BMC Cancer

Inhalt (619 Artikel)

Benign prostatic hyperplasia is a significant risk factor for bladder cancer in diabetic patients: a population-based cohort study using the National Health Insurance in Taiwan

Open Access
Research article

Chin-Hsiao Tseng

Elevated cyclin B2 expression in invasive breast carcinoma is associated with unfavorable clinical outcome

Open Access
Research article

Emman Shubbar, Anikó Kovács, Shahin Hajizadeh, Toshima Z Parris, Szilárd Nemes, Katrin Gunnarsdóttir, Zakaria Einbeigi, Per Karlsson, Khalil Helou

Prognostic value of α-fetoprotein and des-γ-carboxy prothrombin responses in patients with hepatocellular carcinoma treated with transarterial chemoembolization

Open Access
Research article

Yong Kang Lee, Seung Up Kim, Do Young Kim, Sang Hoon Ahn, Kwang Hun Lee, Do Yun Lee, Kwang-Hyub Han, Chae Yoon Chon, Jun Yong Park

Increased MiR-221 expression in hepatocellular carcinoma tissues and its role in enhancing cell growth and inhibiting apoptosis in vitro

Open Access
Research article

Minhua Rong, Gang Chen, Yiwu Dang

Functional significance of erythropoietin in renal cell carcinoma

Open Access
Review

Christudas Morais, David W Johnson, David A Vesey, Glenda C Gobe

IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells

Open Access
Research article

Erin M McCoy, Huixian Hong, Hawley C Pruitt, Xu Feng

APC/β-catenin-rich complexes at membrane protrusions regulate mammary tumor cell migration and mesenchymal morphology

Open Access
Research article

Matthew A Odenwald, Jenifer R Prosperi, Kathleen H Goss

A population-based cross-sectional study of colorectal cancer screening practices of first-degree relatives of colorectal cancer patients

Open Access
Research article

Ryan J Courtney, Christine L Paul, Mariko L Carey, Robert W Sanson-Fisher, Finlay A Macrae, Catherine D’Este, David Hill, Daniel Barker, Jody Simmons

Human endogenous retroviruses and cancer prevention: evidence and prospects

Open Access
Debate

Luca Cegolon, Cristiano Salata, Elisabete Weiderpass, Paolo Vineis, Giorgio Palù, Giuseppe Mastrangelo

Pegfilgrastim prophylaxis is associated with a lower risk of hospitalization of cancer patients than filgrastim prophylaxis: a retrospective United States claims analysis of granulocyte colony-stimulating factors (G-CSF)

Open Access
Research article

Arash Naeim, Henry J Henk, Laura Becker, Victoria Chia, Sejal Badre, Xiaoyan Li, Robert Deeter

Early results of prostate cancer radiation therapy: an analysis with emphasis on research strategies to improve treatment delivery and outcomes

Open Access
Research article

Kosj Yamoah, Kwamena Beecham, Sarah E Hegarty, Terry Hyslop, Timothy Showalter, Joel Yarney

Prospective evaluation of a hydrogel spacer for rectal separation in dose-escalated intensity-modulated radiotherapy for clinically localized prostate cancer

Open Access
Research article

Franziska Eckert, Saladin Alloussi, Frank Paulsen, Michael Bamberg, Daniel Zips, Patrick Spillner, Cihan Gani, Ulrich Kramer, Daniela Thorwarth, David Schilling, Arndt-Christian Müller

Comprehensive knowledge about cervical cancer is low among women in Northwest Ethiopia

Open Access
Research article

Frehiwot Getahun, Fekadu Mazengia, Mulunesh Abuhay, Zelalem Birhanu

Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer

Open Access
Research article

Iván Fernández-Vega, Olivia García, Ainara Crespo, Sonia Castañón, Primitiva Menéndez, Aurora Astudillo, Luis M Quirós

Estimating the clinical benefits of vaccinating boys and girls against HPV-related diseases in Europe

Open Access
Research article

Rémi Marty, Stéphane Roze, Xavier Bresse, Nathalie Largeron, Jayne Smith-Palmer

Cancer incidence and mortality in Serbia 1999–2009

Open Access
Research article

Jovan Mihajlović, Petros Pechlivanoglou, Marica Miladinov-Mikov, Snežana Živković, Maarten J Postma

MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1

Open Access
Research article

Ronald TK Pang, Carmen ON Leung, Cheuk-Lun Lee, Kevin KW Lam, Tian-Min Ye, Philip CN Chiu, William SB Yeung

Preclinical evaluation of Sunitinib as a single agent in the prophylactic setting in a mouse model of bone metastases

Open Access
Research article

Christian Schem, Dirk Bauerschlag, Sascha Bender, Ann-Christin Lorenzen, Daniel Loermann, Sigrid Hamann, Frank Rösel, Holger Kalthoff, Claus C Glüer, Walter Jonat, Sanjay Tiwari

Prognostic significance of the expression of GFRα1, GFRα3 and Syndecan-3, proteins binding ARTEMIN, in mammary carcinoma

Open Access
Research article

Zheng-Sheng Wu, Vijay Pandey, Wen-Yong Wu, Shan Ye, Tao Zhu, Peter E Lobie

Cytostasis and morphological changes induced by mifepristone in human metastatic cancer cells involve cytoskeletal filamentous actin reorganization and impairment of cell adhesion dynamics

Open Access
Research article

BreeAnn N Brandhagen, Chelsea R Tieszen, Tara M Ulmer, Maria S Tracy, Alicia A Goyeneche, Carlos M Telleria

Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma

Open Access
Research article

Ales Sedlar, Simona Kranjc, Tanja Dolinsek, Maja Cemazar, Andrej Coer, Gregor Sersa

Genetic polymorphism of the OPG gene associated with breast cancer

Open Access
Research article

Jasmin Teresa Ney, Ingolf Juhasz-Boess, Frank Gruenhage, Stefan Graeber, Rainer Maria Bohle, Michael Pfreundschuh, Erich Franz Solomayer, Gunter Assmann

Comparison of survival of patients with metastases from known versus unknown primaries: survival in metastatic cancer

Open Access
Research article

Matias Riihimäki, Hauke Thomsen, Akseli Hemminki, Kristina Sundquist, Kari Hemminki

Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin

Open Access
Research article

Angelo Pietro Femia, Piero Dolara, Maddalena Salvadori, Giovanna Caderni

Gene-guided Gefitinib switch maintenance therapy for patients with advanced EGFR mutation-positive Non-small cell lung cancer: an economic analysis

Open Access
Research article

Jun Zhu, Te Li, Xiaohui Wang, Ming Ye, Jian Cai, Yuejuan Xu, Bin Wu

Does phosphorylation of cofilin affect the progression of human bladder cancer?

Open Access
Research article

Hong Chung, Bokyung Kim, Seung-Hyo Jung, Kyung-Jong Won, Xiaowen Jiang, Chang-Kwon Lee, So Dug Lim, Sang-Kuk Yang, Ki Hak Song, Hong Sup Kim

Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3as a novel lung cancer-related gene

Open Access
Research article

Mingsong Wu, Tao Tu, Yunchao Huang, Yi Cao

Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

Open Access
Research article

Linda E Kelemen, Elisa V Bandera, Kathryn L Terry, Mary Anne Rossing, Louise A Brinton, Jennifer A Doherty, Roberta B Ness, Susanne Krüger Kjær, Jenny Chang-Claude, Martin Köbel, Galina Lurie, Pamela J Thompson, Michael E Carney, Kirsten Moysich, Robert Edwards, Clare Bunker, Allan Jensen, Estrid Høgdall, Daniel W Cramer, Allison F Vitonis, Sara H Olson, Melony King, Urmila Chandran, Jolanta Lissowska, Montserrat Garcia-Closas, Hannah Yang, Penelope M Webb, Joellen M Schildkraut, Marc T Goodman, Harvey A Risch

Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients

Open Access
Research article

Liesbeth Hameetman, Suzan Commandeur, Jan Nico Bouwes Bavinck, Hermina C Wisgerhof, Frank R de Gruijl, Rein Willemze, Leon Mullenders, Cornelis P Tensen, Harry Vrieling

SPARC expression in CML is associated to imatinib treatment and to inhibition of leukemia cell proliferation

Open Access
Research article

Cesarina Giallongo, Piera La Cava, Daniele Tibullo, Ignazio Barbagallo, Nunziatina Parrinello, Alessandra Cupri, Fabio Stagno, Carla Consoli, Annalisa Chiarenza, Giuseppe A Palumbo, Francesco Di Raimondo

Serum p53 antibody detection in patients with impaired lung function

Open Access
Research article

Manlio Mattioni, Patrizia Chinzari, Silvia Soddu, Lidia Strigari, Vincenzo Cilenti, Eliuccia Mastropasqua

Early rehabilitation of cancer patients – a randomized controlled intervention study

Open Access
Study protocol

Cecilia Arving, Inger Thormodsen, Guri Brekke, Olav Mella, Sveinung Berntsen, Karin Nordin

The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma

Open Access
Research article

Akiyoshi Kinoshita, Hiroshi Onoda, Nami Imai, Akira Iwaku, Mutumi Oishi, Ken Tanaka, Nao Fushiya, Kazuhiko Koike, Hirokazu Nishino, Masato Matsushima, Chisato Saeki, Hisao Tajiri

Metabolic syndrome biomarkers and early breast cancer in Saudi women: evidence for the presence of a systemic stress response and/or a pre-existing metabolic syndrome-related neoplasia risk?

Open Access
Research article

Majed S Alokail, Nasser Al-Daghri, Amal Abdulkareem, Hossam M Draz, Sobhy M Yakout, Abdullah M Alnaami, Shaun Sabico, Amal M Alenad, George P Chrousos

Plasmacytoid variant of bladder cancer defines patients with poor prognosis if treated with cystectomy and adjuvant cisplatin-based chemotherapy

Open Access
Research article

Bastian Keck, Sven Wach, Robert Stoehr, Frank Kunath, Simone Bertz, Jan Lehmann, Michael Stöckle, Helge Taubert, Bernd Wullich, Arndt Hartmann

The relationship of Vascular endothelial growth factor gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX: VEGF polymorphism in gastric cancer

Open Access
Research article

Sung Yong Oh, Hyuk-Chan Kwon, Sung Hyun Kim, Suee Lee, Ji Hyun Lee, Jung-Ah Hwang, Seung Hyun Hong, Christian A Graves, Kevin Camphausen, Hyo-Jin Kim, Yeon-Su Lee

Identification of somatic and germline mutations using whole exome sequencing of congenital acute lymphoblastic leukemia

Open Access
Research article

Vivian Y Chang, Giuseppe Basso, Kathleen M Sakamoto, Stanley F Nelson

Rib fracture after stereotactic radiotherapy for primary lung cancer: prevalence, degree of clinical symptoms, and risk factors

