Skip to main content
Erschienen in: Current Oral Health Reports 2/2016

01.06.2016 | Oral Neoplasia (F Alawi and A Le, Section Editors)

Benign Odontogenic Tumors: Origins, Immunophenotypic Features, and Genetic Alterations

verfasst von: Chunmiao Jiang, Qilin Xu, Qunzhou Zhang, Steven Wang, Lee R. Carrasco, Anh D. Le

Erschienen in: Current Oral Health Reports | Ausgabe 2/2016

Einloggen, um Zugang zu erhalten

Abstract

Odontogenic tumors are lesions derived from the epithelial and/or mesenchymal elements of the tooth-forming apparatus and are therefore found within the jaw bone or soft tissue overlying teeth. These tooth development-associated tumors are generally benign, but several odontogenic tumors are capable of aggressive growth and locally invasive behavior with a high rate of recurrence. Benign odontogenic tumors can pose diagnostic challenges because of overlapping histology, a lack of distinct phenotypic and molecular features, and an unclear pathogenesis of the tumors. In this article, we will review the possible origins, immunophenotypic features, and genetic alterations of the common benign odontogenic tumors.
Literatur
1.
Zurück zum Zitat Barnes L. Pathology and genetics of head and neck tumours. Vol. 9. Lyon: IARC; 2005. Barnes L. Pathology and genetics of head and neck tumours. Vol. 9. Lyon: IARC; 2005.
2.
Zurück zum Zitat Press SG. Odontogenic tumors of the maxillary sinus. Curr Opin Otolaryngol Head Neck Surg. 2008;16(1):47–54.CrossRefPubMed Press SG. Odontogenic tumors of the maxillary sinus. Curr Opin Otolaryngol Head Neck Surg. 2008;16(1):47–54.CrossRefPubMed
3.
Zurück zum Zitat Sekerci AE et al. Odontogenic tumors: a collaborative study of 218 cases diagnosed over 12 years and comprehensive review of the literature. Med Oral Patol Oral Cir Bucal. 2015;20(1):e34–44.CrossRefPubMedPubMedCentral Sekerci AE et al. Odontogenic tumors: a collaborative study of 218 cases diagnosed over 12 years and comprehensive review of the literature. Med Oral Patol Oral Cir Bucal. 2015;20(1):e34–44.CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Jing W et al. Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg. 2007;36(1):20–5.CrossRefPubMed Jing W et al. Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg. 2007;36(1):20–5.CrossRefPubMed
5.
Zurück zum Zitat Gorlin RJ, Chaudhry AP, Pindborg JJ. Odontogenic tumors. Classification, histopathology, and clinical behavior in man and domesticated animals. Cancer. 1961;14:73–101.CrossRefPubMed Gorlin RJ, Chaudhry AP, Pindborg JJ. Odontogenic tumors. Classification, histopathology, and clinical behavior in man and domesticated animals. Cancer. 1961;14:73–101.CrossRefPubMed
6.
Zurück zum Zitat Takeda Y, Kuroda M, Suzuki A. Ameloblastoma of mucosal origin. Acta Pathol Jpn. 1988;38(8):1053–60.PubMed Takeda Y, Kuroda M, Suzuki A. Ameloblastoma of mucosal origin. Acta Pathol Jpn. 1988;38(8):1053–60.PubMed
7.
Zurück zum Zitat Kim J, Ellis GL. Dental follicular tissue: misinterpretation as odontogenic tumors. J Oral Maxillofac Surg. 1993;51(7):762–7. discussion 767–8.CrossRefPubMed Kim J, Ellis GL. Dental follicular tissue: misinterpretation as odontogenic tumors. J Oral Maxillofac Surg. 1993;51(7):762–7. discussion 767–8.CrossRefPubMed
8.•
Zurück zum Zitat Nagamalini BR et al. Origin of ameloblastoma from basal cells of the oral epithelium-establishing the relation using neuroectodermal markers. J Clin Diagn Res. 2014;8(10):ZC44. The neuroectoderm, ameloblastoma and the basal layer of the oral epithelium have strong relationship with each other, which favours the hypothesis that the basal cell layer of oral mucosa may be a main source of ameloblastoma, espeically in the non-tooth bearing area. Nagamalini BR et al. Origin of ameloblastoma from basal cells of the oral epithelium-establishing the relation using neuroectodermal markers. J Clin Diagn Res. 2014;8(10):ZC44. The neuroectoderm, ameloblastoma and the basal layer of the oral epithelium have strong relationship with each other, which favours the hypothesis that the basal cell layer of oral mucosa may be a main source of ameloblastoma, espeically in the non-tooth bearing area.
9.
