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Current Obstetrics and Gynecology Reports
Erschienen in: Current Obstetrics and Gynecology Reports 4/2015

01.12.2015 | Gynecologic Oncology (R Salani, Section Editor)

Association Between Obesity and Clinical Outcomes in Gynecologic Cancer

verfasst von: Lauren Patterson Cobb, Angeles Alvarez Secord

Erschienen in: Current Obstetrics and Gynecology Reports | Ausgabe 4/2015

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Abstract

Obesity is a known risk factor for many cancers, including gynecologic malignancies. While the association between obesity and risk for endometrial cancer is well established, the association with clinical outcomes has been more controversial. Most studies demonstrate an association between obesity and worse all-cause survival in endometrial cancer; however, it is unclear whether this effect is cancer-specific or secondary to comorbid conditions. In ovarian cancer, studies have shown an association between decreased survival and pre-diagnosis obesity, but not obesity at diagnosis. There are also studies that suggest a modest negative association between obesity and survival in women with cervical cancer. Comorbid conditions, lack of screening, and suboptimal chemotherapy dosing in obese women may contribute to decreased survival. Further research is necessary to understand the role of obesity on mortality in gynecologic malignancies in order to improve cancer prevention and therapeutic strategies.
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Metadaten
Titel
Association Between Obesity and Clinical Outcomes in Gynecologic Cancer
verfasst von
Lauren Patterson Cobb
Angeles Alvarez Secord
Publikationsdatum
01.12.2015
Verlag
Springer US
Erschienen in
Current Obstetrics and Gynecology Reports / Ausgabe 4/2015
Elektronische ISSN: 2161-3303
DOI
https://doi.org/10.1007/s13669-015-0131-1

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