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Erschienen in: Journal of Medical Systems 6/2011

01.12.2011 | Original Paper

Application of Higher Order Spectra to Identify Epileptic EEG

verfasst von: Kuang Chua Chua, V. Chandran, U. Rajendra Acharya, C. M. Lim

Erschienen in: Journal of Medical Systems | Ausgabe 6/2011

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Abstract

Epilepsy is characterized by the spontaneous and seemingly unforeseeable occurrence of seizures, during which the perception or behavior of patients is disturbed. An automatic system that detects seizure onsets would allow patients or the people near them to take appropriate precautions, and could provide more insight into this phenomenon. Various methods have been proposed to predict the onset of seizures based on EEG recordings. The use of nonlinear features motivated by the higher order spectra (HOS) has been reported to be a promising approach to differentiate between normal, background (pre-ictal) and epileptic EEG signals. In this work, we made a comparative study of the performance of Gaussian mixture model (GMM) and Support Vector Machine (SVM) classifiers using the features derived from HOS and from the power spectrum. Results show that the selected HOS based features achieve 93.11% classification accuracy compared to 88.78% with features derived from the power spectrum for a GMM classifier. The SVM classifier achieves an improvement from 86.89% with features based on the power spectrum to 92.56% with features based on the bispectrum.
Literatur
1.
Zurück zum Zitat Cockerell, O. C., Johnson, A. L., Sander, J. W., Hart, Y. M., Goodridge, D. M., and Shorvon, S. D., Mortality from epilepsy: results from a prospective population-based study. Lancet. 344:918–921, 1994.CrossRef Cockerell, O. C., Johnson, A. L., Sander, J. W., Hart, Y. M., Goodridge, D. M., and Shorvon, S. D., Mortality from epilepsy: results from a prospective population-based study. Lancet. 344:918–921, 1994.CrossRef
2.
Zurück zum Zitat Callaway, E., and Harris, P. R., Coupling between cortical potentials from different areas. Science. 183:873–875, 1974.CrossRef Callaway, E., and Harris, P. R., Coupling between cortical potentials from different areas. Science. 183:873–875, 1974.CrossRef
3.
Zurück zum Zitat Babloyantz, A., Nicolis, C., and Salazar, J. M., Evidence of chaotic dynamics of brain activity during the sleep cycle. Phys. Lett. 111 A:152–157, 1985. Babloyantz, A., Nicolis, C., and Salazar, J. M., Evidence of chaotic dynamics of brain activity during the sleep cycle. Phys. Lett. 111 A:152–157, 1985.
4.
Zurück zum Zitat Mormann, F., Thomas, K., Christoph, R., Andrzejak, R., Kraskov, A., David, P., Elger, C. E., and Lehnertz, K., On the predictability of epileptic seizures. Clin. Neurophysiol. 116:569–587, 2005.CrossRef Mormann, F., Thomas, K., Christoph, R., Andrzejak, R., Kraskov, A., David, P., Elger, C. E., and Lehnertz, K., On the predictability of epileptic seizures. Clin. Neurophysiol. 116:569–587, 2005.CrossRef
5.
Zurück zum Zitat Niederhoefer, C., Gollas, F., Chernihovskyi, A., Lehnertz, K., and Tetzlaff, R., Detection of seizure precursors in the EEG with cellular neural networks. Epilepsia. 45(7):245, 2004. Niederhoefer, C., Gollas, F., Chernihovskyi, A., Lehnertz, K., and Tetzlaff, R., Detection of seizure precursors in the EEG with cellular neural networks. Epilepsia. 45(7):245, 2004.
6.
Zurück zum Zitat Kaplan, A. Y., Segmental structure of EEG more likely reveals the dynamic multistability of the brain tissue than the continual plasticity one. Proceedings of ICONIP’ 99, Perth, Australia, 1999, 633–638. Kaplan, A. Y., Segmental structure of EEG more likely reveals the dynamic multistability of the brain tissue than the continual plasticity one. Proceedings of ICONIP’ 99, Perth, Australia, 1999, 633–638.
7.