Open Access
Research article

Atsushi Nambu, Hiroshi Onishi, Shinichi Aoki, Licht Tominaga, Kengo Kuriyama, Masayuki Araya, Ryoh Saito, Yoshiyasu Maehata, Takafumi Komiyama, Kan Marino, Tsuyota Koshiishi, Eiichi Sawada, Tsutomu Araki

MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis

Open Access
Research article

Kensuke Akaogi, Wakana Ono, Yuki Hayashi, Hiroyuki Kishimoto, Junn Yanagisawa

The effects of fluorouracil, epirubicin, and cyclophosphamide (FEC60) on the intestinal barrier function and gut peptides in breast cancer patients: an observational study

Open Access
Research article

Francesco Russo, Michele Linsalata, Caterina Clemente, Benedetta D’Attoma, Antonella Orlando, Giovanna Campanella, Francesco Giotta, Giuseppe Riezzo

A prospective multicenter phase II study evaluating multimodality treatment of patients with peritoneal carcinomatosis arising from appendiceal and colorectal cancer: the COMBATAC trial

Open Access
Study protocol

Gabriel Glockzin, Justine Rochon, Dirk Arnold, Sven A Lang, Frank Klebl, Florian Zeman, Michael Koller, Hans J Schlitt, Pompiliu Piso

High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer

Open Access
Research article

Emman Shubbar, Khalil Helou, Anikó Kovács, Szilárd Nemes, Shahin Hajizadeh, Charlotta Enerbäck, Zakaria Einbeigi

Patient side cost and its predictors for cervical cancer in Ethiopia: a cross sectional hospital based study

Open Access
Research article

Alemayehu Hailu, Damen Haile Mariam

Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14

Open Access
Research article

Liduan Zheng, Dan Li, Xuan Xiang, Ling Tong, Meng Qi, Jiarui Pu, Kai Huang, Qiangsong Tong

Differences in the symptom experience of older versus younger oncology outpatients: a cross-sectional study

Open Access
Research article

Janine K Cataldo, Steven Paul, Bruce Cooper, Helen Skerman, Kimberly Alexander, Bradley Aouizerat, Virginia Blackman, John Merriman, Laura Dunn, Christine Ritchie, Patsy Yates, Christine Miaskowski

Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines

Open Access
Research article

Caroline Gest, Ulrich Joimel, Limin Huang, Linda-Louise Pritchard, Alexandre Petit, Charlène Dulong, Catherine Buquet, Chao-Quan Hu, Pezhman Mirshahi, Marc Laurent, Françoise Fauvel-Lafève, Lionel Cazin, Jean-Pierre Vannier, He Lu, Jeannette Soria, Hong Li, Rémi Varin, Claudine Soria

MiR-200c and HuR in ovarian cancer

Open Access
Research article

Silvia Prislei, Enrica Martinelli, Marisa Mariani, Giuseppina Raspaglio, Steven Sieber, Gabriella Ferrandina, Shohreh Shahabi, Giovanni Scambia, Cristiano Ferlini

Prospective, open, multi-centre phase I/II trial to assess safety and efficacy of neoadjuvant radiochemotherapy with docetaxel and oxaliplatin in patients with adenocarcinoma of the oesophagogastric junction

Open Access
Research article

Markus Moehler, Ines Gockel, Hans-Peter Roessler, Dirk Arnold, Tanja Trarbach, Thomas Thomaidis, Gunther Klautke, Claus Rödel, Baruch Brenner, Hauke Lang, Peter R Galle, Carl C Schimanski, Heinz Schmidberger

Systematic evaluation of the methodology of randomized controlled trials of anticoagulation in patients with cancer

Open Access
Research article

Gabriel Rada, Holger J Schünemann, Nawman Labedi, Pierre El-Hachem, Victor F Kairouz, Elie A Akl

Early onset recall pneumonitis during targeted therapy with sunitinib

Open Access
Case report

Takeshi Yuasa, Shinichi Kitsukawa, Gen Sukegawa, Shinya Yamamoto, Keita Kudo, Kazunari Miyazawa, Takuyo Kozuka, Sohei Harada, Junji Yonese

Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells

Open Access
Research article

Hilary M Collins, Magdy K Abdelghany, Marie Messmer, Baigong Yue, Sian E Deeves, Karin B Kindle, Kempegowda Mantelingu, Akhmed Aslam, G Sebastiaan Winkler, Tapas K Kundu, David M Heery

The maximum standardized uptake value of 18 F-FDG PET scan to determine prognosis of hormone-receptor positive metastatic breast cancer

Open Access
Research article

Jian Zhang, Zhen Jia, Joseph Ragaz, Ying-Jian Zhang, Min Zhou, Yong-Ping Zhang, Gang Li, Bi-Yun Wang, Zhong-Hua Wang, Xi-Chun Hu

The potential prognostic value of connexin 26 and 46 expression in neoadjuvant-treated breast cancer

Open Access
Research article

Ivett Teleki, Tibor Krenacs, Marcell A Szasz, Janina Kulka, Barna Wichmann, Cornelia Leo, Barbel Papassotiropoulos, Cosima Riemenschnitter, Holger Moch, Zsuzsanna Varga

Surgery of highly eloquent gliomas primarily assessed as non-resectable: risks and benefits in a cohort study

Open Access
Research article

Sandro M Krieg, Lea Schnurbus, Ehab Shiban, Doris Droese, Thomas Obermueller, Niels Buchmann, Jens Gempt, Bernhard Meyer, Florian Ringel

Prevalence of cervical infection with HPV type 16 and 18 in Vietnam: implications for vaccine campaign

