Background
Methods
Study population
Data collection
Statistical analyses
Results
Pre-menopausal | Post-menopausal | |||||
---|---|---|---|---|---|---|
Cases | Controls | p value | Cases | Controls | p value | |
(n = 469) | (n = 482) | (n = 509) | (n = 476) | |||
n (%) | n (%) | n (%) | n (%) | |||
Age (yrs)
| ||||||
Mean ± SD | 43.93 ± 6.8 | 42.65 ± 7.1 | 0.005 | 59.68 ± 6.7 | 57.70 ± 6.1 | <0.0001 |
Education
| ||||||
<High school | 57 (12.2) | 67 (13.9) | 0.07 | 90 (17.7) | 57 (12) | 0.003 |
High school graduate | 133 (28.4) | 112 (23.2) | 165 (32.4) | 130 (27.3) | ||
Some college | 136 (29) | 120 (24.9) | 122 (24) | 159 (33.4) | ||
College graduate | 91 (19.4) | 121 (25.1) | 81 (15.9) | 74 (15.6) | ||
Post-graduate degree | 52 (11.1) | 62 (12.9) | 51 (10) | 56 (11.8) | ||
Marital Status
| ||||||
Married | 184 (39.2) | 176 (36.5) | 0.05 | 158 (31.1) | 155 (32.7) | 0.19 |
Living as married | 8 (1.7) | 9 (1.9) | 6 (1.2) | 11 (2.3) | ||
Widowed | 10 (2.1) | 14 (2.9) | 88 (17.3) | 57 (12) | ||
Separated | 35 (7.5) | 22 (4.6) | 38 (7.5) | 38 (8) | ||
Divorced | 71 (15.1) | 55 (11.4) | 102 (20.1) | 93 (19.6) | ||
Single | 161 (34.3) | 206 (42.7) | 116 (22.8) | 120 (25.3) | ||
Country of origin
| ||||||
United States | 297 (63.3) | 378 (78.4) | <0.0001 | 404 (79.4) | 391 (82.1) | 0.54 |
Caribbean | 131 (27.9) | 75 (15.6) | 74 (14.5) | 61 (12.8) | ||
Other | 41 (8.7) | 29 (6) | 31 (6.1) | 24 (5) | ||
Ethnicity
| ||||||
Hispanic | 29 (6.2) | 14 (2.9) | 0.02 | 16 (3.1) | 12 (2.5) | 0.56 |
Non-Hispanic | 440 (93.8) | 468 (97.1) | 493 (96.9) | 464 (97.5) | ||
Age at menarche (yrs)
| ||||||
<12 | 139 (29.6) | 144 (29.9) | 0.52 | 152 (29.9) | 121 (25.5) | 0.23 |
12-13 | 220 (46.9) | 211 (43.8) | 221 (43.4) | 229 (48.2) | ||
>13 | 110 (23.5) | 127 (26.4) | 136 (26.7) | 125 (26.3) | ||
Age at menopause (yrs)
| ||||||
≤45 | 70 (14.1) | 78 (16.5) | <0.001 | |||
46-49 | 64 (12.9) | 107 (22.7) | ||||
50-54 | 311 (62.5) | 242 (51.3) | ||||
≥55 | 53 (10.6) | 45 (9.5) | ||||
Parity (livebirths)
| ||||||
0 | 87 (18.6) | 82 (17) | 0.17 | 67 (13.2) | 75 (15.8) | 0.17 |
1-2 | 257 (54.8) | 241 (50) | 242 (47.5) | 235 (49.4) | ||
3-4 | 104 (22.2) | 127 (26.4) | 137 (26.9) | 126 (26.5) | ||
≥5 | 21 (4.5) | 32 (6.6) | 63 (12.4) | 40 (8.4) | ||
Age at first birth (yrs)
| ||||||