Zurück zum Zitat Stam, C. J., Pijn, J. P., Suffczynski, P., and Lopez da Silva, F. H., Dynamics of the human alpha rhythm: evidence for nonline. Clin. Neurophysiol. 110(10):1801–1813, 1999.CrossRef Stam, C. J., Pijn, J. P., Suffczynski, P., and Lopez da Silva, F. H., Dynamics of the human alpha rhythm: evidence for nonline. Clin. Neurophysiol. 110(10):1801–1813, 1999.CrossRef
8.
Zurück zum Zitat Zhuo, S. M., Gan, J. Q., and Sepulveda, F., Classifying mental tasks based on features of higher-order statistics from EEG signals in brain–computer interface. Inf. Sci. 178(6):1629–1640, 2008.CrossRef Zhuo, S. M., Gan, J. Q., and Sepulveda, F., Classifying mental tasks based on features of higher-order statistics from EEG signals in brain–computer interface. Inf. Sci. 178(6):1629–1640, 2008.CrossRef
9.
Zurück zum Zitat Shen, M., Chan, F. H. Y., Sun, L., and Beadle, B. J., Parametric bispectral estimation of EEG signals in different functional states of the brain. IEE Proc. Sci. Meas. Technol. 147(6):374–377, 2000.CrossRef Shen, M., Chan, F. H. Y., Sun, L., and Beadle, B. J., Parametric bispectral estimation of EEG signals in different functional states of the brain. IEE Proc. Sci. Meas. Technol. 147(6):374–377, 2000.CrossRef
10.
Zurück zum Zitat Chua, K. C., Chandran, V., Acharya, U. R., and Lim, C. M., Analysis of epileptic EEG signals using higher order spectra. J. Med. Eng. Technol. 33(1):42–50, 2009.CrossRef Chua, K. C., Chandran, V., Acharya, U. R., and Lim, C. M., Analysis of epileptic EEG signals using higher order spectra. J. Med. Eng. Technol. 33(1):42–50, 2009.CrossRef
11.
Zurück zum Zitat Chua, K. C., Chandran, V., Acharya, U. R., and Lim, C. M., Automatic identification of epilepsy by HOS and power spectrum parameters using EEG signals: a comparative study. International Conference of the IEEE Engineering in Medicine and Biology Society, 2008, 3824–3827. Chua, K. C., Chandran, V., Acharya, U. R., and Lim, C. M., Automatic identification of epilepsy by HOS and power spectrum parameters using EEG signals: a comparative study. International Conference of the IEEE Engineering in Medicine and Biology Society, 2008, 3824–3827.
13.
Zurück zum Zitat Andrzejak, R. G., Lehnertz, K., Rieke, C., Mormann, F., David, P., and Elger, C. E., Indications of nonlinear deterministic and finite dimensional structures in time series of brain electrical activity: dependence on recording region and brain state. Phys. Rev. E. 64:061907, 2001.CrossRef Andrzejak, R. G., Lehnertz, K., Rieke, C., Mormann, F., David, P., and Elger, C. E., Indications of nonlinear deterministic and finite dimensional structures in time series of brain electrical activity: dependence on recording region and brain state. Phys. Rev. E. 64:061907, 2001.CrossRef
14.
Zurück zum Zitat Inouye, T., Shinosaki, K., Sakamoto, H., Toi, S., Ukai, S., Iyama, A., Katsuda, Y., and Hirano, M., Quantification of EEG irregularity by use of the entropy of the power spectrum. Electroencephalogr. Clin. Neurophysiol. 79:204–210, 1991.CrossRef Inouye, T., Shinosaki, K., Sakamoto, H., Toi, S., Ukai, S., Iyama, A., Katsuda, Y., and Hirano, M., Quantification of EEG irregularity by use of the entropy of the power spectrum. Electroencephalogr. Clin. Neurophysiol. 79:204–210, 1991.CrossRef
15.
