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01.08.2014 | Original paper

Application of the Rosner–Wei risk-prediction model to estimate sexual orientation patterns in colon cancer risk in a prospective cohort of US women

verfasst von: S. Bryn Austin, Mathew J. Pazaris, Esther K. Wei, Bernard Rosner, Grace A. Kennedy, Deborah Bowen, Donna Spiegelman

Erschienen in: Cancer Causes & Control | Ausgabe 8/2014

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Abstract

Purpose

We examined whether lesbian and bisexual women may be at greater risk of colon cancer (CC) than heterosexual women.

Methods

Working with a large cohort of US women ages 25–64 years, we analyzed 20 years of prospective data to estimate CC incidence, based on known risk factors by applying the Rosner–Wei CC risk-prediction model. Comparing to heterosexual women, we calculated for lesbian and bisexual women the predicted 1-year incidence rate (IR) per 100,000 person-years and estimated incidence rate ratios (IRR) and 95 % confidence intervals (CI), based on each woman’s comprehensive risk factor profile.

Results

Analyses included 1,373,817 person-years of data from 66,257 women. For each sexual orientation group, mean predicted 1-year CC IR per 100,000 person-years was slightly over 12 cases for each of the sexual orientation groups. After controlling for confounders in fully adjusted models and compared with heterosexuals, no significant differences in IRR were observed for lesbians (IRR 1.01; 95 % CI 0.99, 1.04) or bisexuals (IRR 1.01; 95 % CI 0.98, 1.04).

Conclusions

CC risk is similar across all sexual orientation subgroups, with all groups comparably affected. Health professionals must ensure that prevention, screening, and treatment programs are adequately reaching each of these communities.

Siegel R, Naishadham D, Jemal A (2013) Cancer statistics, 2013. CA Cancer J Clin 63(1):11–30PubMedCrossRef

Boehmer U, Bowen DJ (2009) Examining factors linked to overweight and obesity in women of different sexual orientations. Prev Med 48:357–361PubMedCrossRef

Boehmer U, Bowen DJ, Bauer GR (2007) Overweight and obesity in sexual-minority women: evidence from population-based data. Am J Public Health 97(6):1134–1140PubMedCentralPubMedCrossRef

Boehmer U, Ozonoff A, Timm A (2011) County-level association of sexual minority density with breast cancer incidence: results from an ecological study. Sex Research and Social Policy 8:139–145CrossRef

Bowen D, Boehmer U (2007) The lack of cancer surveillance data on sexual minorities and strategies for change. Cancer Causes Control 18(4):343–349PubMedCrossRef

Case P, Austin SB, Hunter DJ, Manson JE, Malspeis S, Willett WC et al (2004) Sexual orientation, health risk factors, and physical functioning in the Nurses’ Health Study II. J Women’s Health. 13(9):1033–1047CrossRef

Valanis BG, Bowen DJ, Bassford T, Whitlock E, Charney P, Carter RA (2000) Sexual orientation and health: comparisons in the women’s health initiative sample. Arch Fam Med 9(9):843–853PubMedCrossRef

Yancey AK, Cochran SD, Corliss HL, Mays VM (2003) Correlates of overweight and obesity among lesbian and bisexual women. Prev Med 36(6):676–683PubMedCrossRef

Lee JG, Griffin GK, Melvin CL (2009) Tobacco use among sexual minorities in the USA, 1987 to May 2007: a systematic review. Tob Control. 18(4):275–282PubMedCrossRef

10.

Jun H-J, Corliss HL, Nichols LP, Pazaris MJ, Spiegelman D, Austin SB (2012) BMI trajectories throughout adulthood differ by sexual orientation: prospective evidence from the Nurses’ Health Study II. Am J Prev Med 42(4):348–354PubMedCentralPubMedCrossRef

11.

Calzo JP, Roberts AL, Corliss HL, Blood EA, Kroshus E, Austin SB (2014) Physical activity disparities in heterosexual and sexual minority youth ages 12–22 years old: roles of childhood gender nonconformity and athletic self-esteem. Ann Behav Med 47(1):17–27PubMedCrossRef

12.

Brown JP, Tracy JK (2008) Lesbians and cancer: an overlooked health disparity. Cancer Causes Control 19(10):1009–1020PubMedCrossRef

13.

Austin SB, Pazaris MJ, Rosner B, Bowen D, Rich-Edwards J, Spiegelman D (2012) Application of the Rosner-Colditz risk prediction model to estimate sexual orientation group disparities in breast cancer risk in a US cohort of premenopausal women. Cancer Epidemiol Biomark Prev 21:2201–2208CrossRef

14.

Boehmer U, Miao X, Ozonoff A (2011) Cancer survivorship and sexual orientation. Cancer 117:3796–3804PubMedCrossRef

15.

