Skip to main content
Erschienen in: DNP - Der Neurologe & Psychiater 5/2018

29.09.2018 | Sucht | Fortbildung

Komorbidität psychischer Erkrankungen

Bipolare Störungen und Sucht

verfasst von: PD Dr. med. Heinz Grunze, Dr. med. Thomas Heinrich, Prof. Dr. Dr. med. Dipl.-Psych. Jörg Walden

Erschienen in: DNP – Die Neurologie & Psychiatrie | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Zusammenfassung

Sowohl bipolare Erkrankungen als auch schädlicher Substanzgebrauch beziehungsweise -abhängigkeit sind in der Bevölkerung weit verbreitet. Die Frage der Ätiologie und Kausalität ist dabei nicht abschließend geklärt. Eventuell fördert ein gemeinsamer genetischer Faktor beide Erkrankungen.
Literatur
1.
Zurück zum Zitat Jacobi F, Hofler M, Strehle J et al: Psychische Störungen in der Allgemeinbevölkerung: Studie zur Gesundheit Erwachsener in Deutschland und ihr Zusatzmodul Psychische Gesundheit (DEGS1-MH). Nervenarzt 2014;85:77–87.CrossRef Jacobi F, Hofler M, Strehle J et al: Psychische Störungen in der Allgemeinbevölkerung: Studie zur Gesundheit Erwachsener in Deutschland und ihr Zusatzmodul Psychische Gesundheit (DEGS1-MH). Nervenarzt 2014;85:77–87.CrossRef
2.
Zurück zum Zitat Jacobi F, Klose M, Wittchen HU: Psychische Störungen in der deutschen Allgemeinbevölkerung: Inanspruchnahme von Gesundheitsleistungen und Ausfalltage. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2004;47:736–744.CrossRef Jacobi F, Klose M, Wittchen HU: Psychische Störungen in der deutschen Allgemeinbevölkerung: Inanspruchnahme von Gesundheitsleistungen und Ausfalltage. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2004;47:736–744.CrossRef
3.
Zurück zum Zitat Merikangas KR, Akiskal HS, Angst J et al: Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 2007;64:543–552.CrossRef Merikangas KR, Akiskal HS, Angst J et al: Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 2007;64:543–552.CrossRef
4.
Zurück zum Zitat Wittchen HU, Frohlich C, Behrendt S et al: Cannabis use and cannabis use disorders and their relationship to mental disorders: a 10-year prospective-longitudinal community study in adolescents. Drug Alcohol Depend 2007;88 Suppl 1:S60–S70.CrossRef Wittchen HU, Frohlich C, Behrendt S et al: Cannabis use and cannabis use disorders and their relationship to mental disorders: a 10-year prospective-longitudinal community study in adolescents. Drug Alcohol Depend 2007;88 Suppl 1:S60–S70.CrossRef
5.
Zurück zum Zitat Alonso J, Petukhova M, Vilagut G et al: Days out of role due to common physical and mental conditions: results from the WHO World Mental Health surveys. Mol Psychiatry 2011;16:1234–1246.CrossRef Alonso J, Petukhova M, Vilagut G et al: Days out of role due to common physical and mental conditions: results from the WHO World Mental Health surveys. Mol Psychiatry 2011;16:1234–1246.CrossRef
6.
Zurück zum Zitat Gore FM, Bloem PJ, Patton GC et al: Global burden of disease in young people aged 10-24 years: a systematic analysis. Lancet 2011;377:2093–2102.CrossRef Gore FM, Bloem PJ, Patton GC et al: Global burden of disease in young people aged 10-24 years: a systematic analysis. Lancet 2011;377:2093–2102.CrossRef
7.
Zurück zum Zitat Oquendo MA, Currier D, Liu SM et al: Increased risk for suicidal behavior in comorbid bipolar disorder and alcohol use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). J Clin Psychiatry 2010;71:902–909.CrossRef Oquendo MA, Currier D, Liu SM et al: Increased risk for suicidal behavior in comorbid bipolar disorder and alcohol use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). J Clin Psychiatry 2010;71:902–909.CrossRef
8.
Zurück zum Zitat Cardoso BM, Kauer SM, Dias VV et al: The impact of co-morbid alcohol use disorder in bipolar patients. Alcohol 2008;42:451–457.CrossRef Cardoso BM, Kauer SM, Dias VV et al: The impact of co-morbid alcohol use disorder in bipolar patients. Alcohol 2008;42:451–457.CrossRef
9.
