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Erschienen in:

16.07.2019 | Concise Research Report

Associations of Diabetes Genetic Risk Counseling with Incident Diabetes and Weight: 5-Year Follow-up of a Randomized Controlled Trial

verfasst von: Sridharan Raghavan, MD, PhD, Kerui Xu, PhD, MPH, Cynthia J. Coffman, PhD, Samantha Pabich, MD, David Edelman, MD, Corrine I. Voils, PhD

Erschienen in: Journal of General Internal Medicine | Ausgabe 3/2020

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Excerpt

Despite advances in understanding the genetics of type 2 diabetes (T2D), the benefits of precision medicine—better disease risk prediction and individually tailored prevention or treatment—remain aspirational. While patients have reported that genetic risk information would motivate preventive health behavior change,^{1, 2} this has not been borne out in short-term studies of genetic risk counseling.^{3, 4} The adoption of risk-modifying behaviors may be delayed as patients accumulate T2D risk factors and learn behavior change skills. We report the 5-year follow-up results of a randomized genetic risk counseling intervention on incident T2D and weight in a population of adults with elevated diabetes risk. …

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Vassy JL, Donelan K, Hivert MF, Green RC, Grant RW. Genetic susceptibility testing for chronic disease and intention for behavior change in healthy young adults. J Community Genet 2013; 4: 263–271.CrossRef

Wang C, Gordon ES, Norkunas T, et al. A randomized trial examining the impact of communicating genetic and lifestyle risks for obesity. Obesity. 2016; 24: 2481–2490.CrossRef

Voils CI, Coffman CJ, Grubber JM, et al. Does type 2 diabetes genetic testing and counseling reduce modifiable risk factors? A randomized controlled trial of Veterans. J Gen Intern Med 2015; 30: 1591–1598.CrossRef

Hollands GJ, French DP, Griffin SJ, et al. The impact of communicating genetic risks of disease on risk-reducing health behavior: systematic review with meta-analysis. BMJ. 2016; 352: i1102.CrossRef

Maciejewski ML, Arterburn DE, Van Scoyoc L, et al. Bariatric surgery and long-term durability of weight loss. JAMA Surg 2016; 15: 1046–1055.CrossRef

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Titel: Associations of Diabetes Genetic Risk Counseling with Incident Diabetes and Weight: 5-Year Follow-up of a Randomized Controlled Trial
verfasst von: Sridharan Raghavan, MD, PhD
Kerui Xu, PhD, MPH
Cynthia J. Coffman, PhD
Samantha Pabich, MD
David Edelman, MD
Corrine I. Voils, PhD
Publikationsdatum: 16.07.2019
Verlag: Springer US
Erschienen in: Journal of General Internal Medicine / Ausgabe 3/2020
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI: https://doi.org/10.1007/s11606-019-05126-z

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Associations of Diabetes Genetic Risk Counseling with Incident Diabetes and Weight: 5-Year Follow-up of a Randomized Controlled Trial

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