Cleft lip and/or palate is among the most prevalent congenital birth defects, and negatively affects maternal psychological status and may consequently result in higher prevalence of child maltreatment. However, the association of childbirths of infants with cleft lip and/or palate with maternal emotional involvement still remains unclear. We examined the association between childbirths of infants with cleft lip and/or palate and mother-to-infant bonding, using data from the Japan Environment and Children’s Study, a nationwide birth cohort study.
Methods
A cross-sectional study using the jecs-an-20,180,131 dataset was performed. A total 104,065 fetuses in 15 regional centres in Japan were enrolled after obtaining informed written consent. The Mother-to-Infant Bonding Scale, a self-report scale consisting of 10 items, was used to evaluate maternal bonding at one year after childbirth. Finally, the participants consisted of 79,140 mother-infant pairs, of which 211 mothers of infants with cleft lip and/or palate were included in our analyses. Multivariable logistic regression analysis using multiple imputation for missing data was performed to calculate the odds ratio and 95% confidence interval in the estimation of the association between bonding disorders and childbirths with cleft lip and/or palate.
Results
No increased risk of bonding disorders was observed among all the mothers of infants with cleft lip and/or palate (odds ratio [95% confidence interval]; 0.97 [0.63–1.48], p = 0.880), however, advanced maternal age or multiple parity may adversely affect the associations between bonding disorders and cleft lip and/or palate, respectively. After stratification with a combination of maternal age and parity, a significant association of cleft lip and/or palate with bonding disorders was found only among advanced-age multiparae (odds ratio [95% confidence interval] = 2.51 [1.17–5.37], p = 0.018), but it was weakened after additional adjustment for maternal depression.
Conclusions
Childbirths of infants with cleft lip and/or palate may increase the risk of bonding disorders among advanced-age multiparae, possibly through maternal depression. This finding provides valuable information for the provision of multidisciplinary cleft care.
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Abkürzungen
CI
Confidence interval
CL ± P
Cleft lip with or without cleft palate
CL/P
Cleft lip and/or cleft palate
CP
Isolated cleft palate
IQR
Interquartile range
JECS
Japan Environment and Children’s Study
K6
Kessler Psychological Distress Scale scores
MIBS
Mother-to-Infant Bonding Scale
OR
Odds ratio
SD
Standard deviation
Background
Cleft lip and/or cleft palate (CL/P), namely cleft lip with or without cleft palate (CL ± P), and isolated cleft palate (CP) are among the most common birth defects and happen at a rate of approximately 1 in 700 births [1]. A nationwide survey in Japan showed that the prevalence of CL/P per 10,000 births was in a range of 14.4–24.8 [1‐3], which is higher than the global prevalence. CL/P can be repaired with craniofacial plastic surgeries [2, 4]; however, parents of infants with CL/P generally suffer from parenting and/or caregiving issues as a result of lower infant weight gain due to difficulties in direct breastfeeding and higher risk for upper respiratory infection [5‐7]. Mothers of infants with CL/P reportedly tend to show negative moods such as depression and anxiety [8, 9]. Johns et al. found a higher tendency of postpartum depression among older mothers of infants with CL/P [9].
Importantly, Van Horne et al. reported that children with CL/P have higher prevalence rates (7.62% as cumulative probability) of child maltreatment in the U.S. state of Texas, compared with children with congenital diseases such as Down syndrome and spina bifida (approximately 5%) [10]. Most of this maltreatment was in the form of supervisory neglect (about 70%); however, a significantly higher risk of medical neglect was also observed [10, 11]. Boztepe et al. also indicated that, in comparison with congenital heart disease, cleft lip was more likely to adversely affect maternal emotional connection toward the infant possibly due to the visual aspects of the condition [12]. Indeed, there is increasing evidence suggesting potential impairments of infant-maternal relationships among children with CL/P [13‐15]. However, the association of childbirths of infants with CL/P on maternal emotional involvement toward infants still remains unclear.