Open Access
Research article

Lan TH Vu, Dieu Bui, Ha TT Le

Correlation of MLH1 and MGMTexpression and promoter methylation with genomic instability in patients with thyroid carcinoma

Open Access
Research article

Juliana Carvalho Santos, André Uchimura Bastos, Janete Maria Cerutti, Marcelo Lima Ribeiro

OCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular carcinoma

Open Access
Research article

Lu Cao, Chunguang Li, Shuwen Shen, Yan Yan, Weidan Ji, Jinghan Wang, Haihua Qian, Xiaoqing Jiang, Zhigang Li, Mengchao Wu, Ying Zhang, Changqing Su

A mixed exercise training programme is feasible and safe and may improve quality of life and muscle strength in multiple myeloma survivors

Open Access
Research article

Lara Groeneveldt, Gill Mein, Rachel Garrod, Andrew P Jewell, Ken Van Someren, Richard Stephens, Shirley P D’Sa, Kwee L Yong

Prognostic value of C-reactive protein and neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma

Open Access
Research article

Byong Sun Oh, Jeong Won Jang, Jung Hyun Kwon, Chan Ran You, Kyu Won Chung, Chul Seung Kay, Hyun Suk Jung, Seungok Lee

Effect of dabrafenib on melanoma cell lines harbouring the BRAF V600D/R mutations

Open Access
Correspondence

Giusy Gentilcore, Gabriele Madonna, Nicola Mozzillo, Antoni Ribas, Antonio Cossu, Giuseppe Palmieri, Paolo A Ascierto

A pri-miR-218variant and risk of cervical carcinoma in Chinese women

Open Access
Research article

Ting-Yan Shi, Xiao-Jun Chen, Mei-Ling Zhu, Meng-Yun Wang, Jing He, Ke-Da Yu, Zhi-Ming Shao, Meng-Hong Sun, Xiao-Yan Zhou, Xi Cheng, Xiaohua Wu, Qingyi Wei

Cell-line-specific stimulation of tumor cell aggressiveness by wound healing factors – a central role for STAT3

Open Access
Research article

Lars Ekblad, Gustaf Lindgren, Emma Persson, Elisabeth Kjellén, Johan Wennerberg

Up-regulated microRNA-143 in cancer stem cells differentiation promotes prostate cancer cells metastasis by modulating FNDC3B expression

Open Access
Research article

Xinlan Fan, Xu Chen, Weixi Deng, Guangzheng Zhong, Qingqing Cai, Tianxin Lin

E-cadherin gene re-expression in chronic lymphocytic leukemia cells by HDAC inhibitors

Open Access
Research article

Gwen Jordaan, Wei Liao, Sanjai Sharma

Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells

Open Access
Research article

Nikolaos Ioannou, Alan M Seddon, Angus Dalgleish, David Mackintosh, Helmout Modjtahedi

Molecular profiles of screen detected vs. symptomatic breast cancer and their impact on survival: results from a clinical series

Open Access
Research article

Anna Crispo, Maddalena Barba, Giuseppe D’Aiuto, Michelino De Laurentiis, Maria Grimaldi, Massimo Rinaldo, Giuseppina Caolo, Massimiliano D’Aiuto, Immacolata Capasso, Emanuela Esposito, Alfonso Amore, Maurizio Di Bonito, Gerardo Botti, Maurizio Montella

The significance and robustness of a plasma free amino acid (PFAA) profile-based multiplex function for detecting lung cancer

Open Access
Research article

Masato Shingyoji, Toshihiko Iizasa, Masahiko Higashiyama, Fumio Imamura, Nobuhiro Saruki, Akira Imaizumi, Hiroshi Yamamoto, Takashi Daimon, Osamu Tochikubo, Toru Mitsushima, Minoru Yamakado, Hideki Kimura

A randomised controlled trial of a mindfulness intervention for men with advanced prostate cancer

Open Access
Study protocol

Suzanne K Chambers, David P Smith, Martin Berry, Stephen J Lepore, Elizabeth Foley, Samantha Clutton, Robert McDowall, Stefano Occhipinti, Mark Frydenberg, Robert A Gardiner

Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D

Open Access
Research article

Jennifer Laurent, Céline Frongia, Martine Cazales, Odile Mondesert, Bernard Ducommun, Valérie Lobjois

Use of ß-blockers and mortality following ovarian cancer diagnosis: a population-based cohort study

Open Access
Research article

Sigrun A Johannesdottir, Morten Schmidt, Gary Phillips, Ronald Glaser, Eric V Yang, Michael Blumenfeld, Stanley Lemeshow

Regional differences in prostaglandin E2 metabolism in human colorectal cancer liver metastases

Open Access
Research article

Alastair L Young, Claire R Chalmers, Gillian Hawcroft, Sarah L Perry, Darren Treanor, Giles J Toogood, Pamela F Jones, Mark A Hull

Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics

Open Access
Research article

Li Chen, Lynda Stuart, Toshiro K Ohsumi, Shawn Burgess, Gaurav K Varshney, Anahita Dastur, Mark Borowsky, Cyril Benes, Adam Lacy-Hulbert, Emmett V Schmidt

Factors related with symptom duration until diagnosis and treatment of symptomatic colorectal cancer

Open Access
Research article

Magdalena Esteva, Alfonso Leiva, María Ramos, Salvador Pita-Fernández, Luis González-Luján, Montse Casamitjana, María A Sánchez, Sonia Pértega-Díaz, Amador Ruiz, Paloma Gonzalez-Santamaría, María Martín-Rabadán, Ana M Costa-Alcaraz, Alejandro Espí, Francesc Macià, Josep M Segura, Sergio Lafita, Francisco Arnal-Monreal, Isabel Amengual, Marta M Boscá-Watts, Angels Hospital, Hermini Manzano, Rosa Magallón

