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16.04.2021 | Neurology • Original Article

Augmentation in patients with restless legs syndrome receiving pramipexole therapy: a retrospective study in a single center from China

verfasst von: Tiantian Wang, Miaofa Ying, Rui Zhao, Danyan Zhu, Lisan Zhang

Erschienen in: Sleep and Breathing | Ausgabe 1/2022

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Abstract

Purpose

Augmentation is a major complication of long-term pramipexole treatment of restless legs syndrome (RLS). However, there have been no studies on augmentation in Chinese patients with RLS. We therefore investigated the clinical characteristics of augmentation in RLS patients treated with pramipexole in a real-world Chinese setting.

Methods

This study was an observational, retrospective assessment of 103 patients with RLS, who had been continuously treated with pramipexole for at least one month between January 2016 and December 2018 in a tertiary hospital in East China. Demographic data and disease and drug treatment information were collected from electronic medical records and telephone interviews to analyze the rate and clinical features of augmentation. Augmentation was confirmed by Max Planck Institute criteria. Comparisons were made between patients with and without augmentation.

Results

Fifteen patients (15%) were classified as having augmentation. Compared to RLS patients without augmentation, more patients with augmentation switched from other dopaminergic drugs (P<0.05) and had a longer duration of RLS symptoms before pramipexole treatment (P<0.05). In addition, patients with augmentation had a longer duration (P<0.05) and higher dosage (P<0.05) of pramipexole than those without augmentation. Augmentation was possibly associated with pramipexole tolerance (P<0.01).

Conclusion

The augmentation rate of the Chinese RLS patients in our study was 15%. Augmentation may be associated with switching from other dopaminergic drugs, long disease duration before pramipexole use, the dose and duration of pramipexole, and tolerance to pramipexole.

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Titel: Augmentation in patients with restless legs syndrome receiving pramipexole therapy: a retrospective study in a single center from China
verfasst von: Tiantian Wang
Miaofa Ying
Rui Zhao
Danyan Zhu
Lisan Zhang
Publikationsdatum: 16.04.2021
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 1/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02353-9

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