Skip to main content
Erschienen in: Quality of Life Research 3/2019

07.11.2018

Apathy and health-related quality of life in nursing home residents

verfasst von: Johanna M. H. Nijsten, Ruslan Leontjevas, Martin Smalbrugge, Raymond T. C. M. Koopmans, Debby L. Gerritsen

Erschienen in: Quality of Life Research | Ausgabe 3/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To explore the association between apathy and health-related quality of life (HRQoL) from resident and proxy perspectives and whether cognition and depression moderate this relationship.

Methods

Secondary analyses with baseline data from a cluster randomized trial on the effects of a care program for depression in Nursing Homes (NHs) were conducted. For HRQoL, the Visual Analogue Scale (VAS) and the Dutch version of the European Quality of Life (EQ-5D) were administered to 521 NH residents, and to professional caregivers reporting from the perspective of the NH resident (Resident–Proxy) and from their own perspective (Proxy–Proxy). Utility scores (U) were calculated for the three perspectives. Apathy, depression, and cognition were measured using the 10-item Apathy Evaluation Scale, the Cornell Scale for Depression in Dementia, and the standardized Mini-Mental State Examination, respectively.

Results

Mixed models adjusted for clustering within NH units revealed that apathy was negatively associated with HRQoL both from the Resident–Proxy perspective (EQ-5D VAS: estimated effect, − 0.31, P < 0.001; EQ-5D Utility: − 0.30, P < 0.001) and from the Proxy–Proxy perspective (VAS: − 0.29, P < 0.001; U: − 0.03, P < 0.001), but not from the Resident–Resident perspective (VAS: − 0.05, P = 0.423; Utility: − 0.08, P = 0.161). Controlling for depression and cognition and their interaction terms with apathy did not change the results.

Conclusion

Apathy is negatively associated with NH resident HRQoL as reported by proxies. Depression and cognitive functioning do not moderate this association. NH residents do not self-report a relationship between apathy and HRQoL. More research is needed to understand caregiver and NH resident attitudes and underlying assumptions regarding apathy and HRQoL.
Literatur
1.
Zurück zum Zitat Cipriani, G., et al. (2014). Apathy and dementia. Nosology, assessment and management. The Journal of Nervous and Mental Disease, 202(10), 718–724.CrossRefPubMed Cipriani, G., et al. (2014). Apathy and dementia. Nosology, assessment and management. The Journal of Nervous and Mental Disease, 202(10), 718–724.CrossRefPubMed
2.
Zurück zum Zitat Zuidema, S. U., et al. (2009). Predictors of neuropsychiatric symptoms in nursing home patients: Influence of gender and dementia severity. International Journal of Geriatric Psychiatry, 24(10), 1079–1086.CrossRefPubMed Zuidema, S. U., et al. (2009). Predictors of neuropsychiatric symptoms in nursing home patients: Influence of gender and dementia severity. International Journal of Geriatric Psychiatry, 24(10), 1079–1086.CrossRefPubMed
3.
Zurück zum Zitat Richard, I. H. (2007). Depression and apathy in Parkinson’s disease. Current Neurology and Neuroscience Reports, 7(4), 295–301.CrossRefPubMed Richard, I. H. (2007). Depression and apathy in Parkinson’s disease. Current Neurology and Neuroscience Reports, 7(4), 295–301.CrossRefPubMed
4.
Zurück zum Zitat van Almenkerk, S., et al. (2015). Apathy among institutionalized stroke patients: Prevalence and clinical correlates. The American Journal of Geriatric Psychiatry, 23(2), 180–188.CrossRefPubMed van Almenkerk, S., et al. (2015). Apathy among institutionalized stroke patients: Prevalence and clinical correlates. The American Journal of Geriatric Psychiatry, 23(2), 180–188.CrossRefPubMed
5.