Sugary food and beverage consumption and epithelial ovarian cancer risk: a population-based case–control study

Open Access
Research article

Melony G King, Sara H Olson, Lisa Paddock, Urmila Chandran, Kitaw Demissie, Shou-En Lu, Niyati Parekh, Lorna Rodriguez-Rodriguez, Elisa V Bandera

Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis

Open Access
Research article

Anja Bruchmann, Corinna Roller, Tamara Vanessa Walther, Georg Schäfer, Sara Lehmusvaara, Tapio Visakorpi, Helmut Klocker, Andrew C B Cato, Danilo Maddalo

Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes

Open Access
Research article

Hironori Ninomiya, Motohiro Kato, Masashi Sanada, Kengo Takeuchi, Kentaro Inamura, Noriko Motoi, Hiroko Nagano, Kimie Nomura, Yukinori Sakao, Sakae Okumura, Hiroyuki Mano, Seishi Ogawa, Yuichi Ishikawa

Comparative performances of prognostic indexes for breast cancer patients presenting with brain metastases

Open Access
Research article

Antoine-Laurent Braccini, David Azria, Simon Thezenas, Gilles Romieu, Jean-Marc Ferrero, William Jacot

Association of plasma endotoxin, inflammatory cytokines and risk of colorectal adenomas

Open Access
Research article

Melissa Kang, Patrick Edmundson, Felix Araujo-Perez, Amber N McCoy, Joseph Galanko, Temitope O Keku

Negative transcriptional control of ERBB2 gene by MBP-1 and HDAC1: diagnostic implications in breast cancer

Open Access
Research article

Flavia Contino, Claudia Mazzarella, Arianna Ferro, Mariavera Lo Presti, Elena Roz, Carmelo Lupo, Giovanni Perconti, Agata Giallongo, Salvatore Feo

Targeting and killing of glioblastoma with activated T cells armed with bispecific antibodies

Open Access
Research article

Ian M Zitron, Archana Thakur, Oxana Norkina, Geoffrey R Barger, Lawrence G Lum, Sandeep Mittal

Adaptive and innovative Radiation Treatment FOR improving Cancer treatment outcomE (ARTFORCE); a randomized controlled phase II trial for individualized treatment of head and neck cancer

Open Access
Study protocol

Jolien Heukelom, Olga Hamming, Harry Bartelink, Frank Hoebers, Jordi Giralt, Teresa Herlestam, Marcel Verheij, Michiel van den Brekel, Wouter Vogel, Nick Slevin, Eric Deutsch, Jan-Jakob Sonke, Philippe Lambin, Coen Rasch

Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer

Open Access
Research article

Fang-Fang Bi, Da Li, Qing Yang

Intraoperative detection of 18F-FDG-avid tissue sites using the increased probe counting efficiency of the K-alpha probe design and variance-based statistical analysis with the three-sigma criteria

Open Access
Research article

Stephen P Povoski, Gregg J Chapman, Douglas A Murrey, Robert Lee, Edward W Martin, Nathan C Hall

Multicenter phase II study of weekly docetaxel, cisplatin, and S-1 (TPS) induction chemotherapy for locally advanced squamous cell cancer of the head and neck

Open Access
Research article

Woo Kyun Bae, Jun Eul Hwang, Hyun Jeong Shim, Sang Hee Cho, Ki Hyeong Lee, Hye Suk Han, Eun-Kee Song, Hwan Jung Yun, In Sung Cho, Joon Kyoo Lee, Sang-Chul Lim, Woong-Ki Chung, Ik-Joo Chung

BRCA1 and ERCC1mRNA levels are associated with lymph node metastasis in Chinese patients with colorectal cancer

Open Access
Research article

Lu Yuanming, Zhang Lineng, Song Baorong, Peng Junjie, Cai Sanjun

Aluminum concentrations in central and peripheral areas of malignant breast lesions do not differ from those in normal breast tissues

Open Access
Research article

Raquel Mary Rodrigues-Peres, Solange Cadore, Stefanny Febraio, Juliana Karina Heinrich, Katia Piton Serra, Sophie F M Derchain, Jose Vassallo, Luis Otavio Sarian

Hierarchical cluster analysis of immunophenotype classify AML patients with NPM1 gene mutation into two groups with distinct prognosis

Open Access
Research article

Chien-Yuan Chen, Wen-Chien Chou, Woei Tsay, Jih-Luh Tang, Ming Yao, Sheng-Yi Huang, Hwei-Fang Tien

Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes

Open Access
Research article

George Pentheroudakis, Vassiliki Kotoula, Wendy De Roock, George Kouvatseas, Pavlos Papakostas, Thomas Makatsoris, Demetris Papamichael, Ioannis Xanthakis, Joseph Sgouros, Despina Televantou, Georgia Kafiri, Athanassios C Tsamandas, Evangelia Razis, Eleni Galani, Dimitrios Bafaloukos, Ioannis Efstratiou, Iliada Bompolaki, Dimitrios Pectasides, Nicholas Pavlidis, Sabine Tejpar, George Fountzilas

The prospective application of a hypoxic radiosensitizer, doranidazole to rat intracranial glioblastoma with blood brain barrier disruption

Open Access
Research article

Hironobu Yasui, Taketoshi Asanuma, Junichi Kino, Tohru Yamamori, Shunsuke Meike, Masaki Nagane, Nobuo Kubota, Mikinori Kuwabara, Osamu Inanami

