Erschienen in:
10.08.2020 | ASO Author Reflections
ASO Author Reflections: Location of Microvascular Invasion in Hepatocellular Carcinoma—Intratumoral or Extratumoral Microvascular Invasion
verfasst von:
Hidetoshi Nitta, MD, PhD, René Adam, MD, PhD
Erschienen in:
Annals of Surgical Oncology
|
Sonderheft 3/2020
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Excerpt
Vascular invasion is one of the strongest risk factors for poor prognosis after both hepatic resection (HR) and liver transplantation (LT) for hepatocellular carcinoma (HCC).
1,
2 In the process of cancer cell metastasis, tumor cells initially invade the nearest microvessels, such as small vascular intratumoral spaces, and then disseminate via these microvessels. This leads to the hypothesis that extratumoral microvascular invasion (MVI) is a high risk factor for tumor recurrence. Although there is agreement on defining some forms of MVI, such as tumor emboli in portal radicle veins, large capsule vessels, or vascular spaces lined by endothelial cells, the histological locations of MVI have not been clearly defined. Therefore, we studied the prognostic significance of the degree of intratumoral MVI, extratumoral MVI, and macrovascular invasion.
3 We also established a nomogram for predicting extratumoral MVI, and validated it with two different patient cohorts. …