Zurück zum Zitat Selbaek, G., Engedal, S., Fau -, K., Bergh, & Bergh, S. (2013). The prevalence and course of neuropsychiatric symptoms in nursing home patients with dementia: A systematic review. Journal of the American Medical Directors Association, 14(3), 161–169.CrossRefPubMed Selbaek, G., Engedal, S., Fau -, K., Bergh, & Bergh, S. (2013). The prevalence and course of neuropsychiatric symptoms in nursing home patients with dementia: A systematic review. Journal of the American Medical Directors Association, 14(3), 161–169.CrossRefPubMed
6.
Zurück zum Zitat Robert, P., et al. (2009). Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. European Psychiatry, 24(2), 98–104.CrossRefPubMed Robert, P., et al. (2009). Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. European Psychiatry, 24(2), 98–104.CrossRefPubMed
7.
Zurück zum Zitat Ishii, S., Weintraub, N., & Mervis, J. R. (2009). Apathy: A common psychiatric syndrome in the elderly. Journal of the American Medical Directors Association, 10(6), 381–393.CrossRefPubMed Ishii, S., Weintraub, N., & Mervis, J. R. (2009). Apathy: A common psychiatric syndrome in the elderly. Journal of the American Medical Directors Association, 10(6), 381–393.CrossRefPubMed
8.
Zurück zum Zitat Starkstein, S. E., & Leentjens, A. F. (2008). The nosological position of apathy in clinical practice. Journal of Neurology, Neurosurgery, and Psychiatry, 79(10), 1088–1092.CrossRefPubMed Starkstein, S. E., & Leentjens, A. F. (2008). The nosological position of apathy in clinical practice. Journal of Neurology, Neurosurgery, and Psychiatry, 79(10), 1088–1092.CrossRefPubMed
9.
Zurück zum Zitat Starkstein, S. E., et al. (2006). A prospective longitudinal study of apathy in Alzheimer’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 77(1), 8–11.CrossRefPubMedPubMedCentral Starkstein, S. E., et al. (2006). A prospective longitudinal study of apathy in Alzheimer’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 77(1), 8–11.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Vilalta-Franch, J., et al. (2013). Apathy syndrome in Alzheimer’s disease epidemiology: Prevalence, incidence, persistence, and risk and mortality factors. Journal of Alzheimer’s Disease, 33(2), 535–543.CrossRefPubMed Vilalta-Franch, J., et al. (2013). Apathy syndrome in Alzheimer’s disease epidemiology: Prevalence, incidence, persistence, and risk and mortality factors. Journal of Alzheimer’s Disease, 33(2), 535–543.CrossRefPubMed
11.
Zurück zum Zitat Zakzanis, K. K., & Grimes, K. M. (2016) Relationship among apathy, cognition, and real-world disability after mild traumatic brain injury. Applied Neuropsychology: Adult, 24(6), 559–565.CrossRef Zakzanis, K. K., & Grimes, K. M. (2016) Relationship among apathy, cognition, and real-world disability after mild traumatic brain injury. Applied Neuropsychology: Adult, 24(6), 559–565.CrossRef
12.
Zurück zum Zitat Holtta, E. H., et al. (2012). Apathy: Prevalence, associated factors, and prognostic value among frail, older inpatients. Journal of the American Medical Directors Association, 13(6), 541–545.CrossRefPubMed Holtta, E. H., et al. (2012). Apathy: Prevalence, associated factors, and prognostic value among frail, older inpatients. Journal of the American Medical Directors Association, 13(6), 541–545.CrossRefPubMed
13.
Zurück zum Zitat Nijsten, J. M. H., et al. (2017). Apathy: Risk Factor for Mortality in Nursing Home Patients. Journal of the American Geriatrics Society, 65(10), 2182–2189.CrossRefPubMed Nijsten, J. M. H., et al. (2017). Apathy: Risk Factor for Mortality in Nursing Home Patients. Journal of the American Geriatrics Society, 65(10), 2182–2189.CrossRefPubMed
14.
Zurück zum Zitat Beerens, H. C., et al. (2013) Factors associated with quality of life of people with dementia in long-term care facilities: A systematic review. International Journal of Nursing Studies, 50(9), 1259–1270. Beerens, H. C., et al. (2013) Factors associated with quality of life of people with dementia in long-term care facilities: A systematic review. International Journal of Nursing Studies, 50(9), 1259–1270.