Using a state cancer registry to recruit young breast cancer survivors and high-risk relatives: protocol of a randomized trial testing the efficacy of a targeted versus a tailored intervention to increase breast cancer screening

Open Access
Study protocol

Maria C Katapodi, Laurel L Northouse, Ann M Schafenacker, Debra Duquette, Sonia A Duffy, David L Ronis, Beth Anderson, Nancy K Janz, Jennifer McLosky, Kara J Milliron, Sofia D Merajver, Linh M Duong, Glenn Copeland

The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis

Open Access
Research article

Yoshiki Murakami, Akihiro Tamori, Saori Itami, Toshihito Tanahashi, Hidenori Toyoda, Masami Tanaka, Weihong Wu, Nariso Brojigin, Yuji Kaneoka, Atsuyuki Maeda, Takashi Kumada, Norifumi Kawada, Shoji Kubo, Masahiko Kuroda

Case report: long-term survival of an infant syndromic patient affected by atypical teratoid-rhabdoid tumor

Open Access
Case report

Piergiorgio Modena, Iacopo Sardi, Monica Brenca, Laura Giunti, Anna Maria Buccoliero, Bianca Pollo, Veronica Biassoni, Lorenzo Genitori, Manila Antonelli, Roberta Maestro, Felice Giangaspero, Maura Massimino

Pancreatic cancer clusters and arsenic-contaminated drinking water wells in Florida

Open Access
Research article

Wen Liu-Mares, Jill A MacKinnon, Recinda Sherman, Lora E Fleming, Caio Rocha-Lima, Jennifer J Hu, David J Lee

A phase 1b study of humanized KS-interleukin-2 (huKS-IL2) immunocytokine with cyclophosphamide in patients with EpCAM-positive advanced solid tumors

Open Access
Research article

Joseph P Connor, Mihaela C Cristea, Nancy L Lewis, Lionel D Lewis, Philip B Komarnitsky, Maria R Mattiacci, Mildred Felder, Sarah Stewart, Josephine Harter, Jean Henslee-Downey, Daniel Kramer, Roland Neugebauer, Roger Stupp

An Australian translational Study to evaluate the prognostic role of inflammatory markers in patients with metastatic ColorEctal caNcer Treated with bevacizumab (Avastin™) [ASCENT]

Open Access
Study protocol

Stephen Clarke, Matt Burge, Cassandra Cordwell, Peter Gibbs, William Reece, Niall Tebbutt

A case–control study on the association between bladder cancer and prior bladder calculus

Open Access
Research article

Shiu-Dong Chung, Ming-Chieh Tsai, Ching-Chun Lin, Herng-Ching Lin

Results of a phase I dose escalation study of eltrombopag in patients with advanced soft tissue sarcoma receiving doxorubicin and ifosfamide

Open Access
Research article

Sant P Chawla, Arthur Staddon, Andrew Hendifar, Conrad A Messam, Rita Patwardhan, Yasser Yasser Mostafa Kamel

A population-based study of rates of childbirth in recurrence-free female young adult survivors of Non-gynecologic malignancies

Open Access
Research article

Nancy N Baxter, Rinku Sutradhar, M Elizabeth DelGuidice, Shawn Forbes, Lawrence F Paszat, Andrew S Wilton, David Urbach, Linda Rabeneck

The prognostic value of estrogen receptor beta and proline-, glutamic acid- and leucine-rich protein 1 (PELP1) expression in ovarian cancer

Open Access
Research article

Stefanie Aust, Peter Horak, Dietmar Pils, Sophie Pils, Christoph Grimm, Reinhard Horvat, Dan Tong, Bernd Schmid, Paul Speiser, Alexander Reinthaller, Stephan Polterauer

Combination of Albendazole and 2-Methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice

Open Access
Research article

Anahid Ehteda, Peter Galettis, Krishna Pillai, David L Morris

Preoperative serum C- reactive protein: a prognostic marker in patients with upper urinary tract urothelial carcinoma

Open Access
Research article

Barbara Stein, Andres Jan Schrader, Gerd Wegener, Christoph Seidel, Markus A Kuczyk, Sandra Steffens

Association of decreased mitochondrial DNA content with the progression of colorectal cancer

Open Access
Research article

HaiHong Cui, Ping Huang, ZhiJing Wang, YunXin Zhang, ZhenHua Zhang, Wei Xu, XiaoPeng Wang, Ying Han, XiaoMing Guo

Uptake of a web-based oncology protocol system: how do cancer clinicians use eviQ cancer treatments online?

Open Access
Research article

Julia M Langton, Nicole Pesa, Shelley Rushton, Robyn L Ward, Sallie-Anne Pearson

Identification of TRPC6 as a possible candidate target gene within an amplicon at 11q21-q22.2 for migratory capacity in head and neck squamous cell carcinomas

Open Access
Research article

Sandra Bernaldo de Quirós, Anna Merlo, Pablo Secades, Iriana Zambrano, Ines Saenz de Santa María, Nerea Ugidos, Eloisa Jantus-Lewintre, Rafael Sirera, Carlos Suarez, María-Dolores Chiara

αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma

Open Access
Research article

Chantal van de Schootbrugge, Johan Bussink, Paul N Span, Fred CGJ Sweep, Reidar Grénman, Hanneke Stegeman, Ger JM Pruijn, Johannes HAM Kaanders, Wilbert C Boelens