Zurück zum Zitat Gagari E. Neuroendocrine markers in ameloblastoma: an immunohistochemical study of 32 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(2):194.CrossRef Gagari E. Neuroendocrine markers in ameloblastoma: an immunohistochemical study of 32 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(2):194.CrossRef
10.
Zurück zum Zitat Takeda Y et al. Immunohistochemical expression of neural tissue markers (neuron-specific enolase, glial fibrillary acidic protein, S100 protein) in ameloblastic fibrodentinoma: a comparative study with ameloblastic fibroma. Pathol Int. 2000;50(8):610–5.CrossRefPubMed Takeda Y et al. Immunohistochemical expression of neural tissue markers (neuron-specific enolase, glial fibrillary acidic protein, S100 protein) in ameloblastic fibrodentinoma: a comparative study with ameloblastic fibroma. Pathol Int. 2000;50(8):610–5.CrossRefPubMed
11.
Zurück zum Zitat Philipsen HP et al. Peripheral ameloblastoma: biological profile based on 160 cases from the literature. Oral Oncol. 2001;37(1):17–27.CrossRefPubMed Philipsen HP et al. Peripheral ameloblastoma: biological profile based on 160 cases from the literature. Oral Oncol. 2001;37(1):17–27.CrossRefPubMed
12.
Zurück zum Zitat Kishino M et al. A immunohistochemical study of the peripheral ameloblastoma. Oral Dis. 2007;13(6):575–80.CrossRefPubMed Kishino M et al. A immunohistochemical study of the peripheral ameloblastoma. Oral Dis. 2007;13(6):575–80.CrossRefPubMed
13.
Zurück zum Zitat Ide F et al. Peripheral ameloblastoma in-situ: an evidential fact of surface epithelium origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(5):763–7.CrossRefPubMed Ide F et al. Peripheral ameloblastoma in-situ: an evidential fact of surface epithelium origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(5):763–7.CrossRefPubMed
14.
Zurück zum Zitat Ide F. Peripheral ameloblastoma of the buccal mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(5):653–4. author reply 654–5.CrossRefPubMed Ide F. Peripheral ameloblastoma of the buccal mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(5):653–4. author reply 654–5.CrossRefPubMed
15.
Zurück zum Zitat Kanzaki H et al. Dual regulation of osteoclast differentiation by periodontal ligament cells through RANKL stimulation and OPG inhibition. J Dent Res. 2001;80(3):887–91.CrossRefPubMed Kanzaki H et al. Dual regulation of osteoclast differentiation by periodontal ligament cells through RANKL stimulation and OPG inhibition. J Dent Res. 2001;80(3):887–91.CrossRefPubMed
16.
Zurück zum Zitat Rani CS, MacDougall M. Dental cells express factors that regulate bone resorption. Mol Cell Biol Res Commun. 2000;3(3):145–52.CrossRefPubMed Rani CS, MacDougall M. Dental cells express factors that regulate bone resorption. Mol Cell Biol Res Commun. 2000;3(3):145–52.CrossRefPubMed
17.
Zurück zum Zitat Sakata M et al. Expression of osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells. J Bone Miner Res. 1999;14(9):1486–92.CrossRefPubMed Sakata M et al. Expression of osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells. J Bone Miner Res. 1999;14(9):1486–92.CrossRefPubMed
18.
Zurück zum Zitat Pripatnanont P et al. In situ hybridisation and immunocytochemical localisation of osteolytic cytokines and adhesion molecules in ameloblastomas. J Oral Pathol Med. 1998;27(10):496–500.CrossRefPubMed Pripatnanont P et al. In situ hybridisation and immunocytochemical localisation of osteolytic cytokines and adhesion molecules in ameloblastomas. J Oral Pathol Med. 1998;27(10):496–500.CrossRefPubMed
19.
Zurück zum Zitat Ahlem B et al. Study of Ki67 and CD10 expression as predictive factors of recurrence of ameloblastoma. Eur Ann Otorhinolaryngol Head Neck Dis. 2015;132(5):275–9.CrossRefPubMed Ahlem B et al. Study of Ki67 and CD10 expression as predictive factors of recurrence of ameloblastoma. Eur Ann Otorhinolaryngol Head Neck Dis. 2015;132(5):275–9.CrossRefPubMed
20.
Zurück zum Zitat Cavalcante RB et al. Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(1):99–105.CrossRefPubMed Cavalcante RB et al. Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(1):99–105.CrossRefPubMed
21.