15.
Zurück zum Zitat Appelhof, B., et al. (2017). The determinants of quality of life of nursing home residents with young-onset dementia and the differences between dementia subtypes. Dementia and Geriatric Cognitive Disorders, 43, 320–329.CrossRefPubMed Appelhof, B., et al. (2017). The determinants of quality of life of nursing home residents with young-onset dementia and the differences between dementia subtypes. Dementia and Geriatric Cognitive Disorders, 43, 320–329.CrossRefPubMed
16.
Zurück zum Zitat Wetzels, R., et al. (2010). Determinants of quality of life in nursing home residents with dementia. Dementia and Geriatric Cognitive Disorders, 29(3), 189–197.CrossRefPubMed Wetzels, R., et al. (2010). Determinants of quality of life in nursing home residents with dementia. Dementia and Geriatric Cognitive Disorders, 29(3), 189–197.CrossRefPubMed
17.
Zurück zum Zitat Mjorud, M., et al. (2014). Variables associated to quality of life among nursing home patients with dementia. Aging and Mental Health, 18(8), 1013–1021.CrossRefPubMed Mjorud, M., et al. (2014). Variables associated to quality of life among nursing home patients with dementia. Aging and Mental Health, 18(8), 1013–1021.CrossRefPubMed
18.
Zurück zum Zitat Gerritsen, D. L., et al. (2005). Down and drowsy? Do apathetic nursing home residents experience low quality of life? Aging and Mental Health, 9(2), 135–141.CrossRefPubMed Gerritsen, D. L., et al. (2005). Down and drowsy? Do apathetic nursing home residents experience low quality of life? Aging and Mental Health, 9(2), 135–141.CrossRefPubMed
19.
Zurück zum Zitat Yeager, C. A., & Hyer, L. (2008). Apathy in dementia: Relations with depression, functional competence, and quality of life. Psychological Reports, 102(3), 718–722.CrossRefPubMed Yeager, C. A., & Hyer, L. (2008). Apathy in dementia: Relations with depression, functional competence, and quality of life. Psychological Reports, 102(3), 718–722.CrossRefPubMed
21.
Zurück zum Zitat Moretti, R., & Signori, R. (2016). Neural correlates for apathy: Frontal-prefrontal and parietal cortical- subcortical circuits. Frontiers in Aging Neuroscience, 8, 289.PubMedPubMedCentral Moretti, R., & Signori, R. (2016). Neural correlates for apathy: Frontal-prefrontal and parietal cortical- subcortical circuits. Frontiers in Aging Neuroscience, 8, 289.PubMedPubMedCentral
22.
Zurück zum Zitat Robert, S., & Marin, P. A. W. (2005). Disorders of diminished motivation. Journal of Head Trauma Rehabilitation, 20(4), 377–388.CrossRef Robert, S., & Marin, P. A. W. (2005). Disorders of diminished motivation. Journal of Head Trauma Rehabilitation, 20(4), 377–388.CrossRef
23.
Zurück zum Zitat Esposito, F., et al. (2012). Apathy and prospective memory in aging. Dementia and Geriatric Cognitive Disorders, 2(1), 456–467.CrossRef Esposito, F., et al. (2012). Apathy and prospective memory in aging. Dementia and Geriatric Cognitive Disorders, 2(1), 456–467.CrossRef
24.
Zurück zum Zitat Robert, P. H., et al. (2006). Neuropsychological performance in mild cognitive impairment with and without apathy. Dementia and Geriatric Cognitive Disorders, 21(3), 192–197.CrossRefPubMed Robert, P. H., et al. (2006). Neuropsychological performance in mild cognitive impairment with and without apathy. Dementia and Geriatric Cognitive Disorders, 21(3), 192–197.CrossRefPubMed
25.
