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Erschienen in:
01.08.2012
B Cell Immunity in Allergic Nasal Mucosa Induces T helper 2 Cell Differentiation
Erschienen in: Journal of Clinical Immunology | Ausgabe 4/2012
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Background
The pathogenesis of allergic diseases is to be further understood. Recent studies indicate that B cells are involved in the immune regulation. The present study aimed to investigate the role of B cells in the initiation of skewed T helper (Th)2 polarization.
Methods
The surgically removed nasal mucosal specimens from 24 patients with allergic rhinitis (AR) and 22 patients with non-AR (nAR) were collected. B cells isolated from the AR nasal mucosa were characterized. The effect of B cells on inducing naïve CD4+ T cells to differentiate into Th2 cells was evaluated with a cell culture model.
Results
Abundant B cells were detected in the nasal mucosa of patients with AR, which also expressed high levels of T cell immunoglobulin mucin domain (TIM)4 and costimulatory molecules. High levels of Staphylococcal enterotoxin B (SEB) were detected in the AR nasal mucosa. Expression of TIM4 could be induced in naïve B cells in the presence of SEB in culture. TIM4+ B cells could induce naïve CD4+ T cells to differentiate into Th2 cells.
Conclusions
TIM4+ B cells from AR nasal mucosa can induce skewed Th2 polarization. It may be a potential therapeutic target in the treatment of AR.
Capsule summary
B cells plays an important role in the initiation of Th2 polarization
Key Messages
• High frequency of B cells exists in nasal mucosa of allergic rhinitis
• These B cells express high levels of TIM4
• TIM4+ B cells can initiate the skewed Th2 polarization