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Clinical and Experimental Nephrology

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01.10.2010 | Original Article

Association between IGF-1 and chronic kidney disease among US adults

verfasst von: Srinivas Teppala, Anoop Shankar, Charumathi Sabanayagam

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 5/2010

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Abstract

Background

Insulin-like growth factor (IGF-1) has been associated with cardiovascular disease, hypertension and diabetes in previous studies. However, the association between IGF-1 and chronic kidney disease (CKD) has not been previously studied. Therefore, we examined the association between serum IGF-1 and CKD in a representative sample of US adults.

Methods

We conducted a cross-sectional study of 5388 Third National Health and Nutrition Examination Survey (NHANES III) participants aged ≥20 years of age (55.2% women). Serum IGF-1 was categorized into quartiles for the analysis. CKD (n = 241) was defined as an estimated glomerular filtration rate of <60 mL/min/1.73/m².

Results and conclusion

Higher serum IGF-1 levels were positively associated with CKD after adjusting for age, sex, race/ethnicity, education levels, smoking, alcohol intake, body mass index, diabetes, hypertension and serum cholesterol. Compared to quartile 1 of IGF-1 (referent), the odds ratio (95% confidence interval) of CKD associated with quartile 4 was 2.66 (1.18–5.99); p trend = 0.008. Subgroup analysis that examined the relation between IGF-1 and CKD by gender showed a consistent positive association. In summary, increasing levels of serum IGF-1 were positively associated with CKD in a representative sample of US adults. Our results suggest that IGF-1 might be a predictor of CKD in Western populations.

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Titel: Association between IGF-1 and chronic kidney disease among US adults
verfasst von: Srinivas Teppala
Anoop Shankar
Charumathi Sabanayagam
Publikationsdatum: 01.10.2010
Verlag: Springer Japan
Erschienen in: Clinical and Experimental Nephrology / Ausgabe 5/2010
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-010-0307-y

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Abstract

Background

Methods

Results and conclusion

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