Zurück zum Zitat Ng, T. T., Chang, S. F., and Sun, Q., Blind detection of photomontage using higher order statistics, IEEE International Symposium on Circuits and Systems (ISCAS), Vancouver, Canada, May 2004. Ng, T. T., Chang, S. F., and Sun, Q., Blind detection of photomontage using higher order statistics, IEEE International Symposium on Circuits and Systems (ISCAS), Vancouver, Canada, May 2004.
16.
Zurück zum Zitat Bilmes, J. A., A gentle tutorial of the EM algorithm and its application to parameter estimation for gaussian mixture and hidden Markov models. International Computer Science Institute, 1998. Bilmes, J. A., A gentle tutorial of the EM algorithm and its application to parameter estimation for gaussian mixture and hidden Markov models. International Computer Science Institute, 1998.
17.
Zurück zum Zitat Vapnik, V., Statistical learning theory. Willey, New York, 1998.MATH Vapnik, V., Statistical learning theory. Willey, New York, 1998.MATH
18.
Zurück zum Zitat Burgess, C. J., A tutorial on support vector machines for pattern recognition. Data Min. Knowl. Discov. 2(2):1–47, 1998.CrossRef Burgess, C. J., A tutorial on support vector machines for pattern recognition. Data Min. Knowl. Discov. 2(2):1–47, 1998.CrossRef
19.
Zurück zum Zitat Christianini, N., and Taylor, J., Support vector machines and other kernel-based learning methods. Cambridge University Press, Cambridge, 2000. Christianini, N., and Taylor, J., Support vector machines and other kernel-based learning methods. Cambridge University Press, Cambridge, 2000.
20.
Zurück zum Zitat Muller, K. R., Mika, S., Ratsch, G., Tsuda, K., and Scholkopf, B., An introduction to Kernel based learning algorithms. IEEE Trans. Neural Netw. 12:181–201, 2001.CrossRef Muller, K. R., Mika, S., Ratsch, G., Tsuda, K., and Scholkopf, B., An introduction to Kernel based learning algorithms. IEEE Trans. Neural Netw. 12:181–201, 2001.CrossRef
21.
Zurück zum Zitat Hsu, C. W., Chang, C. C., and Lin, C. J., A practical guide to support vector classification. Technical report, Department of Computer Science, National Taiwan University 2003. Hsu, C. W., Chang, C. C., and Lin, C. J., A practical guide to support vector classification. Technical report, Department of Computer Science, National Taiwan University 2003.
22.
Zurück zum Zitat Ceruti, G. M., and Rubin, S. H., Infodynamics: analogical analysis of states of matter and information. Inf. Sci. 177(4):969–987, 2007.CrossRef Ceruti, G. M., and Rubin, S. H., Infodynamics: analogical analysis of states of matter and information. Inf. Sci. 177(4):969–987, 2007.CrossRef
23.
Zurück zum Zitat He, M., Wen-Jian, C., and Shao-Yuan, L., Multiple fuzzy model-based temperature predictive control for HVAC systems. Inf. Sci. 169(1–2):155–174, 2005.CrossRefMATH He, M., Wen-Jian, C., and Shao-Yuan, L., Multiple fuzzy model-based temperature predictive control for HVAC systems. Inf. Sci. 169(1–2):155–174, 2005.CrossRefMATH
24.
Zurück zum Zitat DeLeo, J. M., Receiver operating characteristic laboratory (ROCLAB): software for developing decision strategies that account for uncertainty. Proceedings of the Second International Symposium on Uncertainty Modeling and Analysis, IEEE Computer Society Press, 1993, 318–325. DeLeo, J. M., Receiver operating characteristic laboratory (ROCLAB): software for developing decision strategies that account for uncertainty. Proceedings of the Second International Symposium on Uncertainty Modeling and Analysis, IEEE Computer Society Press, 1993, 318–325.
25.
Zurück zum Zitat Downey, T. J., Meyer, D. J., Price, R. K., and Spitznagel, E. L., Using the receiver operating characteristic to assess the performance of neural classifiers. Int. Joint Conf. Neural Networks. 5:3642–3646, 1999. Downey, T. J., Meyer, D. J., Price, R. K., and Spitznagel, E. L., Using the receiver operating characteristic to assess the performance of neural classifiers. Int. Joint Conf. Neural Networks. 5:3642–3646, 1999.
