Skip to main content
Erschienen in: Pneumo News 6/2019

17.10.2019 | Asthma bronchiale | fortbildung

Neue Agenzien und Anwendungsgebiete

Die blühende Zukunft der Immuntherapie bei Allergien

verfasst von: Dr. Ina Haasler, Prof. Dr. Christian Taube

Erschienen in: Pneumo News | Ausgabe 6/2019

Einloggen, um Zugang zu erhalten

Zusammenfassung

Bei der Allergen-Immuntherapie (AIT) rührt sich was. Es sind inzwischen neue Therapeutika verfügbar, etwa Antikörper, rekombinante Proteine oder Peptide, die nur 13 bis 17 Aminosäuren lang sind. Auch verschiedene neue sublinguale Therapien stehen bereit. Zudem ist es nun möglich, Nahrungsmittelallergien durch frühzeitige Induktion der oralen Toleranz in der Säuglingszeit vorzubeugen.
Literatur
1.
Zurück zum Zitat Pfaar O, Demoly P, Gerth van Wijk R et al. Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy. 2014;69(7):854–67CrossRef Pfaar O, Demoly P, Gerth van Wijk R et al. Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy. 2014;69(7):854–67CrossRef
2.
Zurück zum Zitat Demoly P, Emminger W, Rehm D et al. Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: Results from a randomized, double-blind, placebo-controlled phase III trial. J Allergy Clin Immunol. 2016;137(2):444–51.e8CrossRef Demoly P, Emminger W, Rehm D et al. Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: Results from a randomized, double-blind, placebo-controlled phase III trial. J Allergy Clin Immunol. 2016;137(2):444–51.e8CrossRef
3.
Zurück zum Zitat Durham SR, Yang WH et al. Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2006;117(4):802–9CrossRef Durham SR, Yang WH et al. Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2006;117(4):802–9CrossRef
4.
Zurück zum Zitat Maloney J, Bernstein DI, Nelson H et al. Efficacy and safety of grass sublingual immunotherapy tablet, MK-7243: a large randomized controlled trial. Ann Allergy Asthma Immunol. 2014;112(2):146–53.e2CrossRef Maloney J, Bernstein DI, Nelson H et al. Efficacy and safety of grass sublingual immunotherapy tablet, MK-7243: a large randomized controlled trial. Ann Allergy Asthma Immunol. 2014;112(2):146–53.e2CrossRef
5.
Zurück zum Zitat Biedermann T, Kuna P, Panzner P et al. The SQ tree SLIT-tablet is highly effective and well tolerated: Results from a randomized, double-blind, placebo-controlled phase III trial. J Allergy Clin Immunol. 2019;143(3):1058–66.e6CrossRef Biedermann T, Kuna P, Panzner P et al. The SQ tree SLIT-tablet is highly effective and well tolerated: Results from a randomized, double-blind, placebo-controlled phase III trial. J Allergy Clin Immunol. 2019;143(3):1058–66.e6CrossRef
6.
Zurück zum Zitat Couroux P, Patel D, Armstrong K et al. Fel d 1-derived synthetic peptide immuno-regulatory epitopes show a long-term treatment effect in cat allergic subjects. Clin Exp Allergy. 2015;45(5):974–81CrossRef Couroux P, Patel D, Armstrong K et al. Fel d 1-derived synthetic peptide immuno-regulatory epitopes show a long-term treatment effect in cat allergic subjects. Clin Exp Allergy. 2015;45(5):974–81CrossRef
7.
Zurück zum Zitat Klimek L, Pfaar O, Worm M. New opportunities for allergen immunotherapy using synthetic peptide immuno-regulatory epitopes (SPIREs). Expert Rev Clin Immunol. 2016;12(10):1123–35CrossRef Klimek L, Pfaar O, Worm M. New opportunities for allergen immunotherapy using synthetic peptide immuno-regulatory epitopes (SPIREs). Expert Rev Clin Immunol. 2016;12(10):1123–35CrossRef
8.
Zurück zum Zitat Worm M, Patel D, Creticos PS. Cat peptide antigen desensitisation for treating cat allergic rhinoconjunctivitis. Expert Opin Investig Drugs. 2013;22(10):1347–57CrossRef Worm M, Patel D, Creticos PS. Cat peptide antigen desensitisation for treating cat allergic rhinoconjunctivitis. Expert Opin Investig Drugs. 2013;22(10):1347–57CrossRef
9.
Zurück zum Zitat Abramson MJ, Puy RM, Weiner JM. Injection allergen immunotherapy for asthma. Cochrane Database Syst Rev. 2010(8):Cd001186 Abramson MJ, Puy RM, Weiner JM. Injection allergen immunotherapy for asthma. Cochrane Database Syst Rev. 2010(8):Cd001186
10.
Zurück zum Zitat Mosbech H, Deckelmann R, de Blay F et al. Standardized quality (SQ) house dust mite sublingual immunotherapy tablet (ALK) reduces inhaled corticosteroid use while maintaining asthma control: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol. 2014;134(3):568–75.e7CrossRef Mosbech H, Deckelmann R, de Blay F et al. Standardized quality (SQ) house dust mite sublingual immunotherapy tablet (ALK) reduces inhaled corticosteroid use while maintaining asthma control: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol. 2014;134(3):568–75.e7CrossRef
11.
