Erschienen in:
01.08.2010 | Letter
Bcl-xL affects the development of functional CD4 Tregs
verfasst von:
Amir Sharabi, Edna Mozes
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 4/2010
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Excerpt
We read with great interest the article by Haque and colleagues [
1] in a recent issue of
Arthritis Research & Therapy. They hypothesized that co-transduction of CD4
+ T cells with both forkhead box P3 transcription factor (FoxP3) and Bcl-xL will generate highly reactive regulatory T cells (Tregs) that can be used to prevent auto immune disease. The authors showed that the accumulation, persistence, and efficient function of Tregs were attributable to the expression of Bcl-xL in CD4 Tregs. …