nach oben

Environmental Health and Preventive Medicine

Erschienen in:

01.07.2013 | Regular Article

Beta-3-adrenergic receptor Trp64Arg polymorphism: does it modulate the relationship between exercise and percentage of body fat in young adult Japanese males?

verfasst von: Hiroshi Nakashima, Kazuyuki Omae, Tetsuo Nomiyama, Yuko Yamano, Toru Takebayashi, Yutaka Sakurai

Erschienen in: Environmental Health and Preventive Medicine | Ausgabe 4/2013

Einloggen, um Zugang zu erhalten

Abstract

Objectives

The Trp64Arg polymorphism of the beta-3-adrenergic receptor gene has been studied as a potential genetic factor contributing to the development of obesity. Several studies have investigated whether or not this polymorphism affects weight reduction due to exercise, but the results of these studies have not been consistent. Moreover, information on a population characterized by a wide ranges of physical activities is scarce. Thus, to further understand the impact of this polymorphism, we examined whether the polymorphism modulates the relationship between physical activity due to exercise (PAE) and percentage of body fat (%BF).

Methods

The study population was 70 Japanese male young adults with a high prevalence of habitual exercise. PAE was estimated by a questionnaire, and %BF was measured by bioelectrical impedance analysis. Genotyping was done by PCR–restriction fragment length polymorphism analysis.

Results

The median PAE value of the subjects was 6.9 MET-h/day with an interquartile range of 1.5–10.3 MET-h/day. PAE correlated significantly with %BF in the entire population and within the two subpopulations, namely, carriers or non-carriers of the Arg allele. Multiple regression analysis of PAE, Trp64Arg polymorphism, and the interaction term revealed that while the PAE-derived independent variable was statistically significant, the interaction term was insignificant. When the two regression lines of subjects with and without the Arg allele were considered, the difference between the two slopes did not deviate from zero, nor did the vertical distance of the two regression lines. These findings suggest that the impact of this polymorphism is limited.

Conclusions

In our study population of young adult Japanese males, the impact of the Trp64Arg polymorphism on the association between exercise and body composition was weak, if it existed at all.

Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S, et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med. 1995;333:343–7.PubMedCrossRef

Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns. Diabetes. 1997;46:77–80.PubMedCrossRef

Kadowaki H, Yasuda K, Iwamoto K, Otabe S, Shimokawa K, Silver K, et al. A mutation in the beta 3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects. Biochem Biophys Res Commun. 1995;215:555–60.PubMedCrossRef

Nagase T, Aoki A, Yamamoto M, Yasuda H, Kado S, Nishikawa M, et al. Lack of association between the Trp64Arg mutation in the beta 3-adrenergic receptor gene and obesity in Japanese men: a longitudinal analysis. J Clin Endocrinol Metab. 1997;82:1284–7.PubMedCrossRef

Kurokawa N, Nakai K, Kameo S, Liu ZM, Satoh H. Association of BMI with the beta3-adrenergic receptor gene polymorphism in Japanese: meta-analysis. Obes Res. 2001;9:741–5.PubMedCrossRef

Kawaguchi H, Masuo K, Katsuya T, Sugimoto K, Rakugi H, Ogihara T, et al. beta2- and beta3-Adrenoceptor polymorphisms relate to subsequent weight gain and blood pressure elevation in obese normotensive individuals. Hypertens Res. 2006;29:951–9.PubMedCrossRef

Garenc C, Pérusse L, Rankinen T, Gagnon J, Leon AS, Skinner JS, et al. The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is not associated with training-induced changes in body composition: the HERITAGE Family Study. Obes Res. 2001;9:337–41.PubMedCrossRef

Tahara A, Osaki Y, Kishimoto T. Effect of the beta-3-adrenergic receptor gene polymorphism Trp64Arg on BMI reduction associated with an exercise based intervention program in Japanese middle-aged males. Environ Health Prev Med. 2010;15:392–7.PubMedCrossRef

Bea JW, Lohman TG, Cussler EC, Going SB, Thompson PA. Lifestyle modifies the relationship between body composition and adrenergic receptor genetic polymorphism, ADRB2, ADRB3 and ADRA2B: a secondary analysis of a randomized controlled trial of physical activity among postmenopausal women. Behav Genet. 2010;40:649–59.PubMedCrossRef

10.

Yoshida T, Sakane N, Umekawa T, Sakai M, Takahashi T, Kondo M. Mutation of β3-adrenergic–receptor gene and response to treatment of obesity. Lancet. 1995;346:1433–4.PubMedCrossRef

11.

Sakane N, Yoshida T, Umekawa T, Kogure A, Takakura Y, Kondo M. Effects of Trp64Arg mutation in the β3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients. Diabetes Care. 1997;20:1887–90.PubMedCrossRef

12.

