence can have significant effects, but these tend to be small and to diminish over time; sustained improvements in biomarkers are particularly elusive. In this article, we update current reviews, focusing specifically on the 13 studies evaluating behavioral interventions to promote ART adherence published since September 2007. We describe the range of intervention strategies employed and qualitatively summarize findings of their efficacy. In conclusion, we consider implications and offer strategies for enhancing adherence in clinic-based HIV care prior to ART initiation, at initiation, and over the course of treatment.
Literatur
1.
Zurück zum Zitat Chesney MA, Morin M, Sherr L: Adherence to HIV combination therapy. Soc Sci Med 2000, 50:1599–1605.CrossRefPubMed Chesney MA, Morin M, Sherr L: Adherence to HIV combination therapy. Soc Sci Med 2000, 50:1599–1605.CrossRefPubMed
2.
Zurück zum Zitat Williams AB: Adherence to highly active antiretroviral therapy. Nurs Clin North Am 1999, 34:113–129.PubMed Williams AB: Adherence to highly active antiretroviral therapy. Nurs Clin North Am 1999, 34:113–129.PubMed
3.
Zurück zum Zitat Mannheimer S, Friedland G, Matts J, et al.: The consistency of adherence to an antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials. Clin Infect Dis 2002, 34:1115–1121.CrossRefPubMed Mannheimer S, Friedland G, Matts J, et al.: The consistency of adherence to an antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials. Clin Infect Dis 2002, 34:1115–1121.CrossRefPubMed
4.
Zurück zum Zitat Paterson DL, Swindells S, et al.: Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med 2000, 133:21–30.PubMed Paterson DL, Swindells S, et al.: Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med 2000, 133:21–30.PubMed
5.
Zurück zum Zitat Ross L, Lim LM, Wine B, et al.: Prevalence of antiretroviral drug resistance and resistance-associated mutations in antiretroviral therapy-naïve HIV-infected individuals from 40 United States cities. HIV Clin Trial 2007, 8:1–8.CrossRef Ross L, Lim LM, Wine B, et al.: Prevalence of antiretroviral drug resistance and resistance-associated mutations in antiretroviral therapy-naïve HIV-infected individuals from 40 United States cities. HIV Clin Trial 2007, 8:1–8.CrossRef
6.
Zurück zum Zitat Amico KR, Harman JJ, Johnson BT: Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials, 1996 to 2004. J Acquir Immune Defic Syndr 2006, 41:285–297.CrossRefPubMed Amico KR, Harman JJ, Johnson BT: Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials, 1996 to 2004. J Acquir Immune Defic Syndr 2006, 41:285–297.CrossRefPubMed
7.
Zurück zum Zitat Simoni JM, Pearson CR, Pantalone DW, et al.: Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load: a meta-analytic review of randomized controlled trials. J Acquir Immune Defic Syndr December 2006, 43(Suppl 1):S23–S35.CrossRef Simoni JM, Pearson CR, Pantalone DW, et al.: Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load: a meta-analytic review of randomized controlled trials. J Acquir Immune Defic Syndr December 2006, 43(Suppl 1):S23–S35.CrossRef
8.
Zurück zum Zitat • Amico KR, Harman JJ, O’Grady M, Johnson B: Research synthesis of ART adherence interventions: A synthesis of published adherence intervention outcomes research from 1996 to September. Paper presented at 4th Annual HIV Treatment Adherence Conference of the International Association of Providers in AIDS Care. Miami, FL; April 2009. A meta-analysis of 48 published studies of antiretroviral adherence promotion interventions through September 2007 that systematically considers their efficacy. • Amico KR, Harman JJ, O’Grady M, Johnson B: Research synthesis of ART adherence interventions: A synthesis of published adherence intervention outcomes research from 1996 to September. Paper presented at 4th Annual HIV Treatment Adherence Conference of the International Association of Providers in AIDS Care. Miami, FL; April 2009. A meta-analysis of 48 published studies of antiretroviral adherence promotion interventions through September 2007 that systematically considers their efficacy.
9.
