Background
Methods
Study participants
Assessment of ABO blood groups
Systematic review and meta-analysis
Statistical analyses
Results
Genetic analysis of case-control study
rs8176746 × rs687289 | No. of cases | Genotype frequency in cases, % | No. of controls | Genotype frequency in controls, % | Phenotype A alleles | Phenotype B alleles | Phenotype AB alleles | Phenotype O alleles |
---|---|---|---|---|---|---|---|---|
AA×AA | 224 | 4.54 | 315 | 5.12 |
BB
| |||
AA×AG | 8 | 0.16 | 3 | 0.05 |
BO
a
| |||
AA×GG | 1 | 0.02 | 0 | 0.00 |
BO
b
| |||
AC×AA | 496 | 10.06 | 547 | 8.88 |
AB
| |||
AC×AG | 1146 | 23.24 | 1563 | 25.38 |
BO
| |||
AC×GG | 14 | 0.28 | 3 | 0.05 |
BO
b
| |||
CC×AA | 255 | 5.17 | 313 | 5.08 |
AA
| |||
CC×AG | 1308 | 26.52 | 1508 | 24.49 |
AO
| |||
CC×GG | 1480 | 30.01 | 1906 | 30.95 |
OO
|
Blood group | No. of cases | Phenotype frequency in cases, % | No. of controls | Phenotype frequency in controls, % | OR | 95% CI |
P
|
---|---|---|---|---|---|---|---|
O (alleles OO) | 1480 | 30.01 | 1906 | 30.95 | 1.00 | ||
A (alleles AA, AO) | 1563 | 31.69 | 1821 | 29.57 | 1.13 | 1.02–1.24 | 0.018* |
B (alleles BB, BO) | 1393 | 28.24 | 1884 | 30.59 | 0.96 | 0.87–1.06 | 0.410 |
AB (alleles AB) | 496 | 10.06 | 547 | 8.88 | 1.18 | 1.02–1.36 | 0.024* |
First allele | |||
---|---|---|---|
Second allele |
O
|
A
|
B
|
O
| |||
No. of cases | 1480 | 1308 | 1169 |
No. of controls | 1906 | 1508 | 1569 |
Multivariable-adjusted OR (95% CI) | Reference | 1.14 (1.03–1.26)* | 0.96 (0.87–1.07) |
A
| |||
No. of cases | – | 255 | – |
No. of controls | 313 | ||
Multivariable-adjusted OR (95% CI) | 1.07 (0.89–1.29) | ||
B
| |||
No. of cases | – | 496 | 224 |
No. of controls | 547 | 315 | |
Multivariable-adjusted OR (95% CI) | 1.18 (1.02–1.36)* | 0.95 (0.78–1.15) |