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Erschienen in:

21.09.2023 | Review Article

Assessment of comorbid symptoms in pediatric autonomic dysfunction

verfasst von: Sally E. Tarbell, Erin L. Olufs, Philip R. Fischer, Gisela Chelimsky, Mohammed T. Numan, Marvin Medow, Hasan Abdallah, Shelley Ahrens, Jeffrey R. Boris, Ian J. Butler, Thomas C. Chelimsky, Craig Coleby, John E. Fortunato, Raewyn Gavin, Janice Gilden, Renato Gonik, Kelsey Klaas, Lauren Marsillio, Erin Marriott, Laura A. Pace, Paul Pianosi, Pippa Simpson, Julian Stewart, Natalie Van Waning, Debra E. Weese-Mayer

Erschienen in: Clinical Autonomic Research | Ausgabe 6/2023

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Abstract

Purpose

Pediatric patients with autonomic dysfunction and orthostatic intolerance (OI) often present with co-existing symptoms and signs that might or might not directly relate to the autonomic nervous system. Our objective was to identify validated screening instruments to characterize these comorbidities and their impact on youth functioning.

Methods

The Pediatric Assembly of the American Autonomic Society reviewed the current state of practice for identifying symptom comorbidities in youth with OI. The assembly includes physicians, physician-scientists, scientists, advanced practice providers, psychologists, and a statistician with expertise in pediatric disorders of OI. A total of 26 representatives from the various specialties engaged in iterative meetings to: (1) identify and then develop consensus on the symptoms to be assessed, (2) establish committees to review the literature for screening measures by member expertise, and (3) delineate the specific criteria for systematically evaluating the measures and for making measure recommendations by symptom domains.

Results

We review the measures evaluated and recommend one measure per system/concern so that assessment results from unrelated clinical centers are comparable. We have created a repository to apprise investigators of validated, vetted assessment tools to enhance comparisons across cohorts of youth with autonomic dysfunction and OI.

Conclusion

This effort can facilitate collaboration among clinical settings to advance the science and clinical treatment of these youth. This effort is essential to improving management of these vulnerable patients as well as to comparing research findings from different centers.

Low P, Sandroni P, Joyner M, Shen W (2009) Postural tachycardia syndrome (POTS). J Cardiovasc Electrophysiol 20:352–358PubMedPubMedCentralCrossRef

Stewart JM, Boris JR, Chelimsky G, Fischer PR, Fortunato JE, Grubb BP et al (2018) Pediatric disorders of orthostatic intolerance. Pediatrics 141(1):e20171673PubMedCrossRef

Benarroch E (2012) Postural tachycardia syndrome: a heterogeneous and multifactorial disorder. Mayo Clin Proc 87:1214–1225PubMedPubMedCentralCrossRef

El Nemnom P, Lauwerys B, Marot L, Tennstedt D, Dekeuleneer V (2020) Bier anemic spots, cyanosis, and urticaria-like eruption (BASCULE) syndrome: report of two new cases and literature review. Pediatr Dermatol 37:864–867PubMedCrossRef

Garland E, Celedonio J, Raj S (2015) Postural tachycardia syndrome: beyond orthostatic intolerance. Curr Neurol Neurosci Rep 15(9):60PubMedPubMedCentralCrossRef

Ojha A, Chelimsky T, Chelimsky G (2011) Comorbidities in pediatric patients with postural orthostatic tachycardia syndrome. J Pediatr 158:20–23PubMedCrossRef

Thieben M, Sandroni P, Sletten D, Benrud-Larson L, Fealey R, Vernino S et al (2007) Postural orthostatic tachycardia syndrome: the Mayo Clinic experience. Mayo Clin Proc 82:308–313PubMedCrossRef

Cohen LL, La Greca AM, Blount RL, Kazak AE, Holmbeck GN, Lemanek KL (2008) Introduction to special issue: evidence-based assessment in pediatric psychology. J Pediatr Psychol 33:911–915PubMedCrossRef

Sletten DM, Suarez GA, Low PA, Mandrekar J, Singer W (2012) COMPASS 31: a refined and abbreviated Composite Autonomic Symptom Score. Mayo Clin Proc 87:1196–1201PubMedPubMedCentralCrossRef

10.

PROMIS^® (Patient-Reported Outcomes Measurement Information System). https://www.healthmeasures.net/explore-measurement-systems/promis

11.

Hershey AD, Powers SW, Vockell AL, LeCates S, Kabbouche MA, Maynard MK (2001) PedMIDAS: development of a questionnaire to asses disability of migraines in children. Neurology 57:2034–2039PubMedCrossRef

12.