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Attachment theory, proposed by Bowlby consists of bidirectional interactions in mother-infant dyads for making children feel secure [16]. In distinction to the infant’s feelings of the attachment, maternal affectionate feelings toward the infant during the perinatal period has been referred to as “mother-to-infant bonding” [17‐19]. Bonding disorders, less maternal affection and behaviour toward the infant, have been acknowledged as predictors of impairment in infant development due to child maltreatment [18‐21]. Recently, the Mother-to-Infant Bonding Scale (MIBS), which is based on Kumar’s Mother-Infant Bonding Questionnaire [17], has been used for quantitative screening of bonding disorders in mother-infant dyads among the general population [22]. Recent cohort studies, including longitudinal studies, have provided increasingly more evidence [19, 23]. Brockington et al. found that bonding disorders were diagnosed in 29% of mothers with maternal postpartum depression. Indeed, as associated with lifestyle behaviours (drinking and smoking habits) [24], the parity status impacts mother-to-infant bonding because of more requirements regarding maternal attention, especially when a new infant with congenital diseases arrives [25, 26]. Thus, the parity status would confound mother-to-infant bonding with CL/P. Taken together, a better understanding the antecedents of maternal bonding issues after giving birth to a child with CL/P will promote developments in multidisciplinary cleft care.
The aim of this study was to investigate the influence of childbirths of infants with CL/P on bonding disorders using a large-scale sample of the Japan Environment and Children’s Study (JECS), a nationwide, multicentre, prospective birth cohort in Japan and the MIBS.
Methods
Study design and participants
The present study is based on the jecs-an-20,180,131 dataset, which was released in March 2018. In brief, pregnant women in their first trimester were recruited at the first prenatal examination in cooperating hospitals or at local government offices from January 2011 until March 2014. After obtaining informed written consent, participants completed self-administered and medical records/transcripts, and subsequently underwent clinical measurements by medical doctors and trained nurses. To confirm the health status, check-up for both mother and infant was conducted at delivery and one month later. We enrolled 104,065 fetuses in 15 regional centres in JECS. In the fixed data of the JECS, 3921 were miscarriages, stillbirths, and unknown; 1889 were multiple births. Among the 98,255 mother-infant pairs, 10,045 pairs did not reply to the questionnaire sent out at one year after childbirth, and 9070 pairs with other congenital disease(s) without CL/P were excluded from the analysis. A final sample size of 79,140 mother-infant pairs was included in this study (Fig. 1).
Fig. 1
Flow chart of the study participants. MIBS = Mother-to-Infant Bonding Scale
×
Prevalence of CL/P (exposure measure)
The data on CL/P and other congenital anomalies were ascertained from medical records/transcripts, which were filled by a doctor, a midwife, a nurses or a trained research coordinator at delivery and at one month of age onto JECS transcription forms [3, 27, 28]. The details of data processing, validation, and verification with regards to congenital anomalies were previously described [3]. There are three types of CL/P: cleft lip, cleft palate, or cleft lip with palate. A checkbox for each type was listed on the transcription form. A tick was entered into the corresponding checkbox when any interests of CL/P were observed. Using the fixed JECS dataset, Mezawa et al. reported that total prevalence rates of CL/P per 10,000 births was 24.8 [3].
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Furthermore, to examine the influence of visibility of CL/P on the mother-to-infant bonding, the mothers of infants with CL/P were divided into two groups: (1) CL ± P group (mothers of infants with cleft lip with or without cleft palate) and (2) CP group (mothers of infants with isolated cleft palate) as a group with less visible issues.
The MIBS is a self-report scale consisting of 10 items with responses based on a four-point scale (from 0 to 3), and is used to evaluate mother-to-infant bonding at one year after childbirth. The total score ranges from 0 to 30, and higher scores indicate worse mother-to-infant bonding. The MIBS had been translated into Japanese and validated in a previous study [22]. Cronbach’s alpha of the MIBS for the current sample was 0.73. Because the optimal cut-off score is 4/5 [18], the presence of bonding disorders in mother-infant dyads was defined as ≥5 in this study.