Nulliparous | 87 (18.6) | 82 (17) | 0.32 | 67 (13.2) | 75 (15.8) | 0.41 |
≤19 | 127 (27.1) | 148 (30.7) | 190 (37.3) | 168 (35.4) | ||
20-24 | 108 (23.1) | 117 (24.3) | 131 (25.7) | 120 (25.3) | ||
25-30 | 89 (19) | 70 (14.5) | 82 (16.1) | 64 (13.5) | ||
≥31 | 57 (12.2) | 65 (13.5) | 39 (7.7) | 47 (9.9) | ||
Breastfeeding
| ||||||
Nulliparous | 87 (18.6) | 82 (17) | 0.32 | 67 (13.2) | 75 (15.8) | 0.34 |
Never (among parous) | 158 (33.7) | 185 (38.4) | 267 (52.5) | 230 (48.3) | ||
Ever | 224 (47.8) | 215 (44.6) | 175 (34.4) | 171 (35.9) | ||
Family history
| ||||||
No | 370 (78.9) | 416 (86.3) | 0.003 | 365 (71.7) | 389 (81.7) | <0.001 |
Yes | 99 (21.1) | 66 (13.7) | 144 (28.3) | 87 (18.3) | ||
History of benign breast disease
| ||||||
Never | 333 (71.3) | 393 (81.7) | <0.001 | 330 (64.8) | 345 (72.5) | 0.01 |
Ever | 134 (28.7) | 88 (18.3) | 179 (35.2) | 131 (27.5) | ||
HRT use
| ||||||
Never | 449 (96.2) | 467 (96.9) | 0.53 | 375 (74.4) | 378 (79.8) | 0.05 |
Ever | 18 (3.9) | 15 (3.1) | 129 (25.6) | 96 (20.3) | ||
Oral contraceptive use
| ||||||
Never | 175 (37.3) | 189 (39.2) | 0.55 | 212 (41.7) | 220 (46.4) | 0.14 |
Ever | 294 (62.7) | 293 (60.8) | 296 (58.3) | 254 (53.6) | ||
Smoking status
| ||||||
Never smoker | 297 (71.4) | 287 (60.7) | <0.001 | 219 (53.4) | 226 (52.3) | 0.13 |
Former smoker | 62 (14.9) | 76 (16.1) | 127 (31) | 117 (27.1) | ||
Current smoker | 57 (13.7) | 110 (23.3) | 64 (15.6) | 89 (20.6) |
Pre-menopausal | Post-menopausal | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | |
Current BMI*
| ||||||||||
Underweight/Normal (<25) | 102/103 | Ref | Ref | 74/68 | Ref | Ref | ||||
Overweight (25–29.99) | 150/142 | 1.02 | 0.70–1.49 | 1.05 | 0.70–1.57 | 131/132 | 0.93 | 0.60–1.44 | 0.93 | 0.59–1.47 |
Obese (≥30) | 217/237 | 0.89 | 0.61–1.28 | 0.92 | 0.54–1.56 | 304/276 | 0.98 | 0.66–1.45 | 1.00 | 0.58–1.72 |
p for trend |
0.40
|
0.65
|
0.94
|
0.86
| ||||||
Current BMI*
| ||||||||||
Underweight/Normal (<25) | 102/103 | Ref | Ref | 74/68 | Ref | Ref | ||||
Pre–obese (25–29.99) | 150/142 | 1.01 | 0.69–1.48 | 0.98 | 0.64–1.49 | 131/132 | 0.93 | 0.60–1.44 | 0.88 | 0.55–1.41 |
Obese Class I (30–34.99) | 111/94 | 1.06 | 0.70–1.61 | 0.93 | 0.54–1.62 | 146/121 | 1.08 | 0.70–1.68 | 0.98 | 0.56–1.72 |