Zurück zum Zitat Modestin J, Wuermle O: Criminality in men with major mental disorder with and without comorbid substance abuse. Psychiatry Clin Neurosci 2005;59:25–29.CrossRef Modestin J, Wuermle O: Criminality in men with major mental disorder with and without comorbid substance abuse. Psychiatry Clin Neurosci 2005;59:25–29.CrossRef
10.
Zurück zum Zitat Hunt GE, Malhi GS, Cleary M et al: Comorbidity of bipolar and substance use disorders in national surveys of general populations, 1990-2015: Systematic review and meta-analysis. J Affect Disord 2016;206:321–330. doi: 10.1016/j.jad.2016.06.051. Epub;%2016 Jun 25.:321-330.CrossRef Hunt GE, Malhi GS, Cleary M et al: Comorbidity of bipolar and substance use disorders in national surveys of general populations, 1990-2015: Systematic review and meta-analysis. J Affect Disord 2016;206:321–330. doi: 10.1016/j.jad.2016.06.051. Epub;%2016 Jun 25.:321-330.CrossRef
11.
Zurück zum Zitat Kemp DE, Gao K, Ganocy SJ et al: A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependence. J Clin Psychiatry 2009;70:113–121.CrossRef Kemp DE, Gao K, Ganocy SJ et al: A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependence. J Clin Psychiatry 2009;70:113–121.CrossRef
12.
Zurück zum Zitat Ostacher MJ, Perlis RH, Nierenberg AA et al: Impact of substance use disorders on recovery from episodes of depression in bipolar disorder patients: prospective data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry 2010;167:289–297.CrossRef Ostacher MJ, Perlis RH, Nierenberg AA et al: Impact of substance use disorders on recovery from episodes of depression in bipolar disorder patients: prospective data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry 2010;167:289–297.CrossRef
13.
Zurück zum Zitat Frye MA, Altshuler LL, McElroy SL et al: Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder. Am J Psychiatry 2003;160:883–889.CrossRef Frye MA, Altshuler LL, McElroy SL et al: Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder. Am J Psychiatry 2003;160:883–889.CrossRef
14.
Zurück zum Zitat Manwani SG, Szilagyi KA, Zablotsky B et al: Adherence to pharmacotherapy in bipolar disorder patients with and without co-occurring substance use disorders. J Clin Psychiatry 2007;68:1172–1176.CrossRef Manwani SG, Szilagyi KA, Zablotsky B et al: Adherence to pharmacotherapy in bipolar disorder patients with and without co-occurring substance use disorders. J Clin Psychiatry 2007;68:1172–1176.CrossRef
15.
Zurück zum Zitat Levander E, Frye MA, McElroy S et al: Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism. J Affect Disord 2007;101:211–217.CrossRef Levander E, Frye MA, McElroy S et al: Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism. J Affect Disord 2007;101:211–217.CrossRef
16.
Zurück zum Zitat Cerullo MA, Strakowski SM: The prevalence and significance of substance use disorders in bipolar type I and II disorder. Subst Abuse Treat Prev Policy 2007;2:29. doi: 10.1186/1747-597X-2-29.:29-2.CrossRef Cerullo MA, Strakowski SM: The prevalence and significance of substance use disorders in bipolar type I and II disorder. Subst Abuse Treat Prev Policy 2007;2:29. doi: 10.1186/1747-597X-2-29.:29-2.CrossRef
17.
Zurück zum Zitat McElroy SL, Altshuler LL, Suppes T et al: Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. Am J Psychiatry 2001;158:420–426.CrossRef McElroy SL, Altshuler LL, Suppes T et al: Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. Am J Psychiatry 2001;158:420–426.CrossRef
18.
Zurück zum Zitat Regier DA, Farmer ME, Rae DS: Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiologic Catchment Area (ECA) study. JAMA 1990;264:2511–2518.CrossRef Regier DA, Farmer ME, Rae DS: Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiologic Catchment Area (ECA) study. JAMA 1990;264:2511–2518.CrossRef
19.
Zurück zum Zitat Dittmann S, Biedermann NC, Grunze H et al: The Stanley Foundation Bipolar Network: Results of the naturalistic follow-up study (NFS) after 2 ½ years of follow-up in the German centres. Neuropsychobiology 2002;46 Suppl 1:2–9.CrossRef Dittmann S, Biedermann NC, Grunze H et al: The Stanley Foundation Bipolar Network: Results of the naturalistic follow-up study (NFS) after 2 ½ years of follow-up in the German centres. Neuropsychobiology 2002;46 Suppl 1:2–9.CrossRef
20.
