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Magnetic Resonance Materials in Physics, Biology and Medicine

Erschienen in:

01.08.2014 | Research Article

Association of white matter deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized VBM study using 3T

verfasst von: Li Yao, Su Lui, Wei Deng, Min Wu, Lizhou Chen, Yuan Xiao, Sunima Lama, Wenjing Zhang, Xiaoqi Huang, Tao Li, Qiyong Gong

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 4/2014

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Abstract

Object

To examine the whole brain white matter morphology in antipsychotic-naive patients with first-episode schizophrenia (FES) and its correlations with symptom severity.

Materials and methods

High-resolution T1-weighted images of 64 drug-naive FES patients and 64 matched healthy controls were acquired using a 3 T MR imaging system. Then, optimized voxel-based morphometry was performed to compare the group differences. Finally, correlation analyses were conducted between the white matter volume (WMV) changes and clinical symptoms.

Results

The FES showed significantly decreased WMV in the bilateral posterior limb of the internal capsule (PLIC) and right subgyral frontal white matter. The volume of the bilateral PLIC was negatively correlated with the Positive and Negative Syndrome Scale positive scores. Positive correlations were observed between all of the changed WMV measures and the Global Assessment of Functioning scores.

Conclusion

The current findings provide further evidence to support internal capsule and subgyral frontal white matter deficits at the early stage of schizophrenia that are potentially related to the core pathophysiology of the disease. Furthermore, these anatomical alterations were related to the clinical symptoms but not the untreated illness duration, suggesting that these deficits are related to aberrations in the neurodevelopmental process and may be relatively stable during the early course of schizophrenia.

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Titel: Association of white matter deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized VBM study using 3T
verfasst von: Li Yao
Su Lui
Wei Deng
Min Wu
Lizhou Chen
Yuan Xiao
Sunima Lama
Wenjing Zhang
Xiaoqi Huang
Tao Li
Qiyong Gong
Publikationsdatum: 01.08.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 4/2014
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-013-0411-6

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Association of white matter deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized VBM study using 3T