Obese Class II (35–39.99) | 50/68 | 0.71 | 0.43–1.17 | 0.62 | 0.31–1.26 | 94/89 | 0.90 | 0.56–1.44 | 0.80 | 0.41–1.58 |
Obese Class III (≥40) | 56/75 | 0.79 | 0.49–1.29 | 0.64 | 0.26–1.56 | 64/66 | 0.89 | 0.53–1.48 | 0.74 | 0.31–1.78 |
p for trend |
0.17
|
0.20
|
0.65
|
0.47
| ||||||
BMI one year before reference date**
| ||||||||||
Underweight/Normal (<25) | 115/113 | Ref | Ref | 66/77 | Ref | Ref | ||||
Overweight (25–29.99) | 138/143 | 0.86 | 0.59–1.25 | 0.90 | 0.61–1.33 | 147/140 | 1.27 | 0.82–1.96 | 1.32 | 0.84–2.07 |
Obese (≥30) | 214/221 | 0.91 | 0.63–1.30 | 1.00 | 0.62–1.62 | 293/254 | 1.27 | 0.85–1.89 | 1.46 | 0.87–2.44 |
p for trend |
0.74
|
0.88
|
0.41
|
0.22
| ||||||
BMI one year before reference date**
| ||||||||||
Underweight/Normal (<25) | 115/113 | Ref | Ref | 66/77 | Ref | Ref | ||||
Pre-obese (25–29.99) | 138/143 | 0.86 | 0.59–1.25 | 0.87 | 0.58–1.29 | 147/140 | 1.27 | 0.82–1.96 | 1.32 | 0.83–2.08 |
Obese Class I (30–34.99) | 121/92 | 1.17 | 0.77–1.76 | 1.16 | 0.71–1.90 | 143/129 | 1.23 | 0.79–1.90 | 1.34 | 0.80–2.27 |
Obese Class II (35–39.99) | 43/73 | 0.55 | 0.33–0.90 | 0.54 | 0.28–1.02 | 87/55 | 1.70 | 1.02–2.82 | 1.97 | 1.02–3.82 |
Obese Class III (≥40) | 50/56 | 0.93 | 0.56–1.54 | 0.93 | 0.43–2.00 | 63/70 | 0.98 | 0.58–1.64 | 1.19 | 0.55–2.55 |
p for trend |
0.39
|
0.61
|
0.86
|
0.64
|
Pre-menopausal | Post-menopausal | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | |
Waist to hip ratio
| ||||||||||
≤0.82 | 123/144 | Ref | Ref | 65/93 | Ref | Ref | ||||
0.83–0.87 | 128/120 | 1.14 | 0.79–1.65 | 1.20 | 0.82–1.74 | 146/117 | 1.58 | 1.03–2.40 | 1.59 | 1.04–2.42 |
0.88–0.92 | 105/121 | 0.98 | 0.66–1.44 | 1.07 | 0.72–1.60 | 120/116 | 1.22 | 0.79–1.88 | 1.24 | 0.80–1.92 |
>0.92 | 104/93 | 1.19 | 0.80–1.79 | 1.38 | 0.89–2.12 | 169/144 | 1.43 | 0.95–2.18 | 1.48 | 0.97–2.26 |
p for trend |
0.55
|
0.22
|
0.33
|
0.27
| ||||||
Waist circumference (cm)
| ||||||||||
≤87.88 | 137/143 | Ref | Ref | 87/94 | Ref | Ref | ||||
87.89–97.75 | 124/119 | 1.02 | 0.70–1.46 | 1.26 | 0.85–1.88 | 119/118 | 1.07 | 0.71–1.61 | 1.13 | 0.73–1.76 |
97.76–110.25 | 107/116 | 0.93 | 0.64–1.37 | 1.47 | 0.88–2.44 | 154/121 | 1.35 | 0.90–2.02 | 1.51 | 0.92–2.48 |
>110.25 | 92/100 | 0.98 | 0.65–1.48 | 2.25 | 1.07–4.74 | 140/137 | 1.00 | 0.67–1.50 | 1.23 | 0.64–2.34 |
p for trend |
0.84
|
0.04
|
0.96
|
0.48
| ||||||
