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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 2/2014

01.06.2014 | Biomechanics (M Silva and P Zysset, Section Editors)

Atypical Femoral Fractures, Bisphosphonates, and Mechanical Stress

verfasst von: Per Aspenberg, Jörg Schilcher

Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2014

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Abstract

Atypical fractures are stress fractures occurring in the femoral shaft and closely related to bisphosphonate use. We here discuss their radiographic definition and different putative etiologies, apart from mechanical stress. Long time reduction of skeletal remodeling because of bisphosphonate use is thought to allow time for the bone to deteriorate mechanically, resulting in reduced toughness. However, the risk of atypical fracture diminishes rapidly after cessation of treatment, which suggests more acute effects of bisphosphonate use. Microdamage normally accumulates at areas of high stress. Possibly, ongoing bisphosphonate use reduces the ability to resorb and replace areas of microdamage by targeted remodeling. This could lead to crack propagation beyond a point of no return, ending in macroscopic stress fracture.
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Metadaten
Titel
Atypical Femoral Fractures, Bisphosphonates, and Mechanical Stress
verfasst von
Per Aspenberg
Jörg Schilcher
Publikationsdatum
01.06.2014
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 2/2014
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-014-0200-9

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