Background
Methods
Ethics statement
Subjects
Brachial-ankle pulse wave velocity (baPWV) and ABPI measurement
Definition of normal and abnormal baPWV
Air quality status and analysis
Statistical analysis
Results
Subject characteristics
Characteristic | Studied patients (n = 127) |
---|---|
Age (y) | 58.5 ± 9.9 |
Male sex (%) | 40.9 |
baPWV (cm/s) | 1767.2 ± 651.5 |
DM (%) | 23.6 |
Inradialytic hypotension (%) | 20.5 |
Always hypotension (%) | 3.9 |
HDF (%) | 16.5 |
Hb (g/dL) | 10.5 ± 1.3 |
BUN (mg/dL) | 64.7 ± 15.8 |
Cr (mg/dL) | 10.8 ± 2.4 |
Na (mEq/L) | 139.8 ± 3.1 |
K (mEq/L) | 4.8 ± 0.7 |
Calcium (mg/dL) | 9.8 ± 1.0 |
Phosphorous (mg/dL) | 4.6 ± 1.4 |
Calcium-phosphorous product (mg/dL)2 | 46.0 ± 16.3 |
Alb (g/dL) | 4.1 ± 0.3 |
Total cholesterol (mg/dL) | 185.3 ± 38.6 |
Triglyceride (mg/dL) | 211.86 ± 157.37 |
Ultrafiltration amount per dialysis session (L) | 2.3 ± 1.1 |
SBP (mmHg) | 139.2 ± 27.0 |
ABI | 1.0 ± 0.1 |
TBI | 0.7 ± 0.1 |
Body Mass Index (kg/m2) | 22.6 ± 3.5 |
iPTH (pg/mL) | 191.3 ± 219.2 |
Urea reduction rate | 0.8 ± 0.1 |
Kt/V | 1.8 ± 0.3 |
Net protein catabolic rate (g/day/kg body weight) | 1.2 ± 0.4 |
Aluminum (ng/mL) | 10 ± 8 |
Hemodialysis duration (months) | 72.5 ± 61.8 |
hsCRP (mg/L) | 4.7 ± 6.4 |
NO2 (ppb) | 22.9 ± 3.8 |
CO (ppm) | 0.6 ± 0.2 |
SO2 (ppb) | 6.9 ± 2.1 |
PM10 (ug/m3) | 57.9 ± 5.7 |
PM2.5 (ug/m3) | 31.8 ± 2.8 |
O3 (ppb) | 25.9 ± 2.9 |
NO (ppb) | 10.1 ± 7.8 |
Characteristic | Studied patients (n = 127) | ||
---|---|---|---|
Normal PWV (n = 59) | Abnormal PWV (n = 68) |
P
| |
Age (y) | 56.4 ± 10.9 | 60.3 ± 8.7 | 0.032 |
Male sex (%) | 30.5 | 48.5 | 0.039 |
baPWV (cm/s) | 1247.2 ± 292.0 | 2218.4 ± 528.7 | <0.001 |
DM (%) | 10.2 | 35.3 | 0.001 |
Inradialytic hypotension (%) | 34.5 | 8.8 | <0.001 |
Always hypotension (%) | 8.8 | 0 | 0.013 |
HDF (%) | 18.6 | 14.7 | 0.551 |
Hb (g/dL) | 10.5 ± 1.4 | 10.5 ± 1.3 | 0.744 |
BUN (mg/dL) | 65.0 ± 15.7 | 64.5 ± 16.1 | 0.864 |
Cr (mg/dL) | 11.1 ± 2.1 | 10.6 ± 2.7 | 0.223 |
Na (mEq/L) | 139.6 ± 3.2 | 140.0 ± 3.1 | 0.518 |
K (mEq/L) | 4.8 ± 0.7 | 4.9 ± 0.6 | 0.511 |
Calcium (mg/dL) | 9.7 ± 1.0 | 9.9 ± 1.0 | 0.276 |
Phosphorous (mg/dL) | 4.6 ± 1.5 | 4.6 ± 1.4 | 0.815 |
Calcium-phosphorous product (mg/dL)2 | 46.7 ± 16.5 | 45.4 ± 16.2 | 0.667 |
Alb (g/dL) | 4.0 ± 0.2 | 4.1 ± 0.4 | 0.429 |
Total cholesterol (mg/dL) | 180.5 ± 39.1 | 189.4 ± 38.0 | 0.199 |
Triglyceride (mg/dL) | 195.5 ± 130.0 | 226.1 ± 177.5 | 0.276 |
Ultrafiltration amount per dialysis session (L) | 2.5 ± 1.2 | 2.0 ± 0.9 | 0.017 |
SBP (mmHg) | 129.2 ± 29.3 | 147.9 ± 21.5 | <0.001 |
ABI | 1.00 ± 0.15 | 1.05 ± 0.12 | 0.055 |
TBI | 0.72 ± 0.16 | 0.73 ± 0.15 | 0.545 |
Body Mass Index (kg/m2) | 22.6 ± 3.1 | 22.5 ± 3.4 | 0.916 |
iPTH (pg/mL) | 188.6 ± 201.9 | 193.7 ± 234.6 | 0.898 |
Urea reduction rate | 0.78 ± 0.06 | 0.78 ± 0.06 | 0.747 |
Kt/V | 1.8 ± 0.3 | 1.8 ± 0.4 | 0.655 |
Net protein catabolic rate (g/day/kg body weight) | 1.2 ± 0.4 | 1.2 ± 0.4 | 0.946 |
Al (ng/mL) | 8.8 ± 5.7 | 10.4 ± 8.9 | 0.232 |
Hemodialysis duration (months) | 78.7 ± 67.8 | 67.2 ± 56.0 | 0.298 |
hsCRP (mg/L) | 3.4 ± 3.5 | 5.8 ± 7.7 | 0.023 |
NO2 (ppb) | 22.9 ± 3.6 | 22.9 ± 4.0 | 0.984 |
CO (ppm) | 0.63 ± 0.17 | 0.64 ± 0.22 | 0.890 |
SO2 (ppb) | 6.7 ± 2.0 | 7.2 ± 2.1 | 0.184 |
PM10 (ug/m3) | 57.2 ± 5.4 | 58. ± 5.9 | 0.226 |
PM2.5 (ug/m3) | 31.6 ± 2.9 | 31.9 ± 2.8 | 0.513 |
O3 (ppb) | 25.7 ± 2.8 | 26.0 ± 2.9 | 0.480 |
NO (ppb) | 9.9 ± 4.7 | 10.4 ± 9.8 | 0.707 |
Factors associated with baPWV level in patients undergoing HD
Variable | Unstandardized coefficients | Standardized coefficients |
P value | |
---|---|---|---|---|
B | Std. error | Beta | ||
Univariate | ||||
Fasting glucose (mg/dL) | 2.758 | 0.873 | 0.272 | 0.002 |
Gender (female as reference group) | 330.763 | 114.639 | 0.250 | 0.005 |
Age (y) | 24.567 | 5.426 | 0.375 | <0.001 |
Log Al (ng/mL) | 417.573 | 181.613 | 0.201 | 0.023 |
DM | 447.395 | 130.649 | 0.293 | 0.001 |
Intra-dialytic hypotension | −334.493 | 140.764 | −0.209 | 0.019 |
Log hsCRP (mg/L) | 308.112 | 116.982 | 0.229 | 0.010 |
SO2 (ppb) | 65.722 | 27.617 | 0.208 | 0.019 |
PM10 (ug/m3) | 23.512 | 10.043 | 0.205 | 0.021 |
Heart rate (/min) | 33.727 | 4.647 | 0.545 | <0.001 |
Log triglyceride (mg/dL) | 60.834 | 199.684 | 0.027 | 0.761 |
Hb (g/dL) | 12.615 | 44.066 | 0.026 | 0.775 |
Alb (g/dL) | −76.401 | 179.385 | −0.038 | 0.671 |
Total cholesterol (mg/dL) | −0.373 | 1.510 | −0.022 | 0.805 |
Calcium (mg/dL) | 27.205 | 59.121 | 0.041 | 0.646 |
Phosphorous (mg/dL) | −56.563 | 40.098 | −0.125 | 0.161 |
Calcium-phosphorous product (mg/dL)2 | −5.512 | 3.573 | −0.137 | 0.125 |
Body Mass Index (kg/m2) | 22.999 | 16.460 | 0.124 | 0.165 |
Urea reduction rate | −1100.164 | 999.288 | −0.098 | 0.273 |
Kt/V | −244.671 | 172.193 | −0.127 | 0.158 |
Net protein catabolic rate (g/day/kg body weight) | −197.253 | 156.598 | −0.116 | 0.210 |
Hemodialysis duration (months) | −1.334 | 0.936 | −0.126 | 0.156 |
NO2 (ppb) | −5.595 | 15.351 | −0.033 | 0.716 |
CO (ppm) | −163.429 | 295.340 | −0.050 | 0.581 |
PM2.5 (ug/m3) | 22.878 | 20.493 | 0.099 | 0.266 |
O3 (ppb) | 23.474 | 20.080 | 0.104 | 0.245 |
NO (ppb) | −1.728 | 7.433 | −0.021 | 0.817 |
ARB/ACEi | 246.279 | 173.512 | 0.216 | 0.158 |
CCB | −7.177 | 145.965 | −0.004 | 0.961 |
Beta blocker | 47.806 | 139.934 | 0.031 | 0.733 |
Multivariate | ||||
Heart rate (/min) | 26.849 | 4.775 | 0.433 | <0.001 |
Intra-dialytic hypotension | −317.174 | 112.815 | −0.198 | 0.006 |
Age (y) | 12.615 | 4.978 | 0.193 | 0.013 |
Log Al (ng/mL) | 297.553 | 146.640 | 0.144 | 0.045 |
PM10 (ug/m3) | 17.517 | 8.234 | 0.150 | 0.035 |