Background
Methods
Clinical specimens and experimental materials
RT-PCR
Western blot
Immunohistochemistry
Statistical analysis
Results
BMP4 expression in human glioma tissues at mRNA and protein levels
Expression of BMP4 ingliomas and the relationship between BMP4 expression and clinicopathological characteristics
Variable | n | BMP4 (n(%)) | X2 | P value | |
---|---|---|---|---|---|
+ | - | ||||
Sex | 0.517 | 0.472 | |||
Male | 347 | 124(35.73) | 223(64.27%) | ||
Female | 283 | 109(38.52) | 174(61.48) | ||
Age (years) | 2.982 | 0.099 | |||
≤35 | 307 | 124(40.39) | 183(59.61) | ||
>35 | 323 | 109(33.75) | 214(66.25) | ||
KPS score | 3.208 | 0.201 | |||
10-50 | 83 | 38(45.78) | 45(54.22) | ||
60-70 | 135 | 49(36.30) | 86(63.70) | ||
80-100 | 412 | 146(35.44) | 266(64.56) | ||
Extent of resection | 21.702 | 0.001 | |||
Partial | 139 | 28(20.14) | 111(79.86) | ||
Total | 491 | 205(41.75) | 286(58.25) | ||
Ki67 | 78.795 | 0.001 | |||
+ | 291 | 54(18.56) | 237(81.44) | ||
_ | 339 | 179(52.80) | 160(47.20) | ||
WHO grade | 40.996 | 0.001 | |||
II | 247 | 128(51.82) | 119(48.18) | ||
III-IV | 383 | 105(27.42) | 278(72.58) |
Characteristic | Hazard ratio | 95% CI | P value |
---|---|---|---|
Sex | 1.147 | 0.683-1.925 | 0.604 |
Age | 0.998 | 0.624-1.597 | 0.998 |
KPS | 1.140 | 0.843-1.541 | 0.396 |
Extent of resection | 0.581 | 0.369-2.728 | 0.182 |
Ki67 | 1.605 | 1.241-2.076 | 0.001 |
WHO grade | 3.901 | 1.705-8.928 | 0.001 |
Constant | 1.704 |