Zurück zum Zitat de Blay F, Kuna P, Prieto L et al. SQ HDM SLIT-tablet (ALK) in treatment of asthma—post hoc results from a randomised trial. Respir Med. 2014;108(10):1430–7CrossRef de Blay F, Kuna P, Prieto L et al. SQ HDM SLIT-tablet (ALK) in treatment of asthma—post hoc results from a randomised trial. Respir Med. 2014;108(10):1430–7CrossRef
12.
Zurück zum Zitat Virchow JC, Backer V, Kuna P et al. Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma: A Randomized Clinical Trial. JAMA. 2016;315(16):1715–25CrossRef Virchow JC, Backer V, Kuna P et al. Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma: A Randomized Clinical Trial. JAMA. 2016;315(16):1715–25CrossRef
13.
Zurück zum Zitat Agache I, Lau S, Akdis CA et al. EAACI Guidelines on Allergen Immunotherapy: House dust mite-driven allergic asthma. Allergy. 2019;74(5):855–73CrossRef Agache I, Lau S, Akdis CA et al. EAACI Guidelines on Allergen Immunotherapy: House dust mite-driven allergic asthma. Allergy. 2019;74(5):855–73CrossRef
14.
Zurück zum Zitat Gupta RS, Springston EE, Warrier MR et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011;128(1):e9–17CrossRef Gupta RS, Springston EE, Warrier MR et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011;128(1):e9–17CrossRef
15.
Zurück zum Zitat Venter C, Maslin K, Patil V et al. The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart. Pediatr Allergy Immunol. 2016;27(8):804–11CrossRef Venter C, Maslin K, Patil V et al. The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart. Pediatr Allergy Immunol. 2016;27(8):804–11CrossRef
16.
Zurück zum Zitat Chinthrajah RS, Hernandez JD, Boyd SD et al. Molecular and cellular mechanisms of food allergy and food tolerance. J Allergy Clin Immunol. 2016;137(4):984–97CrossRef Chinthrajah RS, Hernandez JD, Boyd SD et al. Molecular and cellular mechanisms of food allergy and food tolerance. J Allergy Clin Immunol. 2016;137(4):984–97CrossRef
17.
Zurück zum Zitat Kim KS, Hong SW, Han D et al. Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine. Science. 2016;351(6275):858–63CrossRef Kim KS, Hong SW, Han D et al. Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine. Science. 2016;351(6275):858–63CrossRef
18.
Zurück zum Zitat Du Toit G, Roberts G, Sayre PH et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015;372(9):803–13CrossRef Du Toit G, Roberts G, Sayre PH et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015;372(9):803–13CrossRef
19.
Zurück zum Zitat Valovirta E, Petersen TH, Piotrowska T et al. Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy. J Allergy Clin Immunol. 2018;141(2):529–38.e13CrossRef Valovirta E, Petersen TH, Piotrowska T et al. Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy. J Allergy Clin Immunol. 2018;141(2):529–38.e13CrossRef
20.
Zurück zum Zitat Humbert M, Beasley R, Ayres J et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy. 2005;60(3):309–16CrossRef Humbert M, Beasley R, Ayres J et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy. 2005;60(3):309–16CrossRef
21.
Zurück zum Zitat Brandstrom J, Vetander M, Lilja G et al. Individually dosed omalizumab: an effective treatment for severe peanut allergy. Clin Exp Allergy. 2017;47(4):540–50CrossRef Brandstrom J, Vetander M, Lilja G et al. Individually dosed omalizumab: an effective treatment for severe peanut allergy. Clin Exp Allergy. 2017;47(4):540–50CrossRef
22.
Zurück zum Zitat Tsabouri S, Tseretopoulou X, Priftis K, Ntzani EE. Omalizumab for the treatment of inadequately controlled allergic rhinitis: a systematic review and meta-analysis of randomized clinical trials. J Allergy Clin Immunol Pract. 2014;2(3):332–40.e1CrossRef Tsabouri S, Tseretopoulou X, Priftis K, Ntzani EE. Omalizumab for the treatment of inadequately controlled allergic rhinitis: a systematic review and meta-analysis of randomized clinical trials. J Allergy Clin Immunol Pract. 2014;2(3):332–40.e1CrossRef
24.
Zurück zum Zitat Ryan D, Gerth van Wijk R, Angier E et al. Challenges in the implementation of the EAACI AIT guidelines: A situational analysis of current provision of allergen immunotherapy. Allergy. 2018;73(4):827–36CrossRef Ryan D, Gerth van Wijk R, Angier E et al. Challenges in the implementation of the EAACI AIT guidelines: A situational analysis of current provision of allergen immunotherapy. Allergy. 2018;73(4):827–36CrossRef
Metadaten
Titel
Neue Agenzien und Anwendungsgebiete
Die blühende Zukunft der Immuntherapie bei Allergien
verfasst von
Dr. Ina Haasler
Prof. Dr. Christian Taube
Publikationsdatum
17.10.2019
Verlag
Springer Medizin
Erschienen in
Pneumo News / Ausgabe 6/2019
Print ISSN: 1865-5467
Elektronische ISSN: 2199-3866
DOI
https://doi.org/10.1007/s15033-019-1286-7

Weitere Artikel der Ausgabe 6/2019

Pneumo News 6/2019 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.