Covariates
In addition to maternal smoking during pregnancy, maternal drinking habits during pregnancy was assessed with a self-administered questionnaire [29]. Maternal age at delivery, parity, and infant sex were ascertained from medical records/transcripts filled by doctors, midwifes, nurses, or trained research coordinators. In a follow-up questionnaire after childbirth, participants also reported feeding pattern and Kessler Psychological Distress Scale scores (K6) at one year after childbirth. The design of the questionnaire has been previously described in detail [27, 28, 30].
Using the data from self-administered and medical records/transcripts, an advanced-age mother was defined as ≥35 years old [31]. In addition, participants were categorized into the following groups by parity (‘primipara’ or ‘multipara’). Smoking status was divided into three categories: ‘never’, ‘stopped smoking before or during pregnancy’, or ‘current smoking’. Alcohol consumption was divided into three categories: ‘never’, ‘stopped drinking’, or ‘current drinking’. Categories for infant sex were ‘male’ or ‘female’, and categories for feeding pattern were ‘breastfeeding’, ‘formula’, or ‘mixed’.
Statistical analysis
Continuous variables were presented as medians with interquartile ranges, and categorical variables were presented as numbers and percentages (Table 1). With regard to missing data, we applied the ‘missing at random’ assumption, and used multiple imputation with the multivariate normal imputation method [32]. The numbers of participants with missing data in each of the variables are shown in Additional file 1: Table S1. An imputation model including all variables were independently applied for 10 copies of the data, each with missing values suitably imputed. Estimates of the variables were averaged to compute a single mean estimate and adjusted standard errors using Rubin’s rule [33]. We performed crude and multivariate logistic regression analyses using the hierarchical multiple regression model for potential covariates to examine the association of bonding disorders with the prevalence of CL/P within each subgroup. These analyses were performed after adjustment for potential confounding factors, including maternal smoking and drinking habits, feeding pattern, and infant sex (model 1). All parameters in model 1 plus maternal depression (model 2) were included. The OR and 95% CI were calculated for bonding disorders. The results of the multiple imputation analyses are shown in Tables 2 and 3. All statistical analyses were performed using SPSS (version 24.0; IBM Corp., Armonk, NY, USA). In the analysis of the data, P values < 0.05 were considered statistically significant.
Table 1
Basic characteristics of participating mothers
maternal age
< 35
≥35
parity
primiparae
multiparae
primiparae
multiparae
Healthy
CL/P
Healthy
CL/P
Healthy
CL/P
Healthy
CL/P
(n = 25,628)
(n = 71)
(n = 31,693)
(n = 85)
(n = 6536)
(n = 18)
(n = 15,072)
(n = 37)
Age, Median (IQR)
28 (26, 31)
28 (25.7, 31)
30 (28, 32)
30 (27, 33)
37 (36, 39)
37.5 (36, 40)
37 (36, 39)
37 (35.5, 38)
MIBS score, Mean (SD)
2.23 (2.38)
1.75 (1.90)
1.74 (2.20)
2.02 (2.69)
2.21 (2.41)
2.14 (2.57)
1.74 (2.21)
3.08 (3.85)
Bonding disorders (≥5)
3528 (13.8)
5 (7.0)
3104 (9.8)
9 (10.6)
895 (13.7)
3 (16.7)
1503 (10.0)
9 (24.3)
K6 score, Mean (SD)
2.85 (3.63)
