Erschienen in:
16.10.2018 | ASO Author Reflections
ASO Author Reflections: The Significance of Tumor Rupture in Gastric Gastrointestinal Stromal Tumors
verfasst von:
Toto Hølmebakk, MD
Erschienen in:
Annals of Surgical Oncology
|
Sonderheft 3/2018
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Excerpt
In 2008, tumor rupture was included as a high-risk feature in the modified National Institutes of Health criteria for localized gastrointestinal stromal tumor (GIST).
1 Based on an analysis of pooled population-based series, rupture has been established as an independent risk factor.
2 However, in that retrospective study, tumor rupture was not predefined, the incidence ranged from 4 to 22% across the series, and certain criteria, e.g. R1 resection and mucosal defects, were inconsistently coded as rupture. A strict definition of tumor rupture has been proposed by the Oslo Sarcoma Group, distinguishing six criteria—termed rupture—from four clinical settings with minor defects of tumor integrity not considered rupture.
3 In an analysis of small intestinal GISTs, rupture according to this definition was independently associated with recurrence on multivariable analysis. Adjuvant imatinib, possibly for life, is currently recommended after rupture, and a clear-cut definition is needed. In the present study, the Oslo definition was applied on a larger cohort of gastric GIST patients. …
