Erschienen in:
17.12.2018 | ASO Author Reflections
ASO Author Reflections: ARL4C and Peritoneal Dissemination in Gastric Cancer
verfasst von:
Qingjiang Hu, MD, Koshi Mimori, MD, PhD
Erschienen in:
Annals of Surgical Oncology
|
Sonderheft 3/2019
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Excerpt
Gastric cancer (GC) is the leading cause of death by cancer in the world, particularly in East Asia.
1 Peritoneal dissemination (PD), the most frequent metastasis in GC, is incurable. In a clinical study, PD was detected in 14% of GC patients at initial examination, and the median survival period for GC patients with PD averaged only 4 months.
2 According to the Japanese Gastric Cancer Association, the most frequent recurrence pattern of GC is PD in Japan. Although palliative surgery and systemic chemotherapy have improved the prognosis of GC patients with PD, the outcome remains unsatisfactory.
3‐
5 The biomarkers and therapeutic targets for PD still are insufficient. This study identified
ARL4C as a novel PD-associated gene and investigated its biologic and clinical significance in GC. …