3.30 (4.24)
2.86 (3.75)
2.95 (4.15)
2.63 (3.34)
2.22 (2.71)
2.62 (3.39)
3.26 (4.57)
Depression (≥13)
715 (2.8)
2 (2.8)
955 (3.0)
3 (3.5)
128 (2.0)
0 (0)
299 (2.0)
3 (8.1)
Smoking habit, n (%)
Never
15,988 (62.4)
41 (57.7)
17,665 (55.7)
50 (58.8)
3983 (61.0)
12 (66.7)
9153 (60.7)
24 (64.9)
Stopped
8735 (34.1)
27 (38.0)
12,418 (39.2)
30 (35.3)
2379 (36.4)
6 (33.3)
5311 (35.2)
12 (32.4)
Smoking
905 (3.5)
3 (4.2)
1610 (5.1)
5 (5.9)
174 (2.7)
0 (0)
608 (4.0)
1 (2.7)
Alcohol intake, n (%)
Never
8332 (32.5)
26 (36.6)
11,906 (37.6)
31 (36.5)
2009 (30.7)
7 (38.9)
5200 (34.5)
15 (40.5)
Stopped
15,373 (60.0)
42 (59.2)
16,643 (52.5)
43 (50.6)
3894 (59.6)
11 (61.1)
7719 (51.2)
20 (54.1)
Drinking
1923 (7.5)
3 (4.2)
3144 (9.9)
11 (12.9)
633 (9.7)
0 (0)
2153 (14.3)
2 (5.4)
sex, n (%)
Male
12,957 (50.6)
38 (53.5)
16,076 (50.7)
48 (56.5)
3359 (51.4)
11 (61.1)
7809 (51.8)
20 (54.1)
Female
12,671 (49.4)
33 (46.5)
15,617 (49.3)
37 (43.5)
3177 (48.6)
7 (38.9)
7263 (48.2)
17 (45.9)
Feeding pattern, n (%)
Breast
7442 (29.0)
5 (7.0)
11,932 (37.6)
17 (20.0)
1220 (18.7)
0 (0)
5346 (35.5)
5 (13.5)
Mixed
17,670 (68.9)
53 (74.6)
19,008 (60.0)
62 (72.9)
5146 (78.7)
17 (94.4)
9344 (62.0)
26 (70.3)
Formula
516 (2.0)
13 (18.3)
753 (2.4)
6 (7.1)
170 (2.7)
1 (5.6)
382 (2.5)
6 (16.2)
Table 2
Association of bonding disorders with the prevalence of CL/P
< 35, Primiparae,
Healthy (n = 25,628)
CL/P (n = 71)
p value
Bonding disorders, n (%)
3,528 (13.8)
5 (7.0)
Crude
1.00
0.51 (0.21-1.26)
0.146
Model 1a
1.00
0.44 (0.18-1.09)
0.076
Model 2b
1.00
0.44 (0.18-1.12)
0.085
< 35, Multiparae
Healthy (n = 31,693)
CL/P (n = 85)
p value
Bonding disorders, n (%)
3,104 (9.8)
9 (10.1)
Crude
1.00
1.11 (0.55-2.23)
0.780
Model 1a
1.00
1.03 (0.51-2.07)
0.946
Model 2b
1.00
1.03 (0.50-2.10)
0.941
≥ 35, Primiparae
Healthy (n = 6,536)
CL/P (n = 18)
p value
Bonding disorders, n (%)
895 (13.7)
3 (16.7)
Crude
1.00
1.26 (0.67-2.38)
0.714
Model 1a
1.00
1.14 (0.61-2.15)
0.836
Model 2b
1.00
1.24 (0.66-2.33)
0.739
≥ 35, Multiparae
Healthy (n = 15,072)
CL/P (n = 37)
p value
Bonding disorders, n (%)
1,503 (10.0)
9 (24.3)
Crude
1.00
2.90 (1.58-5.34)
0.006
Model 1a
1.00
2.51 (1.17-5.37)
0.018
Model 2b
1.00
2.18 (0.96-4.95)
0.062
Odds ratio (95% confidence interval) (all such values) for bonding disorders were compered with the reference participants
aAdjusted for maternal factors (smoking and drinking habits, feeding pattern, and infant sex)
bAdditionally adjusted for maternal depression with Model 1
P values representing significant differences (<0.05) are indicated in bold
Table 3
Association of bonding disorders with the prevalence of cleft lip among advanced-age multiparae
≥35, Multiparae
Healthy (n = 15,072)
CL ± P (n = 29)
p value
CP (n = 8)
p value
Bonding Disorders, n (%)
1503 (10.0)
7 (24.1)
2 (25.0)
Crude
1.00
2.87 (1.86–4.44)
0.015
3.01 (1.33–6.81)
0.178
Model 1a
1.00
2.56 (1.07–6.10)
0.033
2.36 (0.46–11.95)
0.308
Model 2b
1.00
2.31 (0.93–5.73)
0.072
1.76 (0.28–10.93)
0.545
Odds ratio (95% confidence interval) (all such values) for bonding disorders were compared with the reference participants
aAdjusted for maternal factors (smoking and drinking habits, feeding pattern, and infant sex)
bAdditionally adjusted for maternal depression with Model 1
P values representing significant differences (< 0.05) are indicated in bold
Results