Zurück zum Zitat Cross JJL et al. Value of computed tomography and magnetic resonance imaging in the treatment of a calcifying epithelial odontogenic (Pindborg) tumour. Br J Oral Maxillofac Surg. 2000;38(2):154–7.CrossRefPubMed Cross JJL et al. Value of computed tomography and magnetic resonance imaging in the treatment of a calcifying epithelial odontogenic (Pindborg) tumour. Br J Oral Maxillofac Surg. 2000;38(2):154–7.CrossRefPubMed
22.
Zurück zum Zitat Martinez-Mata G et al. Odontogenic myxoma: clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series. Oral Oncol. 2008;44(6):601–7.CrossRefPubMed Martinez-Mata G et al. Odontogenic myxoma: clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series. Oral Oncol. 2008;44(6):601–7.CrossRefPubMed
23.
Zurück zum Zitat Miyagi SPH et al. Expression of matrix metalloproteinases 2 and 9 in odontogenic myxoma in vivo and in vitro. J Oral Sci. 2008;50(2):187–92.CrossRefPubMed Miyagi SPH et al. Expression of matrix metalloproteinases 2 and 9 in odontogenic myxoma in vivo and in vitro. J Oral Sci. 2008;50(2):187–92.CrossRefPubMed
24.
Zurück zum Zitat Olimid DA et al. The evaluation of p16 and Ki67 immunoexpression in ameloblastomas. Rom J Morphol Embryol. 2014;55(2):363–7.PubMed Olimid DA et al. The evaluation of p16 and Ki67 immunoexpression in ameloblastomas. Rom J Morphol Embryol. 2014;55(2):363–7.PubMed
25.
Zurück zum Zitat Lo Muzio L et al. Expression of cell cycle and apoptosis-related proteins in sporadic odontogenic keratocysts and odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome. J Dent Res. 1999;78(7):1345–53.CrossRefPubMed Lo Muzio L et al. Expression of cell cycle and apoptosis-related proteins in sporadic odontogenic keratocysts and odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome. J Dent Res. 1999;78(7):1345–53.CrossRefPubMed
26.
Zurück zum Zitat Gadbail AR et al. Actual Proliferating Index and p53 protein expression as prognostic marker in odontogenic cysts. Oral Dis. 2009;15(7):490–8.CrossRefPubMed Gadbail AR et al. Actual Proliferating Index and p53 protein expression as prognostic marker in odontogenic cysts. Oral Dis. 2009;15(7):490–8.CrossRefPubMed
27.
Zurück zum Zitat Razavi SM, Khalesi S, Torabinia N. Investigation of clinicopathological parameters alongside with p53 expression in primary and recurrent keratocysticodontogenic tumours. Malays J Pathol. 2014;36(2):105–13.PubMed Razavi SM, Khalesi S, Torabinia N. Investigation of clinicopathological parameters alongside with p53 expression in primary and recurrent keratocysticodontogenic tumours. Malays J Pathol. 2014;36(2):105–13.PubMed
28.
Zurück zum Zitat Deyhimi P, Hashemzadeh Z. Study of the biologic behavior of odontogenic keratocyst and orthokeratinaized odontogenic cyst using TGF-alpha and P53 markers. Pathol Res Pract. 2014;210(4):201–4.CrossRefPubMed Deyhimi P, Hashemzadeh Z. Study of the biologic behavior of odontogenic keratocyst and orthokeratinaized odontogenic cyst using TGF-alpha and P53 markers. Pathol Res Pract. 2014;210(4):201–4.CrossRefPubMed
29.
Zurück zum Zitat Meghji S et al. Interleukin-1: the principal osteolytic cytokine produced by keratocysts. Arch Oral Biol. 1992;37(11):935–43.CrossRefPubMed Meghji S et al. Interleukin-1: the principal osteolytic cytokine produced by keratocysts. Arch Oral Biol. 1992;37(11):935–43.CrossRefPubMed
30.
Zurück zum Zitat Ogata S et al. Signaling pathways regulating IL-1alpha-induced COX-2 expression. J Dent Res. 2007;86(2):186–91.CrossRefPubMed Ogata S et al. Signaling pathways regulating IL-1alpha-induced COX-2 expression. J Dent Res. 2007;86(2):186–91.CrossRefPubMed
31.
Zurück zum Zitat Siar CH, Ishak I, Ng KH. Podoplanin, E-cadherin, beta-catenin, and CD44v6 in recurrent ameloblastoma: their distribution patterns and relevance. J Oral Pathol Med. 2015;44(1):51–8.CrossRefPubMed Siar CH, Ishak I, Ng KH. Podoplanin, E-cadherin, beta-catenin, and CD44v6 in recurrent ameloblastoma: their distribution patterns and relevance. J Oral Pathol Med. 2015;44(1):51–8.CrossRefPubMed
32.••
Zurück zum Zitat Saunders S et al. Molecular cloning of syndecan, an integral membrane proteoglycan. J Cell Biol. 1989;108(4):1547–56. Ameloblastoma cells harboring an activating BRAF mutation encoding p.Val600Glu are sensitive to the BRAF inhibitor vemurafenib, making a new paradigm for the diagnostic classification and treatment of ameloblastomas. Saunders S et al. Molecular cloning of syndecan, an integral membrane proteoglycan. J Cell Biol. 1989;108(4):1547–56. Ameloblastoma cells harboring an activating BRAF mutation encoding p.Val600Glu are sensitive to the BRAF inhibitor vemurafenib, making a new paradigm for the diagnostic classification and treatment of ameloblastomas.