Zurück zum Zitat Hunt GE, Malhi GS, Cleary M et al: Prevalence of comorbid bipolar and substance use disorders in clinical settings, 1990-2015: Systematic review and meta-analysis. J Affect Disord 2016;206:331–349. doi: 10.1016/j.jad.2016.07.011. Epub;%2016 Jul 9.:331-349.CrossRef Hunt GE, Malhi GS, Cleary M et al: Prevalence of comorbid bipolar and substance use disorders in clinical settings, 1990-2015: Systematic review and meta-analysis. J Affect Disord 2016;206:331–349. doi: 10.1016/j.jad.2016.07.011. Epub;%2016 Jul 9.:331-349.CrossRef
21.
Zurück zum Zitat Kessler RC, McGonagle KA, Zhao S et al: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 1994;51:8–19.CrossRef Kessler RC, McGonagle KA, Zhao S et al: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 1994;51:8–19.CrossRef
22.
Zurück zum Zitat Frank E, Boland E, Novick DM et al: Association between illicit drug and alcohol use and first manic episode. Pharmacol Biochem Behav 2007;86:395–400.CrossRef Frank E, Boland E, Novick DM et al: Association between illicit drug and alcohol use and first manic episode. Pharmacol Biochem Behav 2007;86:395–400.CrossRef
23.
Zurück zum Zitat Winokur G, Coryell W, Akiskal HS et al: Alcoholism in manic-depressive (bipolar) illness: familial illness, course of illness, and the primary-secondary distinction. Am J Psychiatry 1995;152:365–372.CrossRef Winokur G, Coryell W, Akiskal HS et al: Alcoholism in manic-depressive (bipolar) illness: familial illness, course of illness, and the primary-secondary distinction. Am J Psychiatry 1995;152:365–372.CrossRef
24.
Zurück zum Zitat Weiss RD, Kolodziej M, Griffin ML et al: Substance use and perceived symptom improvement among patients with bipolar disorder and substance dependence. J Affect Disord 2004;79:279–283.CrossRef Weiss RD, Kolodziej M, Griffin ML et al: Substance use and perceived symptom improvement among patients with bipolar disorder and substance dependence. J Affect Disord 2004;79:279–283.CrossRef
25.
Zurück zum Zitat Sonne SC, Brady KT, Morton WA: Substance abuse and bipolar affective disorder. J Nerv Ment Dis 1994;182:349–352.CrossRef Sonne SC, Brady KT, Morton WA: Substance abuse and bipolar affective disorder. J Nerv Ment Dis 1994;182:349–352.CrossRef
26.
Zurück zum Zitat Bizzarri JV, Sbrana A, Rucci P et al: The spectrum of substance abuse in bipolar disorder: reasons for use, sensation seeking and substance sensitivity. Bipolar Disord 2007;9:213–220.CrossRef Bizzarri JV, Sbrana A, Rucci P et al: The spectrum of substance abuse in bipolar disorder: reasons for use, sensation seeking and substance sensitivity. Bipolar Disord 2007;9:213–220.CrossRef
27.
Zurück zum Zitat Haro G, Calabrese JR, Larsson C et al: The relationship of personality traits to substance abuse in patients with bipolar disorder. Eur Psychiatry 2007;22:305–308.CrossRef Haro G, Calabrese JR, Larsson C et al: The relationship of personality traits to substance abuse in patients with bipolar disorder. Eur Psychiatry 2007;22:305–308.CrossRef
28.
Zurück zum Zitat Berrettini WH: Genetics of psychiatric disease. Annu Rev Med 2000;51:465–479.CrossRef Berrettini WH: Genetics of psychiatric disease. Annu Rev Med 2000;51:465–479.CrossRef
29.
Zurück zum Zitat Chang YH, Lee SY, Wang TY et al: Comorbid alcohol dependence disorder may be related to aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) in bipolar II disorder, but only to ALDH2 in bipolar I disorder, in Han Chinese. Bipolar Disord 2015;17:536–542.CrossRef Chang YH, Lee SY, Wang TY et al: Comorbid alcohol dependence disorder may be related to aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) in bipolar II disorder, but only to ALDH2 in bipolar I disorder, in Han Chinese. Bipolar Disord 2015;17:536–542.CrossRef
30.
Zurück zum Zitat Schellekens AF, Franke B, Ellenbroek B et al: Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the role of the COMT Val158Met and DRD2 Taq1A genotypes. Arch Gen Psychiatry 2012;69:339–348.CrossRef Schellekens AF, Franke B, Ellenbroek B et al: Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the role of the COMT Val158Met and DRD2 Taq1A genotypes. Arch Gen Psychiatry 2012;69:339–348.CrossRef
31.