Mara C, Kashikar-Zuck S, Cunningham N, Goldschneider K, Huang B, Dampier C et al (2021) Development and psychometric evaluation of the PROMIS Pediatric Pain Intensity Measure in children and adolescents with chronic pain. J Pain 22:48–56PubMedCrossRef

13.

Di Lorenzo C, Nurko S, Committee PRI (2016) Rome IV functional pediatric gastrointestinal disorders: disorders of gut-brain interaction. In: Drossman D, Chang L, Chey W, Kellow J, Tack J, Whitehead W (eds) Rome Foundation, Raleigh

14.

Russell AC, Stone AL, Wang A, Walker LS (2018) Development and validation of a Nausea Severity Scale for assessment of nausea in children with abdominal pain-related functional gastrointestinal disorders. Children (Basel) 5(6):68PubMed

15.

Walker LS, Greene JW (1991) The functional disability inventory: measuring a neglected dimension of child health status. J Pediatr Psychol 16:39–58PubMedCrossRef

16.

Connor-Smith J, Compas B, Wadsworth M, Thomsen A, Saltzman H (2000) Responses to stress in adolescence: measurement of coping and involuntary stress responses. J Consult Clin Psychol 68:976–992PubMedCrossRef

17.

Suarez G, Opfer-Gehrking T, Offord K, Atkinson E, O’Brien P, Low P (1999) The Autonomic Symptom Profile: a new instrument to assess autonomic symptoms. Neurology 52:523–528PubMedCrossRef

18.

Kaufmann H, Malamut R, Norcliffe-Kaufmann L, Rosa K, Freeman R (2012) The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. Clin Auton Res 22:79–90PubMedCrossRef

19.

Baker J, Paturel JR, Sletten DM, Low PA, Kimpinski K (2020) The Orthostatic Discriminant and Severity Scale (ODSS): an assessment of orthostatic intolerance. Clin Auton Res 30:69–77PubMedCrossRef

20.

McGrath PA, Seifert CE, Speechley KN, Booth JC, Stitt L, Gibson MC (1996) A new analogue scale for assessing children’s pain: an initial validation study. Pain 64:435–443PubMedCrossRef

21.

Hicks CL, von Baeyer CL, Spafford PA, van Korlaar I, Goodenough B (2001) The Faces Pain Scale-Revised: toward a common metric in pediatric pain measurement. Pain 93:173–183PubMedCrossRef

22.

Castarlenas E, Jensen M, von Baeyer C, Miro J (2017) Psychometric properties of the Numerical Rating Scale to assess self-reported pain intensity in children and adolescents: a systematic review. Clin J Pain 33:376–383PubMedCrossRef

23.

Eccleston C, Jordan A, McCracken LM, Sleed M, Connell H, Clinch J (2005) The Bath Adolescent Pain Questionnaire (BAPQ): development and preliminary psychometric evaluation of an instrument to assess the impact of chronic pain on adolescents. Pain 118:263–270PubMedCrossRef

24.

Varni JW, Thompson KL, Hanson V (1987) The Varni/Thompson Pediatric Pain Questionnaire. I. Chronic musculoskeletal pain in juvenile rheumatoid arthritis. Pain 28:27–38PubMedCrossRef

25.

Muth E, Stern R, Thayer J, Koch K (1996) Assessment of the multiple dimensions of nausea: the Nausea Profile (NP). J Psychosom Med 40:511–520CrossRef

26.

Varni J, Bendo C, Denham J, Shulman R, Self M, Neigut D et al (2014) PedsQL gastrointestinal symptoms module: feasibility, reliability, and validity. J Pediatr Gastroenterol Nutr 59:347–355PubMedCrossRef

27.

Baxter AL, Watcha MF, Baxter WV, Leong T, Wyatt MM (2011) Development and validation of a pictorial nausea rating scale for children. Pediatrics 127:e1542–e1549PubMedCrossRef

28.

Banzett RB, O’Donnell CR, Guilfoyle TE, Parshall MB, Schwartzstein RM, Meek PM et al (2015) Multidimensional Dyspnea Profile: an instrument for clinical and laboratory research. Eur Respir J 45:1681–1691PubMedPubMedCentralCrossRef

29.

Khan F, Reddy R, Baptist A (2009) Pediatric dyspnea scale for use in hospitalized patients with asthma. J Allergy Clin Immunol 123:660–664PubMedPubMedCentralCrossRef

30.

