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Journal of Diabetes & Metabolic Disorders

Erschienen in:

06.01.2021 | Research article

Beneficial effect of Zingiber officinale on olanzapine-induced weight gain and metabolic changes

verfasst von: Mrityunjaya B. Ullagaddi, B. M. Patil, Pukar Khanal

Erschienen in: Journal of Diabetes & Metabolic Disorders | Ausgabe 1/2021

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Abstract

Aim

The present study aimed to investigate the effect of Zingiber officinale (ZO) extract on weight gain, food intake, locomotor activity, and lipid and glucose metabolism in olanzapine-treated rats.

Methods

The hydroalcoholic extract of ZO was prepared by macerating the coarse dry powder in 70% v/v ethanol for 7 days, filtered, and concentrated under reduced pressure. Animals were divided into six groups containing six animals in each. Three doses of extract (100, 200, and 400 mg/kg, p.o.) were co-administered with olanzapine 2 mg/kg i.p for 21 days. Bodyweight and food intake were recorded at the interval of three days and locomotor activity once a week. At the end of the study oral glucose tolerance test was performed followed by the estimation of lipid profile.

Results

Co-administration of hydroalcoholic extract of ZO with olanzapine ameliorated olanzapine-induced weight gain and hyperphagia. Similarly, ZO extract also improved pancreatic β-cell function and glucose and lipid metabolism.

Conclusions

ZO extract ameliorated olanzapine-induced weight gain and hyperphagia by improving pancreatic β-cell functions and lipid metabolism.

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Titel: Beneficial effect of Zingiber officinale on olanzapine-induced weight gain and metabolic changes
verfasst von: Mrityunjaya B. Ullagaddi
B. M. Patil
Pukar Khanal
Publikationsdatum: 06.01.2021
Verlag: Springer International Publishing
Erschienen in: Journal of Diabetes & Metabolic Disorders / Ausgabe 1/2021
Elektronische ISSN: 2251-6581
DOI: https://doi.org/10.1007/s40200-020-00695-x

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Abstract

Aim

Methods

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Conclusions

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