Zurück zum Zitat Levy, M. L., et al. (1998). Apathy is not depression. The Journal of Neuropsychiatry and Clinical Neurosciences, 10, 314–319.CrossRefPubMed Levy, M. L., et al. (1998). Apathy is not depression. The Journal of Neuropsychiatry and Clinical Neurosciences, 10, 314–319.CrossRefPubMed
26.
Zurück zum Zitat Starkstein, S. E., Mizrahi, R., & Power, B. D. (2008). Depression in Alzheimer’s disease: Phenomenology, clinical correlates and treatment. Int Rev Psychiatry, 20(4), 382–388.CrossRefPubMed Starkstein, S. E., Mizrahi, R., & Power, B. D. (2008). Depression in Alzheimer’s disease: Phenomenology, clinical correlates and treatment. Int Rev Psychiatry, 20(4), 382–388.CrossRefPubMed
27.
Zurück zum Zitat Gerritsen, D. L., et al. (2004) Finding a useful conceptual basis for enhancing the quality of life of nursing home residents. Quality of Life Research, 13(3), 611–624.CrossRefPubMed Gerritsen, D. L., et al. (2004) Finding a useful conceptual basis for enhancing the quality of life of nursing home residents. Quality of Life Research, 13(3), 611–624.CrossRefPubMed
28.
Zurück zum Zitat Ettema, T. P., et al. (2007). Qualidem: Development and evaluation of a dementia specific quality of life instrument-validation. International Journal of Geriatric Psychiatry, 22, 424–430.CrossRefPubMed Ettema, T. P., et al. (2007). Qualidem: Development and evaluation of a dementia specific quality of life instrument-validation. International Journal of Geriatric Psychiatry, 22, 424–430.CrossRefPubMed
29.
Zurück zum Zitat Logsdon, R. G., Gibbons, L. E., McCurry, S. M., & Teri, L. (1999). Quality of life in Alzheimer’s Disease: Patient and caregiver reports. Journal of Mental Health and Aging, 5, 21–32. Logsdon, R. G., Gibbons, L. E., McCurry, S. M., & Teri, L. (1999). Quality of life in Alzheimer’s Disease: Patient and caregiver reports. Journal of Mental Health and Aging, 5, 21–32.
30.
Zurück zum Zitat Whitehouse, P. J., et al. (1997) Quality-of-life assessment in dementia drug development. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. 1997(0893-0341 (Print)). Whitehouse, P. J., et al. (1997) Quality-of-life assessment in dementia drug development. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. 1997(0893-0341 (Print)).
31.
Zurück zum Zitat Leontjevas, R., et al. (2016). Quality of life assessments in nursing homes revealed a tendency of proxies to moderate patients’ self-reports. Journal of Clinical Epidemiology, 80, 123–133.CrossRefPubMed Leontjevas, R., et al. (2016). Quality of life assessments in nursing homes revealed a tendency of proxies to moderate patients’ self-reports. Journal of Clinical Epidemiology, 80, 123–133.CrossRefPubMed
32.
Zurück zum Zitat Leontjevas, R., et al. (2013). A structural multidisciplinary approach to depression management in nursing-home residents: A multicentre, stepped-wedge cluster-randomised trial. The Lancet, 381(9885), 2255–2264.CrossRef Leontjevas, R., et al. (2013). A structural multidisciplinary approach to depression management in nursing-home residents: A multicentre, stepped-wedge cluster-randomised trial. The Lancet, 381(9885), 2255–2264.CrossRef
33.
Zurück zum Zitat Gerritsen, D. L., et al., Act in case of depression: The evaluation of a care program to improve the detection and treatment of depression in nursing homes. Study Protocol. BioMedCentral Psychiatry, 2011. 11(1), 91. Gerritsen, D. L., et al., Act in case of depression: The evaluation of a care program to improve the detection and treatment of depression in nursing homes. Study Protocol. BioMedCentral Psychiatry, 2011. 11(1), 91.
34.
