Erschienen in:
20.04.2020 | ASO Author Reflections
ASO Author Reflections: Peritumoral Lymphatic Vessels as a Predictor of Response to Chemotherapy and Survival in Esophageal Cancer
verfasst von:
Tomoki Makino, MD, PhD, Takeo Hara, MD, PhD, Yuichiro Doki, MD, PhD
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 10/2020
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Excerpt
Previous studies have investigated the clinical impact of intra-tumoral lymphatic vessel density (LVD) in several types of cancer including esophageal cancer (EC). These studies have reported an induction of intra-tumoral lymphatic vessels (LVs), leading to a greater incidence of lymphovascular invasion, lymph node metastasis,
1,
2 and poorer prognosis.
3,
4 Meanwhile, because LVs maintain oncotic pressure in tissue via drainage and facilitate an immune response against tumors as a communication pathway between tumors and lymph nodes, the authors hypothesized that peritumoral LVs may play biologically more distinct roles in EC than intra-tumoral LVs.
5 Because little is known about the significance of peritumoral LVs in EC, this study
5 aimed to compare peritumoral LVs with non-tumoral LVs in resected specimens from EC and clarify its association with tumor characteristics and response to neoadjuvant chemotherapy (NAC). …
