Erschienen in:
08.07.2020 | ASO Author Reflections
ASO Author Reflections: The Moment That BRAF V600E Mutation Starts Evolving into “Precision Oncosurgery” in Colorectal Liver Metastases
verfasst von:
Shin Kobayashi, MD, PhD, Shinichiro Takahashi, MD, PhD, Takayuki Yoshino, MD, PhD, Hiroya Taniguchi, MD, PhD
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 9/2020
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Excerpt
Hepatectomy is the standard of treatment for technically resectable colorectal liver metastases (CRLM). Numerous studies had tried to stratify the risk of recurrence to optimize a perioperative therapy, among which the clinical risk score (CRS) was established by Fong et al. It was the most notable scoring system with lymph node metastasis, size and number of CRLM, carcinoembryonic antigen level, and disease-free interval before CRLM.
1 Although the CRS was recently modified to incorporate
RAS mutation,
2 no other predictive genomic alteration to change the surgical intervention of CRLM has been established yet. …