nach oben

Clinical Oral Investigations

Erschienen in:

18.07.2019 | Original Article

Assessment of bone healing after mineral trioxide aggregate and platelet-rich fibrin application in periapical lesions using cone-beam computed tomographic imaging

verfasst von: Nazife Begüm Karan, Banu Aricioğlu

Erschienen in: Clinical Oral Investigations | Ausgabe 2/2020

Einloggen, um Zugang zu erhalten

Abstract

Objectives

The aim of this study was to compare the effects of mineral trioxide aggregate (MTA) and platelet-rich fibrin (PRF) use on periapical healing in surgically treated periapical lesions using three-dimensional (3D) cone-beam computed tomographic (CBCT) imaging.

Materials and methods

A total of 40 periapical lesions undergoing apical surgery were selected between December 2016 and November 2017. The participants were randomly divided into four study groups: control, MTA, PRF, and MTA+PRF. No interventions were made in the control group except root-end resection. Routine radiographs were taken in the 3rd, 6th, and 12th months. The volume and density of periapical lesions at the 1-year follow-up were compared with the pre-op values using the MIMICS software program. Primary healing of the periapical tissues was evaluated, and the outcomes were noted.

Results

Post-op volume values were significantly decreased, and density values were significantly increased according to the pre-op measurements. In the post-op volume evaluation between the groups, significant differences were observed in the MTA and MTA+PRF groups compared with the control group (p < 0.005). However, no substantial significance was noted between the control and PRF groups. There were no significant differences in post-op density calculations between all groups.

Conclusion and clinical relevance

High success rates were achieved using MTA in periapical lesions in endodontic microsurgery. The application of PRF to the surgical cavity may not necessarily improve outcomes. Further studies are needed with long-term follow-up.

Trial registration number:

NCT03743987 (The Effect of MTA and PRF Application in Periapical Lesions).

Siqueira JF (2002) Endodontic infections: concepts, paradigms, and perspectives. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94(3):281–293CrossRef

Chandler N, Koshy S (2002) The changing role of the apicectomy operation in dentistry. Journal-Royal College Of Surgeons Edinburgh 47(5):660–667

von Arx T, AlSaeed M (2011) The use of regenerative techniques in apical surgery: a literature review. Saudi Dent J 23(3):113–127CrossRef

Saxena P, Gupta SK, Newaskar V (2013) Biocompatibility of root-end filling materials: recent update. Restor Dent Endod 38(3):119–127CrossRef

Sauveur G, Sobel M, Boucher Y (2000) Utilization of gutta-percha for retrograde root fillings. Dent Traumatol 16(3):128–131. https://doi.org/10.1034/j.1600-9657.2000.016003128.x CrossRef

Metzger Z, Abramovitz I, Bergenholtz G (2003) Apical periodontitis. Textbook of endodontology. Blackwell, Oxford, England, pp 113–126

Kim S, Kratchman S (2006) Modern endodontic surgery concepts and practice: a review. J Endod 32(7):601–623CrossRef

Ma X, Li C, Jia L, Wang Y, Liu W, Zhou X, Johnson TM, Huang D, Cochrane Oral Health Group (2016) Materials for retrograde filling in root canal therapy. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.cd005517.pub2

Islam I, Chng HK, Yap AUJ (2006) Comparison of the physical and mechanical properties of MTA and Portland cement. J Endod 32(3):193–197CrossRef

10.

Torabinejad M (2014) Mineral trioxide aggregate: properties and clinical applications. Wiley-Blackwell, HobokenCrossRef

11.

Xavier CB et al (2005) Root-end filling materials: apical microleakage and marginal adaptation. J Endod 31(7):539–542CrossRef

12.

Ha WN, Duckmanton P, Kahler B, Walsh LJ (2016) A survey of various endodontic procedures related to mineral trioxide aggregate usage by members of the Australian Society of Endodontology. Aust Endod J 42(3):132–138CrossRef

13.

Kiran N, Mukunda K, Tilak Raj T (2011) Platelet concentrates: a promising innovation in dentistry. J Dental Sci 2(1):50–61

14.

Dohan DM et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101(3):45–50CrossRef

15.

Choukroun J et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101(3):56–60CrossRef

16.

Patel S, Wilson R, Dawood A, Mannocci F (2011) The detection of periapical pathosis using periapical radiography and cone beam computed tomography - part 1: pre-operative status. Int Endod J 45(8):702–710. https://doi.org/10.1111/j.1365-2591.2011.01989.x CrossRefPubMed

17.