Zurück zum Zitat • Cote J, Godin G, Ramirez-Garcia P, et al: Program development for enhancing adherence to antiretroviral therapy among persons living with HI. AIDS Patient Care STD 2008, 22:965–975. An excellent example of intervention mapping and its application in the development of theory-based adherence interventions. • Cote J, Godin G, Ramirez-Garcia P, et al: Program development for enhancing adherence to antiretroviral therapy among persons living with HI. AIDS Patient Care STD 2008, 22:965–975. An excellent example of intervention mapping and its application in the development of theory-based adherence interventions.
10.
Zurück zum Zitat Lester RT, Mills EJ, Kariri A, et al.: The HAART cell phone adherence trial (WelTel Kenya I): a randomized controlled trial protocol. Trials 2009, 10:87–95.CrossRefPubMed Lester RT, Mills EJ, Kariri A, et al.: The HAART cell phone adherence trial (WelTel Kenya I): a randomized controlled trial protocol. Trials 2009, 10:87–95.CrossRefPubMed
11.
Zurück zum Zitat Nishigaki M, Shimada M, Ideda K, et al.: Process and contents of telephone concultations between registered nurses and clients with HIV/AIDS in Japan. J Assoc Nurses AIDS Care 2007, 18:85–96.CrossRefPubMed Nishigaki M, Shimada M, Ideda K, et al.: Process and contents of telephone concultations between registered nurses and clients with HIV/AIDS in Japan. J Assoc Nurses AIDS Care 2007, 18:85–96.CrossRefPubMed
12.
Zurück zum Zitat • Hirsch JD, Rosenquist A, Best BM, Miller TA, et al.: Evaluation of the first year of a pilot program in a community pharmacy: HIV/AIDS Medication Therapy Managment for Medi-Cal Beneficiaries. J Manag Care Pharmacy 2009, 15:32–41. This intervention approach was at the level of providing incentives through state funding for pharmacies to adopt more comprehensive approaches to adherence. • Hirsch JD, Rosenquist A, Best BM, Miller TA, et al.: Evaluation of the first year of a pilot program in a community pharmacy: HIV/AIDS Medication Therapy Managment for Medi-Cal Beneficiaries. J Manag Care Pharmacy 2009, 15:32–41. This intervention approach was at the level of providing incentives through state funding for pharmacies to adopt more comprehensive approaches to adherence.
13.
Zurück zum Zitat Fisher JD, Fisher WA: Theoretical approaches to individual-level change in HIV risk behavior. In Handbook of HIV Prevention. Edited by Peterson R, DiClemente J. New York: Klewer Academic/Plenum; 2000:3–55 Fisher JD, Fisher WA: Theoretical approaches to individual-level change in HIV risk behavior. In Handbook of HIV Prevention. Edited by Peterson R, DiClemente J. New York: Klewer Academic/Plenum; 2000:3–55
14.
Zurück zum Zitat Fisher JD, Fisher WA, Amico KR, Harman JJ: An information-motivation-behavioral skills model fo adherence to antoretroviral therapy. Health Psychology 2006, 25:262–473.CrossRef Fisher JD, Fisher WA, Amico KR, Harman JJ: An information-motivation-behavioral skills model fo adherence to antoretroviral therapy. Health Psychology 2006, 25:262–473.CrossRef
15.
Zurück zum Zitat Prochazka JO, DiClemente CC: Stages of change in the modification of problem behaviors. In Progress in Behavior Change Modification. Edited by Herson M, Miller PM, Eisler R. New York: Wadsworth Publishing; 1992:184–218. Prochazka JO, DiClemente CC: Stages of change in the modification of problem behaviors. In Progress in Behavior Change Modification. Edited by Herson M, Miller PM, Eisler R. New York: Wadsworth Publishing; 1992:184–218.
16.
Zurück zum Zitat Rosenbaum MA: A model for research on self-regulation: reducing the schism between behaviorism and general psychology. In Unifying Behavior Therapy. Edited Eifert GH, Evans IM. New York: Springer Publishing Co.; 1990:126–149. Rosenbaum MA: A model for research on self-regulation: reducing the schism between behaviorism and general psychology. In Unifying Behavior Therapy. Edited Eifert GH, Evans IM. New York: Springer Publishing Co.; 1990:126–149.
