Background
Methods
Publication search
Inclusion and exclusion criteria
Data extraction and quality assessment
Statistical analysis
Results
Description of search results
First author | Year | Country/Region | Ethnicity | Cancer type | Genotyping method | Age(y) Case/Control | Control source | Case | Control | HWE | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GG | GC | CC | GG | GC | CC | |||||||||
Chia [15] | 2008 | USA | Mix | TGCT | Taqman | ≤45/≤45 | PB | 332 | 209 | 32 | 395 | 252 | 50 | Y |
Patel [17] | 2008 | USA/Europe | Mix | Breast cancer | Taqman | NR | PB | 434 | 2440 | 3699 | 532 | 3121 | 4819 | Y |
Birmann [18] | 2009 | USA | Caucasian | Multiple myeloma | Taqman | 30–75/30–75 | PB | 9 | 26 | 43 | 11 | 63 | 85 | Y |
Dong [19] | 2011 | USA | Mix | Pancreatic cancer | MassArray and TaqMan | 14–80/14–80 | HB | 385 | 270 | 40 | 409 | 260 | 35 | Y |
Ennishi [20] | 2011 | Japan | Asian | Stomach cancer | Taqman | NR | HB | 230 | 346 | 127 | 447 | 703 | 312 | Y |
Nakao [21] | 2011 | Japan | Asian | Pancreatic cancer | Taqman | 20–79/20–79 | HB | 54 | 95 | 27 | 431 | 673 | 298 | Y |
Qian [22] | 2011 | China | Asian | Breast cancer | Taqman | NR | HB | 147 | 181 | 75 | 135 | 193 | 75 | Y |
Shi [23] | 2016 | Canada | Mix | Breast cancer | Illumina GoldenGate | 40–80/40–80 | PB | 349 | 267 | 25 | 453 | 301 | 52 | Y |
First author | Year | Country/Region | Ethnicity | Cancer type | Genotyping method | Age(y) Case/Control | Control source | Case | Control | HWE | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | AG | GG | AA | AG | GG | |||||||||
Canzian [14] | 2006 | Europe | Caucasian | Breast cancer | Taqman | 35–69/35–69 | PB | 570 | 212 | 19 | 1060 | 446 | 61 | Y |
Chia [15] | 2008 | USA | Mix | TGCT | Taqman | ≤45/≤45 | PB | 408 | 149 | 16 | 492 | 188 | 23 | Y |
Lonn [16] | 2008 | USA | Mix | Brain tumor | Taqman | ≥18/≥18 | HB | 313 | 97 | 10 | 300 | 103 | 9 | Y |
Ennishi [20] | 2011 | Japan | Asian | Stomach cancer | Taqman | NR | HB | 330 | 293 | 80 | 608 | 637 | 217 | N |
Nakao [21] | 2011 | Japan | Asian | Pancreatic cancer | Taqman | 20–79/20–79 | HB | 70 | 87 | 19 | 580 | 613 | 209 | N |
Meta-analysis
Subgroup | No. | Allele model | Homozygote model | Heterozygote model | Dominant model | Recessive model | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR(95% Cl) |
P
OR
|
P
h
| OR(95% Cl) |
P
OR
|
P
h
| OR(95% Cl) |
P
OR
|
P
h
| OR(95% Cl) |
P
OR
|
P
h
| OR(95% Cl) |
P
OR
|
P
h
| ||
rs2195239 | C vs. G | CC vs. GG | GC vs. GG | CC + GC vs. GG | CC vs. GC + GG | |||||||||||
Overall | 8 | 0.97(0.93–1.01) | 0.103 | 0.722 |
0.88(0.80–0.98)
|
0.018
| 0.454 | 1.00 (0.93–1.10) | 0.972 | 0.526 | 0.97(0.90–1.05) | 0.466 | 0.659 | 0.95 (0.90–1.01) | 0.083 | 0.162 |
Asian | 3 |
0.91 (0.82–1.00)
|
0.044
| 0.906 |
0.81 (0.66–0.99)
|
0.035
| 0.731 | 0.96 (0.83–1.12) | 0.616 | 0.534 | 0.92 (0.79–1.06) | 0.232 | 0.831 |
0.83 (0.69–0.98)
|
0.031
| 0.362 |
Breast cancer | 3 | 0.97(0.93–1.02) | 0.282 | 0.939 | 0.91 (0.81–1.03) | 0.152 | 0.294 | 0.99 (0.89–1.10) | 0.866 | 0.238 | 0.97(0.87–1.07) | 0.536 | 0.474 | 0.97(0.91–1.03) | 0.308 | 0.131 |
Pancreatic cancer | 2 | 1.02 (0.89–1.16) | 0.833 | 0.139 | 0.94 (0.67–1.31) | 0.710 | 0.134 | 1.11 (0.92–1.34) | 0.275 | 0.921 | 1.08 (0.91–1.30) | 0.466 | 0.600 | 0.88(0.51–1.51)* | 0.640 | 0.087 |
rs2162679 | G vs. A | GG vs. AA | AG vs. AA | GG + AG vs. AA | GG vs. AG + AA | |||||||||||
Overall | 5 |
0.87 (0.80–0.94)
|
0.001
| 0.693 |
0.70 (0.57–0.87)
|
0.001
| 0.787 | 0.91 (0.82–1.02) | 0.209 | 0.556 |
0.88(0.79–0.97)
|
0.011
| 0.578 |
0.73 (0.60–0.89)
|
0.002
| 0.817 |
Asian | 2 |
0.85 (0.76–0.96)
|
0.007
| 0.302 |
0.70 (0.54–0.90)
|
0.005
| 0.737 | 0.97(0.71–1.33)* | 0.845 | 0.096 | 0.86 (0.74–1.01) | 0.065 | 0.131 |
0.73 (0.57–0.92)
|
0.009
| 0.824 |
Quality score ≥ 12 | 2 |
0.87 (0.77–0.99)
|
0.037
| 0.389 |
0.67 (0.44–1.00)
|
0.049
| 0.385 | 0.91 (0.78–1.06) | 0.225 | 0.629 | 0.88(0.76–1.02) | 0.093 | 0.492 | 0.68 (0.46–1.02) | 0.064 | 0.412 |
Sensitivity analysis
Publication bias
Polymorphism | Genetic model | Egger’s test | ||
---|---|---|---|---|
t | 95% Cl |
P
| ||
rs2195239 | C vs. G | −0.58 | −1.599-0.982 | 0.580 |
CC vs. GG | −1.46 | −2.322~0.586 | 0.194 | |
GC vs. GG | −0.66 | −2.785~1.596 | 0.531 | |
CC + GC vs. GG | −0.76 | −2.581~1.364 | 0.479 | |
CC vs. GC + GG | −1.48 | − 2.177~0.534 | 0.189 | |
rs2162679 | G vs. A | 4.55 | 0.750–4.235 | 0.020 |
GG vs. AA | 1.38 | −1.276~3.225 | 0.262 | |
AG vs. AA | 2.14 | −1.298~6.601 | 0.122 | |
GG + AG vs. AA | 3.28 | 0.088~5.706 | 0.046 | |
GG vs. AG + AA | 0.71 | −1.883~2.973 | 0.527 |