Background
Methods
Study identification and selection
Inclusion and exclusion criteria
Data extraction
Statistical analysis
Results
First author | Year | Ethnicity | Numbers | RA/controls (allele) | HWE (P) | ||
---|---|---|---|---|---|---|---|
OA | Controls |
T
|
C
| ||||
Southam et al.a
| 2007 | Caucasian | 349 | 822 | 450/1020 | 248/624 | 0.262 |
Southam et al.a
| 2007 | Caucasian | 274 | 1196 | 340/1441 | 208/951 | 0.550 |
Miyamoto et al.a
| 2007 | Asian | 718 | 861 | 1131/1276 | 305/446 | 0.966 |
Miyamoto et al.b
| 2007 | Asian | 313 | 485 | 491/681 | 135/289 | 0.283 |
Tsezou et al. | 2007 | Caucasian | 251 | 268 | 316/323 | 186/213 | 0.669 |
Valdes et al. | 2009 | Caucasian | 735 | 654 | 987/805 | 483/487 | 0.320 |
Cao et al. | 2010 | Asian | 276 | 298 | 415/431 | 137/165 | 0.360 |
Tawonsawatruk et al. | 2011 | Asian | 103 | 103 | 117/113 | 63/93 | 0.424 |
Mishra et al. | 2013 | Asian | 300 | 300 | 378/328 | 222/272 | 0.188 |
Comparison | Ethnic group | Studies | Sample size | Test of association | Test of heterogeneity | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
OA | Control | OR | 95 % CI |
p value | Model |
Q test |
p value |
I
2 (%) | ||||
Allelic contrast | Overall | 9 | 3319 | 4987 | 0.808 | 0.754 | 0.866 | 0.000 |
R
| 10.12 | 0.698 | 0 |
(T vs C allele) | Caucasian | 4 | 1609 | 2940 | 0.872 | 0.794 | 0.957 | 0.004 | 1.43 | 0.518 | 0 | |
Asian | 5 | 1710 | 2047 | 0.738 | 0.665 | 0.818 | 0.000 | 3.25 | 0.257 | 21 | ||
Dominant model | Overall | 9 | 3319 | 4987 | 0.777 | 0.708 | 0.852 | 0.000 |
F
| 17.1 | 0.029 | 53.2 |
(TC + CC vs TT) | Caucasian | 4 | 1609 | 2940 | 0.853 | 0.749 | 0.972 | 0.017 | 5.99 | 0.112 | 49.9 | |
Asian | 5 | 1710 | 2047 | 0.706 | 0.619 | 0.806 | 0.000 | 7.16 | 0.128 | 44.1 | ||
Recessive model | Overall | 9 | 3319 | 4987 | 0.723 | 0.623 | 0.839 | 0.000 |
R
| 6.66 | 0.574 | 0 |
(CC vs TC + TT) | Caucasian | 4 | 1609 | 2940 | 0.797 | 0.659 | 0.965 | 0.02 | 1.60 | 0.659 | 0 | |
Asian | 5 | 1710 | 2047 | 0.621 | 0.489 | 0.789 | 0.000 | 2.57 | 0.633 | 0 | ||
Additive model | Overall | 9 | 3319 | 4987 | 0.648 | 0.552 | 0.760 | 0.000 |
R
| 5.84 | 0.665 | 0 |
(CC vs TT) | Caucasian | 4 | 1609 | 2940 | 0.754 | 0.613 | 0.927 | 0.007 | 0.15 | 0.986 | 0 | |
Asian | 5 | 1710 | 2047 | 0.518 | 0.402 | 0.668 | 0.000 | 0.69 | 0.953 | 0 | ||
Additive model | Overall | 9 | 3319 | 4987 | 0.801 | 0.685 | 0.936 | 0.005 |
R
| 9.64 | 0.291 | 17 |
(CC vs TC) | Caucasian | 4 | 1609 | 2940 | 0.84 | 0.688 | 1.026 | 0.088 | 4.49 | 0.213 | 33.2 | |
Asian | 5 | 1710 | 2047 | 0.743 | 0.578 | 0.955 | 0.021 | 4.63 | 0.328 | 13.6 |