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Current Breast Cancer Reports

Erschienen in:

01.09.2013 | Risk, Prevention, and Screening (DL Hershman, Section Editor)

Biomarker Endpoints for Early-Phase Cancer-Prevention Studies

verfasst von: Parijatham S. Sivasubramanian, Katherine D. Crew

Erschienen in: Current Breast Cancer Reports | Ausgabe 3/2013

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Abstract

Breast cancer is the most common malignancy among women in the US, and prevention of this disease is therefore a major public health concern. Chemoprevention with anti-estrogens, including tamoxifen, raloxifene, and exemestane, has been shown to reduce the incidence of hormone receptor (HR)-positive breast cancer. However, breast cancer chemoprevention uptake has been poor and effective chemopreventive agents for HR-negative tumors are yet to be identified. A priority for breast cancer prevention research is improving the efficiency of chemoprevention trials by use of intermediate biomarkers correlated with breast cancer risk. This review provides an overview of the literature on breast-imaging-based, tissue-based, and circulating biomarkers which have been associated with breast cancer risk by observational studies and are being investigated as intermediate endpoints for early-phase chemoprevention trials.

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Titel: Biomarker Endpoints for Early-Phase Cancer-Prevention Studies
verfasst von: Parijatham S. Sivasubramanian
Katherine D. Crew
Publikationsdatum: 01.09.2013
Verlag: Springer US
Erschienen in: Current Breast Cancer Reports / Ausgabe 3/2013
Print ISSN: 1943-4588
Elektronische ISSN: 1943-4596
DOI: https://doi.org/10.1007/s12609-013-0116-x

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