Zurück zum Zitat Preisig M, Fenton BT, Stevens DE et al: Familial relationship between mood disorders and alcoholism. Compr Psychiatry 2001;42:87–95.CrossRef Preisig M, Fenton BT, Stevens DE et al: Familial relationship between mood disorders and alcoholism. Compr Psychiatry 2001;42:87–95.CrossRef
32.
Zurück zum Zitat Nolen WA, Luckenbaugh DA, Altshuler LL et al: Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network. Am J Psychiatry 2004;161:1447–1454.CrossRef Nolen WA, Luckenbaugh DA, Altshuler LL et al: Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network. Am J Psychiatry 2004;161:1447–1454.CrossRef
33.
Zurück zum Zitat Monteleone P, Bifulco M, Maina G et al: Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. Pharmacol Res 2010;61:400–404.CrossRef Monteleone P, Bifulco M, Maina G et al: Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. Pharmacol Res 2010;61:400–404.CrossRef
34.
Zurück zum Zitat Micale V, Di M V, Sulcova A et al: Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacol Ther 2013;138:18–37.CrossRef Micale V, Di M V, Sulcova A et al: Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacol Ther 2013;138:18–37.CrossRef
35.
Zurück zum Zitat Jaffee WB, Griffin ML, Gallop R et al: Depression precipitated by alcohol use in patients with co-occurring bipolar and substance use disorders. J Clin Psychiatry 2009;70:171–176.CrossRef Jaffee WB, Griffin ML, Gallop R et al: Depression precipitated by alcohol use in patients with co-occurring bipolar and substance use disorders. J Clin Psychiatry 2009;70:171–176.CrossRef
36.
Zurück zum Zitat Henquet C, Krabbendam L, de GR et al: Cannabis use and expression of mania in the general population. J Affect Disord 2006;95:103–110.CrossRef Henquet C, Krabbendam L, de GR et al: Cannabis use and expression of mania in the general population. J Affect Disord 2006;95:103–110.CrossRef
37.
Zurück zum Zitat Prisciandaro JJ, Desantis SM, Chiuzan C et al: Impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate. Alcohol Clin Exp Res 2012;36:490–496.CrossRef Prisciandaro JJ, Desantis SM, Chiuzan C et al: Impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate. Alcohol Clin Exp Res 2012;36:490–496.CrossRef
38.
Zurück zum Zitat AWMF S3 Leitline Screening, Diagnose und Behandlung alkoholbezogener Störungen: in Mann K, Hoch E, Batra A, (eds): 2016. AWMF S3 Leitline Screening, Diagnose und Behandlung alkoholbezogener Störungen: in Mann K, Hoch E, Batra A, (eds): 2016.
39.
Zurück zum Zitat Weiss RD, Griffin ML, Kolodziej ME et al: A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. Am J Psychiatry 2007;164:100–107.CrossRef Weiss RD, Griffin ML, Kolodziej ME et al: A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. Am J Psychiatry 2007;164:100–107.CrossRef
40.
Zurück zum Zitat Weiss RD, Griffin ML, Jaffee WB et al: A „community-friendly“ version of integrated group therapy for patients with bipolar disorder and substance dependence: a randomized controlled trial. Drug Alcohol Depend 2009;104:212–219.CrossRef Weiss RD, Griffin ML, Jaffee WB et al: A „community-friendly“ version of integrated group therapy for patients with bipolar disorder and substance dependence: a randomized controlled trial. Drug Alcohol Depend 2009;104:212–219.CrossRef
41.
Zurück zum Zitat Geller B, Cooper TB, Sun K et al: Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency. J Am Acad Child Adolesc Psychiatry 1998;37:171–178.CrossRef Geller B, Cooper TB, Sun K et al: Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency. J Am Acad Child Adolesc Psychiatry 1998;37:171–178.CrossRef
42.
Zurück zum Zitat Brady KT, Myrick H, Henderson S et al: The use of divalproex in alcohol relapse prevention: a pilot study. Drug Alcohol Depend 2002;67:323–330.CrossRef Brady KT, Myrick H, Henderson S et al: The use of divalproex in alcohol relapse prevention: a pilot study. Drug Alcohol Depend 2002;67:323–330.CrossRef
43.