Shiwaku K, Nogi A, Anuurad E, Kitajima K, Enkhmaa B, Shimono K, et al. Difficulty in losing weight by behavioral intervention for women with Trp64Arg polymorphism of the β3-adrenergic receptor gene. Int J Obes Relat Metab Disord. 2003;27:1028–36.PubMedCrossRef

13.

de Luis DA, Gonzalez Sagrado M, Aller R, Izaola O, Conde R. Influence of the Trp64Arg polymorphism in the beta 3 adrenoreceptor gene on insulin resistance, adipocytokine response, and weight loss secondary to lifestyle modification in obese patients. Eur J Intern Med. 2007;18:587–92.PubMedCrossRef

14.

Kuriyama S, Shimazu T, Hozawa A, Kure S, Kurokawa N, Kakizaki M, et al. No effect of the Trp64Arg variant of the beta3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults. Metabolism. 2008;57:1570–5.PubMedCrossRef

15.

Gourlan MJ, Trouilloud DO, Sarrazin PG. Interventions promoting physical activity among obese populations: a meta-analysis considering global effect, long-term maintenance, physical activity indicators and dose characteristics. Obes Rev. 2011;12:e633–45.PubMedCrossRef

16.

Westerterp KR, Goran MI. Relationship between physical activity related energy expenditure and body composition: a gender difference. Int J Obes Relat Metab Disord. 1997;21:184–8.PubMedCrossRef

17.

Paul DR, Novotony JA, Rumpler WV. Effects of the interaction of sex and food intake on the relation between energy expenditure and body composition. Am J Clin Nutr. 2004;79:385–9.PubMed

18.

den Hoed M, Westerterp KR. Body composition is associated with physical activity in daily life as measured using a triaxial accelerometer in both men and women. Int J Obes. 2008;32:1264–70.CrossRef

19.

Heyward VH. Gross energy expenditure for conditioning exercises, sports and recreational activities; in: advanced fitness assessment and exercise prescription. 6th ed. Champaign: Human Kinetics; 2010. p. 382–4.

20.

Kraemer HC, Blasey CM. Centering in regression analyses: a strategy to prevent errors in statistical inference. Int J Methods Psychiatr Res. 2004;13:141–51.PubMedCrossRef

21.

Armitage P, Berry G, Matthews JSN (editors). Regression in groups. Statistical method in medical research. 4th ed. Malden: Blackwell Science. 2002. p. 322–30.

22.

Armitage P, Berry G, Matthews JSN (editors). Analysis of covariance. Statistical method in medical research. 4th ed. Malden: Blackwell Science. 2002. p. 331–7.

23.

Matsushita Y, Yokoyama T, Yoshiike Y, Matsumura Y, Date C, Kawahara K, et al. The Trp(64)Arg polymorphism of the beta(3)-adrenergic receptor gene is not associated with body weight or body mass index in Japanese: a longitudinal analysis. J Clin Endocrinol Metab. 2003;88:5914–20.PubMedCrossRef

24.

Samani-Radia D, McCarthy HD. Comparison of children’s body fatness between two contrasting income groups: contribution of height difference. Int J Obes (Lond). 2011;35:128–33.CrossRef

25.

Li SC, Liu YH, Liu JF, Chang WH, Chen CM, Chen CY. Almond consumption improved glycemic control and lipid profiles in patients with type 2 diabetes mellitus. Metabolism. 2011;60:474–9.PubMedCrossRef

26.

Parkinson KN, Drewett RF, Jones AR, Dale A, Pearce MS, Wright CM, Gateshead Millennium Study Core Team, et al. When do mothers think their child is overweight? Int J Obes (Lond). 2011;35:510–6.CrossRef

27.

Sahni S, Hannan MT, Blumberg J, Cupples LA, Kiel DP, Tucker KL. Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study. J Bone Miner Res. 2009;24:1086–94.PubMedCrossRef

28.

Haskell WL. Physical activity by self-report: a brief history and future issues. J Phys Act Health. 2012;9:S5–10.PubMed

Titel: Beta-3-adrenergic receptor Trp64Arg polymorphism: does it modulate the relationship between exercise and percentage of body fat in young adult Japanese males?
verfasst von: Hiroshi Nakashima
Kazuyuki Omae
Tetsuo Nomiyama
Yuko Yamano
Toru Takebayashi
Yutaka Sakurai
Publikationsdatum: 01.07.2013
Verlag: Springer Japan
Erschienen in: Environmental Health and Preventive Medicine / Ausgabe 4/2013
Print ISSN: 1342-078X
Elektronische ISSN: 1347-4715
DOI: https://doi.org/10.1007/s12199-012-0325-3

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2013

A cross-sectional survey of factors influencing bone mass in junior high school students

Factors related to the intention to leave and the decision to resign among newly graduated nurses: a complete survey in a selected prefecture in Japan

Social capital and suicide: an ecological study in Tokyo, Japan

Assessing willingness to pay for improved sanitation in rural Vietnam

Evaluation of a real-time method for monitoring volatile organic compounds in indoor air in a Japanese university

The change in lifestyle data during 9 years: the reliability and continuity of baseline health practices