IL-22 is related to development of human colon cancer by activation of STAT3

Open Access
Research article

Runqiu Jiang, Haiyang Wang, Lei Deng, Jiajie Hou, Ruihua Shi, Ming Yao, Yun Gao, Aihua Yao, Xuehao Wang, Lianzhen Yu, Beicheng Sun

Low expression of TFPI-2 associated with poor survival outcome in patients with breast cancer

Open Access
Research article

Cheng Xu, Huijun Wang, Hongyu He, Fengyun Zheng, Yating Chen, Jin Zhang, Xiaoyan Lin, Duan Ma, Hongwei Zhang

Time-dependent endpoints as predictors of overall survival in multiple myeloma

Open Access
Research article

Jorge Félix, Filipa Aragão, João M Almeida, Frederico JM Calado, Diana Ferreira, António BS Parreira, Ricardo Rodrigues, João FR Rijo

A word of caution: do not wake sleeping dogs; micrometastases of melanoma suddenly grew after progesterone treatment

Open Access
Case report

Jose Mordoh, Ivana Jaqueline Tapia, Maria Marcela Barrio

Detection and characterization of classical and “uncommon” exon 19 Epidermal Growth Factor Receptor mutations in lung cancer by pyrosequencing

Open Access
Technical advance

Luisella Righi, Alessandra Cuccurullo, Simona Vatrano, Susanna Cappia, Daniela Giachino, Paolo De Giuli, Mara Ardine, Silvia Novello, Marco Volante, Giorgio V Scagliotti, Mauro Papotti

Long-term prospective longitudinal evaluation of emotional distress and quality of life in cervical cancer patients who remained disease-free 2-years from diagnosis

Open Access
Research article

Giovanna Mantegna, Marco Petrillo, Gilda Fuoco, Laura Venditti, Serena Terzano, Luigi Pedone Anchora, Giovanni Scambia, Gabriella Ferrandina

Increased phosphorylation of histone H3 at serine 10 is involved in Epstein-Barr virus latent membrane protein-1-induced carcinogenesis of nasopharyngeal carcinoma

Open Access
Research article

Binbin Li, Guoliang Huang, Xiangning Zhang, Rong Li, Jian Wang, Ziming Dong, Zhiwei He

Wdr66 is a novel marker for risk stratification and involved in epithelial-mesenchymal transition of esophageal squamous cell carcinoma

Open Access
Research article

Qing Wang, Chenming Ma, Wolfgang Kemmner

The impact of KRAS mutations on VEGF-A production and tumour vascular network

Open Access
Research article

Agnès Figueras, Maria Antonia Arbos, Maria Teresa Quiles, Francesc Viñals, Josep Ramón Germà, Gabriel Capellà

Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma

Open Access
Research article

Lin Zhang, Gang Huang, Xiaowu Li, Yujun Zhang, Yan Jiang, Junjie Shen, Jia Liu, Qingliang Wang, Jin Zhu, Xiaobin Feng, Jiahong Dong, Cheng Qian

Exome profiling of primary, metastatic and recurrent ovarian carcinomas in a BRCA1-positive patient

Open Access
Research article

Jian Zhang, Yuhao Shi, Emilie Lalonde, Lili Li, Luca Cavallone, Alex Ferenczy, Walter H Gotlieb, William D Foulkes, Jacek Majewski

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

Open Access
Research article

Paola Longati, Xiaohui Jia, Johannes Eimer, Annika Wagman, Michael-Robin Witt, Stefan Rehnmark, Caroline Verbeke, Rune Toftgård, Matthias Löhr, Rainer L Heuchel

Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer

Open Access
Research article

Shawn Llopis, Brittany Singleton, Tamika Duplessis, Latonya Carrier, Brian Rowan, Christopher Williams

Snail1 expression in colorectal cancer and its correlation with clinical and pathological parameters

Open Access
Research article

Feride Kroepil, Georg Fluegen, Daniel Vallböhmer, Stephan E Baldus, Levent Dizdar, Andreas M Raffel, Dieter Hafner, Nikolas H Stoecklein, Wolfram T Knoefel

Randomized controlled trial to evaluate the effects of progressive resistance training compared to progressive muscle relaxation in breast cancer patients undergoing adjuvant radiotherapy: the BEST study

Open Access
Study protocol

Karin Potthoff, Martina E Schmidt, Joachim Wiskemann, Holger Hof, Oliver Klassen, Nina Habermann, Philipp Beckhove, Juergen Debus, Cornelia M Ulrich, Karen Steindorf

A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2gene carriers

Open Access
Study protocol

Emer M Guinan, Juliette Hussey, Sarah A McGarrigle, Laura A Healy, Jacintha N O’Sullivan, Kathleen Bennett, Elizabeth M Connolly

Alcohol dehydrogenase, iron containing, 1promoter hypermethylation associated with colorectal cancer differentiation

Open Access
Research article

Chung Hyun Tae, Kyung Ju Ryu, Seok-Hyung Kim, Hee Cheol Kim, Ho-Kyung Chun, Byung-Hoon Min, Dong Kyung Chang, Poong-Lyul Rhee, Jae J Kim, Jong Chul Rhee, Young-Ho Kim

Derepression of Cancer/Testis Antigens in cancer is associated with distinct patterns of DNA Hypomethylation

Open Access
Research article

Robert Kim, Prakash Kulkarni, Sridhar Hannenhalli

HP1γ expression is elevated in prostate cancer and is superior to Gleason score as a predictor of biochemical recurrence after radical prostatectomy