33.••
Zurück zum Zitat Al-Otaibi O et al. Syndecan-1 (CD 138) surface expression marks cell type and differentiation in ameloblastoma, keratocystic odontogenic tumor, and dentigerous cyst. J Oral Pathol Med. 2013;42(2):186–93. Activating FGFR2-RAS-BRAF mutations play a critical role in the pathogenesis of most cases of ameloblastoma. BRAF V600E mutations have both diagnostic and prognostic implications. Al-Otaibi O et al. Syndecan-1 (CD 138) surface expression marks cell type and differentiation in ameloblastoma, keratocystic odontogenic tumor, and dentigerous cyst. J Oral Pathol Med. 2013;42(2):186–93. Activating FGFR2-RAS-BRAF mutations play a critical role in the pathogenesis of most cases of ameloblastoma. BRAF V600E mutations have both diagnostic and prognostic implications.
34.
Zurück zum Zitat Cairns L et al. CD56 (NCAM) expression in ameloblastomas and other odontogenic lesions. Histopathology. 2010;57(4):544–8.CrossRefPubMed Cairns L et al. CD56 (NCAM) expression in ameloblastomas and other odontogenic lesions. Histopathology. 2010;57(4):544–8.CrossRefPubMed
35.
Zurück zum Zitat Nakano K, Nagatsuka H, Kawakami T. Wingless-type protein-1 (Wnt-1) expression in primary conventional and unicystic ameloblastomas and their recurrent tumors. J Hard Tissue Biol. 2009;18(2):63–70.CrossRef Nakano K, Nagatsuka H, Kawakami T. Wingless-type protein-1 (Wnt-1) expression in primary conventional and unicystic ameloblastomas and their recurrent tumors. J Hard Tissue Biol. 2009;18(2):63–70.CrossRef
36.
Zurück zum Zitat Siar CH et al. Differential expression of canonical and non-canonical Wnt ligands in ameloblastoma. J Oral Pathol Med. 2012;41(4):332–9.CrossRefPubMed Siar CH et al. Differential expression of canonical and non-canonical Wnt ligands in ameloblastoma. J Oral Pathol Med. 2012;41(4):332–9.CrossRefPubMed
37.
Zurück zum Zitat González‐Alva P et al. Enhanced expression of podoplanin in ameloblastomas. J Oral Pathol Med. 2010;39(1):103–9.CrossRefPubMed González‐Alva P et al. Enhanced expression of podoplanin in ameloblastomas. J Oral Pathol Med. 2010;39(1):103–9.CrossRefPubMed
38.
Zurück zum Zitat Ren C et al. Differential enamel and osteogenic gene expression profiles in odontogenic tumors. Cells Tissues Organs. 2011;194(2–4):296–301.CrossRefPubMed Ren C et al. Differential enamel and osteogenic gene expression profiles in odontogenic tumors. Cells Tissues Organs. 2011;194(2–4):296–301.CrossRefPubMed
40.
Zurück zum Zitat Brown NA et al. Activating FGFR2-RAS-BRAF mutations in ameloblastoma. Clin Cancer Res. 2014;20(21):5517–26.CrossRefPubMed Brown NA et al. Activating FGFR2-RAS-BRAF mutations in ameloblastoma. Clin Cancer Res. 2014;20(21):5517–26.CrossRefPubMed
41.
Zurück zum Zitat Kaminagakura E et al. Detection of cytokeratins in ghost cells of calcifying cystic odontogenic tumor indicates an altered keratinization and hair follicle differentiation for their development. Ann Diagn Pathol. 2013;17(6):514–7.CrossRefPubMed Kaminagakura E et al. Detection of cytokeratins in ghost cells of calcifying cystic odontogenic tumor indicates an altered keratinization and hair follicle differentiation for their development. Ann Diagn Pathol. 2013;17(6):514–7.CrossRefPubMed
42.
Zurück zum Zitat Ribeiro BF et al. Immunohistochemical expression of matrix metalloproteinases 1, 2, 7, 9, and 26 in the calcifying cystic odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(5):609–15.CrossRefPubMed Ribeiro BF et al. Immunohistochemical expression of matrix metalloproteinases 1, 2, 7, 9, and 26 in the calcifying cystic odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(5):609–15.CrossRefPubMed
44.
Zurück zum Zitat Er N et al. Neural cell adhesion molecule and neurothelin expression in human ameloblastoma. J Oral Maxillofac Surg. 2001;59(8):900–3. discussion 904.CrossRefPubMed Er N et al. Neural cell adhesion molecule and neurothelin expression in human ameloblastoma. J Oral Maxillofac Surg. 2001;59(8):900–3. discussion 904.CrossRefPubMed
