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05.08.2019 | Original Article | Ausgabe 12/2019

European Journal of Nuclear Medicine and Molecular Imaging 12/2019

Association of aortic vascular uptake of 18FDG by PET/CT and aortic wall thickness by MRI in psoriasis: a prospective observational study

Zeitschrift:
European Journal of Nuclear Medicine and Molecular Imaging > Ausgabe 12/2019
Autoren:
Jacob W. Groenendyk, Parag Shukla, Amit K. Dey, Youssef A. Elnabawi, Milena Aksentijevich, Harry Choi, Leonard D. Genovese, Charlotte L. Harrington, Balaji Natarajan, Aditya Goyal, Aarthi S. Reddy, Justin Rodante, Mohammad Tarek Kabbany, Ahmed Sadek, Mina Al Najafi, Martin P. Playford, Aditya A. Joshi, Mark A. Ahlman, Joel M. Gelfand, David A. Bluemke, Nehal N. Mehta
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00259-019-04454-w) contains supplementary material, which is available to authorized users.
This article is part of the Topical Collection on Cardiology

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Abstract

Background

The contribution of inflammation to the incidence of cardiovascular disease (CVD) has been increasingly recognized in recent years. We investigated the relationship of aortic vascular uptake of 18F-FDG by PET/CT and aortic wall thickness (AWT) by MRI in psoriasis, a chronic inflammatory disease with increased incidence of CVD. One hundred sixty-five patients with plaque psoriasis participated in an ongoing longitudinal cohort study. Subclinical atherosclerosis was assessed as aortic uptake of 18F-FDG by PET/CT reported as target-to-background ratio (TBR) and AWT by MRI reported as maximal thickness.

Results

Patients with psoriasis were middle aged, predominantly male, and had mild CV risk by traditional risk factors. Psoriasis severity as measured by PASI score was a notable determinant of AWT (ρ = 0.20, p = 0.01). Moreover, aortic vascular uptake of 18F-FDG associated with AWT by MRI at baseline in unadjusted analysis (β = 0.27 p = 0.001) and following adjustment for traditional cardiovascular risk factors, waist-to-hip ratio, and statin use (β = 0.21 p = 0.01). Finally, following 1 year of psoriasis treatment, a decrease in aortic vascular uptake of 18F-FDG was associated with a reduction in AWT in fully adjusted models (β = 0.33, p = 0.02).

Conclusion

In conclusion, we demonstrate that psoriasis severity and aortic vascular uptake of 18F-FDG in the aorta were associated with AWT. Following treatment of psoriasis, a decrease in aortic vascular uptake of 18F-FDG was associated with a reduction in AWT at 1 year. These findings suggest that aortic vascular uptake of 18F-FDG is associated with early evidence of vascular disease assessed by aortic wall thickness. Prospective studies in larger populations including other inflammatory diseases are warranted.

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