McGrath P, Pianosi P, Unruh A, Buckley C (2005) Dalhousie dyspnea scales: construct and content validity of pictoral scales for measuring dyspnea. BMC Pediatr 5:33PubMedPubMedCentralCrossRef

31.

Bockhorn LN, Vera AM, Dong D, Delgado DA, Varner KE, Harris JD (2021) Interrater and intrarater reliability of the Beighton Score: a systematic review. Orthop J Sports Med 9:2325967120968099PubMedPubMedCentralCrossRef

32.

Hakim A, Grahame R (2003) A simple questionnaire to detect hypermobility: an adjunct to the assessment of patients with diffuse musculoskeletal pain. Int J Clin Pract 57:163–166PubMedCrossRef

33.

Birmaher B, Brent DA, Chiappetta L, Bridge J, Monga S, Baugher M (1999) Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a replication study. J Am Acad Child Adolesc Psychiatry 38:1230–1236PubMedCrossRef

34.

Spitzer RL, Kroenke K, Williams JB, Löwe B (2006) A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 166:1092–1097PubMedCrossRef

35.

Spence SH (1998) A measure of anxiety symptoms among children. Behav Res Ther 36:545–566PubMedCrossRef

36.

La Greca A (1999) The Social Anxiety Scales for Children and Adolescents. Behav Ther 22:133–136

37.

Beidel D, Turner S, Morris T (1995) A new inventory to assess childhood social anxiety and phobia: the Social Phobia and Anxiety Inventory for Children. Psychol Assess 7:73–79CrossRef

38.

Spielberger C, Edwards C, Lushene R, Montuori J, Platzek D (1973) State-Trait Anxiety Inventory for Children. Consulting Psychologists Press, Palo Alto

39.

Kovacs M (2015) Children’s Depression Inventory (CDI and CDI 2). https://doi.org/10.1002/9781118625392.wbecp419

40.

Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16:606–613PubMedPubMedCentralCrossRef

41.

Kroenke K, Spitzer RL, Williams JB (2003) The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care 41:1284–1292PubMedCrossRef

42.

Faulstich ME, Carey MP, Ruggiero L, Enyart P, Gresham F (1986) Assessment of depression in childhood and adolescence: an evaluation of the Center for Epidemiological Studies Depression Scale for Children (CES-DC). Am J Psychiatry 143:1024–1027PubMedCrossRef

43.

Laurent J, Catanzaro S, Joiner T Jr, Rudolph K, Potter K, Lambert S et al (1999) A measure of positive and negative affect for children: scale development and preliminary validation. Psychol Assess 11:326–338CrossRef

44.

Palermo TM, Lewandowski AS, Long AC, Burant CJ (2008) Validation of a self-report questionnaire version of the Child Activity Limitations Interview (CALI): The CALI-21. Pain 139:644–652PubMedPubMedCentralCrossRef

45.

Starfield B, Riley A, Green B, Ensminger M, Forrest C, Robertson J et al (1999) Manual for the child health and illness profile: adolescent edition (CHIP-AE). The Johns Hopkins University, Baltimore

46.

Landgraf J, Abetz L, Ware J (1999) The CHQ: a user’s manual (2nd Printing). The Health Institute, New England Medical Center, Boston [No longer in print]. See www.healthactchq.com/survey/chq for CHQ Scoring and Interpretation Manual

47.

Varni JW, Seid M, Rode CA (1999) The PedsQL: measurement model for the pediatric quality of life inventory. Med Care 37:126–139PubMedCrossRef

48.

Edwards TC, Huebner CE, Connell FA, Patrick DL (2002) Adolescent quality of life, part I: conceptual and measurement model. J Adolesc 25:275–286PubMedCrossRef

49.

Patrick DL, Edwards TC, Topolski TD (2002) Adolescent quality of life, part II: initial validation of a new instrument. J Adolesc 25:287–300PubMedCrossRef

50.

Muris P (2001) A brief questionnaire for measuring self-efficacy in youths. J Psychopathol Behav Assess 23:145–149CrossRef

51.

NIH Toolbox. https://www.healthmeasures.net/explore-measurement-systems/nih-toolbox

52.

Drake C, Nickel C, Burduvali E, Roth T, Jefferson C, Pietro B (2003) The pediatric daytime sleepiness scale (PDSS): sleep habits and school outcomes in middle-school children. Sleep 26:455–458PubMed

53.

Spilsbury JC, Drotar D, Rosen CL, Redline S (2007) The Cleveland adolescent sleepiness questionnaire: a new measure to assess excessive daytime sleepiness in adolescents. J Clin Sleep Med 3:603–612PubMedPubMedCentralCrossRef

54.