Zurück zum Zitat Lueken, U., et al. (2007). Development of a short version of the Apathy Evaluation Scale specifically adapted for demented nursing home residents. The American Journal of Geriatric Psychiatry, 15(5), 376–385.CrossRefPubMed Lueken, U., et al. (2007). Development of a short version of the Apathy Evaluation Scale specifically adapted for demented nursing home residents. The American Journal of Geriatric Psychiatry, 15(5), 376–385.CrossRefPubMed
35.
Zurück zum Zitat Leontjevas, R., et al. (2012). A comparative validation of the abbreviated Apathy Evaluation Scale (AES-10) with the Neuropsychiatric Inventory apathy subscale against diagnostic criteria of apathy. Journal of the American Medical Directors Association, 13(3), 308.e1–308.e6.CrossRef Leontjevas, R., et al. (2012). A comparative validation of the abbreviated Apathy Evaluation Scale (AES-10) with the Neuropsychiatric Inventory apathy subscale against diagnostic criteria of apathy. Journal of the American Medical Directors Association, 13(3), 308.e1–308.e6.CrossRef
36.
Zurück zum Zitat Rabin, R., & Charro, F. d. (2001). EQ-SD: A measure of health status from the EuroQol Group. Annals of Medicine, 33(5), 337–343.CrossRefPubMed Rabin, R., & Charro, F. d. (2001). EQ-SD: A measure of health status from the EuroQol Group. Annals of Medicine, 33(5), 337–343.CrossRefPubMed
37.
Zurück zum Zitat Alexopoulos, G. S., et al. (1988). Cornell Scale for Depression in Dementia. Biological Psychiatry, 23(3), 271–284.CrossRefPubMed Alexopoulos, G. S., et al. (1988). Cornell Scale for Depression in Dementia. Biological Psychiatry, 23(3), 271–284.CrossRefPubMed
38.
Zurück zum Zitat Alexopoulos, G. S., et al. (1988). Use of the Cornell scale in nondemented patients. Journal of the American Geriatrics Society, 36(3), 230–236.CrossRefPubMed Alexopoulos, G. S., et al. (1988). Use of the Cornell scale in nondemented patients. Journal of the American Geriatrics Society, 36(3), 230–236.CrossRefPubMed
39.
Zurück zum Zitat Leontjevas, R., et al. (2012). Comparative validation of proxy-based Montgomery-Asberg depression rating scale and cornell scale for depression in dementia in nursing home residents with dementia. The American Journal of Geriatric Psychiatry, 20(11), 985–993.CrossRefPubMed Leontjevas, R., et al. (2012). Comparative validation of proxy-based Montgomery-Asberg depression rating scale and cornell scale for depression in dementia in nursing home residents with dementia. The American Journal of Geriatric Psychiatry, 20(11), 985–993.CrossRefPubMed
40.
Zurück zum Zitat Molloy, D. W., Alemayehu, E., & Roberts, R. (1991). Reliability of a Standardized Mini-Mental State Examination compared with the traditional Mini-Mental State Examination. The American Journal of Psychiatry, 148(1), 102–105.CrossRefPubMed Molloy, D. W., Alemayehu, E., & Roberts, R. (1991). Reliability of a Standardized Mini-Mental State Examination compared with the traditional Mini-Mental State Examination. The American Journal of Psychiatry, 148(1), 102–105.CrossRefPubMed
41.
Zurück zum Zitat Lamers, L. M., et al. (2006). The Dutch tariff: Results and arguments for an effective design for national EQ-5D valuation studies. Health Economics, 15(10), 1121–1132.CrossRefPubMed Lamers, L. M., et al. (2006). The Dutch tariff: Results and arguments for an effective design for national EQ-5D valuation studies. Health Economics, 15(10), 1121–1132.CrossRefPubMed
42.
Zurück zum Zitat Fielding, S., et al. (2008). Simple imputation methods were inadequate for missing not at random (MNAR) quality of life data. Health and Quality Life Outcomes, 6, 57.CrossRef Fielding, S., et al. (2008). Simple imputation methods were inadequate for missing not at random (MNAR) quality of life data. Health and Quality Life Outcomes, 6, 57.CrossRef
43.