17.
Zurück zum Zitat Sampaio-Sa M, Page-Shafer K, Bangsberg DR, et al.: 100% Adherence study: educational workshops vs. video sessions to improve adherence among ART-naïve patients in Salvador, Brazil. AIDS Behav 2008, 12:S54–S62.CrossRefPubMed Sampaio-Sa M, Page-Shafer K, Bangsberg DR, et al.: 100% Adherence study: educational workshops vs. video sessions to improve adherence among ART-naïve patients in Salvador, Brazil. AIDS Behav 2008, 12:S54–S62.CrossRefPubMed
18.
Zurück zum Zitat Whol AR, Garland WH, Witt MD, et al.: An adherence-focused case management intervention for HIV-positive patients in a public care setting. J HIV/AIDS Social Serv 2009, 8:80–94.CrossRef Whol AR, Garland WH, Witt MD, et al.: An adherence-focused case management intervention for HIV-positive patients in a public care setting. J HIV/AIDS Social Serv 2009, 8:80–94.CrossRef
19.
Zurück zum Zitat Deering KN, Shannon K, Sinclair H, et al.: Piloting a peer-driven intervention model to increase access and adherence to antiretroviral therapy and HIV care among street-entrenched HIV-positive women in Vancouver. AIDS Patient Care STD 2009, 23:603–609.CrossRef Deering KN, Shannon K, Sinclair H, et al.: Piloting a peer-driven intervention model to increase access and adherence to antiretroviral therapy and HIV care among street-entrenched HIV-positive women in Vancouver. AIDS Patient Care STD 2009, 23:603–609.CrossRef
20.
Zurück zum Zitat Simoni JM, Huh D, Frick PA, et al.: Peer support and pager messaging to promote antiretroviral modifying therapy in Seattle: a randomized controlled Trial. J Acquir Immune Defic Syndr 2009, 52:499–507. Simoni JM, Huh D, Frick PA, et al.: Peer support and pager messaging to promote antiretroviral modifying therapy in Seattle: a randomized controlled Trial. J Acquir Immune Defic Syndr 2009, 52:499–507.
21.
Zurück zum Zitat Pearson CR, Micek MA, Simoni JM, et al.: Randomized control trial of peer-delivered, modified directly observed therapy for HAART in Mozambique. J Acquir Immune Defic Syndr 2007, 46:238–244.CrossRefPubMed Pearson CR, Micek MA, Simoni JM, et al.: Randomized control trial of peer-delivered, modified directly observed therapy for HAART in Mozambique. J Acquir Immune Defic Syndr 2007, 46:238–244.CrossRefPubMed
22.
Zurück zum Zitat DiIorio C, McCarty F, Resnicow K, et al.: Using motivational interviewing to promote adherence to antiretroviral medications: a randomized controlled study. AIDS Care 2008, 20:273–283.CrossRefPubMed DiIorio C, McCarty F, Resnicow K, et al.: Using motivational interviewing to promote adherence to antiretroviral medications: a randomized controlled study. AIDS Care 2008, 20:273–283.CrossRefPubMed
23.
Zurück zum Zitat Parsons JT, Colub SA, Rosof E, Holder C: Motivational interviewing and Cognitive-Behavioral interventiont o improve HIV medication adherence among hazardous drinkers: a randomized controlled trial. J Acquir Immune Defic Syndr 2007, 46:443–450.CrossRefPubMed Parsons JT, Colub SA, Rosof E, Holder C: Motivational interviewing and Cognitive-Behavioral interventiont o improve HIV medication adherence among hazardous drinkers: a randomized controlled trial. J Acquir Immune Defic Syndr 2007, 46:443–450.CrossRefPubMed
24.
Zurück zum Zitat Reynolds NR, Testa MA, Su M, et al.: Telephone support to improve antiretroviral medication adherence: a multisite, randomized controlled trial. J Acquir Immune Defic Syndr 2008, 47:62–68.CrossRefPubMed Reynolds NR, Testa MA, Su M, et al.: Telephone support to improve antiretroviral medication adherence: a multisite, randomized controlled trial. J Acquir Immune Defic Syndr 2008, 47:62–68.CrossRefPubMed
25.