Zurück zum Zitat Salloum IM, Cornelius JR, Daley DC et al: Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study. Arch Gen Psychiatry 2005;62:37–45.CrossRef Salloum IM, Cornelius JR, Daley DC et al: Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study. Arch Gen Psychiatry 2005;62:37–45.CrossRef
44.
Zurück zum Zitat Goldberg JF, Garno JL, Leon AC et al: A history of substance abuse complicates remission from acute mania in bipolar disorder. J Clin Psychiatry 1999;60:733–740.CrossRef Goldberg JF, Garno JL, Leon AC et al: A history of substance abuse complicates remission from acute mania in bipolar disorder. J Clin Psychiatry 1999;60:733–740.CrossRef
45.
Zurück zum Zitat Fawcett J, Kravitz HM, McGuire M et al: Pharmacological treatments for alcoholism: revisiting lithium and considering buspirone. Alcohol Clin Exp Res 2000;24:666–674.CrossRef Fawcett J, Kravitz HM, McGuire M et al: Pharmacological treatments for alcoholism: revisiting lithium and considering buspirone. Alcohol Clin Exp Res 2000;24:666–674.CrossRef
46.
Zurück zum Zitat Brady KT, Sonne SC, Anton R et al: Valproate in the treatment of acute bipolar affective episodes complicated by substance abuse: a pilot study. J Clin Psychiatry 1995;56:118–121.PubMed Brady KT, Sonne SC, Anton R et al: Valproate in the treatment of acute bipolar affective episodes complicated by substance abuse: a pilot study. J Clin Psychiatry 1995;56:118–121.PubMed
47.
Zurück zum Zitat Salloum IM, Douaihy A, Cornelius JR et al: Divalproex utility in bipolar disorder with co-occurring cocaine dependence: a pilot study. Addict Behav 2007;32:410–415.CrossRef Salloum IM, Douaihy A, Cornelius JR et al: Divalproex utility in bipolar disorder with co-occurring cocaine dependence: a pilot study. Addict Behav 2007;32:410–415.CrossRef
48.
Zurück zum Zitat Brady KT, Sonne SC, Malcolm RJ et al: Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder. Exp Clin Psychopharmacol 2002;10:276–285.CrossRef Brady KT, Sonne SC, Malcolm RJ et al: Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder. Exp Clin Psychopharmacol 2002;10:276–285.CrossRef
49.
Zurück zum Zitat Brown ES, Nejtek VA, Perantie DC et al: Lamotrigine in patients with bipolar disorder and cocaine dependence. J Clin Psychiatry 2003;64:197–201.CrossRef Brown ES, Nejtek VA, Perantie DC et al: Lamotrigine in patients with bipolar disorder and cocaine dependence. J Clin Psychiatry 2003;64:197–201.CrossRef
50.
Zurück zum Zitat Brown ES, Perantie DC, Dhanani N et al: Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study. J Affect Disord 2006;93:219–222.CrossRef Brown ES, Perantie DC, Dhanani N et al: Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study. J Affect Disord 2006;93:219–222.CrossRef
51.
Zurück zum Zitat Brown ES, Sunderajan P, Hu LT et al: A randomized, double-blind, placebo-controlled, trial of lamotrigine therapy in bipolar disorder, depressed or mixed phase and cocaine dependence. Neuropsychopharmacology 2012;37:2347–2354.CrossRef Brown ES, Sunderajan P, Hu LT et al: A randomized, double-blind, placebo-controlled, trial of lamotrigine therapy in bipolar disorder, depressed or mixed phase and cocaine dependence. Neuropsychopharmacology 2012;37:2347–2354.CrossRef
52.
Zurück zum Zitat Kishi T, Sevy S, Chekuri R et al: Antipsychotics for primary alcohol dependence: a systematic review and meta-analysis of placebo-controlled trials. J Clin Psychiatry 2013;74:e642–e654.CrossRef Kishi T, Sevy S, Chekuri R et al: Antipsychotics for primary alcohol dependence: a systematic review and meta-analysis of placebo-controlled trials. J Clin Psychiatry 2013;74:e642–e654.CrossRef
53.
Zurück zum Zitat Brown ES, Garza M, Carmody TJ: A randomized, double-blind, placebo-controlled add-on trial of quetiapine in outpatients with bipolar disorder and alcohol use disorders. J Clin Psychiatry 2008;69:701–705.CrossRef Brown ES, Garza M, Carmody TJ: A randomized, double-blind, placebo-controlled add-on trial of quetiapine in outpatients with bipolar disorder and alcohol use disorders. J Clin Psychiatry 2008;69:701–705.CrossRef
54.
