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Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus

verfasst von: Hossein Nazemiyeh, M. Mukhlesur Rahman, Simon Gibbons, Lutfun Nahar, Abbas Delazar, Mohammed-Ali Ghahramani, Amir-Hossein Talebpour, Satyajit D. Sarker

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2008

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Abstract

Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations.

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Titel: Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus
verfasst von: Hossein Nazemiyeh
M. Mukhlesur Rahman
Simon Gibbons
Lutfun Nahar
Abbas Delazar
Mohammed-Ali Ghahramani
Amir-Hossein Talebpour
Satyajit D. Sarker
Publikationsdatum: 01.01.2008
Verlag: Springer-Verlag
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2008
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-007-0194-z

Springer Medizin

Abstract

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