Erschienen in:
Open Access
01.12.2012 | Poster presentation
Application of tetraspanin CD81 RNAi for diagnosis and therapy of rheumatoid arthritis (RA)
verfasst von:
Tohru Nakanishi, Yuji Arai, Hiroki Mori, Toshihiro Nakajima, Toshikazu Kubo
Erschienen in:
Arthritis Research & Therapy
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Sonderheft 1/2012
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Excerpt
CD81 belomgs to a family of cell-surface protein (tetraspanin) which has four transmembrane domains and two outer-membrane loops.Under the DNA chip analysis, we found several genes highly expressed in rheumatoid arthritis (RA) synoviocytes comparing with the expression in OA or normal synoviocytes. Among these genes, tetraspanin CD81 was shown to be involved in the progression of RA through the promotion of Synoviolin expression.Synoviolin is already known as one of the important progressive elements of RA in synoviocytes. We also showed Synoviolin and CD81 highly distributed in RA tissues. …