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24.08.2018 | ORIGINAL ARTICLE

Arctigenin Ameliorates Inflammation by Regulating Accumulation and Functional Activity of MDSCs in Endotoxin Shock

verfasst von: Hui Shi, Guanjun Dong, Fenglian Yan, Hui Zhang, Chunxia Li, Qun Ma, Junfeng Zhang, Zhaochen Ning, Zhihua Li, Jun Dai, Jiankuo Ming, Runping Fang, Chuanping Si, Huabao Xiong

Erschienen in: Inflammation | Ausgabe 6/2018

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Abstract

Endotoxin shock is a life-threatening response caused by a disordered immune response to an infection. MDSCs are accumulated and play a protective role in the pathogenesis of endotoxin shock. However, the regulation of MDSCs by small molecule remains unrevealed. Here, we report that arctigenin, a small molecule extracted from Arctium lappa, induces accumulation of functional MDSCs. Arctigenin was able to ameliorate LPS-induced inflammation through accumulating MDSCs, especially granulocytic MDSCs (G-MDSCs), and enhancing the immunosuppressive function of MDSCs in vivo and in vitro. Mechanistically, arctigenin promoted the accumulation of MDSCs through upregulating miR-127-5p which targets the 3′UTR of interferon regulatory factor-8 (IRF8) mRNA. In addition, arctigenin enhanced the immunosuppressive activity of MDSCs on M1 macrophage polarization by elevating the expression of arginase 1 (Arg-1) and inducible nitric oxide synthase (iNOS). Our study provides new insights into the regulation of functional MDSCs by arctigenin in exerting immune responses and pathogenesis of inflammatory diseases.

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Titel: Arctigenin Ameliorates Inflammation by Regulating Accumulation and Functional Activity of MDSCs in Endotoxin Shock
verfasst von: Hui Shi
Guanjun Dong
Fenglian Yan
Hui Zhang
Chunxia Li
Qun Ma
Junfeng Zhang
Zhaochen Ning
Zhihua Li
Jun Dai
Jiankuo Ming
Runping Fang
Chuanping Si
Huabao Xiong
Publikationsdatum: 24.08.2018
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 6/2018
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-018-0852-1

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