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Clinical Autonomic Research

Erschienen in:

01.02.2016 | Review Article

Autonomic dysfunction, immune regulation, and multiple sclerosis

verfasst von: Juan Manuel Racosta, Kurt Kimpinski

Erschienen in: Clinical Autonomic Research | Ausgabe 1/2016

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Abstract

Objective

To review existing evidence regarding interactions between the autonomic nervous system and the immune system functions in multiple sclerosis.

Methods

We reviewed the literature regarding new insights linking autonomic dysfunction to immune deregulation in multiple sclerosis, with particular focus on the specific influence of sympathetic and parasympathetic dysfunction on inflammatory and neurodegenerative processes.

Results

Autonomic dysfunction is common in multiple sclerosis, representing a significant cause of disability. Several connections between pathologic immune pathways and the autonomic nervous system function were found.

Conclusions

Autonomic dysfunction may enhance inflammatory and neurodegenerative pathways that are of major importance in multiple sclerosis. Autonomic dysfunction can present with highly variable manifestations. Sympathetic and parasympathetic dysfunction displays different patterns in multiple sclerosis, with specific impact on inflammation and neurodegeneration.

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Titel: Autonomic dysfunction, immune regulation, and multiple sclerosis
verfasst von: Juan Manuel Racosta
Kurt Kimpinski
Publikationsdatum: 01.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Autonomic Research / Ausgabe 1/2016
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-015-0325-7

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Abstract

Objective

Methods

Results

Conclusions

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