Per 5 cm | 0.99 | 0.95–1.03 | 1.10 | 1.00–1.22 | 1.00 | 0.96–1.04 | 1.03 | 0.94–1.13 | ||
Hip circumference (cm)
| ||||||||||
≤103.18 | 127/138 | Ref | Ref | 107/99 | Ref | Ref | ||||
103.19–111.63 | 133/111 | 1.25 | 0.86–1.81 | 1.60 | 1.07–2.39 | 129/126 | 0.99 | 0.67–1.47 | 0.99 | 0.65–1.51 |
111.64–123.15 | 101/116 | 1.00 | 0.68–1.46 | 1.60 | 0.98–2.60 | 145/122 | 1.16 | 0.79–1.72 | 1.16 | 0.71–1.89 |
>123.15 | 100/113 | 1.07 | 0.72–1.59 | 2.91 | 1.39–6.10 | 119/123 | 0.88 | 0.59–1.31 | 0.87 | 0.45–1.71 |
p for trend |
0.99
|
0.01
|
0.54
|
0.69
| ||||||
Per 5 cm | 0.98 | 0.93–1.03 | 1.12 | 0.99–1.27 | 0.98 | 0.94–1.03 | 0.97 | 0.87–1.08 |
Pre-menopausal | Post-menopausal | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | |
Fat mass (kg)
| ||||||||||
≤25.3 | 128/125 | Ref | Ref | 101/102 | Ref | Ref | ||||
25.4–34.1 | 131/116 | 1.08 | 0.74–1.56 | 1.24 | 0.82–1.87 | 126/107 | 1.16 | 0.78–1.74 | 1.34 | 0.86–2.07 |
34.2–44.3 | 96/100 | 0.92 | 0.62–1.37 | 1.19 | 0.70–2.03 | 124/123 | 0.94 | 0.63–1.40 | 1.21 | 0.72–2.04 |
>44.3 | 87/114 | 0.82 | 0.54–1.23 | 1.39 | 0.61–3.14 | 120/110 | 1.05 | 0.70–1.57 | 1.69 | 0.82–3.49 |
p for trend |
0.24
|
0.49
|
0.93
|
0.22
| ||||||
Fat free mass (kg)
| ||||||||||
≤44.1 | 112/108 | Ref | Ref | 130/118 | Ref | Ref | ||||
44.2–48 | 121/125 | 0.94 | 0.64–1.39 | 1.04 | 0.70–1.55 | 134/99 | 1.28 | 0.87–1.88 | 1.32 | 0.88–1.96 |
48.1–52.6 | 106/99 | 1.00 | 0.67–1.51 | 1.24 | 0.78–1.98 | 107/124 | 0.87 | 0.59–1.27 | 0.92 | 0.59–1.43 |
>52.6 | 103/123 | 0.84 | 0.57–1.26 | 1.32 | 0.70–2.47 | 101/101 | 0.96 | 0.65–1.43 | 1.05 | 0.61–1.83 |
p for trend |
0.44
|
0.35
|
0.47
|
0.88
| ||||||
Percent body fat
| ||||||||||
≤35.9 | 145/137 | Ref | Ref | 93/94 | Ref | Ref | ||||
36–41.6 | 118/118 | 0.92 | 0.64–1.33 | 1.02 | 0.69–1.52 | 123/107 | 1.14 | 0.75–1.71 | 1.27 | 0.83–1.96 |
41.7–46.5 | 96/104 | 0.88 | 0.60–1.30 | 1.07 | 0.67–1.72 | 119/124 | 0.85 | 0.57–1.29 | 1.05 | 0.65–1.70 |
>46.5 | 83/106 | 0.82 | 0.55–1.23 | 1.22 | 0.62–2.42 | 137/119 | 1.09 | 0.73–1.63 | 1.59 | 0.87–2.93 |
p for trend |
0.32
|
0.65
|
0.98
|
0.26
| ||||||
Fat mass index
| ||||||||||
≤9.37 | 128/129 | Ref | – | – | 86/96 | Ref | - | - | ||
9.38–12.78 | 138/119 | 1.09 | 0.75–1.58 | - | - | 124/104 | 1.39 | 0.92–2.11 | - | - |