Zurück zum Zitat Klapwijk, M. S., et al. (2016). Characteristics associated with quality of life in long-term care residents with dementia: A cross-sectional study. Dementia and Geriatric Cognitive Disorders, 42, 186–197.CrossRefPubMedPubMedCentral Klapwijk, M. S., et al. (2016). Characteristics associated with quality of life in long-term care residents with dementia: A cross-sectional study. Dementia and Geriatric Cognitive Disorders, 42, 186–197.CrossRefPubMedPubMedCentral
44.
Zurück zum Zitat Hongisto, K. A., et al. (2018). Quality of Life in relation to neuropsychiatric symptoms in Alzheimer’s disease: 5-year prospective ALSOVA cohort study. International Journal of Geriatric Psychiatry, 33, 47–57.CrossRefPubMed Hongisto, K. A., et al. (2018). Quality of Life in relation to neuropsychiatric symptoms in Alzheimer’s disease: 5-year prospective ALSOVA cohort study. International Journal of Geriatric Psychiatry, 33, 47–57.CrossRefPubMed
45.
Zurück zum Zitat Zuidema, S. U., et al. (2007). Prevalence of neuropsychiatric symptoms in a large sample of Dutch nursing home patients with dementia. International Journal of Geriatric Psychiatry, 22(7), 632–638.CrossRefPubMed Zuidema, S. U., et al. (2007). Prevalence of neuropsychiatric symptoms in a large sample of Dutch nursing home patients with dementia. International Journal of Geriatric Psychiatry, 22(7), 632–638.CrossRefPubMed
46.
Zurück zum Zitat Beerens, H. C., et al. (2014). Quality of life and quality of care for people with dementia receiving long term institutional care or professional home care: The European RightTimePlaceCare study. Journal of the American Medical Directors Association, 15(1), 54–61.CrossRefPubMed Beerens, H. C., et al. (2014). Quality of life and quality of care for people with dementia receiving long term institutional care or professional home care: The European RightTimePlaceCare study. Journal of the American Medical Directors Association, 15(1), 54–61.CrossRefPubMed
47.
Zurück zum Zitat Leone, E., et al. (2013). Management of apathy in nursing homes using a teaching program for care staff: The STIM-EHPAD study. International Journal of Geriatric Psychiatry, 28(4), 383–392.CrossRefPubMed Leone, E., et al. (2013). Management of apathy in nursing homes using a teaching program for care staff: The STIM-EHPAD study. International Journal of Geriatric Psychiatry, 28(4), 383–392.CrossRefPubMed
48.
Zurück zum Zitat Zwijsen, S. A., et al. (2014). Nurses in distress? An explorative study into the relation between distress and individual neuropsychiatric symptoms of people with dementia in nursing homes. International Journal of Geriatric Psychiatry, 29(4), 384–391.CrossRefPubMed Zwijsen, S. A., et al. (2014). Nurses in distress? An explorative study into the relation between distress and individual neuropsychiatric symptoms of people with dementia in nursing homes. International Journal of Geriatric Psychiatry, 29(4), 384–391.CrossRefPubMed
49.
Zurück zum Zitat Albrecht, G. L., & Devlieger, P. J. (1999). The disability paradox: High quality of life against all odds. Social Science & Medicine, 48(8), 977–988.CrossRef Albrecht, G. L., & Devlieger, P. J. (1999). The disability paradox: High quality of life against all odds. Social Science & Medicine, 48(8), 977–988.CrossRef
50.
Zurück zum Zitat Samus, Q. M., et al. (2005). The association of neuropsychiatric symptoms and environment with quality of life in assisted living residents with dementia. Gerontologist, 45(1), 19–26.CrossRefPubMed Samus, Q. M., et al. (2005). The association of neuropsychiatric symptoms and environment with quality of life in assisted living residents with dementia. Gerontologist, 45(1), 19–26.CrossRefPubMed
51.