Kanagasingam S, Lim CX, Yong CP, Mannocci F, Patel S (2017) Diagnostic accuracy of periapical radiography and cone beam computed tomography in detecting apical periodontitis using histopathological findings as a reference standard. Int Endod J 50(5):417–426CrossRef

18.

de Paula-Silva FW et al (2009) Accuracy of periapical radiography and cone-beam computed tomography scans in diagnosing apical periodontitis using histopathological findings as a gold standard. J Endod 35(7):1009–1012CrossRef

19.

von Arx T, Hänni S, Jensen SS (2007) Correlation of bone defect dimensions with healing outcome one year after apical surgery. J Endod 33(9):1044–1048CrossRef

20.

Goyal B, Tewari S, Duhan J, Sehgal PK (2011) Comparative evaluation of platelet-rich plasma and guided tissue regeneration membrane in the healing of apicomarginal defects: a clinical study. J Endod 37(6):773–780CrossRef

21.

Christiansen R, Kirkevang LL, Hørsted-Bindslev P, Wenzel A (2009) Randomized clinical trial of root-end resection followed by root-end filling with mineral trioxide aggregate or smoothing of the orthograde gutta-percha root filling–1-year follow-up. Int Endod J 42(2):105–114CrossRef

22.

Gupta SK, Saxena P, Pant VA, Pant AB (2013) Adhesion and biologic behavior of human periodontal fibroblast cells to resin ionomer Geristore: a comparative analysis. Dent Traumatol 29(5):389–393CrossRef

23.

Chong B, Pitt Ford T, Hudson M (2003) A prospective clinical study of mineral trioxide aggregate and IRM when used as root-end filling materials in endodontic surgery. Int Endod J 36(8):520–526CrossRef

24.

Lindeboom JA et al (2005) A comparative prospective randomized clinical study of MTA and IRM as root-end filling materials in single-rooted teeth in endodontic surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100(4):495–500CrossRef

25.

Kogan P, He J, Glickman GN, Watanabe I (2006) The effects of various additives on setting properties of MTA. J Endod 32(6):569–572CrossRef

26.

Lee SJ, Wu MK, Wesselink P (2004) The effectiveness of syringe irrigation and ultrasonics to remove debris from simulated irregularities within prepared root canal walls. Int Endod J 37(10):672–678CrossRef

27.

Angerame D, de Biasi M, Kastrioti I, Franco V, Castaldo A, Maglione M (2015) Application of platelet-rich fibrin in endodontic surgery: a pilot study. G Ital Endod 29(2):51–57CrossRef

28.

Singh S, Singh A, Singh S, Singh R (2013) Application of PRF in surgical management of periapical lesions. Natl J Maxillofac Surg 4(1):94–99CrossRef

29.

Dhiman M, Kumar S, Duhan J, Sangwan P, Tewari S (2015) Effect of platelet-rich fibrin on healing of apicomarginal defects: a randomized controlled trial. J Endod 41(7):985–991CrossRef

30.

Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D (2009) Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 80(2):244–252CrossRef

31.

Soffer E, Ouhayoun JP, Anagnostou F (2003) Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95(5):521–528CrossRef

32.

Albanese A, Licata ME, Polizzi B, Campisi G (2013) Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing 10(1):23. https://doi.org/10.1186/1742-4933-10-23 CrossRefPubMedPubMedCentral

33.

Khairy NM, Shendy EE, Askar NA, El-Rouby DH (2013) Effect of platelet rich plasma on bone regeneration in maxillary sinus augmentation (randomized clinical trial). Int J Oral Maxillofac Surg 42(2):249–255. https://doi.org/10.1016/j.ijom.2012.09.009 CrossRefPubMed

34.

Estrela C, Holland R, Estrela CRA, Alencar AHG, Sousa-Neto MD, Pécora JD (2014) Characterization of successful root canal treatment. Braz Dent J 25(1):3–11CrossRef

35.

Liao WC, Lee YL, Tsai YL, Lin HJ, Chang MC, Chang SF, Jeng JH (2018) Outcome assessment of apical surgery: a study of 234 teeth. J Formos Med Assoc 118:1055–1061. https://doi.org/10.1016/j.jfma.2018.10.019 CrossRefPubMed

36.