12.79–16.77 | 93/98 | 0.95 | 0.63–1.42 | - | - | 140/127 | 1.13 | 0.75–1.70 | - | - |
>16.77 | 83/109 | 0.80 | 0.53–1.21 | - | - | 121/115 | 1.10 | 0.72–1.66 | - | - |
p for trend |
0.35
| - | - |
0.58
| - | - | ||||
Fat free mass index
| - | - | - | - | ||||||
≤16.64 | 126/118 | Ref | - | - | 123/106 | Ref | - | - | ||
16.65-18.04 | 116/121 | 0.88 | 0.60–1.28 | - | - | 108/104 | 0.94 | 0.63–1.40 | - | - |
18.05–19.80 | 99/99 | 0.85 | 0.57–1.28 | - | - | 129/124 | 0.89 | 0.60–1.30 | - | - |
>19.80 | 101/117 | 0.81 | 0.54–1.21 | - | - | 112/108 | 0.86 | 0.58–1.28 | - | - |
p for trend |
0.33
| - | - |
0.45
| - | - |
Pre-menopausal | Post-menopausal | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | Cases/Controls | OR1 | 95% CI | OR2 | 95% CI | |
Current BMI*
| ||||||||||
Underweight/Normal (<25) | 96/102 | Ref | Ref | 55/53 | Ref | Ref | ||||
Overweight (25–29.99) | 147/136 | 1.09 | 0.74–1.61 | 1.12 | 0.74–1.69 | 86/107 | 0.76 | 0.46–1.26 | 0.77 | 0.46–1.31 |
Obese (≥30) | 206/229 | 0.91 | 0.63–1.32 | 0.92 | 0.54–1.58 | 234/218 | 0.97 | 0.62–1.52 | 1.05 | 0.57–1.95 |
p for trend |
0.41
|
0.60
|
0.56
|
0.49
| ||||||
% Body Fat
| ||||||||||
≤35.9 | 139/133 | Ref | Ref | 69/73 | Ref | Ref | ||||
36–41.6 | 112/114 | 0.90 | 0.62–1.31 | 0.98 | 0.65–1.46 | 85/86 | 1.05 | 0.66–1.68 | 1.18 | 0.72–1.95 |
41.7–46.5 | 94/101 | 0.89 | 0.60–1.32 | 1.03 | 0.63–1.66 | 90/95 | 0.87 | 0.54–1.39 | 1.06 | 0.61–1.84 |
>46.5 | 79/103 | 0.81 | 0.53–1.22 | 1.08 | 0.54–2.17 | 102/96 | 1.03 | 0.65–1.64 | 1.49 | 0.74–2.99 |
p for trend |
0.31
|
0.88
|
0.94
|
0.38
| ||||||
Waist to hip ratio
| ||||||||||
≤0.82 | 118/144 | Ref | Ref | 52/70 | Ref | Ref | ||||
0.83–0.87 | 122/113 | 1.21 | 0.83–1.77 | 1.27 | 0.87–1.86 | 97/94 | 1.16 | 0.72–1.88 | 1.17 | 0.72–1.90 |
0.88–0.92 | 100/116 | 1.02 | 0.69–1.52 | 1.11 | 0.74–1.67 | 78/88 | 0.97 | 0.58–1.59 | 0.99 | 0.60–1.64 |
>0.92 | 100/90 | 1.22 | 0.80–1.84 | 1.38 | 0.89–2.14 | 140/121 | 1.29 | 0.81–2.06 | 1.34 | 0.83–2.16 |
p for trend |
0.51
|
0.22
|
0.35
|
0.28
| ||||||
Waist circumference (cm)
| ||||||||||
≤87.88 | 130/140 | Ref | Ref | 62/75 | Ref | Ref | ||||
87.89–97.75 | 120/114 | 1.04 | 0.71–1.50 | 1.25 | 0.83–1.88 | 82/91 | 1.04 | 0.64–1.67 | 1.18 | 0.70–1.97 |
97.76–110.25 | 102/112 | 0.94 | 0.64–1.39 | 1.40 | 0.83–2.35 | 114/98 | 1.39 | 0.87–2.20 | 1.74 | 0.99–3.06 |