Spahic J, Hamrefors V, Johansson M, Ricci F, Melander O, Sutton R et al (2023) Malmö POTS symptom score: assessing symptom burden in postural orthostatic tachycardia syndrome. J Intern Med 293:91–99PubMedCrossRef

55.

Rabner J, Kaczynski K, Simons L, Lebel A (2017) The sleep hygiene inventory for pediatrics: development and validation of a new measure of sleep in a sample of children and adolescents with chronic headache. J Child Neurol 32:1040–1046PubMedCrossRef

56.

Owens JA, Spirito A, McGuinn M (2000) The Children’s Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children. Sleep 23:1043–1051PubMedCrossRef

57.

Chervin RD, Hedger K, Dillon JE, Pituch KJ (2000) Pediatric sleep questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems. Sleep Med 1:21–32PubMedCrossRef

58.

Bruni O, Ottaviano S, Guidetti V, Romoli M, Innocenzi M, Cortesi F et al (1996) The Sleep Disturbance Scale for Children (SDSC). Construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence. J Sleep Res 5:251–261PubMedCrossRef

59.

Byars K, Simon S, Peugh J, Beebe D (2017) Validation of a Brief Insomnia Severity Measure in youth clinically referred for sleep evaluation. J Pediatr Psychol 42:466–475PubMed

60.

Lai JS, Nowinski CJ, Zelko F, Wortman K, Burns J, Nordli DR et al (2015) Validation of the Neuro-QoL measurement system in children with epilepsy. Epilepsy Behav 46:209–214PubMedPubMedCentralCrossRef

61.

McGrath PJ, Walco GA, Turk DC, Dworkin RH, Brown MT, Davidson K et al (2008) Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendations. J Pain 9:771–783PubMedCrossRef

62.

Birnie K, Hundert A, Lalloo C, Nguyen C, Stinson J (2019) Recommendations for selection of self-report pain intensity measures in children and adolescents: a systematic review and quality assessment of measurement properties. Pain 160:5–18PubMedCrossRef

63.

Drossman D, Hasler W (2016) Rome IV—functional gastrointestinal disorders: disorders of gut-brain interaction. Gastroenterology 150:1257–1261PubMedCrossRef

64.

Tarbell SE, Shaltout HA, Wagoner AL, Diz DI, Fortunato JE (2014) Relationship among nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained nausea. Exp Brain Res 232:2645–2650PubMedPubMedCentralCrossRef

65.

Wagoner AL, Tarbell SE, Shaltout HA, Diz DI, Weese-Mayer DE, Fortunato JE (2018) Chronic nausea and orthostatic intolerance: diagnostic utility of orthostatic challenge duration, Nausea Profile Questionnaire, and neurohumoral measures. Neurogastroenterol Motil 30:e13433PubMedPubMedCentralCrossRef

66.

Mahler DA, Wells CK (1988) Evaluation of clinical methods for rating dyspnea. Chest 93:580–586PubMedCrossRef

67.

Juul-Kristensen B, Schmedling K, Rombaut L, Lund H, Engelbert RH (2017) Measurement properties of clinical assessment methods for classifying generalized joint hypermobility—a systematic review. Am J Med Genet C Semin Med Genet 175:116–147PubMedCrossRef

68.

Remvig L, Flycht L, Christensen KB, Juul-Kristensen B (2014) Lack of consensus on tests and criteria for generalized joint hypermobility, Ehlers-Danlos syndrome: hypermobile type and joint hypermobility syndrome. Am J Med Genet A 164A:591–596PubMedCrossRef

69.

Gilden J (2017) The most accurate autonomic function test: the medical history. Clin Auton Res 27:209–210PubMedPubMedCentralCrossRef

Titel: Assessment of comorbid symptoms in pediatric autonomic dysfunction
verfasst von: Sally E. Tarbell
Erin L. Olufs
Philip R. Fischer
Gisela Chelimsky
Mohammed T. Numan
Marvin Medow
Hasan Abdallah
Shelley Ahrens
Jeffrey R. Boris
Ian J. Butler
Thomas C. Chelimsky
Craig Coleby
John E. Fortunato
Raewyn Gavin
Janice Gilden
Renato Gonik
Kelsey Klaas
Lauren Marsillio
Erin Marriott
Laura A. Pace
Paul Pianosi
Pippa Simpson
Julian Stewart
Natalie Van Waning
Debra E. Weese-Mayer
Publikationsdatum: 21.09.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Autonomic Research / Ausgabe 6/2023
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-023-00984-4

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Assessment of comorbid symptoms in pediatric autonomic dysfunction