26.
Zurück zum Zitat Myles, P. S., Leslie, K., McNeil, J., Forbes, A., and Chan, M. T. V., Bispectral index monitoring to prevent awareness during anesthesia: the B-Aware randomized controlled trial. Lancet. 363(9423):1757–1763, 2004.CrossRef Myles, P. S., Leslie, K., McNeil, J., Forbes, A., and Chan, M. T. V., Bispectral index monitoring to prevent awareness during anesthesia: the B-Aware randomized controlled trial. Lancet. 363(9423):1757–1763, 2004.CrossRef
27.
Zurück zum Zitat Huang, L., Zhao, J., Singare, S., Wang, J., and Wang, Y., Discrimination of cerebral ischemic states using bispectrum analysis of EEG and artificial neural network. Med. Eng. Phys. 29(1):1–7, 2007.CrossRef Huang, L., Zhao, J., Singare, S., Wang, J., and Wang, Y., Discrimination of cerebral ischemic states using bispectrum analysis of EEG and artificial neural network. Med. Eng. Phys. 29(1):1–7, 2007.CrossRef
29.
Zurück zum Zitat Ravelli, F., and Antolini, R., Complex dynamics underlying the human electroencephalogram. Biol. Cybern. 67:57–65, 1992.CrossRefMATH Ravelli, F., and Antolini, R., Complex dynamics underlying the human electroencephalogram. Biol. Cybern. 67:57–65, 1992.CrossRefMATH
30.
Zurück zum Zitat Petitmengin, C., Baulac, M., and Navarro, V., Seizure anticipation: are neurophenomenological approaches able to detect preictal symptoms? Epilepsy Behav. 9(2):298–306, 2006.CrossRef Petitmengin, C., Baulac, M., and Navarro, V., Seizure anticipation: are neurophenomenological approaches able to detect preictal symptoms? Epilepsy Behav. 9(2):298–306, 2006.CrossRef
31.
Zurück zum Zitat Lehnertz, K., and Elger, C. E., Can epileptic seizures be predicted? Evidence from nonlinear time series analyses of brain electrical activity. Phys. Rev. Lett. 80:5019–5023, 1988.CrossRef Lehnertz, K., and Elger, C. E., Can epileptic seizures be predicted? Evidence from nonlinear time series analyses of brain electrical activity. Phys. Rev. Lett. 80:5019–5023, 1988.CrossRef
32.
Zurück zum Zitat Martinerie, J., Adam, C., Le van Quyen, M., Baulac, M., Renault, B., and Varela, F. J., Can epileptic crisis be anticipated? Nat. Med. 4:1173–1176, 1998.CrossRef Martinerie, J., Adam, C., Le van Quyen, M., Baulac, M., Renault, B., and Varela, F. J., Can epileptic crisis be anticipated? Nat. Med. 4:1173–1176, 1998.CrossRef
33.
Zurück zum Zitat Kannathal, N., Lim, C. M., Acharya, U. R., and Sadasivan, P. K., Entropies for detection of epilepsy in EEG. Comput. Methods Programs Biomed. 80(3):187–94, 2005.CrossRef Kannathal, N., Lim, C. M., Acharya, U. R., and Sadasivan, P. K., Entropies for detection of epilepsy in EEG. Comput. Methods Programs Biomed. 80(3):187–94, 2005.CrossRef
34.
Zurück zum Zitat Lasemidis, L. D., Shiau, D. S., Sackellares, J. C., Pardalos, P. M., and Prasad, A., Dynamical resetting of the human brain at epileptic seizures: application of nonlinear dynamics and global optimization techniques. IEEE Trans. Biomed. Eng. 51(3):493–506, 2004.CrossRef Lasemidis, L. D., Shiau, D. S., Sackellares, J. C., Pardalos, P. M., and Prasad, A., Dynamical resetting of the human brain at epileptic seizures: application of nonlinear dynamics and global optimization techniques. IEEE Trans. Biomed. Eng. 51(3):493–506, 2004.CrossRef
35.