Boehmer U, Ozonoff A, Miao X (2011) An ecological analysis of colorectal cancer incidence and mortality: differences by sexual orientation. BMC Cancer 11:1–8CrossRef

16.

Gail MH, Brinton LA, Byar DP, Corle DK, Green SB, Schairer C et al (1989) Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst 81:1879–1886PubMedCrossRef

17.

Colditz GA, Rosner B (2000) Cumulative risk of breast cancer to age 70 years according to risk factor status: data from the Nurses’ Health Study. Am J Epidemiol 152(10):950–964PubMedCrossRef

18.

Rosner B, Colditz GA (1996) Nurses’ health study: log-incidence mathematical model of breast cancer incidence. J Natl Cancer Inst 88(6):359–364PubMedCrossRef

19.

Spiegelman D, Colditz GA, Hunter DJ, Hertzmark E (1994) Validation of the Gail et al. model for predicting individual breast cancer risk. J Natl Cancer Inst 86:600–607PubMedCrossRef

20.

Dibble SL, Roberts SA, Nussey B (2004) Comparing breast cancer risk between lesbians and their heterosexual sisters. Women’s Health Issues. 14:6068CrossRef

21.

McTiernan A, Kuniyuki A, Yasui Y, Bowen D, Burke W, Culver JB et al (2001) Comparisons of two breast cancer risk estimates in women with a family history of breast cancer. Cancer Epidemiol Biomarkers Prev. 10:333–338PubMed

22.

Brandenburg DL, Matthews AK, Johnson TP, Hughes TL (2007) Breast cancer risk and screening: a comparison of lesbian and heterosexual women. Women Health 45(4):109–130PubMedCrossRef

23.

Wei EK, Colditz GA, Giovannucci E, Fuchs CS, Rosner BA (2009) Cumulative risk of colon cancer to age 70 years by risk factor status using data from the Nurses’ Health Study. Am J Epidemiol 170(7):863–872PubMedCentralPubMedCrossRef

24.

Brigham and Women’s Hospital/Harvard Medical School. Nurses’ Health Study. Boston: Brigham and Women’s Hospital/Harvard Medical School; 2012 [cited 2012 Sept. 5]; http://www.channing.harvard.edu/nhs/

25.

Baer HJ, Colditz GA, Rosner B, Michels KB, Rich-Edwards JW, Hunter DJ et al (2005) Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study. Breast Cancer Res 7(3):R314–R325PubMedCentralPubMedCrossRef

26.

Rimm EB, Stampfer MJ, Colditz GA, Chute CG, Litin LB, Willett W (1990) Validity of self-reported waist and hip circumferences in men and women. Epidemiology. 1:466–473PubMedCrossRef

27.

Troy LM, Hunter DJ, Manson JE, Colditz GA, Stampfer MJ, Willett W (1995) The validity of recalled weight among youner women. Int J Obes Relat Metab Disord 19(8):570–572PubMed

28.

Willett WC, Sampson L, Browne ML, Stampfer MJ, Rosner B, Hennekens CH et al (1988) The use of a self-administered questionnaire to assess diet four years in the past. Am J Epidemiol 127(1):188–199PubMed

29.

Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J et al (1985) Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 122(1):51–65PubMed

30.

Holmes MD, Stampfer MJ, Wolf AM, Jones CP, Spiegelman D, Manson JE et al (1998) Can behavioral risk factors explain the difference in body mass index between African-American and European-American women? Ethn Dis 8(3):331–339PubMed

31.

Hu FB, Stampfer MJ, Rimm E, Ascherio A, Rosner BA, Spiegelman D et al (1999) Dietary fat and coronary heart disease: a comparison of approaches to adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol 149:531–540PubMedCrossRef

32.

Liang K-Y, Zeger SL (1986) Longitudinal data analysis using generalized linear models. Biometrika 73:13–22CrossRef

33.

Cancer of the colon, age-adjusted SEER incidence rates, 2006-2010 [database on the Internet]2013 [cited July 17, 2013]. http://seer.cancer.gov/csr/1975_2010/browse_csr.php?section=6&page=sect_06_table.11.html

34.

Austin SB, Pazaris MJ, Nichols LP, Bowen D, Wei EK, Spiegelman D (2013) An examination of sexual orientation group patterns in mammographic and colorectal screening in a cohort of U.S. women. Cancer Causes Control 24(3):539–547PubMedCentralPubMedCrossRef

Titel: Application of the Rosner–Wei risk-prediction model to estimate sexual orientation patterns in colon cancer risk in a prospective cohort of US women
verfasst von: S. Bryn Austin
Mathew J. Pazaris
Esther K. Wei
Bernard Rosner
Grace A. Kennedy
Deborah Bowen
Donna Spiegelman
Publikationsdatum: 01.08.2014
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 8/2014
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-014-0399-x

Springer Medizin

Application of the Rosner–Wei risk-prediction model to estimate sexual orientation patterns in colon cancer risk in a prospective cohort of US women