45.
Zurück zum Zitat Kumamoto H, Ooya K. Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors. J Oral Pathol Med. 2006;35(6):345–51.CrossRefPubMed Kumamoto H, Ooya K. Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors. J Oral Pathol Med. 2006;35(6):345–51.CrossRefPubMed
46.
47.
Zurück zum Zitat Barreto DC et al. PTCH gene mutations in odontogenic keratocysts. J Dent Res. 2000;79(6):1418–22.CrossRefPubMed Barreto DC et al. PTCH gene mutations in odontogenic keratocysts. J Dent Res. 2000;79(6):1418–22.CrossRefPubMed
48.
Zurück zum Zitat Andrade FR et al. Expression of bone resorption regulators (RANK, RANKL, and OPG) in odontogenic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(4):548–55.CrossRefPubMed Andrade FR et al. Expression of bone resorption regulators (RANK, RANKL, and OPG) in odontogenic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(4):548–55.CrossRefPubMed
49.
Zurück zum Zitat Wan PT et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 2004;116(6):855–67.CrossRefPubMed Wan PT et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 2004;116(6):855–67.CrossRefPubMed
50.
Zurück zum Zitat Shear M, Speight P. Cysts of the oral and maxillofacial regions. New York: John Wiley & Sons; 2008. Shear M, Speight P. Cysts of the oral and maxillofacial regions. New York: John Wiley & Sons; 2008.
51.
Zurück zum Zitat Da Silva MJA et al. Immunohistochemical study of the orthokeratinized odontogenic cyst: a comparison with the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94(6):732–7.CrossRefPubMed Da Silva MJA et al. Immunohistochemical study of the orthokeratinized odontogenic cyst: a comparison with the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94(6):732–7.CrossRefPubMed
52.
Zurück zum Zitat Yoshida M et al. Histopathological and immunohistochemical analysis of calcifying odontogenic cysts. J Oral Pathol Med. 2001;30(10):582–8.CrossRefPubMed Yoshida M et al. Histopathological and immunohistochemical analysis of calcifying odontogenic cysts. J Oral Pathol Med. 2001;30(10):582–8.CrossRefPubMed
53.
Zurück zum Zitat Yagyuu T et al. Recurrence of keratocystic odontogenic tumor: clinicopathological features and immunohistochemical study of the Hedgehog signaling pathway. Pathobiology. 2008;75(3):171–6.CrossRefPubMed Yagyuu T et al. Recurrence of keratocystic odontogenic tumor: clinicopathological features and immunohistochemical study of the Hedgehog signaling pathway. Pathobiology. 2008;75(3):171–6.CrossRefPubMed
54.
55.
Zurück zum Zitat Da Silva TA et al. Comparative expression of RANK, RANKL, and OPG in keratocystic odontogenic tumors, ameloblastomas, and dentigerous cysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(3):333–41.CrossRefPubMed Da Silva TA et al. Comparative expression of RANK, RANKL, and OPG in keratocystic odontogenic tumors, ameloblastomas, and dentigerous cysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(3):333–41.CrossRefPubMed
56.
Zurück zum Zitat Bologna-Molina R et al. Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma. Pathol Int. 2009;59(4):229–33.CrossRefPubMed Bologna-Molina R et al. Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma. Pathol Int. 2009;59(4):229–33.CrossRefPubMed
57.
Zurück zum Zitat Bello IO et al. Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth. J Oral Pathol Med. 2007;36(1):48–54.CrossRefPubMed Bello IO et al. Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth. J Oral Pathol Med. 2007;36(1):48–54.CrossRefPubMed
59.•
Zurück zum Zitat Ribeiro BF et al. Immunoexpression of MMPs-1, −2, and −9 in ameloblastoma and odontogenic adenomatoid tumor. Oral Dis. 2009;15(7):472–7. TGF-beta, a potent EMT inducer, and Slug, a master transcription factor, were highly expressed in KCOT, suggesting EMT might be involved in the locally aggressive behavior of KCOT. CrossRefPubMed Ribeiro BF et al. Immunoexpression of MMPs-1, −2, and −9 in ameloblastoma and odontogenic adenomatoid tumor. Oral Dis. 2009;15(7):472–7. TGF-beta, a potent EMT inducer, and Slug, a master transcription factor, were highly expressed in KCOT, suggesting EMT might be involved in the locally aggressive behavior of KCOT. CrossRefPubMed
60.
