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Current Oncology Reports

Erschienen in:

01.12.2017 | Integrative Care (C Lammersfeld, Section Editor)

B Vitamin Complex and Chemotherapy-Induced Peripheral Neuropathy

verfasst von: Janet Schloss, Maree Colosimo

Erschienen in: Current Oncology Reports | Ausgabe 12/2017

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Abstract

Purpose of Review

The purpose of this mini review is to evaluate the literature on B vitamins and chemotherapy-induced peripheral neuropathy.

Recent Findings

One hundred and five journal articles were evaluated and nine manuscripts were included. There was one in vitro, one was an animal and seven were human studies. The in vitro study was a safety study on vitamin B₆ and oxaliplatin which was not directly related to CIPN. The animal study evaluated vitamin B₃ on paclitaxel administration with positive results. The human studies varied using a vitamin B complex, vitamin B₁₂ only and vitamin B₆.

Summary

Chemotherapy-induced peripheral neuropathy (CIPN) continues to plague patients and the medical fraternity. Currently, there are still no conclusive protective or treatment options. B vitamins have been found to play a role in CIPN prevention, but further studies are required to ascertain possible protection and treatment options.

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Wolf SL, Barton DL, Qin R, Wos EJ, Sloan JA, Liu H, et al. The relationship between numbness, tingling, and shooting/burning pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN20 instrument, N06CA. Support Care Cancer. 2012;20(3):625–32.CrossRefPubMed

Scott JWD. Folate/vitamin B₁₂ inter-relationships. Essays Biochem. 1994;28:63–72.PubMed

Kancheria V, Elliot JL Jr, Patel BB, Holland NW, Johnson TM 2nd, Khakharia A, et al. Long-Term Metform Therapy and Monitoring for Vitamin B12 Deficiency Among Older Veterans. J Am Geriatr Soc 2017;65(5):1061–66.

•• Soloman L. Functional vitamin B12 deficiency in advanced malignancy: implications for the management of neuropathy and neuropathic pain. Support Care Cancer. 2016;24(8):3489–94. This paper highlights the importance of a functional B12 deficiency in peripheral neuropathy and neuropathic pain in cancer patients which is not always recognised. CrossRef

•• Ghavanini AA, Kimpinski K. Revisiting the evidence for neuropathy caused by pyridoxine deficiency and excess. J Clin Neuromuscul Dis. 2014;16(1):25–31. Recognising the impact of vitamin B ₆ supplementation on neuropathy is important as it is not normally highlighted in an algorithm associated with cancer neuropathy, although most nutrient supplements contain B6. CrossRefPubMed

Shenoy AM. An asymmetric sensory polyneuropathy related to thiamine deficiency from a gluten-free diet. J Clin Neuromuscul Dis. 2015;16(4):224–6.CrossRefPubMed

Vu TAJ, Ramos M, Flener V, Vanyo L, Tisman G. New assay for the rapid determination of plasma holotranscobalamin II levels: preliminary evaluation in cancer patients. Am J Hematol. 1993;42:202–11.CrossRefPubMed

Schloss JM, Colosimo M, Airey C, Vitetta L. Chemotherapy-induced peripheral neuropathy (CIPN) and vitamin B12 deficiency. Support Care Cancer. 2015;23(7):1843–50.CrossRefPubMed

10.

Garg MB, Ackland SP. Pyridoxine to protect from oxaliplatin-induced neurotoxicity without compromising antitumour effect. Cancer Chemother Pharmacol. 2011;67(4):963–6.CrossRefPubMed

11.

Hamity MV, White SR, Walder RY, Schmidt MS, Brenner C, Hammond DL. Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats. Pain. 2017.

12.

Wiernik PH, Yeap B, Vogl SE, Kaplan BH, Comis RL, Falkson G, et al. Hexamethylmelamine and low or moderate dose cisplatin with or without pyridoxine for treatment of advanced ovarian carcinoma: a study of the Eastern Cooperative Oncology Group. Cancer Investig. 1992;10(1):1–9.CrossRef

13.

Rostock M, Jaroslawski K, Guethlin C, Ludtke R, Schröder S, Bartsch HH. Chemotherapy-induced peripheral neuropathy in cancer patients: a four-arm randomized trial on the effectiveness of electroacupuncture. Evid Based Complement Alternat Med. 2013;2013:349653.CrossRefPubMedPubMedCentral

14.

•• Hirayama Y, Ishitani K, Sato Y, Iyama S, Takada K, Murase K, et al. Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial. Int J Clin Oncol. 2015;20(5):866–71. Treatments for CIPN are limited, and this paper finds duloxetine statistically significant for neuropathic pain treatment. CrossRefPubMed

15.

Schloss JM, Colosimo M, Airey C, Masci P, Linnane AW, Vitetta L. A randomised, placebo-controlled trial assessing the efficacy of an oral B group vitamin in preventing the development of chemotherapy-induced peripheral neuropathy (CIPN). Support Care Cancer. 2017;25(1):195–204.CrossRefPubMed

16.

Han X, Wang L, Shi H, Zheng G, He J, Wu W, et al. Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma. BMC Cancer. 2017;17(1):40.CrossRefPubMedPubMedCentral

17.

Schloss JCM, Vitetta L. New insights into potential prevention and management options for chemotherapy-induced peripheral neuropathy. Asia Pac J Oncol Nurs. 2016;3(1):73–85.CrossRefPubMedPubMedCentral

Titel: B Vitamin Complex and Chemotherapy-Induced Peripheral Neuropathy
verfasst von: Janet Schloss
Maree Colosimo
Publikationsdatum: 01.12.2017
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 12/2017
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-017-0636-z

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B Vitamin Complex and Chemotherapy-Induced Peripheral Neuropathy

Abstract

Purpose of Review

Recent Findings

Summary

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