Zurück zum Zitat Johnson MO, Charlebois E, Morin SF, et al.: Effects of a behavioral intervention on antiretroviral medication adherence among people living with HIV: The Healty Living Project randomized controlled study. J Acquir Immune Defic Syndr 2007, 46:574–580.CrossRefPubMed Johnson MO, Charlebois E, Morin SF, et al.: Effects of a behavioral intervention on antiretroviral medication adherence among people living with HIV: The Healty Living Project randomized controlled study. J Acquir Immune Defic Syndr 2007, 46:574–580.CrossRefPubMed
26.
Zurück zum Zitat Lopez E, Jones DL, Ishii M, et al.: HIV mediation adherence and substance use: The Smartest Women’s Project. Am J Infect Dis 2007, 3:240–247.CrossRefPubMed Lopez E, Jones DL, Ishii M, et al.: HIV mediation adherence and substance use: The Smartest Women’s Project. Am J Infect Dis 2007, 3:240–247.CrossRefPubMed
27.
Zurück zum Zitat Koenig LJ, Pals SL, Bush T, et al.: Raondomized controlled trila of an interventiont o prevent adherence failure among HIV-infected patients initiating antiretroviral therapy. Health Psychol 2008, 27:159–169.CrossRefPubMed Koenig LJ, Pals SL, Bush T, et al.: Raondomized controlled trila of an interventiont o prevent adherence failure among HIV-infected patients initiating antiretroviral therapy. Health Psychol 2008, 27:159–169.CrossRefPubMed
28.
Zurück zum Zitat Sabin LL, Bachman DeSilva M, Hamer DH, et al.: Using electronic drug monitor feedback to improve adherence to antiretroviral therapy among HIV-positive patients in China. AIDS Behav 2009 Sept 22 (Epub ahead of print). Sabin LL, Bachman DeSilva M, Hamer DH, et al.: Using electronic drug monitor feedback to improve adherence to antiretroviral therapy among HIV-positive patients in China. AIDS Behav 2009 Sept 22 (Epub ahead of print).
29.
Zurück zum Zitat • Simoni JS, Amico KR, Pearson CR, Malow RM: Strategies for promoting adherence to antiretroviral therapy: a review of the liteature. Curr Infect Dis Rep 2008, 10:515–521. This is a qualitative review of adherence intervention studies that highlights some of the most recent and innovative research in the areas of patient education and case management, modified early direct observed therapy, contingency management, and interventions emphasizing social support. • Simoni JS, Amico KR, Pearson CR, Malow RM: Strategies for promoting adherence to antiretroviral therapy: a review of the liteature. Curr Infect Dis Rep 2008, 10:515–521. This is a qualitative review of adherence intervention studies that highlights some of the most recent and innovative research in the areas of patient education and case management, modified early direct observed therapy, contingency management, and interventions emphasizing social support.
30.
Zurück zum Zitat Sandelowski M, Voils CI, Chang Y, Lee E: A systematic review comparing antiretroviral adherence descriptive intervention studies conducted in the USA. AIDS Care 2009, 21:953–966.CrossRefPubMed Sandelowski M, Voils CI, Chang Y, Lee E: A systematic review comparing antiretroviral adherence descriptive intervention studies conducted in the USA. AIDS Care 2009, 21:953–966.CrossRefPubMed
31.
Zurück zum Zitat Segal-Isaacson CJ, Tobin JN, Weiss SM, et al.: Improving dietary habits in disadvantaged women with HIV/AIDS: The SMART/EST Women’s Project. AIDS Behav 2006, 10:659–670.CrossRefPubMed Segal-Isaacson CJ, Tobin JN, Weiss SM, et al.: Improving dietary habits in disadvantaged women with HIV/AIDS: The SMART/EST Women’s Project. AIDS Behav 2006, 10:659–670.CrossRefPubMed
Metadaten
Titel
Antiretroviral Adherence Interventions: Translating Research Findings to the Real World Clinic
Publikationsdatum
01.02.2010
Erschienen in
Current HIV/AIDS Reports / Ausgabe 1/2010
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-009-0037-5

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.