Zurück zum Zitat Stone DM et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 1996;384(6605):129–34.CrossRefPubMed Stone DM et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 1996;384(6605):129–34.CrossRefPubMed
61.
Zurück zum Zitat Kawabata T et al. Polymorphisms in PTCH1 affect the risk of ameloblastoma. J Dent Res. 2005;84(9):812–6.CrossRefPubMed Kawabata T et al. Polymorphisms in PTCH1 affect the risk of ameloblastoma. J Dent Res. 2005;84(9):812–6.CrossRefPubMed
62.
Zurück zum Zitat Dalati T, Zhou H. Gorlin syndrome with ameloblastoma: a case report and review of literature. Cancer Invest. 2008;26(10):975–6.CrossRefPubMed Dalati T, Zhou H. Gorlin syndrome with ameloblastoma: a case report and review of literature. Cancer Invest. 2008;26(10):975–6.CrossRefPubMed
63.
Zurück zum Zitat Stoelinga PJW. Etiology and pathogenesis of keratocysts. Oral Maxillofac Surg Clin North Am. 2003;15(3):317–24.CrossRefPubMed Stoelinga PJW. Etiology and pathogenesis of keratocysts. Oral Maxillofac Surg Clin North Am. 2003;15(3):317–24.CrossRefPubMed
64.
Zurück zum Zitat Stoelinga PJW. The treatment of odontogenic keratocysts by excision of the overlying, attached mucosa, enucleation, and treatment of the bony defect with Carnoy solution. J Oral Maxillofac Surg. 2005;63(11):1662–6.CrossRefPubMed Stoelinga PJW. The treatment of odontogenic keratocysts by excision of the overlying, attached mucosa, enucleation, and treatment of the bony defect with Carnoy solution. J Oral Maxillofac Surg. 2005;63(11):1662–6.CrossRefPubMed
65.
Zurück zum Zitat Voorsmit RA, Stoelinga PJ, van Haelst UJ. The management of keratocysts. J Maxillofac Surg. 1981;9(4):228–36.CrossRefPubMed Voorsmit RA, Stoelinga PJ, van Haelst UJ. The management of keratocysts. J Maxillofac Surg. 1981;9(4):228–36.CrossRefPubMed
66.
Zurück zum Zitat Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 2. Proliferation and genetic studies. Oral Oncol. 2002;38(4):323–31.CrossRefPubMed Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 2. Proliferation and genetic studies. Oral Oncol. 2002;38(4):323–31.CrossRefPubMed
68.•
Zurück zum Zitat Porto LPA et al. E-cadherin regulators are differentially expressed in the epithelium and stroma of keratocystic odontogenic tumors. J Oral Pathol Med. 2016;45(4):302–11. Porto LPA et al. E-cadherin regulators are differentially expressed in the epithelium and stroma of keratocystic odontogenic tumors. J Oral Pathol Med. 2016;45(4):302–11.
69.
Zurück zum Zitat Zhong WQ et al. Epithelial-mesenchymal transition in keratocystic odontogenic tumor: possible role in locally aggressive behavior. Biomed Res Int. 2015;2015:168089.PubMedPubMedCentral Zhong WQ et al. Epithelial-mesenchymal transition in keratocystic odontogenic tumor: possible role in locally aggressive behavior. Biomed Res Int. 2015;2015:168089.PubMedPubMedCentral
70.
Zurück zum Zitat Cildir SK et al. Delayed eruption of a mandibular primary cuspid associated with compound odontoma. J Contemp Dent Pract. 2005;6(4):152–9.PubMed Cildir SK et al. Delayed eruption of a mandibular primary cuspid associated with compound odontoma. J Contemp Dent Pract. 2005;6(4):152–9.PubMed
71.
Zurück zum Zitat Kramer IRH, Pindborg JJ, Shear M. Histological typing of odontogenic tumors. World Health Organization. International Histological Classification of Tumors. 1992.CrossRef Kramer IRH, Pindborg JJ, Shear M. Histological typing of odontogenic tumors. World Health Organization. International Histological Classification of Tumors. 1992.CrossRef
72.
Zurück zum Zitat Noffke CE, Chabikuli NJ, Nzima N. Impaired tooth eruption: a review. SADJ. 2005;60(10):422. 424–5.PubMed Noffke CE, Chabikuli NJ, Nzima N. Impaired tooth eruption: a review. SADJ. 2005;60(10):422. 424–5.PubMed
74.
Zurück zum Zitat Gonzalez-Alva P et al. Podoplanin expression in odontomas: clinicopathological study and immunohistochemical analysis of 86 cases. J Oral Sci. 2011;53(1):67–75.CrossRefPubMed Gonzalez-Alva P et al. Podoplanin expression in odontomas: clinicopathological study and immunohistochemical analysis of 86 cases. J Oral Sci. 2011;53(1):67–75.CrossRefPubMed
76.