Zurück zum Zitat Stedman M, Pettinati HM, Brown ES et al: A double-blind, placebo-controlled study with quetiapine as adjunct therapy with lithium or divalproex in bipolar I patients with coexisting alcohol dependence. Alcohol Clin Exp Res 2010;34:1822–1831.CrossRef Stedman M, Pettinati HM, Brown ES et al: A double-blind, placebo-controlled study with quetiapine as adjunct therapy with lithium or divalproex in bipolar I patients with coexisting alcohol dependence. Alcohol Clin Exp Res 2010;34:1822–1831.CrossRef
55.
Zurück zum Zitat Brown ES, Nejtek VA, Perantie DC et al: Quetiapine in bipolar disorder and cocaine dependence. Bipolar Disord 2002;4:406–411.CrossRef Brown ES, Nejtek VA, Perantie DC et al: Quetiapine in bipolar disorder and cocaine dependence. Bipolar Disord 2002;4:406–411.CrossRef
56.
Zurück zum Zitat Brown ES, Jeffress J, Liggin JD et al: Switching outpatients with bipolar or schizoaffective disorders and substance abuse from their current antipsychotic to aripiprazole. J Clin Psychiatry 2005;66:756–760.CrossRef Brown ES, Jeffress J, Liggin JD et al: Switching outpatients with bipolar or schizoaffective disorders and substance abuse from their current antipsychotic to aripiprazole. J Clin Psychiatry 2005;66:756–760.CrossRef
57.
Zurück zum Zitat Pacchiarotti I, Bond DJ, Baldessarini RJ et al: The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. Am J Psychiatry 2013;170:1249–1262.CrossRef Pacchiarotti I, Bond DJ, Baldessarini RJ et al: The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. Am J Psychiatry 2013;170:1249–1262.CrossRef
58.
Zurück zum Zitat Brown ES, Carmody TJ, Schmitz JM et al: A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence. Alcohol Clin Exp Res 2009;33:1863–1869.CrossRef Brown ES, Carmody TJ, Schmitz JM et al: A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence. Alcohol Clin Exp Res 2009;33:1863–1869.CrossRef
59.
Zurück zum Zitat Brown ES, Beard L, Dobbs L et al: Naltrexone in patients with bipolar disorder and alcohol dependence. Depress Anxiety 2006;23:492–495.CrossRef Brown ES, Beard L, Dobbs L et al: Naltrexone in patients with bipolar disorder and alcohol dependence. Depress Anxiety 2006;23:492–495.CrossRef
60.
Zurück zum Zitat Tolliver BK, Desantis SM, Brown DG et al: A randomized, double-blind, placebo-controlled clinical trial of acamprosate in alcohol-dependent individuals with bipolar disorder: a preliminary report. Bipolar Disord 2012;14:54–63.CrossRef Tolliver BK, Desantis SM, Brown DG et al: A randomized, double-blind, placebo-controlled clinical trial of acamprosate in alcohol-dependent individuals with bipolar disorder: a preliminary report. Bipolar Disord 2012;14:54–63.CrossRef
61.
Zurück zum Zitat Brown ES, Todd JP, Hu LT et al: A Randomized, Double-Blind, Placebo-Controlled Trial of Citicoline for Cocaine Dependence in Bipolar I Disorder. Am J Psychiatry 2015;172:1014–1021.CrossRef Brown ES, Todd JP, Hu LT et al: A Randomized, Double-Blind, Placebo-Controlled Trial of Citicoline for Cocaine Dependence in Bipolar I Disorder. Am J Psychiatry 2015;172:1014–1021.CrossRef
Metadaten
Titel
Komorbidität psychischer Erkrankungen
Bipolare Störungen und Sucht
verfasst von
PD Dr. med. Heinz Grunze
Dr. med. Thomas Heinrich
Prof. Dr. Dr. med. Dipl.-Psych. Jörg Walden
Publikationsdatum
29.09.2018
Verlag
Springer Medizin
Schlagwörter
Sucht
Sucht
Erschienen in
DNP – Die Neurologie & Psychiatrie / Ausgabe 5/2018
Print ISSN: 2731-8168
Elektronische ISSN: 2731-8176
DOI
https://doi.org/10.1007/s15202-018-2062-y

Weitere Artikel der Ausgabe 5/2018

DNP - Der Neurologe & Psychiater 5/2018 Zur Ausgabe

Neu in den Fachgebieten Neurologie und Psychiatrie

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärzte und Psychotherapeuten.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.