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Medical Oncology

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01.09.2013 | Original Paper

Association analysis between MDR1 genetic variant and breast cancer risk factors in Chinese Han population

verfasst von: Yi Hu, Jingliang Wang, Haitao Tao, Huan Wang, Xin Zhang, Yao Cheng, Ruixin Li

Erschienen in: Medical Oncology | Ausgabe 3/2013

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Abstract

The multidrug resistance 1 gene (MDR1) is an important candidate gene for influencing breast cancer susceptibility. This study aimed to evaluate the association between MDR1 genetic variants and breast cancer susceptibility. A total of 340 breast cancer patients and 348 cancer-free controls were enrolled in this study. The patients’ general characteristics and related risk factors of breast cancer were collected by questionnaires. The c.4125A>C genetic variant was genotyped through created restriction site polymerase chain reaction method. Our data suggest that there are no significant differences in the allelic and genotypic frequencies between breast cancer patients and cancer-free controls. Moreover, the distribution of breast cancer patients’ risk factors is not different among AA, AC, and CC genotypes. These preliminary results suggest that the c.4125A>C genetic variant is not significantly associated with breast cancer susceptibility.

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Titel: Association analysis between MDR1 genetic variant and breast cancer risk factors in Chinese Han population
verfasst von: Yi Hu
Jingliang Wang
Haitao Tao
Huan Wang
Xin Zhang
Yao Cheng
Ruixin Li
Publikationsdatum: 01.09.2013
Verlag: Springer US
Erschienen in: Medical Oncology / Ausgabe 3/2013
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-013-0683-8

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25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Association analysis between MDR1 genetic variant and breast cancer risk factors in Chinese Han population

Abstract

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