Zurück zum Zitat Ziebart T et al. The original family revisited after 37 years: odontoma-dysphagia syndrome is most likely caused by a microduplication of chromosome 11q13.3, including the FGF3 and FGF4 genes. Clin Oral Investig. 2013;17(1):123–30.CrossRefPubMed Ziebart T et al. The original family revisited after 37 years: odontoma-dysphagia syndrome is most likely caused by a microduplication of chromosome 11q13.3, including the FGF3 and FGF4 genes. Clin Oral Investig. 2013;17(1):123–30.CrossRefPubMed
77.
Zurück zum Zitat Moleri AB, Moreira LC, Carvalho JJ. Comparative morphology of 7 new cases of calcifying odontogenic cysts. J Oral Maxillofac Surg. 2002;60(6):689–96.CrossRefPubMed Moleri AB, Moreira LC, Carvalho JJ. Comparative morphology of 7 new cases of calcifying odontogenic cysts. J Oral Maxillofac Surg. 2002;60(6):689–96.CrossRefPubMed
78.
Zurück zum Zitat Praetorius F et al. Calcifying odontogenic cyst. Range, variations and neoplastic potential. Acta Odontol Scand. 1981;39(4):227–40.CrossRefPubMed Praetorius F et al. Calcifying odontogenic cyst. Range, variations and neoplastic potential. Acta Odontol Scand. 1981;39(4):227–40.CrossRefPubMed
79.
Zurück zum Zitat Buchner A et al. Peripheral (extraosseous) calcifying odontogenic cyst. A review of forty-five cases. Oral Surg Oral Med Oral Pathol. 1991;72(1):65–70.CrossRefPubMed Buchner A et al. Peripheral (extraosseous) calcifying odontogenic cyst. A review of forty-five cases. Oral Surg Oral Med Oral Pathol. 1991;72(1):65–70.CrossRefPubMed
80.
Zurück zum Zitat Gong Y et al. The expression of NF-kappaB, Ki-67 and MMP-9 in CCOT. DGCT and GCOC Oral Oncol. 2009;45(6):515–20.CrossRefPubMed Gong Y et al. The expression of NF-kappaB, Ki-67 and MMP-9 in CCOT. DGCT and GCOC Oral Oncol. 2009;45(6):515–20.CrossRefPubMed
81.
Zurück zum Zitat Sekine S et al. Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas. Am J Pathol. 2003;163(5):1707–12.CrossRefPubMedPubMedCentral Sekine S et al. Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas. Am J Pathol. 2003;163(5):1707–12.CrossRefPubMedPubMedCentral
82.
Zurück zum Zitat Ahn SG et al. Beta-catenin gene alterations in a variety of so-called calcifying odontogenic cysts. APMIS. 2008;116(3):206–11.CrossRefPubMed Ahn SG et al. Beta-catenin gene alterations in a variety of so-called calcifying odontogenic cysts. APMIS. 2008;116(3):206–11.CrossRefPubMed
83.
Zurück zum Zitat Kaplan I et al. Radiological and clinical features of calcifying epithelial odontogenic tumour. Dentomaxillofac Radiol. 2001;30(1):22–8.CrossRefPubMed Kaplan I et al. Radiological and clinical features of calcifying epithelial odontogenic tumour. Dentomaxillofac Radiol. 2001;30(1):22–8.CrossRefPubMed
84.
Zurück zum Zitat Azevedo RS et al. Calcifying epithelial odontogenic tumor (CEOT): a clinicopathologic and immunohistochemical study and comparison with dental follicles containing CEOT-like areas. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(6):759–68.CrossRefPubMed Azevedo RS et al. Calcifying epithelial odontogenic tumor (CEOT): a clinicopathologic and immunohistochemical study and comparison with dental follicles containing CEOT-like areas. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(6):759–68.CrossRefPubMed
85.
Zurück zum Zitat Crivelini MM et al. Cytokeratins in epithelia of odontogenic neoplasms. Oral Dis. 2003;9(1):1–6.CrossRefPubMed Crivelini MM et al. Cytokeratins in epithelia of odontogenic neoplasms. Oral Dis. 2003;9(1):1–6.CrossRefPubMed
86.
Zurück zum Zitat Crivelini MM et al. Expression of odontogenic ameloblast-associated protein, amelotin, ameloblastin, and amelogenin in odontogenic tumors: immunohistochemical analysis and pathogenetic considerations. J Oral Pathol Med. 2012;41(3):272–80.CrossRefPubMed Crivelini MM et al. Expression of odontogenic ameloblast-associated protein, amelotin, ameloblastin, and amelogenin in odontogenic tumors: immunohistochemical analysis and pathogenetic considerations. J Oral Pathol Med. 2012;41(3):272–80.CrossRefPubMed
87.
Zurück zum Zitat Mori M et al. Expression of tenascin in odontogenic tumours. Eur J Cancer B Oral Oncol. 1995;31B(4):275–9.CrossRefPubMed Mori M et al. Expression of tenascin in odontogenic tumours. Eur J Cancer B Oral Oncol. 1995;31B(4):275–9.CrossRefPubMed
88.
Zurück zum Zitat Zhang L et al. Epithelial expression of SHH signaling pathway in odontogenic tumors. Oral Oncol. 2006;42(4):398–408.CrossRefPubMed Zhang L et al. Epithelial expression of SHH signaling pathway in odontogenic tumors. Oral Oncol. 2006;42(4):398–408.CrossRefPubMed
