Erschienen in:
Open Access
01.12.2012 | Poster presentation
Association of microRNA-221/222 and -323-3p with rheumatoid arthritis via predictions using the human TNF transgenic mouse model
verfasst von:
Ioannis Pandis, Caroline Ospelt, Niki Karagianni, Maria Denis, Martin Reczko, Carme Camps, Artemis Hatzigeorgiou, Jiannis Ragoussis, Steffen Gay, George Kollias
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 1/2012
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Excerpt
MicroRNAs (miRs), a class of small non-coding RNA molecules, act as posttranscriptional regulators and are involved in a plethora of cellular functions. miRs have attracted a great deal of attention as potential therapeutic targets, as the sequence-specific mode in which they act, allows the simultaneous targeting of multiple target genes, often members of the same biological pathway(s) [
1]. Previous studies have demonstrated that miRs are dysregulated and functionally involved in rheumatoid arthritis (RA) [
2‐
9]. In this study we sought to identify novel miR associations in synovial fibroblasts (SFs), a key pathogenic cell type in RA [
10,
11], by performing miR expression profiling on cells isolated from the human TNF transgenic mouse model (TghuTNF, Tg197) [
12] and patients biopsies. …
