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01.01.2012 | Original paper

Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica

verfasst von: Maria D. Jackson, Susan P. Walker, Candace M. Simpson-Smith, Carole M. Lindsay, Garret Smith, Norma McFarlane-Anderson, Franklyn I. Bennett, Kathleen C. M. Coard, William D. Aiken, Trevor Tulloch, Tomlin J. Paul, Robert L. Wan

Erschienen in: Cancer Causes & Control | Ausgabe 1/2012

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Abstract

Objective

To investigate the association of whole-blood fatty acids and reported intakes of fats with risk of prostate cancer (PCa).

Design

Case–control study of 209 men 40–80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men attending the same urology clinics. Whole-blood fatty acid composition (mol%) was measured by gas chromatography and diet assessed by food frequency questionnaire.

Results

High whole-blood oleic acid composition (tertile 3 vs. tertile 1: OR, 0.37; CI, 0.14–0.0.98) and moderate palmitic acid proportions (tertile 2: OR, 0.29; CI, 0.12–0.70) (tertile 3: OR, 0.53; CI, 0.19–1.54) were inversely related to risk of PCa, whereas men with high linolenic acid proportions were at increased likelihood of PCa (tertile 3 vs. tertile 1: OR, 2.06; 1.29–3.27). Blood myristic, stearic and palmitoleic acids were not associated with PCa. Higher intakes of dietary MUFA were inversely related to prostate cancer (tertile 3 vs. tertile 1: OR, 0.39; CI 0.16–0.92). The principal source of dietary MUFA was avocado intake. Dietary intakes of other fats were not associated with PCa.

Conclusions

Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes. High blood linolenic acid was directly related to prostate cancer. These associations warrant further investigation.

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Titel: Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica
verfasst von: Maria D. Jackson
Susan P. Walker
Candace M. Simpson-Smith
Carole M. Lindsay
Garret Smith
Norma McFarlane-Anderson
Franklyn I. Bennett
Kathleen C. M. Coard
William D. Aiken
Trevor Tulloch
Tomlin J. Paul
Robert L. Wan
Publikationsdatum: 01.01.2012
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 1/2012
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-011-9850-4

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Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica