nach oben

Clinical Reviews in Allergy & Immunology

Erschienen in:

26.07.2018

Autoimmunity in 2017

verfasst von: Carlo Selmi

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Abstract

The number of peer-reviewed articles published during the 2017 solar year and retrieved using the “autoimmunity” key word increased significantly compared to 2016 while maintaining a stable share within the immunology field, following years with alternated fortunes. A detailed arbitrary analysis of the published articles in leading immunology and autoimmunity journals provides a privileged viewpoint on the current trends of research from both basic and clinical studies. Indeed, we are observing that major steps forward are found for rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, among others. In particular, the new data on pregnancy success in lupus or biomarkers in systemic sclerosis are believed to change our management of these systemic conditions. In the case of rheumatoid arthritis, we have obtained data with significant implications in the understanding of the disease pathogenesis (as in the case of platelets), disease phenotyping, and new treatment options. Furthermore, the exponential growth of treatment options for cancer based on immune checkpoint modulation is paralleled by the need to address the potential autoimmunity side effects while taking advantage of new information obtained in paraneoplastic autoimmune conditions. Cumulatively, 2017 has been a very exciting year for autoimmune diseases, and we foresee that most of the data discussed herein will be followed by more extensive studies in the upcoming months.

Anquetil F, Sabouri S, Thivolet C, Rodriguez-Calvo T, Zapardiel-Gonzalo J, Amirian N, Schneider D, Castillo E, Lajevardi Y, von Herrath MG (2017) Alpha cells, the main source of IL-1beta in human pancreas. J Autoimmun 81:68–73PubMedPubMedCentral

Hull CM, Nickolay LE, Estorninho M, Richardson MW, Riley JL, Peakman M, Maher J, Tree TIM (2017) Generation of human islet-specific regulatory T cells by TCR gene transfer. J Autoimmun 79:63–73PubMed

Kaminitz A, Ash S, Askenasy N (2017) Neutralization versus reinforcement of proinflammatory cytokines to arrest autoimmunity in type 1 diabetes. Clin Rev Allergy Immunol 52(3):460–472PubMed

Kracht MJ et al (2017) Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes. Nat Med 23(4):501–507PubMed

Kuhn C, Rezende RM, da Cunha AP, Valette F, Quintana FJ, Chatenoud L, Weiner HL (2017) Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain. J Autoimmun 76:115–122PubMed

Li CW, Osman R, Menconi F, Concepcion ES, Tomer Y (2017) Flexible peptide recognition by HLA-DR triggers specific autoimmune T-cell responses in autoimmune thyroiditis and diabetes. J Autoimmun 76:1–9PubMed

Li YY, Pearson JA, Chao C, Peng J, Zhang X, Zhou Z, Liu Y, Wong FS, Wen L (2017) Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota. J Autoimmun 82:85–95PubMedPubMedCentral

Lombardi A, Tomer Y (2017) Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress. J Autoimmun 80:48–55PubMedPubMedCentral

Marino E et al (2017) Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol 18(5):552–562PubMed

10.

Ryden AK et al (2017) Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes. J Autoimmun 84:65–74PubMed

11.

Wang Z, Xie Z, Lu Q, Chang C, Zhou Z (2017) Beyond genetics: what causes type 1 diabetes. Clin Rev Allergy Immunol 52(2):273–286PubMed

12.

Wiles TA, Delong T, Baker RL, Bradley B, Barbour G, Powell RL, Reisdorph N, Haskins K (2017) An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse. J Autoimmun 78:11–18PubMed

13.

Zerif E, Maalem A, Gaudreau S, Guindi C, Ramzan M, Véroneau S, Gris D, Stankova J, Rola-Pleszczynski M, Mourad W, Dupuis G, Amrani A (2017) Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression. J Autoimmun 76:63–74PubMed

14.

Harbige J, Eichmann M, Peakman M (2017) New insights into non-conventional epitopes as T cell targets: the missing link for breaking immune tolerance in autoimmune disease? J Autoimmun 84:12–20PubMed

15.

Afzali AM, Ruck T, Wiendl H, Meuth SG (2017) Animal models in idiopathic inflammatory myopathies: how to overcome a translational roadblock? Autoimmun Rev 16(5):478–494PubMed

16.

Bartoloni E, Gonzalez-Gay MA, Scirè C, Castaneda S, Gerli R, Lopez-Longo FJ, Martinez-Barrio J, Govoni M, Furini F, Pina T, Iannone F, Giannini M, Nuño L, Quartuccio L, Ortego-Centeno N, Alunno A, Specker C, Montecucco C, Triantafyllias K, Balduzzi S, Sifuentes-Giraldo WA, Paolazzi G, Bravi E, Schwarting A, Pellerito R, Russo A, Selmi C, Saketkoo LA, Fusaro E, Parisi S, Pipitone N, Franceschini F, Cavazzana I, Neri R, Barsotti S, Codullo V, Cavagna L (2017) Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: results from a multicenter, international and retrospective study. Autoimmun Rev 16(3):253–257PubMed

17.

Cavagna L, Monti S, Caporali R, Gatto M, Iaccarino L, Doria A (2017) How I treat idiopathic patients with inflammatory myopathies in the clinical practice. Autoimmun Rev 16(10):999–1007PubMed

18.

Cavagna L et al (2017) Serum Jo-1 autoantibody and isolated arthritis in the antisynthetase syndrome: review of the literature and report of the experience of AENEAS Collaborative Group. Clin Rev Allergy Immunol 52(1):71–80PubMed

19.

Cavazzana I, Fredi M, Selmi C, Tincani A, Franceschini F (2017) The clinical and histological spectrum of idiopathic inflammatory myopathies. Clin Rev Allergy Immunol 52(1):88–98PubMed

20.

Ceribelli A, de Santis M, Isailovic N, Gershwin ME, Selmi C (2017) The immune response and the pathogenesis of idiopathic inflammatory myositis: a critical review. Clin Rev Allergy Immunol 52(1):58–70PubMed

21.

Cucchiari D, Angelini C (2017) Renal involvement in idiopathic inflammatory myopathies. Clin Rev Allergy Immunol 52(1):99–107PubMed

22.

Day J, Otto S, Proudman S, Hayball JD, Limaye V (2017) Dysregulated innate immune function in the aetiopathogenesis of idiopathic inflammatory myopathies. Autoimmun Rev 16(1):87–95PubMed

23.

Gao S, Luo H, Zhang H, Zuo X, Wang L, Zhu H (2017) Using multi-omics methods to understand dermatomyositis/polymyositis. Autoimmun Rev 16(10):1044–1048PubMed

24.

Gunawardena H (2017) The clinical features of myositis-associated autoantibodies: a review. Clin Rev Allergy Immunol 52(1):45–57PubMed

25.

Hosono Y, Nakashima R, Serada S, Murakami K, Imura Y, Yoshifuji H, Ohmura K, Naka T, Mimori T (2017) Splicing factor proline/glutamine-rich is a novel autoantigen of dermatomyositis and associated with anti-melanoma differentiation-associated gene 5 antibody. J Autoimmun 77:116–122PubMed

26.

Lu X, Tang Q, Lindh M, Dastmalchi M, Alexanderson H, Popovic Silwerfeldt K, Agerberth B, Lundberg IE, Wick C (2017) The host defense peptide LL-37 a possible inducer of the type I interferon system in patients with polymyositis and dermatomyositis. J Autoimmun 78:46–56PubMed

27.

Mainetti C, Terziroli Beretta-Piccoli B, Selmi C (2017) Cutaneous manifestations of dermatomyositis: a comprehensive review. Clin Rev Allergy Immunol 53(3):337–356PubMed

28.

Moghadam-Kia S, Oddis CV, Aggarwal R (2017) Modern therapies for idiopathic inflammatory myopathies (IIMs): role of biologics. Clin Rev Allergy Immunol 52(1):81–87PubMedPubMedCentral

29.

Pagnini I, Vitale A, Selmi C, Cimaz R, Cantarini L (2017) Idiopathic inflammatory myopathies: an update on classification and treatment with special focus on juvenile forms. Clin Rev Allergy Immunol 52(1):34–44PubMed

30.

Santos E, Coutinho E, Martins da Silva A, Marinho A, Vasconcelos C, Taipa R, Pires MM, Gonçalves G, Lopes C, Leite MI (2017) Inflammatory myopathy associated with myasthenia gravis with and without thymic pathology: report of four cases and literature review. Autoimmun Rev 16(6):644–649PubMed

31.

Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EKL (2017) A comprehensive overview on myositis-specific antibodies: new and old biomarkers in idiopathic inflammatory myopathy. Clin Rev Allergy Immunol 52(1):1–19PubMedPubMedCentral

32.

Suzuki S, Uruha A, Suzuki N, Nishino I (2017) Integrated diagnosis project for inflammatory myopathies: an association between autoantibodies and muscle pathology. Autoimmun Rev 16(7):693–700PubMed

33.

Tansley SL, Simou S, Shaddick G, Betteridge ZE, Almeida B, Gunawardena H, Thomson W, Beresford MW, Midgley A, Muntoni F, Wedderburn LR, McHugh NJ (2017) Autoantibodies in juvenile-onset myositis: their diagnostic value and associated clinical phenotype in a large UK cohort. J Autoimmun 84:55–64PubMedPubMedCentral

34.

Tiniakou E, Mammen AL (2017) Idiopathic inflammatory myopathies and malignancy: a comprehensive review. Clin Rev Allergy Immunol 52(1):20–33PubMed

35.

Espitia-Thibault A, Masseau A, Néel A, Espitia O, Toquet C, Mussini JM, Hamidou M (2017) Sjogren’s syndrome-associated myositis with germinal centre-like structures. Autoimmun Rev 16(2):154–158PubMed

36.

Fujimura T, Fujimoto T, Itaya-Hironaka A, Miyaoka T, Yoshimoto K, Sakuramoto-Tsuchida S, Yamauchi A, Takeda M, Tsujinaka H, Tanaka Y, Takasawa S (2017) Significance of interleukin-6/STAT pathway for the gene expression of REG Ialpha, a new autoantigen in Sjogren’s syndrome patients, in salivary duct epithelial cells. Clin Rev Allergy Immunol 52(3):351–363PubMed

37.

Garcia-Carrasco M, Jiménez-Herrera EA, Gálvez-Romero JL, de Lara LV, Mendoza-Pinto C, Etchegaray-Morales I, Munguía-Realpozo P, Ruíz-Argüelles A, Jose R, Vera-Recabarren M, Cervera R (2017) Vitamin D and Sjogren syndrome. Autoimmun Rev 16(6):587–593PubMed

38.

Generali E, Costanzo A, Mainetti C, Selmi C (2017) Cutaneous and mucosal manifestations of Sjogren’s syndrome. Clin Rev Allergy Immunol 53(3):357–370PubMed

39.

Haacke EA, Bootsma H, Spijkervet FKL, Visser A, Vissink A, Kluin PM, Kroese FGM (2017) FcRL4(+) B-cells in salivary glands of primary Sjogren’s syndrome patients. J Autoimmun 81:90–98PubMed

40.

Roca F, Dominique S, Schmidt J, Smail A, Duhaut P, Lévesque H, Marie I (2017) Interstitial lung disease in primary Sjogren’s syndrome. Autoimmun Rev 16(1):48–54PubMed

41.

Chen Y, Chauhan SK, Tan X, Dana R (2017) Interleukin-7 and -15 maintain pathogenic memory Th17 cells in autoimmunity. J Autoimmun 77:96–103PubMed

42.

Vanoni F, Lava SAG, Fossali EF, Cavalli R, Simonetti GD, Bianchetti MG, Bozzini MA, Agostoni C, Milani GP (2017) Neonatal systemic lupus erythematosus syndrome: a comprehensive review. Clin Rev Allergy Immunol 53(3):469–476PubMed

43.

Alba MA, Flores-Suárez LF, Henderson AG, Xiao H, Hu P, Nachman PH, Falk RJ, Charles Jennette J (2017) Interstital lung disease in ANCA vasculitis. Autoimmun Rev 16(7):722–729PubMedPubMedCentral

44.

Andre R et al (2017) Central nervous system involvement in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): report of 26 patients and review of the literature. Autoimmun Rev 16(9):963–969PubMed

45.

Chasset F, Frances C (2017) Cutaneous manifestations of medium- and large-vessel vasculitis. Clin Rev Allergy Immunol 53(3):452–468PubMed

46.

Ciccia F, Rizzo A, Ferrante A, Guggino G, Croci S, Cavazza A, Salvarani C, Triolo G (2017) New insights into the pathogenesis of giant cell arteritis. Autoimmun Rev 16(7):675–683PubMed

47.

Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK (2017) Could lymphocyte profiling be useful to diagnose systemic autoimmune diseases? Clin Rev Allergy Immunol 53(2):219–236PubMed

48.

Cornec D, Berti A, Hummel A, Peikert T, Pers JO, Specks U (2017) Identification and phenotyping of circulating autoreactive proteinase 3-specific B cells in patients with PR3-ANCA associated vasculitis and healthy controls. J Autoimmun 84:122–131PubMed

49.

Danlos FX, Rossi GM, Blockmans D, Emmi G, Kronbichler A, Durupt S, Maynard C, Luca L, Garrouste C, Lioger B, Mourot-Cottet R, Dhote R, Arlet JB, Hanslik T, Rouvier P, Ebbo M, Puéchal X, Nochy D, Carlotti A, Mouthon L, Guillevin L, Vaglio A, Terrier B, French Vasculitis Study Group (2017) Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: a new overlap syndrome. Autoimmun Rev 16(10):1036–1043PubMed

50.

Frumholtz L, Laurent-Roussel S, Aumaître O, Maurier F, le Guenno G, Carlotti A, Dallot A, Kemeny JL, Antunes L, Froment N, Fraitag S, London J, Berezne A, Terris B, le Jeunne C, Mouthon L, Aractingi S, Guillevin L, Dupin N, Terrier B, French Vasculitis Study Group (2017) Clinical and pathological significance of cutaneous manifestations in ANCA-associated vasculitides. Autoimmun Rev 16(11):1138–1146PubMed

51.

Heineke MH, Ballering AV, Jamin A, Ben Mkaddem S, Monteiro RC, van Egmond M (2017) New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schonlein purpura). Autoimmun Rev 16(12):1246–1253PubMed

52.

Hommada M, Mekinian A, Brillet PY, Abad S, Larroche C, Dhôte R, Fain O, Soussan M (2017) Aortitis in giant cell arteritis: diagnosis with FDG PET/CT and agreement with CT angiography. Autoimmun Rev 16(11):1131–1137PubMed

53.

Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH (2017) The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease. Nat Immunol 18(1):26–35PubMed

54.

Xue LJ, Wu R, du GL, Xu Y, Yuan KY, Feng ZC, Pan YL, Hu GY (2017) Effect and safety of TNF inhibitors in immunoglobulin-resistant Kawasaki disease: a meta-analysis. Clin Rev Allergy Immunol 52(3):389–400PubMed

55.

Yilmaz I, Turk M, Bahcecioglu SN (2017) Classification of eosinophilic granulomatosis with polyangiitis phenotypes and treatment based on phenotypes. Autoimmun Rev 16(9):992–993PubMed

56.

Kerstein A, Schüler S, Cabral-Marques O, Fazio J, Häsler R, Müller A, Pitann S, Moosig F, Klapa S, Haas C, Kabelitz D, Riemekasten G, Wolters S, Lamprecht P (2017) Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis. J Autoimmun 78:79–91PubMed

57.

Lefevre G, Ackermann F, Kahn JE (2017) Hypereosinophilia with asthma and systemic (non-vasculitic) manifestations: eosinophilic granulomatosis with polyangiitis or hypereosinophilic syndrome? Autoimmun Rev 16(2):208–209PubMed

58.

Legendre P, Régent A, Thiebault M, Mouthon L (2017) Anti-endothelial cell antibodies in vasculitis: a systematic review. Autoimmun Rev 16(2):146–153PubMed

59.

Lule S, Colpak AI, Balci-Peynircioglu B, Gursoy-Ozdemir Y, Peker S, Kalyoncu U, Can A, Tekin N, Demiralp D, Dalkara T (2017) Behcet disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger. J Autoimmun 84:87–96PubMed

60.

Martinez-Valle F et al (2017) IgG4-related disease: evidence from six recent cohorts. Autoimmun Rev 16(2):168–172PubMed

61.

Marzano AV, Raimondo MG, Berti E, Meroni PL, Ingegnoli F (2017) Cutaneous manifestations of ANCA-associated small vessels vasculitis. Clin Rev Allergy Immunol 53(3):428–438PubMed

62.

Mirouse A, Barete S, Monfort JB, Resche-Rigon M, Bouyer AS, Comarmond C, Sène D, Domont F, Ferfar Y, Cacoub P, Saadoun D (2017) Ustekinumab for Behcet’s disease. J Autoimmun 82:41–46PubMed

63.

Misra DP, Sharma A, Kadhiravan T, Negi VS (2017) A scoping review of the use of non-biologic disease modifying anti-rheumatic drugs in the management of large vessel vasculitis. Autoimmun Rev 16(2):179–191PubMed

64.

Regent A et al (2017) Molecular analysis of vascular smooth muscle cells from patients with giant cell arteritis: targeting endothelin-1 receptor to control proliferation. Autoimmun Rev 16(4):398–406PubMed

65.

Restuccia G, Boiardi L, Cavazza A, Catanoso M, Macchioni P, Muratore F, Soriano A, Cimino L, Aldigeri R, Crescentini F, Pipitone N, Salvarani C (2017) Long-term remission in biopsy proven giant cell arteritis: a retrospective cohort study. J Autoimmun 77:39–44PubMed

66.

Roccatello D (2017) “How I treat” autoimmune diseases: state of the art on the management of rare rheumatic diseases and ANCA-associated systemic idiopathic vasculitis. Autoimmun Rev 16(10):995–998PubMed

67.

Salvarani C, Soriano A, Muratore F, Shoenfeld Y, Blockmans D (2017) Is PET/CT essential in the diagnosis and follow-up of temporal arteritis? Autoimmun Rev 16(11):1125–1130PubMed

68.

Samson M, Corbera-Bellalta M, Audia S, Planas-Rigol E, Martin L, Cid MC, Bonnotte B (2017) Recent advances in our understanding of giant cell arteritis pathogenesis. Autoimmun Rev 16(8):833–844PubMed

69.

Savioli B, Abdulahad WH, Brouwer E, Kallenberg CGM, de Souza AWS (2017) Are cytokines and chemokines suitable biomarkers for Takayasu arteritis? Autoimmun Rev 16(10):1071–1078PubMed

70.

Argollo M, Fiorino G, Hindryckx P, Peyrin-Biroulet L, Danese S (2017) Novel therapeutic targets for inflammatory bowel disease. J Autoimmun 85:103–116PubMed

71.

Chua-Aguilera CJ, Moller B, Yawalkar N (2017) Skin manifestations of rheumatoid arthritis, juvenile idiopathic arthritis, and spondyloarthritides. Clin Rev Allergy Immunol 53(3):371–393PubMed

72.

Boehncke WH, Brembilla NC (2017) Unmet needs in the field of psoriasis: pathogenesis and treatment. Clin Rev Allergy Immunol

73.

Greuter T, Navarini A, Vavricka SR (2017) Skin manifestations of inflammatory bowel disease. Clin Rev Allergy Immunol 53(3):413–427PubMed

74.

Hindryckx P, Laukens D, D’Amico F, Danese S (2017) Unmet needs in IBD: the case of fatigue. Clin Rev Allergy Immunol

75.

Lubrano E, De Socio A, and Perrotta FM (2017) Unmet needs in axial spondyloarthritis. Clin Rev Allergy Immunol

76.

Martin JC, Wolk K, Bériou G, Abidi A, Witte-Händel E, Louvet C, Kokolakis G, Drujont L, Dumoutier L, Renauld JC, Sabat R, Josien R (2017) Limited presence of IL-22 binding protein, a natural IL-22 inhibitor, strengthens psoriatic skin inflammation. J Immunol 198(9):3671–3678PubMed

77.

Martin-Esteban A et al (2017) Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome. J Autoimmun 79:28–38PubMed

78.

McArdle A, Pennington S, and FitzGerald O (2017) Clinical features of psoriatic arthritis: a comprehensive review of unmet clinical needs. Clin Rev Allergy Immunol

79.

Oka T, Sugaya M, Takahashi N, Takahashi T, Shibata S, Miyagaki T, Asano Y, Sato S (2017) CXCL17 attenuates Imiquimod-induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells. J Immunol 198(10):3897–3908PubMed

80.

Park JH, Jeong DY, Peyrin-Biroulet L, Eisenhut M, Shin JI (2017) Insight into the role of TSLP in inflammatory bowel diseases. Autoimmun Rev 16(1):55–63PubMed

81.

Park JH, Peyrin-Biroulet L, Eisenhut M, Shin JI (2017) IBD immunopathogenesis: a comprehensive review of inflammatory molecules. Autoimmun Rev 16(4):416–426PubMed

82.

Peyrin-Biroulet L, Christopher R, Behan D, Lassen C (2017) Modulation of sphingosine-1-phosphate in inflammatory bowel disease. Autoimmun Rev 16(5):495–503PubMed

83.

Pollock RA, Abji F, Gladman DD (2017) Epigenetics of psoriatic disease: a systematic review and critical appraisal. J Autoimmun 78:29–38PubMed

84.

Prinz JC (2017) Autoimmune aspects of psoriasis: heritability and autoantigens. Autoimmun Rev 16(9):970–979PubMed

85.

Raychaudhuri SP, Wilken R, Sukhov AC, Raychaudhuri SK, Maverakis E (2017) Management of psoriatic arthritis: early diagnosis, monitoring of disease severity and cutting edge therapies. J Autoimmun 76:21–37PubMed

86.

Robert M, Miossec P (2017) Effects of interleukin 17 on the cardiovascular system. Autoimmun Rev 16(9):984–991PubMed

87.

Sakkas LI, Bogdanos DP (2017) Are psoriasis and psoriatic arthritis the same disease? The IL-23/IL-17 axis data. Autoimmun Rev 16(1):10–15PubMed

88.

Shabgah AG, Navashenaq JG, Shabgah OG, Mohammadi H, Sahebkar A (2017) Interleukin-22 in human inflammatory diseases and viral infections. Autoimmun Rev 16(12):1209–1218PubMed

89.

Szentpetery A et al (2017) Effects of targeted therapies on the bone in arthritides. Autoimmun Rev 16(3):313–320PubMed

90.

Zanin-Zhorov A, Weiss JM, Trzeciak A, Chen W, Zhang J, Nyuydzefe MS, Arencibia C, Polimera S, Schueller O, Fuentes-Duculan J, Bonifacio KM, Kunjravia N, Cueto I, Soung J, Fleischmann RM, Kivitz A, Lebwohl M, Nunez M, Woodson J, Smith SL, West RF, Berger M, Krueger JG, Ryan JL, Waksal SD (2017) Cutting edge: selective oral ROCK2 inhibitor reduces clinical scores in patients with psoriasis vulgaris and normalizes skin pathology via concurrent regulation of IL-17 and IL-10. J Immunol 198(10):3809–3814PubMedPubMedCentral

91.

Song J, Lleo A, Yang GX, Zhang W, Bowlus CL, Gershwin ME, Leung PSC (2017) Common variable immunodeficiency and liver involvement. Clin Rev Allergy Immunol

92.

Taraldsrud E, Fevang B, Jørgensen SF, Moltu K, Hilden V, Taskén K, Aukrust P, Myklebust JH, Olweus J (2017) Defective IL-4 signaling in T cells defines severe common variable immunodeficiency. J Autoimmun 81:110–119PubMed

93.

Vignesh P, Rawat A, Singh S (2017) An update on the use of Immunomodulators in primary immunodeficiencies. Clin Rev Allergy Immunol 52(2):287–303PubMed

94.

Wong GK, Heather JM, Barmettler S, Cobbold M (2017) Immune dysregulation in immunodeficiency disorders: the role of T-cell receptor sequencing. J Autoimmun 80:1–9PubMed

95.

Dvir R, Sautto GA, Mancini N, Racca S, Diotti RA, Clementi M, Memoli M (2017) Autoimmune hepatitis and occult HCV infection: a prospective single-centre clinical study. Autoimmun Rev 16(3):323–325PubMed

96.

Hardtke-Wolenski M, Dywicki J, Fischer K, Hapke M, Sievers M, Schlue J, Anderson MS, Taubert R, Noyan F, Manns MP, Jaeckel E (2017) The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development. J Autoimmun 78:39–45PubMed

97.

Lian M, Li B, Xiao X, Yang Y, Jiang P, Yan L, Sun C, Zhang J, Wei Y, Li Y, Chen W, Jiang X, Miao Q, Chen X, Qiu D, Sheng L, Hua J, Tang R, Wang Q, Eric Gershwin M, Ma X (2017) Comparative clinical characteristics and natural history of three variants of sclerosing cholangitis: IgG4-related SC, PSC/AIH and PSC alone. Autoimmun Rev 16(8):875–882PubMed

98.

Terziroli Beretta-Piccoli B, Invernizzi P, Gershwin ME, Mainetti C (2017) Skin manifestations associated with autoimmune liver diseases: a systematic review. Clin Rev Allergy Immunol 53(3):394–412PubMed

99.

Wang Z, Sheng L, Yang Y, Yang F, Xiao X, Hua J, Guo C, Wei Y, Tang R, Miao Q, Zhang J, Li Y, Fang J, Qiu D, Krawitt EL, Bowlus CL, Gershwin ME, Wang Q, Ma X (2017) The management of autoimmune hepatitis patients with decompensated cirrhosis: real-world experience and a comprehensive review. Clin Rev Allergy Immunol 52(3):424–435PubMed

100.

Chung BK, Guevel BT, Reynolds GM, Gupta Udatha DBRK, Henriksen EKK, Stamataki Z, Hirschfield GM, Karlsen TH, Liaskou E (2017) Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis. J Autoimmun 77:45–54PubMed

101.

Li Y, Tang R, Leung PSC, Gershwin ME, Ma X (2017) Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases. Autoimmun Rev 16(9):885–896PubMed

102.

Ma HD, Ma WT, Liu QZ, Zhao ZB, Liu MZY, Tsuneyama K, Gao JM, Ridgway WM, Ansari AA, Gershwin ME, Fei YY, Lian ZX (2017) Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8(+) T cell activation. J Autoimmun 78:19–28PubMedPubMedCentral

103.

Jaillon S, Berthenet K, and Garlanda C (2017) Sexual dimorphism in innate immunity. Clin Rev Allergy Immunol

104.

Margery-Muir AA, Bundell C, Nelson D, Groth DM, Wetherall JD (2017) Gender balance in patients with systemic lupus erythematosus. Autoimmun Rev 16(3):258–268PubMed

105.

Castaneda S, Gonzalez-Juanatey C, Gonzalez-Gay MA (2017) Sex and cardiovascular involvement in inflammatory joint diseases. Clin Rev Allergy Immunol

106.

Ma WT, Chang C, Gershwin ME, Lian ZX (2017) Development of autoantibodies precedes clinical manifestations of autoimmune diseases: a comprehensive review. J Autoimmun 83:95–112PubMed

107.

Conrad K, Röber N, Andrade LEC, Mahler M (2017) The clinical relevance of anti-DFS70 autoantibodies. Clin Rev Allergy Immunol 52(2):202–216PubMed

108.

Tozzoli R, Villalta D, Bizzaro N (2017) Challenges in the standardization of autoantibody testing: a comprehensive review. Clin Rev Allergy Immunol 53(1):68–77PubMed

109.

Takeuchi A, Matsushita T, Kaji K, Okamoto Y, Yasui M, Hirata M, Oishi N, Higashi A, Seishima M, Asano T, Fujimoto M, Kuwana M, Takehara K, Hamaguchi Y (2017) Autoantibody to scaffold attachment factor B (SAFB): a novel connective tissue disease-related autoantibody associated with interstitial lung disease. J Autoimmun 76:101–107PubMed

110.

Sperotto F, Seguso M, Gallo N, Plebani M, Zulian F (2017) Anti-DFS70 antibodies in healthy schoolchildren: a follow-up analysis. Autoimmun Rev 16(2):210–211PubMed

111.

Sowa M, Hiemann R, Schierack P, Reinhold D, Conrad K, Roggenbuck D (2017) Next-generation autoantibody testing by combination of screening and confirmation-the CytoBead(R) technology. Clin Rev Allergy Immunol 53(1):87–104PubMed

112.

Hoxha A, Banzato A, Ruffatti A, Pengo V (2017) Detection of lupus anticoagulant in the era of direct oral anticoagulants. Autoimmun Rev 16(2):173–178PubMed

113.

Novak GV, Marques M, Balbi V, Gormezano NWS, Kozu K, Sakamoto AP, Pereira RMR, Terreri MT, Magalhães CS, Guariento A, Sallum AME, Marini R, Ferriani VPL, Barbosa CM, de Castro TCM, Ramos VC, Bonfá E, Silva CA (2017) Anti-RO/SSA and anti-La/SSB antibodies: association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus. Autoimmun Rev 16(2):132–135PubMed

114.

Reed JH, Gorny MK, Li L, Cardozo T, Buyon JP, Clancy RM (2017) Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus. J Autoimmun 79:99–104PubMedPubMedCentral

115.

Alivernini S, Galeazzi M, Peleg H, Tolusso B, Gremese E, Ferraccioli G, Naparstek Y (2017) Is ACPA positivity the main driver for rheumatoid arthritis treatment? Pros and cons. Autoimmun Rev 16(11):1096–1102PubMed

116.

Verheul MK, Yee A, Seaman A, Janssen GM, van Veelen PA, Drijfhout JW, Toes REM, Mahler M, Trouw LA (2017) Identification of carbamylated alpha 1 anti-trypsin (A1AT) as an antigenic target of anti-CarP antibodies in patients with rheumatoid arthritis. J Autoimmun 80:77–84PubMed

117.

Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G (2017) Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. Nat Immunol 18(1):104–113PubMed

118.

Dahan S, Segal Y, Watad A, Azrielant S, Shemer A, Maymon D, Stroev YI, Sobolevskaya PA, Korneva EA, Blank M, Gilburd B, Shovman O, Amital H, Ehrenfeld M, Tanay A, Kivity S, Pras E, Chapman J, Damoiseaux J, Cervera R, Putterman C, Shapiro I, Mouthon L, Perricone R, Bizzaro N, Koren O, Riemekasten G, Chereshnev VA, Mazurov VI, Goloviznin M, Gurevich V, Churilov LP, Shoenfeld Y (2017) Novelties in the field of autoimmunity—1st Saint Petersburg congress of autoimmunity, the bridge between east and west. Autoimmun Rev 16(12):1175–1184PubMed

119.

Doria A, Gatto M, Iaccarino L, Sarzi-Puttini P (2017) Unresolved and critical issues in autoimmune rheumatic diseases. Autoimmun Rev 16(11):1093–1095PubMed

120.

Generali E, Ceribelli A, Stazi MA, Selmi C (2017) Lessons learned from twins in autoimmune and chronic inflammatory diseases. J Autoimmun 83:51–61PubMed

121.

Elieh Ali Komi D and Grauwet K (2017) Role of mast cells in regulation of T cell responses in experimental and clinical settings. Clin Rev Allergy Immunol

122.

Ferreira RC, Simons HZ, Thompson WS, Rainbow DB, Yang X, Cutler AJ, Oliveira J, Castro Dopico X, Smyth DJ, Savinykh N, Mashar M, Vyse TJ, Dunger DB, Baxendale H, Chandra A, Wallace C, Todd JA, Wicker LS, Pekalski ML (2017) Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity. J Autoimmun 84:75–86PubMedPubMedCentral

123.

Fortner KA, Bond JP, Austin JW, Boss JM, Budd RC (2017) The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns. J Autoimmun 82:47–61PubMedPubMedCentral

124.

Gattinoni L, Speiser DE, Lichterfeld M, Bonini C (2017) T memory stem cells in health and disease. Nat Med 23(1):18–27PubMedPubMedCentral

125.

Geng J, Yu S, Zhao H, Sun X, Li X, Wang P, Xiong X, Hong L, Xie C, Gao J, Shi Y, Peng J, Johnson RL, Xiao N, Lu L, Han J, Zhou D, Chen L (2017) The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol 18(7):800–812PubMed

126.

Gravina G, Wasén C, Garcia-Bonete MJ, Turkkila M, Erlandsson MC, Töyrä Silfverswärd S, Brisslert M, Pullerits R, Andersson KM, Katona G, Bokarewa MI (2017) Survivin in autoimmune diseases. Autoimmun Rev 16(8):845–855PubMed

127.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T (2017) Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol 18(1):74–85PubMed

128.

Hemon P, Renaudineau Y, Debant M, le Goux N, Mukherjee S, Brooks W, Mignen O (2017) Calcium signaling: from normal B cell development to tolerance breakdown and autoimmunity. Clin Rev Allergy Immunol 53(2):141–165PubMed

129.

Iizuka-Koga M, Nakatsukasa H, Ito M, Akanuma T, Lu Q, Yoshimura A (2017) Induction and maintenance of regulatory T cells by transcription factors and epigenetic modifications. J Autoimmun 83:113–121PubMed

130.

Jamilloux Y, et al (2017) Geoepidemiology and immunologic features of autoinflammatory diseases: a comprehensive review. Clin Rev Allergy Immunol

131.

Jorch SK, Kubes P (2017) An emerging role for neutrophil extracellular traps in noninfectious disease. Nat Med 23(3):279–287PubMed

132.

Kaur G, Mohindra K, Singla S (2017) Autoimmunity—basics and link with periodontal disease. Autoimmun Rev 16(1):64–71PubMed

133.

Lee KH, Kronbichler A, Park DDY, Park YM, Moon H, Kim H, Choi JH, Choi YS, Shim S, Lyu IS, Yun BH, Han Y, Lee D, Lee SY, Yoo BH, Lee KH, Kim TL, Kim H, Shim JS, Nam W, So H, Choi SY, Lee S, Shin JI (2017) Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review. Autoimmun Rev 16(11):1160–1173PubMed

134.

Manthiram K, Zhou Q, Aksentijevich I, Kastner DL (2017) The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation. Nat Immunol 18(8):832–842PubMed

135.

Mantovani A (2017) Wandering pathways in the regulation of innate immunity and inflammation. J Autoimmun 85:1–5PubMedPubMedCentral

136.

Morell M, Varela N, Maranon C (2017) Myeloid populations in systemic autoimmune diseases. Clin Rev Allergy Immunol 53(2):198–218PubMed

137.

Oftedal BE, Ardesjö Lundgren B, Hamm D, Gan PY, Holdsworth SR, Hahn CN, Schreiber AW, Scott HS (2017) T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ. J Autoimmun 81:24–33PubMed

138.

Papp G, Boros P, Nakken B, Szodoray P, Zeher M (2017) Regulatory immune cells and functions in autoimmunity and transplantation immunology. Autoimmun Rev 16(5):435–444PubMed

139.

Park SH, Kang K, Giannopoulou E, Qiao Y, Kang K, Kim G, Park-Min KH, Ivashkiv LB (2017) Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation. Nat Immunol 18(10):1104–1116PubMedPubMedCentral

140.

Petersen F, Yue X, Riemekasten G, Yu X (2017) Dysregulated homeostasis of target tissues or autoantigens—a novel principle in autoimmunity. Autoimmun Rev 16(6):602–611PubMed

141.

Picard C, Belot A (2017) Does type-I interferon drive systemic autoimmunity? Autoimmun Rev 16(9):897–902PubMed

142.

Renaudineau Y (2017) Immunophenotyping as a new tool for classification and monitoring of systemic autoimmune diseases. Clin Rev Allergy Immunol 53(2):177–180PubMed

143.

Zikherman J, Lowell CA (2017) B cell autoimmunity at the extremes. Nat Immunol 18(10):1065–1066PubMedPubMedCentral

144.

Xiang Z, Yang Y, Chang C, Lu Q (2017) The epigenetic mechanism for discordance of autoimmunity in monozygotic twins. J Autoimmun 83:43–50PubMed

145.

Veldhoen M (2017) Interleukin 17 is a chief orchestrator of immunity. Nat Immunol 18(6):612–621PubMed

146.

Theofilopoulos AN, Kono DH, Baccala R (2017) The multiple pathways to autoimmunity. Nat Immunol 18(7):716–724PubMedPubMedCentral

147.

Brooks WH (2017) A review of autoimmune disease hypotheses with introduction of the “nucleolus” hypothesis. Clin Rev Allergy Immunol 52(3):333–350PubMed

148.

Adorisio S, Fierabracci A, Muscari I, Liberati AM, Ayroldi E, Migliorati G, Thuy TT, Riccardi C, Delfino DV (2017) SUMO proteins: guardians of immune system. J Autoimmun 84:21–28PubMed

149.

Chen K, Liu J, Cao X (2017) Regulation of type I interferon signaling in immunity and inflammation: a comprehensive review. J Autoimmun 83:1–11PubMed

150.

Aune TM, Crooke PS III, Patrick AE, Tossberg JT, Olsen NJ, Spurlock CF III (2017) Expression of long non-coding RNAs in autoimmunity and linkage to enhancer function and autoimmune disease risk genetic variants. J Autoimmun 81:99–109PubMedPubMedCentral

151.

Bansal K, Yoshida H, Benoist C, Mathis D (2017) The transcriptional regulator Aire binds to and activates super-enhancers. Nat Immunol 18(3):263–273PubMedPubMedCentral

152.

Crowe W, Allsopp PJ, Watson GE, Magee PJ, Strain JJ, Armstrong DJ, Ball E, McSorley EM (2017) Mercury as an environmental stimulus in the development of autoimmunity—a systematic review. Autoimmun Rev 16(1):72–80PubMed

153.

Watad A, Azrielant S, Bragazzi NL, Sharif K, David P, Katz I, Aljadeff G, Quaresma M, Tanay G, Adawi M, Amital H, Shoenfeld Y (2017) Seasonality and autoimmune diseases: the contribution of the four seasons to the mosaic of autoimmunity. J Autoimmun 82:13–30PubMed

154.

Qiao YC, Pan YH, Ling W, Tian F, Chen YL, Zhang XX, Zhao HL (2017) The yin and Yang of regulatory T cell and therapy progress in autoimmune disease. Autoimmun Rev 16(10):1058–1070PubMed

155.

Chen B, Sun L, Zhang X (2017) Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases. J Autoimmun 83:31–42PubMed

156.

Dutra RC (2017) Kinin receptors: key regulators of autoimmunity. Autoimmun Rev 16(2):192–207PubMed

157.

Li S, Yang D, Peng T, Wu Y, Tian Z, Ni B (2017) Innate lymphoid cell-derived cytokines in autoimmune diseases. J Autoimmun 83:62–72PubMed

158.

Al-Soudi A, Kaaij MH, Tas SW (2017) Endothelial cells: from innocent bystanders to active participants in immune responses. Autoimmun Rev 16(9):951–962PubMed

159.

Coronel-Restrepo N, Posso-Osorio I, Naranjo-Escobar J, Tobón GJ (2017) Autoimmune diseases and their relation with immunological, neurological and endocrinological axes. Autoimmun Rev 16(7):684–692PubMed

160.

Torres-Ruiz J, Sulli A, Cutolo M, Shoenfeld Y (2017) Air travel, circadian rhythms/hormones, and autoimmunity. Clin Rev Allergy Immunol 53(1):117–125PubMed

161.

Colotta F, Jansson B, Bonelli F (2017) Modulation of inflammatory and immune responses by vitamin D. J Autoimmun 85:78–97PubMed

162.

Zurück zum Zitat Grimaldi-Bensouda L, Rossignol M, Koné-Paut I, Krivitzky A, Lebrun-Frenay C, Clet J, Brassat D, Papeix C, Nicolino M, Benhamou PY, Fain O, Costedoat-Chalumeau N, Courcoux MF, Viallard JF, Godeau B, Papo T, Vermersch P, Bourgault-Villada I, Breart G, Abenhaim L, Abbas F, Abdelmoumni A, Hilliquin P, Requeda E, Adoue D, Brassat D, Agard C, Masseau A, Aladjidi N, Clet J, Fernandes H, Lemasson G, Perel Y, Raymond I, Richer O, Vital A, Allain-Launay E, Bru M, Nicolino M, Thomas C, Altman JJ, Amsallem D, Aras N, Boukari L, Dubrel M, Fain O, Letellier E, Lucidarme N, Mekinian A, Morin AS, Stirnemann J, Atlan C, Audry D, Augustin J, Bakir R, Bartolucci P, Chevalier X, Godeau B, Guillaud C, Khellaf M, Limal N, Lousteau V, Mahevas M, Méliksetyan G, Michel M, Roumier M, Bayart S, Bonnet F, Decaux O, Bekherraz A, Brihaye B, Dachez R, Daugas E, Hayem G, Meyer O, Papo T, Pasqualoni E, Sacre K, Travert F, Bellon H, Beltrand J, Lefrere F, Simon A, Benhamou PY, Benveniste O, Bolgert F, Costedoat-Chalumeau N, de Paz R, Demeret S, Fautrel B, Jacqueminet S, Louapre C, Maillart E, Morel N, Papeix C, Rigabert J, Bensaid P, Berger C, Berquin P, le Moing AG, Berroir S, Besson G, Boutte C, Casez O, Bonnotte B, Audia S, Bossu-Estour C, Bourgarit A, Dupuy A, Keshmandt H, Bourre B, Brac A, Perrin A, Pondarré C, Villar-Fimbel S, Bruckert I, Cosson A, Magy-Bertrand N, Tisserand G, Camu W, Carlander B, Morales RJ, Cances C, Pasquet M, Castilla Lievre MA, Chabroux S, Charif M, Chatelus E, Sibilia J, Chevrant-Breton J, Clavel S, Bille-Turc F, Cohen J, Courcoux MF, Leverger G, Machet L, Cuisset JM, Cony-Makhoul P, Darsy P, Favre S, Giraud P, Leitenschenck L, Monteiro I, Morati C, DeSeze J, Dinulescu M, Dhaoui T, Dommange-Romero F, Drevard E, Dupuis C, Dumuis ML, Durand JM, Farad S, Lecomte P, Pierre P, Fouyssac F, Gaudin P, Gautier A, Gellen-Dautremer J, Jarrin I, Richette P, Georget E, Gras P, Moreau T, Giraud E, Hacini M, Mayer A, Guillaumat C, Guillaume S, Guitton C, Kone-Paut I, Marsaud C, Rossi L, Guyot MH, Hassler P, Heimfert C, Heinzlef O, Hillion B, Hocquelet C, Husson H, Ichai P, Jeziorski E, Deslandre CJ, le Guern V, Kamenov K, Kerlan V, Lemoine P, Misery L, Pan-Petesch B, Krivitzky A, Labauge P, Rodier M, Lacade C, Razafimahefa B, Lachgar K, Larmarau MP, Leblanc T, Lebrun-Frenay C, Lefèbvre P, Lejoyeux P, Leske C, Ly K, Magy L, Mansuy S, Marechaud R, Martin Negrier ML, Sole G, Maupetit J, Mazingue F, Mochon S, Moktar B, Morcamp D, Morlet-Barla N, Nicolas G, Pautot V, Pellier I, Verret JL, Outteryck O, Vermersch P, Pallot-Prades B, Paquet JM, Puechal X, Sortais A, Pelletier J, Rico A, Pez D, Stankoff B, Quittet P, Rémy C, Roba E, Rosario H, Roudaut N, Sonnet E, Ruel M, Sebban S, Schaepelynck P, Simonin MJ, Vial C, Viallard JF, Ladedan I, Zenone T (2017) Risk of autoimmune diseases and human papilloma virus (HPV) vaccines: six years of case-referent surveillance. J Autoimmun 79:84–90PubMed Grimaldi-Bensouda L, Rossignol M, Koné-Paut I, Krivitzky A, Lebrun-Frenay C, Clet J, Brassat D, Papeix C, Nicolino M, Benhamou PY, Fain O, Costedoat-Chalumeau N, Courcoux MF, Viallard JF, Godeau B, Papo T, Vermersch P, Bourgault-Villada I, Breart G, Abenhaim L, Abbas F, Abdelmoumni A, Hilliquin P, Requeda E, Adoue D, Brassat D, Agard C, Masseau A, Aladjidi N, Clet J, Fernandes H, Lemasson G, Perel Y, Raymond I, Richer O, Vital A, Allain-Launay E, Bru M, Nicolino M, Thomas C, Altman JJ, Amsallem D, Aras N, Boukari L, Dubrel M, Fain O, Letellier E, Lucidarme N, Mekinian A, Morin AS, Stirnemann J, Atlan C, Audry D, Augustin J, Bakir R, Bartolucci P, Chevalier X, Godeau B, Guillaud C, Khellaf M, Limal N, Lousteau V, Mahevas M, Méliksetyan G, Michel M, Roumier M, Bayart S, Bonnet F, Decaux O, Bekherraz A, Brihaye B, Dachez R, Daugas E, Hayem G, Meyer O, Papo T, Pasqualoni E, Sacre K, Travert F, Bellon H, Beltrand J, Lefrere F, Simon A, Benhamou PY, Benveniste O, Bolgert F, Costedoat-Chalumeau N, de Paz R, Demeret S, Fautrel B, Jacqueminet S, Louapre C, Maillart E, Morel N, Papeix C, Rigabert J, Bensaid P, Berger C, Berquin P, le Moing AG, Berroir S, Besson G, Boutte C, Casez O, Bonnotte B, Audia S, Bossu-Estour C, Bourgarit A, Dupuy A, Keshmandt H, Bourre B, Brac A, Perrin A, Pondarré C, Villar-Fimbel S, Bruckert I, Cosson A, Magy-Bertrand N, Tisserand G, Camu W, Carlander B, Morales RJ, Cances C, Pasquet M, Castilla Lievre MA, Chabroux S, Charif M, Chatelus E, Sibilia J, Chevrant-Breton J, Clavel S, Bille-Turc F, Cohen J, Courcoux MF, Leverger G, Machet L, Cuisset JM, Cony-Makhoul P, Darsy P, Favre S, Giraud P, Leitenschenck L, Monteiro I, Morati C, DeSeze J, Dinulescu M, Dhaoui T, Dommange-Romero F, Drevard E, Dupuis C, Dumuis ML, Durand JM, Farad S, Lecomte P, Pierre P, Fouyssac F, Gaudin P, Gautier A, Gellen-Dautremer J, Jarrin I, Richette P, Georget E, Gras P, Moreau T, Giraud E, Hacini M, Mayer A, Guillaumat C, Guillaume S, Guitton C, Kone-Paut I, Marsaud C, Rossi L, Guyot MH, Hassler P, Heimfert C, Heinzlef O, Hillion B, Hocquelet C, Husson H, Ichai P, Jeziorski E, Deslandre CJ, le Guern V, Kamenov K, Kerlan V, Lemoine P, Misery L, Pan-Petesch B, Krivitzky A, Labauge P, Rodier M, Lacade C, Razafimahefa B, Lachgar K, Larmarau MP, Leblanc T, Lebrun-Frenay C, Lefèbvre P, Lejoyeux P, Leske C, Ly K, Magy L, Mansuy S, Marechaud R, Martin Negrier ML, Sole G, Maupetit J, Mazingue F, Mochon S, Moktar B, Morcamp D, Morlet-Barla N, Nicolas G, Pautot V, Pellier I, Verret JL, Outteryck O, Vermersch P, Pallot-Prades B, Paquet JM, Puechal X, Sortais A, Pelletier J, Rico A, Pez D, Stankoff B, Quittet P, Rémy C, Roba E, Rosario H, Roudaut N, Sonnet E, Ruel M, Sebban S, Schaepelynck P, Simonin MJ, Vial C, Viallard JF, Ladedan I, Zenone T (2017) Risk of autoimmune diseases and human papilloma virus (HPV) vaccines: six years of case-referent surveillance. J Autoimmun 79:84–90PubMed

163.

De Groof A et al (2017) Dysregulated lymphoid cell populations in mouse models of systemic lupus erythematosus. Clin Rev Allergy Immunol 53(2):181–197PubMed

164.

Choi JY, Seth A, Kashgarian M, Terrillon S, Fung E, Huang L, Wang LC, Craft J (2017) Disruption of pathogenic cellular networks by IL-21 blockade leads to disease amelioration in murine lupus. J Immunol 198(7):2578–2588PubMed

165.

Dai H, He F, Tsokos GC, Kyttaris VC (2017) IL-23 limits the production of IL-2 and promotes autoimmunity in lupus. J Immunol 199(3):903–910PubMed

166.

Goropevsek A, Holcar M, Avcin T (2017) The role of STAT signaling pathways in the pathogenesis of systemic lupus erythematosus. Clin Rev Allergy Immunol 52(2):164–181PubMed

167.

Bird AK, Chang M, Barnard J, Goldman BI, Meednu N, Rangel-Moreno J, Anolik JH (2017) Neutrophils slow disease progression in murine lupus via modulation of autoreactive germinal centers. J Immunol 199(2):458–466PubMed

168.

Bakshi J, Segura BT, Wincup C, Rahman A (2017) Unmet needs in the pathogenesis and treatment of systemic lupus erythematosus. Clin Rev Allergy Immunol

169.

Giannelou M, Mavragani CP (2017) Cardiovascular disease in systemic lupus erythematosus: a comprehensive update. J Autoimmun 82:1–12PubMed

170.

Tektonidou MG, Kravvariti E, Konstantonis G, Tentolouris N, Sfikakis PP, Protogerou A (2017) Subclinical atherosclerosis in systemic lupus erythematosus: comparable risk with diabetes mellitus and rheumatoid arthritis. Autoimmun Rev 16(3):308–312PubMed

171.

Buie JJ, Renaud LL, Muise-Helmericks R, Oates JC (2017) IFN-alpha negatively regulates the expression of endothelial nitric oxide synthase and nitric oxide production: implications for systemic lupus erythematosus. J Immunol 199(6):1979–1988PubMed

172.

Bundhun PK, Soogund MZ, Huang F (2017) Impact of systemic lupus erythematosus on maternal and fetal outcomes following pregnancy: a meta-analysis of studies published between years 2001-2016. J Autoimmun 79:17–27PubMed

173.

Gianfreda D, Quaglini S, Frontini G, Raffiotta F, Messa P, Moroni G (2017) Does pregnancy have any impact on long term damage accrual and on the outcome of lupus nephritis? J Autoimmun 84:46–54PubMed

174.

Yousef Yengej FA, van Royen-Kerkhof A, Derksen RHWM, Fritsch-Stork RDE (2017) The development of offspring from mothers with systemic lupus erythematosus. A systematic review. Autoimmun Rev 16(7):701–711PubMed

175.

Ruiz-Irastorza G, Ugarte A, Saint-Pastou Terrier C, Lazaro E, Iza A, Couzi L, Saenz R, Richez C, Porta S, Blanco P (2017) Repeated pulses of methyl-prednisolone with reduced doses of prednisone improve the outcome of class III, IV and V lupus nephritis: an observational comparative study of the lupus-Cruces and lupus-Bordeaux cohorts. Autoimmun Rev 16(8):826–832PubMed

176.

Parodis I, Sjöwall C, Jönsen A, Ramsköld D, Zickert A, Frodlund M, Sohrabian A, Arnaud L, Rönnelid J, Malmström V, Bengtsson AA, Gunnarsson I (2017) Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus. Autoimmun Rev 16(4):343–351PubMed

177.

Kleinmann JF, Tubach F, le Guern V, Mathian A, Richez C, Saadoun D, Sacre K, Sellam J, Seror R, Amoura Z, Andres E, Audia S, Bader-Meunier B, Blaison G, Bonnotte B, Cacoub P, Caillard S, Chiche L, Chosidow O, Costedoat-Chalumeau N, Daien C, Daugas E, Derdèche N, Doria A, Fain O, Fakhouri F, Farge D, Gabay C, Guillo S, Hachulla E, Hajjaj-Hassouni N, Hamidou M, Houssiau FA, Jourde-Chiche N, Koné-Paut I, Ladjouz-Rezig A, Lambotte O, Lipsker D, Mariette X, Martin-Silva N, Martin T, Maurier F, Meckenstock R, Mékinian A, Meyer O, Mohamed S, Morel J, Moulin B, Mulleman D, Papo T, Poindron V, Puéchal X, Punzi L, Quartier P, Sailler L, Smail A, Soubrier M, Sparsa A, Tazi-Mezalek Z, Zakraoui L, Zuily S, Sibilia J, Gottenberg JE (2017) International and multidisciplinary expert recommendations for the use of biologics in systemic lupus erythematosus. Autoimmun Rev 16(6):650–657PubMed

178.

Kronbichler A, Windpessl M, Pieringer H, Jayne DRW (2017) Rituximab for immunologic renal disease: what the nephrologist needs to know. Autoimmun Rev 16(6):633–643PubMed

179.

Zampeli E, Klinman DM, Gershwin ME, Moutsopoulos HM (2017) A comprehensive evaluation for the treatment of lupus nephritis. J Autoimmun 78:1–10PubMed

180.

Ribero S, Sciascia S, Borradori L, Lipsker D (2017) The cutaneous spectrum of lupus erythematosus. Clin Rev Allergy Immunol 53(3):291–305PubMed

181.

Sciascia S, Radin M, Yazdany J, Levy RA, Roccatello D, Dall'Era M, Cuadrado MJ (2017) Efficacy of belimumab on renal outcomes in patients with systemic lupus erythematosus: a systematic review. Autoimmun Rev 16(3):287–293PubMed

182.

Narain S, Furie R (2016) Update on clinical trials in systemic lupus erythematosus. Curr Opin Rheumatol 28(5):477–487PubMed

183.

Isenberg D, Gordon C, Licu D, Copt S, Rossi CP, Wofsy D (2015) Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial). Ann Rheum Dis 74(11):2006–2015PubMed

184.

Merrill JT, Wallace DJ, Wax S, Kao A, Fraser PA, Chang P, Isenberg D, on behalf of the ADDRESS II Investigators (2018) Efficacy and safety of atacicept in patients with systemic lupus erythematosus: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled, parallel-arm, phase IIb study. Arthritis Rheumatol 70(2):266–276PubMedPubMedCentral

185.

Merrill JT, Shanahan WR, Scheinberg M, Kalunian KC, Wofsy D, Martin RS (2018) Phase III trial results with blisibimod, a selective inhibitor of B-cell activating factor, in subjects with systemic lupus erythematosus (SLE): results from a randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 77(6):883–889PubMed

186.

Isenberg D (2016) Further thoughts about the ILLUMINATE studies of tabalumab in SLE. Ann Rheum Dis 75(2):e11PubMed

187.

Isenberg DA, Petri M, Kalunian K, Tanaka Y, Urowitz MB, Hoffman RW, Morgan-Cox M, Iikuni N, Silk M, Wallace DJ (2016) Efficacy and safety of subcutaneous tabalumab in patients with systemic lupus erythematosus: results from ILLUMINATE-1, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study. Ann Rheum Dis 75(2):323–331PubMed

188.

Mysler EF, Spindler AJ, Guzman R, Bijl M, Jayne D, Furie RA, Houssiau FA, Drappa J, Close D, Maciuca R, Rao K, Shahdad S, Brunetta P (2013) Efficacy and safety of ocrelizumab in active proliferative lupus nephritis: results from a randomized, double-blind, phase III study. Arthritis Rheum 65(9):2368–2379PubMed

189.

Doria A, Cervera R, Gatto M, Chehab G, Schneider M (2017) The new targeted therapy in systemic lupus erythematosus: is the glass half-full or half-empty? Autoimmun Rev 16(11):1119–1124PubMed

190.

Du FH, Mills EA, Mao-Draayer Y (2017) Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment. Auto Immun Highlights 8(1):12PubMedPubMedCentral

191.

Reddy V, Klein C, Isenberg DA, Glennie MJ, Cambridge G, Cragg MS, Leandro MJ (2017) Obinutuzumab induces superior B-cell cytotoxicity to rituximab in rheumatoid arthritis and systemic lupus erythematosus patient samples. Rheumatology (Oxford) 56(7):1227–1237

192.

Baker KF, Isaacs JD (2018) Novel therapies for immune-mediated inflammatory diseases: what can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn’s disease and ulcerative colitis? Ann Rheum Dis 77(2):175–187PubMed

193.

Favoino E, Prete M, Marzullo A, Millo E, Shoenfeld Y, Perosa F (2017) CD20-mimotope peptide active immunotherapy in systemic lupus erythematosus and a reappraisal of vaccination strategies in rheumatic diseases. Clin Rev Allergy Immunol 52(2):217–233PubMed

194.

Wu Q, Wang Q, Mao G, Dowling CA, Lundy SK, Mao-Draayer Y (2017) Dimethyl fumarate selectively reduces memory T cells and shifts the balance between Th1/Th17 and Th2 in multiple sclerosis patients. J Immunol 198(8):3069–3080PubMed

195.

Dudhgaonkar S, Ranade S, Nagar J, Subramani S, Prasad DS, Karunanithi P, Srivastava R, Venkatesh K, Selvam S, Krishnamurthy P, Mariappan TT, Saxena A, Fan L, Stetsko DK, Holloway DA, Li X, Zhu J, Yang WP, Ruepp S, Nair S, Santella J, Duncia J, Hynes J, McIntyre KW, Carman JA (2017) Selective IRAK4 inhibition attenuates disease in murine lupus models and demonstrates steroid sparing activity. J Immunol 198(3):1308–1319PubMed

196.

Leone A, Radin M, Almarzooqi AM, al-Saleh J, Roccatello D, Sciascia S, Khamashta M (2017) Autologous hematopoietic stem cell transplantation in systemic lupus erythematosus and antiphospholipid syndrome: a systematic review. Autoimmun Rev 16(5):469–477PubMed

197.

Salman-Monte TC, Torrente-Segarra V, Vega-Vidal AL, Corzo P, Castro-Dominguez F, Ojeda F, Carbonell-Abelló J (2017) Bone mineral density and vitamin D status in systemic lupus erythematosus (SLE): a systematic review. Autoimmun Rev 16(11):1155–1159PubMed

198.

Elshabrawy HA, Essani AE, Szekanecz Z, Fox DA, Shahrara S (2017) TLRs, future potential therapeutic targets for RA. Autoimmun Rev 16(2):103–113PubMed

199.

Amara K, Clay E, Yeo L, Ramsköld D, Spengler J, Sippl N, Cameron JA, Israelsson L, Titcombe PJ, Grönwall C, Sahbudin I, Filer A, Raza K, Malmström V, Scheel-Toellner D (2017) B cells expressing the IgA receptor FcRL4 participate in the autoimmune response in patients with rheumatoid arthritis. J Autoimmun 81:34–43PubMedPubMedCentral

200.

Banko Z et al (2017) Induction and differentiation of IL-10-producing regulatory B cells from healthy blood donors and rheumatoid arthritis patients. J Immunol 198(4):1512–1520PubMed

201.

Hu F, Liu H, Liu X, Zhang X, Xu L, Zhu H, Li Y, Shi L, Ren L, Zhang J, Li Z, Jia Y (2017) Pathogenic conversion of regulatory B10 cells into osteoclast-priming cells in rheumatoid arthritis. J Autoimmun 76:53–62PubMed

202.

Zamora C, Cantó E, Nieto JC, Bardina J, Diaz-Torné C, Moya P, Magallares B, Ortiz MA, Julià G, Juarez C, Llobet JM, Vidal S (2017) Binding of platelets to lymphocytes: a potential anti-inflammatory therapy in rheumatoid arthritis. J Immunol 198(8):3099–3108PubMed

203.

Wasen C et al (2017) Smoking activates cytotoxic CD8(+) T cells and causes survivin release in rheumatoid arthritis. J Autoimmun 78:101–110PubMed

204.

Vojinovic J, Tincani A, Sulli A, Soldano S, Andreoli L, Dall'Ara F, Ionescu R, Pasalic KS, Balcune I, Ferraz-Amaro I, Tlustochowicz M, Butrimiene I, Punceviciene E, Toroptsova N, Grazio S, Morovic-Vergles J, Masaryk P, Otsa K, Bernardes M, Boyadzhieva V, Salaffi F, Cutolo M (2017) European multicentre pilot survey to assess vitamin D status in rheumatoid arthritis patients and early development of a new Patient Reported Outcome questionnaire (D-PRO). Autoimmun Rev 16(5):548–554PubMed

205.

Ishikawa LLW, Colavite PM, Fraga-Silva TFC, Mimura LAN, França TGD, Zorzella-Pezavento SFG, Chiuso-Minicucci F, Marcolino LD, Penitenti M, Ikoma MRV, Sartori A (2017) Vitamin D deficiency and rheumatoid arthritis. Clin Rev Allergy Immunol 52(3):373–388PubMed

206.

Favalli EG, Raimondo MG, Becciolini A, Crotti C, Biggioggero M, Caporali R (2017) The management of first-line biologic therapy failures in rheumatoid arthritis: current practice and future perspectives. Autoimmun Rev 16(12):1185–1195PubMed

207.

Bystrom J, Clanchy FI, Taher TE, al-Bogami MM, Muhammad HA, Alzabin S, Mangat P, Jawad AS, Williams RO, Mageed RA (2017) Response to treatment with TNFalpha inhibitors in rheumatoid arthritis is associated with high levels of GM-CSF and GM-CSF(+) T lymphocytes. Clin Rev Allergy Immunol 53(2):265–276PubMedPubMedCentral

208.

Gazeau P, Alegria GC, Devauchelle-Pensec V, Jamin C, Lemerle J, Bendaoud B, Brooks WH, Saraux A, Cornec D, Renaudineau Y (2017) Memory B cells and response to abatacept in rheumatoid arthritis. Clin Rev Allergy Immunol 53(2):166–176PubMed

209.

Perez-Sanchez C et al (2017) Diagnostic potential of NETosis-derived products for disease activity, atherosclerosis and therapeutic effectiveness in rheumatoid arthritis patients. J Autoimmun 82:31–40PubMed

210.

Sandigursky S, Silverman GJ, Mor A (2017) Targeting the programmed cell death-1 pathway in rheumatoid arthritis. Autoimmun Rev 16(8):767–773PubMedPubMedCentral

211.

Elieh Ali Komi D, Shafaghat F, Zwiener RD (2017) Immunology of bee venom. Clin Rev Allergy Immunol

212.

Mostmans Y, Cutolo M, Giddelo C, Decuman S, Melsens K, Declercq H, Vandecasteele E, de Keyser F, Distler O, Gutermuth J, Smith V (2017) The role of endothelial cells in the vasculopathy of systemic sclerosis: a systematic review. Autoimmun Rev 16(8):774–786PubMed

213.

Cossu M, Beretta L, Mosterman P, de Hair MJH, Radstake TRDJ (2017) Unmet needs in systemic sclerosis understanding and treatment: the knowledge gaps from a scientist’s, clinician’s, and patient’s perspective. Clin Rev Allergy Immunol

214.

Ferreli C, Gasparini G, Parodi A, Cozzani E, Rongioletti F, Atzori L (2017) Cutaneous manifestations of scleroderma and scleroderma-like disorders: a comprehensive review. Clin Rev Allergy Immunol 53(3):306–336PubMed

215.

Soulaidopoulos S, Triantafyllidou E, Garyfallos A, Kitas GD, Dimitroulas T (2017) The role of nailfold capillaroscopy in the assessment of internal organ involvement in systemic sclerosis: a critical review. Autoimmun Rev 16(8):787–795PubMed

216.

Marie I, Gehanno JF, Bubenheim M, Duval-Modeste AB, Joly P, Dominique S, Bravard P, Noël D, Cailleux AF, Benichou J, Levesque H, Goullé JP (2017) Systemic sclerosis and exposure to heavy metals: a case control study of 100 patients and 300 controls. Autoimmun Rev 16(3):223–230PubMed

217.

Tsou PS, Sawalha AH (2017) Unfolding the pathogenesis of scleroderma through genomics and epigenomics. J Autoimmun 83:73–94PubMedPubMedCentral

218.

Slobodin G, Rimar D (2017) Regulatory T cells in systemic sclerosis: a comprehensive review. Clin Rev Allergy Immunol 52(2):194–201PubMed

219.

Berger M, Steen VD (2017) Role of anti-receptor autoantibodies in pathophysiology of scleroderma. Autoimmun Rev 16(10):1029–1035PubMed

220.

Sanges S, Rivière S, Mekinian A, Martin T, le Quellec A, Chatelus E, Lescoat A, Jego P, Cazalets C, Quéméneur T, le Gouellec N, Senet P, Francès C, Deroux A, Imbert B, Fain O, Boukari L, Sené T, Deligny C, Mathian A, Agard C, Pugnet G, Speca S, Dubucquoi S, Hatron PY, Hachulla É, Launay D (2017) Intravenous immunoglobulins in systemic sclerosis: data from a French nationwide cohort of 46 patients and review of the literature. Autoimmun Rev 16(4):377–384PubMed

221.

Rossi D, Zanatta E, Marson P, Sciascia S, Polito P, Roccatello D, Cozzi F (2017) How I treat patients with systemic sclerosis in clinical practice. Autoimmun Rev 16(10):1024–1028PubMed

222.

Giat E, Ehrenfeld M, Shoenfeld Y (2017) Cancer and autoimmune diseases. Autoimmun Rev 16(10):1049–1057PubMed

223.

Boonstra M, Huizinga TWJ, de Vries-Bouwstra JK (2017) Auto-antibodies and cancer in systemic sclerosis. Autoimmun Rev 16(8):883–884PubMed

224.

Bernal-Bello D, de Tena JG, Guillén-del Castillo A, Selva-O’Callaghan A, Callejas-Moraga EL, Marín-Sánchez AM, Fonollosa-Pla V, Simeón-Aznar CP (2017) Novel risk factors related to cancer in scleroderma. Autoimmun Rev 16(5):461–468PubMed

225.

Wu J, Li X, Song W, Fang Y, Yu L, Liu S, Churilov LP, Zhang F (2017) The roles and applications of autoantibodies in progression, diagnosis, treatment and prognosis of human malignant tumours. Autoimmun Rev 16(12):1270–1281PubMed

226.

June CH, Warshauer JT, Bluestone JA (2017) Is autoimmunity the Achilles’ heel of cancer immunotherapy? Nat Med 23(5):540–547PubMed

227.

He XS, Gershwin ME, Ansari AA (2017) Checkpoint-based immunotherapy for autoimmune diseases—opportunities and challenges. J Autoimmun 79:1–3PubMed

Titel: Autoimmunity in 2017
verfasst von: Carlo Selmi
Publikationsdatum: 26.07.2018
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 3/2018
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-018-8699-7

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Autoimmunity in 2017

Abstract

Neu im Fachgebiet HNO

Kinder mit anhaltender Sinusitis profitieren häufig von Antibiotika

CUP-Syndrom: Künstliche Intelligenz kann Primärtumor finden

Sind Frauen die fähigeren Ärzte?

Akuter Schwindel: Wann lohnt sich eine MRT?

Update HNO

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2018

Unmet Needs in the Field of Psoriasis: Pathogenesis and Treatment

Unmet Needs in IBD: the Case of Fatigue

Common Variable Immunodeficiency and Liver Involvement

Unmet Needs in Axial Spondyloarthritis

The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis

Clinical Features of Psoriatic Arthritis: a Comprehensive Review of Unmet Clinical Needs

Neu im Fachgebiet HNO

Kinder mit anhaltender Sinusitis profitieren häufig von Antibiotika

CUP-Syndrom: Künstliche Intelligenz kann Primärtumor finden

Sind Frauen die fähigeren Ärzte?

Akuter Schwindel: Wann lohnt sich eine MRT?

Update HNO