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International Archives of Occupational and Environmental Health

Erschienen in:

01.06.2018 | Original Article

Biomarkers of respiratory allergy in laboratory animal care workers: an observational study

verfasst von: Federica Tafuro, Luisella Selis, Matteo Goldoni, Mariarita Stendardo, Paola Mozzoni, Erminia Ridolo, Piera Boschetto, Massimo Corradi

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 6/2018

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Abstract

Objectives

Laboratory animal allergy is a highly prevalent occupational disease among exposed workers. The aim of the study was to validate the biomarkers of airway inflammation in laboratory animal (LA) care workers.

Methods

All of the participants in this observational study (63 LA care workers and 64 controls) were administered a clinical questionnaire, underwent spirometry and a skin prick or radioallergosorbent test for common and occupational aeroallergens, and the fraction of exhaled nitric oxide (FeNO₅₀), exhaled breath condensate hydrogen peroxide (EBC H₂O₂) and serum pneumoprotein levels were measured. Multivariate analysis (ANCOVA) was used to assess the interactions of the variables.

Results

FeNO₅₀ levels correlated with exposure (p = 0.002), sensitisation (p = 0.000) and age (p = 0.001), but there was no interaction between exposure and sensitisation when age was considered in the model (p = 0.146). EBC-H₂O₂ levels were higher in the sensitised workers than in the sensitised controls [0.14 (0.08–0.29) µM vs 0.07 (0.05–0.12) µM; p < 0.05]. Serum surfactant protein A (SP-A) levels were unaffected by exposure, sensitisation or age, although higher levels were observed in symptomatic workers; however, SP-D levels were influenced by exposure (p = 0.024) and age (p = 0.022), and club cell 16 levels were influenced by sensitisation (p = 0.027) and age (p = 0.019).

Conclusions

The presence of the clinical symptoms associated with LA exposure and high FeNO levels should prompt further medical assessments in LA workers. Although EBC-H₂O₂ levels do not seem to reflect eosinophilic inflammation, serum SP-A levels could be used to monitor progression from rhinitis to asthma.

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Titel: Biomarkers of respiratory allergy in laboratory animal care workers: an observational study
verfasst von: Federica Tafuro
Luisella Selis
Matteo Goldoni
Mariarita Stendardo
Paola Mozzoni
Erminia Ridolo
Piera Boschetto
Massimo Corradi
Publikationsdatum: 01.06.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 6/2018
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-018-1321-8

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

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