Participants’ baseline characteristics
The median age of the participants was 31 years (interquartile range: 28–35 years), and the mean MIBS and K6 scores were 1.94 (standard deviation [SD]: 2.29) and 2.79 (SD: 3.61), respectively (Additional file 1: Table S1). The total numbers (%) of infants born with cleft lip with or without palate or isolated cleft palate in the present study were 64 (0.08), 90 (0.11), and 57 (0.07), respectively. Interestingly, the mean maternal MIBS scores (SD) of dyads with infants with CL/P were similar to those of the healthy infants (2.13 [2.72] vs. 1.94 [2.29] in Additional file 1: Table S1), but only advanced-age multiparae with infants with CL/P at birth showed higher MIBS scores (SD) compared with healthy infants (3.08 [3.85] vs. 1.74 [2.21]) as well as prevalence of maternal depression (8.1% vs. 2.0%), as shown in Table 1.
Association between bonding disorders and CL/P
No risk of bonding disorders was observed among all the mothers with infants with CL/P (odds ratio [OR] [95% confidence interval (CI)] = 0.97 [0.63–1.48], p = 0.880). After simple stratification by advanced maternal age or parity (Additional file 2: Table S2), ORs of association between bonding disorders and CL/P in multivariate logistic regression analyses tended to be decreased in mothers aged < 35 (OR [95% CI] = 0.71 [0.40–1.24], p = 0.222) or primiparae (OR [95% CI] = 0.58 [0.28–1.22], p = 0.152), while they tended to be increased in mothers aged ≥35 (OR [95% CI] = 1.81 [0.91–3.61], p = 0.086) or multiparae (OR [95% CI] = 1.39 [0.82–2.35], p = 0.222). Thus, the dataset was used after stratification with a combination of maternal age and parity. The characteristics of participants after stratification are shown in Table 1.
In multivariate logistic regression analysis using the imputed dataset, the adjusted ORs (95% CI) for bonding disorders of mothers of infants with CL/P in each group are summarized in Table 2. Compared with the reference participants with healthy infants, analyses without adjustments (crude model) or adjusted for all covariates except for maternal depression (model 1) revealed that the prevalence of bonding disorders was significantly associated with having an infant with CL/P only in the advanced-age multiparae group (OR [95% CI] = 2.51 [1.17–5.37], p = 0.018), but not in the other groups (OR [95% CI]: 0.44 [0.18–1.09], p = 0.076 in younger primiparae; 1.03 [0.51–2.07], p = 0.946 in younger multiparae; and 1.14 [0.61–2.15], p = 0.836 in advanced-age primiparae, respectively, in Table 2). However, additional adjustment for maternal depression (model 2) weakened the statistical association and resulted in no significance between bonding disorders and CL/P among advanced-age multiparae (OR [95% CI] = 2.18 [0.96–4.95], p = 0.062). Interestingly, though not significant, CL/P tended to be negatively associated with bonding disorders only among young primiparae (OR [95% CI] = 0.44 [0.18–1.12], p = 0.085). Furthermore, analyses of the complete dataset (n = 75,361), excluding cases with missing values, also indicated significant association between bonding disorders and CL/P in crude model (OR [95% CI]; 2.39 [1.04–5.51], p = 0.040), but not in other models as shown in Additional file 3: Table S3. There were no significant interaction terms in the model between advanced maternal age and parity.