Zurück zum Zitat Rokstad, A. M., et al. (2013) The effect of person-centred dementia care to prevent agitation and other neuropsychiatric symptoms and enhance quality of life in nursing home patients: A 10-month randomized controlled trial. Dementia and Geriatric Cognitive Disorders, 36(5-6), 340–353.CrossRefPubMed Rokstad, A. M., et al. (2013) The effect of person-centred dementia care to prevent agitation and other neuropsychiatric symptoms and enhance quality of life in nursing home patients: A 10-month randomized controlled trial. Dementia and Geriatric Cognitive Disorders, 36(5-6), 340–353.CrossRefPubMed
52.
Zurück zum Zitat Romhild, J., et al. (2018). Inter-rater agreement of the Quality of Life-Alzheimer’s Disease (QoL-AD) self-rating and proxy rating scale: Secondary analysis of RightTimePlaceCare data. Health and Quality Life Outcomes, 16(1), 131.CrossRef Romhild, J., et al. (2018). Inter-rater agreement of the Quality of Life-Alzheimer’s Disease (QoL-AD) self-rating and proxy rating scale: Secondary analysis of RightTimePlaceCare data. Health and Quality Life Outcomes, 16(1), 131.CrossRef
53.
Zurück zum Zitat Santangelo, G., et al. (2013). Apathy in Parkinson’s disease: Diagnosis, neuropsychological correlates, pathophysiology and treatment. Behavioural Neurology, 27(4), 501–513.CrossRefPubMedPubMedCentral Santangelo, G., et al. (2013). Apathy in Parkinson’s disease: Diagnosis, neuropsychological correlates, pathophysiology and treatment. Behavioural Neurology, 27(4), 501–513.CrossRefPubMedPubMedCentral
54.
Zurück zum Zitat Nakanishi, K., et al. (2011). Evaluating the quality of life of people with dementia in residential care facilities. Dementia and Geriatric Cognitive Disorders, 32(1), 39–44.CrossRefPubMed Nakanishi, K., et al. (2011). Evaluating the quality of life of people with dementia in residential care facilities. Dementia and Geriatric Cognitive Disorders, 32(1), 39–44.CrossRefPubMed
55.
Zurück zum Zitat Ellis, J. M., Doyle, C. J., & Selvarajah, S. (2016). The relationship between apathy and participation in therapeutic activities in nursing home residents with dementia: Evidence for an association and directions for further research. Dementia (London, England), 15(4), 494–509. Ellis, J. M., Doyle, C. J., & Selvarajah, S. (2016). The relationship between apathy and participation in therapeutic activities in nursing home residents with dementia: Evidence for an association and directions for further research. Dementia (London, England), 15(4), 494–509.
56.
Zurück zum Zitat Brodaty, H., & Burns, K. (2012). Nonpharmacological management of apathy in dementia: A systematic review. The American Journal of Geriatric Psychiatry, 20(7), 549–564.CrossRefPubMed Brodaty, H., & Burns, K. (2012). Nonpharmacological management of apathy in dementia: A systematic review. The American Journal of Geriatric Psychiatry, 20(7), 549–564.CrossRefPubMed
57.
Zurück zum Zitat Leontjevas, R., et al. (2013). More insight into the concept of apathy: A multidisciplinary depression management program has different effects on depressive symptoms and apathy in nursing homes. International Psychogeriatrics, 25(12), 1941–1952.CrossRefPubMed Leontjevas, R., et al. (2013). More insight into the concept of apathy: A multidisciplinary depression management program has different effects on depressive symptoms and apathy in nursing homes. International Psychogeriatrics, 25(12), 1941–1952.CrossRefPubMed
Metadaten
Titel
Apathy and health-related quality of life in nursing home residents
verfasst von
Johanna M. H. Nijsten
Ruslan Leontjevas
Martin Smalbrugge
Raymond T. C. M. Koopmans
Debby L. Gerritsen
Publikationsdatum
07.11.2018
Verlag
Springer International Publishing
Erschienen in
Quality of Life Research / Ausgabe 3/2019
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-018-2041-y

Weitere Artikel der Ausgabe 3/2019

Quality of Life Research 3/2019 Zur Ausgabe