Erschienen in:
05.11.2019 | ASO Author Reflections
ASO Author Reflections: Clinical Significance of PD-L1 Expression in Both Cancer and Stroma Cells in Cholangiocarcinoma Patients
verfasst von:
Yuki Kitano, MD, PhD, Hideo Baba, MD, PhD, FACS
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 2/2020
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Excerpt
Programmed death-1 (PD-1) and its ligand (PD-L1) showed promising results as therapeutic targets in various hematologic and solid cancers, in both basic and clinical studies
1,
2. In clinical trials of PD-1/PD-L1 antibodies, an objective response or prolonged disease stabilization were demonstrated in patients with various types of malignancies
3. In contrast, strong expression of the PD-L1 ligand on the surface of cancer cells is associated with poor clinical outcomes in various malignancies. Recently, it was appreciated that PD-L1 expression on stroma cells affects the immunosuppressive tumor microenvironment.
4 Several reports have shown that such stroma cells overexpress PD-L1 themselves, suppressing cytotoxic T lymphocyte function against tumor cells.
5 However, the clinical impact of PD-L1 expression in stroma cells, the relationship between PD-L1 expression in tumor and stroma cells, and how PD-L1 expression affect the immune cell infiltration remain unclear. …