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Association between bonding disorders and cleft lip prevalence
With respect to the association of bonding disorders with the visibility of cleft lip, the prevalence of bonding disorders among advanced-age multiparae was significantly associated with CL ± P in the crude model (OR [95% CI]; 2.87 [1.86–4.44], p = 0.015) or model 1 (OR [95% CI]; 2.56 [1.07–6.10], p = 0.033), but not in adjusted model for all covariates (OR [95% CI]; 2.31 [0.93–5.73], p = 0.072) as shown in Table 3. CP, a group with less visible issues than CL ± P did not also have any significant association with bonding disorders (OR [95% CI]; 1.76 [0.28–10.93], p = 0.545). In addition, there were no significant associations between bonding disorders with CL ± P or CP in the other three groups (younger primiparae, younger multiparae. or advanced-age primiparae).
Discussion
Our present results using the nationwide data from a large-scale birth cohort study in Japan showed no significant association between maternal bonding disorders and CL/P among all the participants (OR [95% CI]; 0.97 [0.63–1.48], p = 0.880). However, our finding revealing the significant association of CL/P with maternal bonding disorders among advanced-age multiparae may serve as valuable information for multidisciplinary cleft care providers in terms of the practical benefits of the MIBS in screening for maternal bonding issues.
To the best of our knowledge, this is the first report showing the association of CL/P with mother-to-infant bonding, though only among advanced-age multiparae. Maternal depression, which has been acknowledged as a predictor for bonding disorders [23, 24], statistically impacts the association of maternal bonding disorders with CL/P, because mothers of infants with CL/P are generally troubled with more parenting and/or caregiving issues with regard to feeding and breathing developments [5‐7]. Furthermore, because the visual impacts of cleft lip possibly influence the processing of maternal-to-infant bonding as suggested by Boztepe et al. [12], we focused on whether the prevalence of cleft lip was associated with bonding disorders among advanced-age multiparae. Consequently, the significant association of bonding disorders with prevalence of CL ± P did not remain after the adjustment using all covariates (OR [95% CI] = 2.31 [0.93–5.73], p = 0.072). This finding may be due to the smaller sample size of mothers having infants with CL/P. Further examination of the confounding effects by visibility of cleft lip in future studies with the appropriate design is warranted.
Our results indicated that the association between bonding disorders and CL/P strongly varies according to parity and maternal age at delivery. Similar to the increasing trends of advanced maternal age and multiple parity on the association between bonding disorders and CL/P (Additional file 2: Table S2), their combined stratification showed a significant association between bonding disorders and CL/P among advanced-age multiparae. A review of relevant studies indicated that the impacts of advanced maternal age and/or parity on mother-to-infant bonding are under some debate; however, several studies have reported adverse effects of older maternal age and multiparity on mother-to-infant bonding [34‐37]. Older mothers generally experience a more severe delivery and have more issues regarding parenting due to physical and psychological limitations [38, 39]. Meanwhile, as shown in our results (Table 1), multiparity generally contributes to better mother-to-infant bonding [40, 41]. Therefore, we speculated that the significant association CL/P and bonding disorders among between multiparous mothers may be related to the presence of healthy siblings. It should be noted that the recurrence rate of nonsyndromic CL/P among siblings is reportedly low, 3.2–9.1% [42, 43]. Similarly, Van Horne et al. reported that child maltreatment among children with CL/P increases as the number of siblings increases [11]. Tanimura et al., using nationwide data in Japan, pointed out that sibling comparison by parents (potentially including caregiving with congenital anomalies) may be a common risk factor for child maltreatment [44]. Differences in caregiving among siblings adversely impact maternal feelings and behaviours toward infants with CL/P, whose care typically involves more daily-life stressors [45], and may lead to maternal bonding issues. In order to further examine these findings, careful longitudinal observations among mothers of infants with CL/P are necessary because there may be potential impacts on the children’s development with CL/P from maternal feelings and/or behaviours, even when the mother is giving birth to a new healthy sibling.
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This study has several strengths and limitations. Since the Japanese nationwide survey covered approximately 45% of infants born in multi-subject area during 2013, our results, mostly based on the Japanese general population, allowed us to compare the experimental participants with abundant controls [27]. In terms of study limitations, first, this was a cross-sectional study using a one-time measurement of mother-to-infant bonding as the outcome. Future longitudinal studies with more appropriate designs that consider episodes of child maltreatment are warranted. Second, this study’s data collection methods did not include a query about antenatal diagnosis and/or screening. Johns et al. suggested that receiving antenatal diagnosis decreases maternal depressive symptoms among mothers of infants with CL/P [9]. Thus, our findings may be limited because the possibility of artificial abortion related to congenital anomaly after antenatal diagnosis as a selection bias cannot be ruled out.