>110.25 | 88/97 | 0.98 | 0.64–1.50 | 2.01 | 0.95–4.29 | 109/109 | 1.08 | 0.68–1.72 | 1.64 | 0.77–3.50 |
p for trend |
0.84
|
0.08
|
0.61
|
0.14
| ||||||
Hip circumference (cm)
| ||||||||||
≤103.18 | 120/134 | Ref | Ref | 76/81 | Ref | Ref | ||||
103.19–111.63 | 129/107 | 1.28 | 0.88–1.86 | 1.60 | 1.06–2.41 | 89/98 | 1.06 | 0.68–1.68 | 1.14 | 0.70–1.86 |
111.64–123.15 | 95/113 | 0.97 | 0.65–1.43 | 1.50 | 0.91–2.46 | 112/98 | 1.31 | 0.84–2.04 | 1.47 | 0.85–2.56 |
>123.15 | 97/109 | 1.10 | 0.74–1.65 | 2.78 | 1.32–5.88 | 90/96 | 0.97 | 0.61–1.54 | 1.22 | 0.56–2.62 |
p for trend |
0.92
|
0.02
|
0.92
|
0.65
|
ER+/PR+ vs. controls | ER-/PR- vs. controls | ER-/PR- cases vs. ER+/PR+ cases | |||||||
---|---|---|---|---|---|---|---|---|---|
CO
|
CA
| OR | 95% CI |
CA
| OR | 95% CI | OR | 95% CI | |
Current BMI*
| |||||||||
Underweight/Normal (<25) | 103 | 42 | Ref | 20 | Ref | Ref | |||
Overweight (25–29.99) | 142 | 58 | 1.15 | 0.67–1.96 | 31 | 1.17 | 0.59–2.34 | 1.05 | 0.47–2.37 |
Obese (≥30) | 237 | 95 | 1.34 | 0.68–2.68 | 51 | 1.26 | 0.53–3.00 | 0.88 | 0.30–2.54 |
p for trend |
0.40
|
0.65
|
0.74
| ||||||
% Body fat
| |||||||||
≤35.9 | 137 | 62 | Ref | 20 | Ref | Ref | |||
36–41.6 | 118 | 51 | 0.99 | 0.59–1.64 | 26 | 1.20 | 0.61–2.34 | 1.23 | 0.58–2.64 |
41.7–46.5 | 104 | 43 | 1.10 | 0.59–2.05 | 21 | 1.28 | 0.58–2.86 | 1.17 | 0.47–2.92 |
>46.5 | 106 | 30 | 0.91 | 0.37–2.24 | 24 | 1.78 | 0.59–5.37 | 1.68 | 0.47–6.08 |
p for trend |
0.96
|
0.36
|
0.52
| ||||||
Waist to hip ratio
| |||||||||
≤0.82 | 144 | 56 | Ref | 20 | Ref | Ref | |||
0.83–0.87 | 120 | 48 | 0.99 | 0.60–1.63 | 27 | 1.13 | 0.61–2.10 | 1.20 | 0.58–2.49 |
0.88–0.92 | 121 | 45 | 1.06 | 0.63–1.78 | 23 | 1.02 | 0.52–2.00 | 0.97 | 0.44–2.15 |
>0.92 | 93 | 43 | 1.33 | 0.76–2.32 | 24 | 1.51 | 0.74–3.05 | 1.30 | 0.57–3.00 |
p for trend |
0.33
|
0.32
|
0.63
| ||||||
Waist circumference (cm)
| |||||||||
≤87.88 | 143 | 57 | Ref | 20 | Ref | Ref | |||
87.89–97.75 | 119 | 52 | 1.28 | 0.76–2.17 | 24 | 1.07 | 0.55–2.10 | 0.80 | 0.37–1.75 |
97.76–110.25 | 116 | 47 | 1.57 | 0.80–3.08 | 25 | 1.52 | 0.67–3.47 | 0.78 | 0.28–2.16 |
>110.25 | 100 | 36 | 2.05 | 0.79–5.35 | 23 | 1.91 | 0.59–6.13 | 0.73 | 0.17–3.08 |
p for trend |
0.13
|
0.25
|
0.67
| ||||||
Hip circumference (cm)
| |||||||||
≤103.18 | 138 | 55 | Ref | 20 | Ref | Ref | |||