Zurück zum Zitat Lasemidis, L. D., Pardalos, P., Sackellares, J. C., and Shiau, D., Quadratic binary programming and dynamical system approach to determine the predictability of epileptic seizures. J. Comb. Optim. 5:9–26, 2001.CrossRefMathSciNet Lasemidis, L. D., Pardalos, P., Sackellares, J. C., and Shiau, D., Quadratic binary programming and dynamical system approach to determine the predictability of epileptic seizures. J. Comb. Optim. 5:9–26, 2001.CrossRefMathSciNet
36.
Zurück zum Zitat Nigam, V. P., and Graupe, D., A neural-network-based detection of epilepsy. Neurol. Res. 26(6):55–60, 2004.CrossRef Nigam, V. P., and Graupe, D., A neural-network-based detection of epilepsy. Neurol. Res. 26(6):55–60, 2004.CrossRef
37.
Zurück zum Zitat Srinivasan, V., Eswaran, C., and Sriraam, N., Artificial neural network based epileptic detection using time-domain and frequency domain features. J. Med. Syst. 29(6):647–60, 2005.CrossRef Srinivasan, V., Eswaran, C., and Sriraam, N., Artificial neural network based epileptic detection using time-domain and frequency domain features. J. Med. Syst. 29(6):647–60, 2005.CrossRef
38.
Zurück zum Zitat Kannathal, N., Acharya, U. R., Lim, C. M., and Sadasivan, P. K., Characterization of EEG—a comparative study. Comp. Meth. Prog. Biomed. 80(1):17–23, 2005.CrossRef Kannathal, N., Acharya, U. R., Lim, C. M., and Sadasivan, P. K., Characterization of EEG—a comparative study. Comp. Meth. Prog. Biomed. 80(1):17–23, 2005.CrossRef
39.
Zurück zum Zitat Polat, K., and Guenes, S., Classification of epileptiform EEG using a hybrid systems based on decision tree classifier and fast fourier transform. Appl. Math. Comput. 32(2):625–31, 2007. Polat, K., and Guenes, S., Classification of epileptiform EEG using a hybrid systems based on decision tree classifier and fast fourier transform. Appl. Math. Comput. 32(2):625–31, 2007.
40.
Zurück zum Zitat Subasi, A., Signal classification using wavelet feature extraction and a mixture of expert model. Exp. Syst. Appl. 32(4):1084–93, 2007.CrossRef Subasi, A., Signal classification using wavelet feature extraction and a mixture of expert model. Exp. Syst. Appl. 32(4):1084–93, 2007.CrossRef
41.
Zurück zum Zitat Guler, N. F., Ubey, E. D., and Guler, I., Recurrent neural network employing Lyapunov exponents for EEG signals classification. Exp. Syst. Appl. 29(3):506–14, 2005.CrossRef Guler, N. F., Ubey, E. D., and Guler, I., Recurrent neural network employing Lyapunov exponents for EEG signals classification. Exp. Syst. Appl. 29(3):506–14, 2005.CrossRef
42.
Zurück zum Zitat Sadati, N., Mohseni, H. R., and Magshoudi, A., Epileptic seizure detection using neural fuzzy networks. In: Proc. Of the IEEE International Conference on Fuzzy Syst., 16–21 Jul 2006, Canada, pp. 596–600. Sadati, N., Mohseni, H. R., and Magshoudi, A., Epileptic seizure detection using neural fuzzy networks. In: Proc. Of the IEEE International Conference on Fuzzy Syst., 16–21 Jul 2006, Canada, pp. 596–600.
Metadaten
Titel
Application of Higher Order Spectra to Identify Epileptic EEG
verfasst von
Kuang Chua Chua
V. Chandran
U. Rajendra Acharya
C. M. Lim
Publikationsdatum
01.12.2011
Verlag
Springer US
Erschienen in
Journal of Medical Systems / Ausgabe 6/2011
Print ISSN: 0148-5598
Elektronische ISSN: 1573-689X
DOI
https://doi.org/10.1007/s10916-010-9433-z

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