Conclusions
This cross-sectional study using Japanese nationwide data indicated that mothers of infants with CL/P had similar rates of bonding disorders as the general population; however, advanced-age multiparae had a significantly higher risk of bonding disorders, and the MIBS may be useful in understanding antecedents of their bonding issues.
We would like to express our gratitude to all of the JECS study participants and to the JECS staff members for conducting the procedure and helping with the data analysis.
The 2019 members of JECS were as follows: Members of the JECS (principal investigator, Michihiro Kamijima) as of 2019: Shin Yamazaki (National Institute for Environmental Studies, Tsukuba, Japan), Yukihiro Ohya (National Center for Child Health and Development, Tokyo, Japan), Reiko Kishi (Hokkaido University, Sapporo, Japan), Nobuo Yaegashi (Tohoku University, Sendai, Japan), Koichi Hashimoto (Fukushima Medical University, Fukushima, Japan), Chisato Mori (Chiba University, Chiba, Japan), Shuichi Ito (Yokohama City University, Yokohama, Japan), Zentaro Yamagata (University of Yamanashi, Chuo, Japan), Hidekuni Inadera (University of Toyama, Toyama, Japan), Michihiro Kamijima (Nagoya City University, Nagoya, Japan), Takeo Nakayama (Kyoto University, Kyoto, Japan), Hiroyasu Iso (Osaka University, Suita, Japan), Masayuki Shima (Hyogo College of Medicine, Nishinomiya, Japan), Youichi Kurozawa (Tottori University, Yonago, Japan), Narufumi Suganuma (Kochi University, Nankoku, Japan), Koichi Kusuhara (University of Occupational and Environmental Health, Kitakyushu, Japan), and Takahiko Katoh (Kumamoto University, Kumamoto, Japan).
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Ethics approval and consent to participate
This study was conducted in accordance with the World Medical Association Declaration of Helsinki. The JECS protocol was approved by the Ministry of the Environment’s Institutional Review Board on Epidemiological Studies (no. 100406001), and approved by the ethics committees of all participating institutions (i.e., Asahikawa Medical College, Chiba University, Doshisha University, Fukushima Medical University, Hokkaido University, Hyogo College of Medicine, Japanese Red Cross Hokkaido College of Nursing, Kochi University, Kumamoto University, Kyoto University, Kyushu University, Nagoya City University, NCCHD, NIES, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka University, Sapporo Medical University, Shinshu University, Tohoku University, Tottori University, University of Occupational and Environmental Health, University of Miyazaki, University of the Ryukyu, University of Toyama, University of Yamanashi, and Yokohama City University). Written informed consent was obtained from all participants. The present study was conducted as a part of JECS and used anonymized data; hence, additional approval from the ethics committee was not required.
Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
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Persistieren Sinusitisbeschwerden bei Kindern länger als zehn Tage, ist eine Antibiotikatherapie häufig gut wirksam: Ein Therapieversagen ist damit zu über 40% seltener zu beobachten als unter Placebo.
Wenn Kinder an Werktagen zum Arzt gehen, werden neu auftretender Typ-1-Diabetes und diabetische Ketoazidosen häufiger erkannt als bei Arztbesuchen an Wochenenden oder Feiertagen.
Augentropfen mit niedrig dosiertem Atropin können helfen, das Fortschreiten einer Kurzsichtigkeit bei Kindern zumindest zu verlangsamen, wie die Ergebnisse einer aktuellen Studie mit verschiedenen Dosierungen zeigen.
Seit 2021 ist die Untersuchung auf spinale Muskelatrophie Teil des Neugeborenen-Screenings in Deutschland. Eine Studie liefert weitere Evidenz für den Nutzen der Maßnahme.
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