89.
Zurück zum Zitat Peacock ZS, Cox D, Schmidt BL. Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor. Oral Oncol. 2010;46(5):387–92.CrossRefPubMed Peacock ZS, Cox D, Schmidt BL. Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor. Oral Oncol. 2010;46(5):387–92.CrossRefPubMed
90.
Zurück zum Zitat Regezi JA, Kerr DA, Courtney RM. Odontogenic tumors: analysis of 706 cases. J Oral Surg. 1978;36(10):771–8.PubMed Regezi JA, Kerr DA, Courtney RM. Odontogenic tumors: analysis of 706 cases. J Oral Surg. 1978;36(10):771–8.PubMed
91.
Zurück zum Zitat Fujita S, Hideshima K, Ikeda T. Nestin expression in odontoblasts and odontogenic ectomesenchymal tissue of odontogenic tumours. J Clin Pathol. 2006;59(3):240–5.CrossRefPubMedPubMedCentral Fujita S, Hideshima K, Ikeda T. Nestin expression in odontoblasts and odontogenic ectomesenchymal tissue of odontogenic tumours. J Clin Pathol. 2006;59(3):240–5.CrossRefPubMedPubMedCentral
92.
Zurück zum Zitat Simon EN et al. Odontogenic myxoma: a clinicopathological study of 33 cases. Int J Oral Maxillofac Surg. 2004;33(4):333–7.CrossRefPubMed Simon EN et al. Odontogenic myxoma: a clinicopathological study of 33 cases. Int J Oral Maxillofac Surg. 2004;33(4):333–7.CrossRefPubMed
93.
Zurück zum Zitat Schmidt-Westhausen A et al. Odontogenic myxoma--characterisation of the extracellular matrix (ECM) of the tumour stroma. Eur J Cancer B Oral Oncol. 1994;30B(6):377–80.CrossRefPubMed Schmidt-Westhausen A et al. Odontogenic myxoma--characterisation of the extracellular matrix (ECM) of the tumour stroma. Eur J Cancer B Oral Oncol. 1994;30B(6):377–80.CrossRefPubMed
94.
95.
Zurück zum Zitat Bast BT, Pogrel MA, Regezi JA. The expression of apoptotic proteins and matrix metalloproteinases in odontogenic myxomas. J Oral Maxillofac Surg. 2003;61(12):1463–6.CrossRefPubMed Bast BT, Pogrel MA, Regezi JA. The expression of apoptotic proteins and matrix metalloproteinases in odontogenic myxomas. J Oral Maxillofac Surg. 2003;61(12):1463–6.CrossRefPubMed
96.
Zurück zum Zitat Sato K et al. Odontogenic myxofibroma with HMGA2 overexpression and HMGA2 rearrangement. Pathol Int. 2010;60(11):760–4.CrossRefPubMed Sato K et al. Odontogenic myxofibroma with HMGA2 overexpression and HMGA2 rearrangement. Pathol Int. 2010;60(11):760–4.CrossRefPubMed
97.
Zurück zum Zitat Carney JA et al. The complex of myxomas, spotty pigmentation, and endocrine overactivity. Medicine (Baltimore). 1985;64(4):270–83.CrossRef Carney JA et al. The complex of myxomas, spotty pigmentation, and endocrine overactivity. Medicine (Baltimore). 1985;64(4):270–83.CrossRef
98.
Zurück zum Zitat Perdigao PF et al. Molecular and immunohistochemical investigation of protein kinase a regulatory subunit type 1A (PRKAR1A) in odontogenic myxomas. Genes Chromosomes Cancer. 2005;44(2):204–11.CrossRefPubMed Perdigao PF et al. Molecular and immunohistochemical investigation of protein kinase a regulatory subunit type 1A (PRKAR1A) in odontogenic myxomas. Genes Chromosomes Cancer. 2005;44(2):204–11.CrossRefPubMed
Metadaten
Titel
Benign Odontogenic Tumors: Origins, Immunophenotypic Features, and Genetic Alterations
verfasst von
Chunmiao Jiang
Qilin Xu
Qunzhou Zhang
Steven Wang
Lee R. Carrasco
Anh D. Le
Publikationsdatum
01.06.2016
Verlag
Springer International Publishing
Erschienen in
Current Oral Health Reports / Ausgabe 2/2016
Elektronische ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-016-0087-x

Weitere Artikel der Ausgabe 2/2016

Current Oral Health Reports 2/2016 Zur Ausgabe

Oral Neoplasia (F Alawi and A Le, Section Editors)

Immunotherapy for Head and Neck Squamous Cell Carcinoma

Oral Neoplasia (F Alawi and A Le, Section Editors)

Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärztinnen und Psychotherapeuten.

Parodontalbehandlung verbessert Prognose bei Katheterablation

19.04.2024 Vorhofflimmern Nachrichten

Werden Personen mit Vorhofflimmern in der Blanking-Periode nach einer Katheterablation gegen eine bestehende Parodontitis behandelt, verbessert dies die Erfolgsaussichten. Dafür sprechen die Resultate einer prospektiven Untersuchung.

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.