103.19–111.63 | 111 | 52 | 1.50 | 0.89–2.54 | 33 | 2.25 | 1.16–4.37 | 1.36 | 0.61–3.00 |
111.64–123.15 | 116 | 40 | 1.69 | 0.89–3.20 | 22 | 1.65 | 0.73–3.73 | 0.75 | 0.28–1.99 |
>123.15 | 113 | 46 | 3.59 | 1.43–9.03 | 24 | 2.60 | 0.79–8.54 | 0.47 | 0.12–1.95 |
p for trend |
0.01
|
0.22
|
0.15
|
ER+/PR+ vs. controls | ER-/PR- vs. controls | ER-/PR- cases vs. ER+/PR+ cases | |||||||
---|---|---|---|---|---|---|---|---|---|
CO
|
CA
| OR | 95% CI |
CA
| OR | 95% CI | OR | 95% CI | |
Current BMI*
| |||||||||
Underweight/Normal (<25) | 68 | 26 | Ref | 20 | Ref | Ref | |||
Overweight (25-29.99) | 132 | 49 | 1.05 | 0.55–1.98 | 34 | 0.77 | 0.38–1.59 | 0.88 | 0.36–2.13 |
Obese (≥30) | 276 | 131 | 1.04 | 0.50–2.18 | 47 | 0.37 | 0.15–0.96 | 0.42 | 0.14–1.25 |
p for trend |
0.95
|
0.03
|
0.07
| ||||||
% Body fat
| |||||||||
≤35.9 | 94 | 34 | Ref | 23 | Ref | Ref | |||
36–41.6 | 107 | 39 | 1.04 | 0.57–1.89 | 29 | 1.41 | 0.70–2.85 | 1.37 | 0.58–3.22 |
41.7–46.5 | 124 | 62 | 1.38 | 0.74–2.58 | 19 | 0.70 | 0.30–1.62 | 0.57 | 0.21–1.52 |
>46.5 | 119 | 57 | 1.39 | 0.62–3.12 | 25 | 1.39 | 0.49–3.99 | 1.11 | 0.33–3.73 |
p for trend |
0.32
|
0.92
|
0.75
| ||||||
Waist to hip ratio
| |||||||||
≤0.82 | 93 | 25 | Ref | 18 | Ref | Ref | |||
0.83–0.87 | 117 | 57 | 1.71 | 0.95–3.07 | 26 | 1.12 | 0.56–2.26 | 0.65 | 0.26–1.57 |
0.88–0.92 | 116 | 53 | 1.55 | 0.85–2.81 | 17 | 0.61 | 0.28–1.33 | 0.36 | 0.14–0.95 |
>0.92 | 144 | 70 | 1.61 | 0.90–2.90 | 39 | 1.26 | 0.63–2.50 | 0.63 | 0.27–1.50 |
p for trend |
0.27
|
0.63
|
0.38
| ||||||
Waist circumference (cm)
| |||||||||
≤87.88 | 94 | 36 | Ref | 23 | Ref | Ref | |||
87.89–97.75 | 118 | 39 | 0.88 | 0.48–1.60 | 25 | 0.93 | 0.45–1.92 | 1.14 | 0.48–2.73 |
97.76–110.25 | 121 | 56 | 1.30 | 0.68–2.48 | 25 | 1.11 | 0.48–2.57 | 0.95 | 0.36–2.45 |
>110.25 | 137 | 74 | 1.55 | 0.68–3.55 | 27 | 1.08 | 0.35–3.31 | 0.59 | 0.17–2.03 |
p for trend |
0.20
|
0.83
|
0.34
| ||||||
Hip circumference (cm)
| |||||||||
≤103.18 | 99 | 47 | Ref | 24 | Ref | Ref | |||
103.19–111.63 | 126 | 42 | 0.72 | 0.40–1.28 | 33 | 1.29 | 0.64–2.59 | 2.10 | 0.90–4.89 |
111.64–123.15 | 122 | 56 | 0.91 | 0.48–1.72 | 23 | 1.06 | 0.45–2.48 | 1.43 | 0.51–4.03 |
>123.15 | 123 | 60 | 0.73 | 0.31–1.73 | 20 | 1.00 | 0.31–3.29 | 1.89 | 0.45–7.98 |
p for trend |
0.65
|
0.81
|
0.61
|