Schulze D, Heiland M, Thurmann H, Adam G (2004) Radiation exposure during midfacial imaging using 4-and 16-slice computed tomography, cone beam computed tomography systems and conventional radiography. Dentomaxillofac Radiol 33(2):83–86CrossRef

37.

Kaya S, Yavuz İ, Uysal İ, Akkuş Z (2012) Measuring bone density in healing periapical lesions by using cone beam computed tomography: a clinical investigation. J Endod 38(1):28–31CrossRef

38.

Kumar M, Shanavas M, Sidappa A, Kiran M (2015) Cone beam computed tomography – know its secrets. J Int Oral Health 7(2):64–68PubMedPubMedCentral

39.

Patel S, Durack C, Abella F, Shemesh H, Roig M, Lemberg K (2015) Cone beam computed tomography in endodontics - a review. Int Endod J 48:3–15. https://doi.org/10.1111/iej.12270 CrossRefPubMed

40.

Simon JH et al (2006) Differential diagnosis of large periapical lesions using cone-beam computed tomography measurements and biopsy. J Endod 32(9):833–837CrossRef

41.

De Vos W, Casselman J, Swennen G (2009) Cone-beam computerized tomography (CBCT) imaging of the oral and maxillofacial region: a systematic review of the literature. Int J Oral Maxillofac Surg 38(6):609–625CrossRef

42.

von Arx T, Jensen SS, Hänni S, Friedman S (2012) Five-year longitudinal assessment of the prognosis of apical microsurgery. J Endod 38(5):570–579CrossRef

Titel: Assessment of bone healing after mineral trioxide aggregate and platelet-rich fibrin application in periapical lesions using cone-beam computed tomographic imaging
verfasst von: Nazife Begüm Karan
Banu Aricioğlu
Publikationsdatum: 18.07.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 2/2020
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-019-03003-x

Neu im Fachgebiet Zahnmedizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

19.04.2024 Vorhofflimmern Nachrichten

Werden Personen mit Vorhofflimmern in der Blanking-Periode nach einer Katheterablation gegen eine bestehende Parodontitis behandelt, verbessert dies die Erfolgsaussichten. Dafür sprechen die Resultate einer prospektiven Untersuchung.

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

11.04.2024 Endokarditis Nachrichten

Bei welchen Personen eine Antibiotikaprophylaxe zur Prävention einer infektiösen Endokarditis nach invasiven zahnärztlichen Eingriffen sinnvoll ist, wird diskutiert. Neue Daten stehen im Einklang mit den europäischen Leitlinienempfehlungen.

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

08.04.2024 Zahnmedizin Nachrichten

Der Aufbau von Geweben und Organen während der Embryonalentwicklung wird von den Zellen bemerkenswert choreografiert. Für diesen Prozess braucht es spezielle sogenannte „Organisatoren“. In einer aktuellen Veröffentlichung im Fachjournal Nature Cell Biology berichten Forschende durch welchen Vorgang diese Organisatoren im Gewebe entstehen und wie sie dann die Bildung von Zähnen orchestrieren.

Die Oralprophylaxe & Kinderzahnheilkunde umbenannt

11.03.2024 Kinderzahnmedizin Nachrichten

Infolge der Umbenennung der Deutschen Gesellschaft für Kinderzahnheilkunde in Deutsche Gesellschaft für Kinderzahnmedizin (DGKiZ) wird deren Mitgliederzeitschrift Oralprophylaxe & Kinderzahnheilkunde in Oralprophylaxe & Kinderzahnmedizin umbenannt. Aus diesem Grunde trägt die erste Ausgabe in 2024 erstmalig den neuen Titel.

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Abstract

Objectives

Materials and methods

Results

Conclusion and clinical relevance

Trial registration number:

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2020

Quaternary ammonium compound as antimicrobial agent in resin-based sealants

Incidence of complications in secondary alveolar bone grafting of bilateral clefts with premaxillary osteotomy: a retrospective cohort study

How to train periodontal endoscopy? Results of a pilot study removing simulated hard deposits in vitro

Levels of growth factors from platelet-rich fibrin from chronic periodontitis versus periodontally healthy subjects: a pilot study

A randomized clinical trial of class II composite restorations using direct and semidirect techniques

Effect of enamel matrix derivative on wound healing following gingival recession coverage using the modified coronally advanced tunnel and subepithelial connective tissue graft: a randomised, controlled, clinical study

Neu im Fachgebiet Zahnmedizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

Die Oralprophylaxe & Kinderzahnheilkunde umbenannt

Newsletter