Open Access
Research article

Jon Slezak, Matthew Truong, Wei Huang, David Jarrard

Study protocol of the B-CAST study: a multicenter, prospective cohort study investigating the tumor biomarkers in adjuvant chemotherapy for stage III colon cancer

Open Access
Study protocol

Megumi Ishiguro, Kenjiro Kotake, Genichi Nishimura, Naohiro Tomita, Wataru Ichikawa, Keiichi Takahashi, Toshiaki Watanabe, Tomohisa Furuhata, Ken Kondo, Masaki Mori, Yoshihiro Kakeji, Akiyoshi Kanazawa, Michiya Kobayashi, Masazumi Okajima, Ichinosuke Hyodo, Keiko Miyakoda, Kenichi Sugihara

Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop

Open Access
Research article

Daniel Öhlund, Oskar Franklin, Erik Lundberg, Christina Lundin, Malin Sund

Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc −/+ ice

Open Access
Research article

Baktiar O Karim, Ki-Jong Rhee, Guosheng Liu, Dongfeng Zheng, David L Huso

Advance lung cancer inflammation index (ALI) at diagnosis is a prognostic marker in patients with metastatic non-small cell lung cancer (NSCLC): a retrospective review

Open Access
Research article

Syed H Jafri, Runhua Shi, Glenn Mills

Ultrasound real-time elastography can predict malignancy in BI-RADS®-US 3 lesions

Open Access
Research article

Sebastian Wojcinski, Esther Boehme, André Farrokh, Philipp Soergel, Friedrich Degenhardt, Peter Hillemanns

UCN-01 induces S and G2/M cell cycle arrest through the p53/p21waf1or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines

Open Access
Research article

Guoyi Wu, Linan Xu, Nan Lin, Bo Liu

Long-term outcome and effect of maintenance therapy in patients with advanced sarcoma treated with trabectedin: an analysis of 181 patients of the French ATU compassionate use program

Open Access
Research article

Jean-Yves Blay, Antoine Italiano, Isabelle Ray-Coquard, Axel Le Cesne, Florence Duffaud, Maria Rios, Olivier Collard, François Bertucci, Emmanuelle Bompas, Nicolas Isambert, Loic Chaigneau, Philippe Cassier, Binh Bui, Gauthier Decanter, Olfa Derbel, Jean-Michel Coindre, Patrick Zintl, Nadia Badri, Nicolas Penel

PRL-3 suppresses c-Fos and integrin α2 expression in ovarian cancer cells

Open Access
Research article

Hao Liu, Abdul Qader Omer Al-aidaroos, Haihe Wang, Ke Guo, Jie Li, Hua Fei Zhang, Qi Zeng

A functional polymorphism T309G in MDM2 gene promoter, intensified by Helicobacter pylori lipopolysaccharide, is associated with both an increased susceptibility and poor prognosis of gastric carcinoma in Chinese patients

Open Access
Research article

Xiaolin Pan, Yuqin Li, Jin Feng, Xiaoyong Wang, Bo Hao, Ruihua Shi, Guoxin Zhang

Diagnostic value of endobronchial and endoscopic ultrasound-guided fine needle aspiration for accessible lung cancer lesions after non-diagnostic conventional techniques: a prospective study

Open Access
Research article

Antonio Bugalho, Dalila Ferreira, Ralf Eberhardt, Sara S Dias, Paula A Videira, Felix J Herth, Luis Carreiro

Early-stage squamous cell carcinoma of the oropharynx: Radiotherapy vs. Trans-Oral Robotic Surgery (ORATOR) – study protocol for a randomized phase II trial

Open Access
Study protocol

Anthony C Nichols, John Yoo, J Alex Hammond, Kevin Fung, Eric Winquist, Nancy Read, Varagur Venkatesan, S Danielle MacNeil, D Scott Ernst, Sara Kuruvilla, Jeff Chen, Martin Corsten, Michael Odell, Libni Eapen, Julie Theurer, Philip C Doyle, Bret Wehrli, Keith Kwan, David A Palma

Cross-sectional study of self-reported physical activity, eating habits and use of complementary medicine in breast cancer survivors

Open Access
Research article

Arnoud J Templeton, Beat Thürlimann, Michael Baumann, Michael Mark, Sarah Stoll, Madeleine Schwizer, Daniel Dietrich, Thomas Ruhstaller

Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials

Open Access
Research article

George Fountzilas, Urania Dafni, Mattheos Bobos, Vassiliki Kotoula, Anna Batistatou, Ioannis Xanthakis, Christos Papadimitriou, Ioannis Kostopoulos, Triantafillia Koletsa, Eleftheria Tsolaki, Despina Televantou, Eleni Timotheadou, Angelos Koutras, George Klouvas, Epaminontas Samantas, Nikolaos Pisanidis, Charisios Karanikiotis, Ioanna Sfakianaki, Nicholas Pavlidis, Helen Gogas, Helena Linardou, Konstantine T Kalogeras, Dimitrios Pectasides, Meletios A Dimopoulos

CD133 expression is not an independent prognostic factor in stage II and III colorectal cancer but may predict the better outcome in patients with adjuvant therapy

Open Access
Research article

Khalilullah Mia-Jan, So Young Jung, Ik-Yong Kim, Sung Soo Oh, EunHee Choi, Sei Jin Chang, Tae Young Kang, Mee-Yon Cho

[18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice

Open Access
Research article

Mette Munk Jensen, Kamille Dumong Erichsen, Camilla Bardram Johnbeck, Fredrik Björkling, Jacob Madsen, Peter Buhl Jensen, Maxwell Sehested, Liselotte Højgaard, Andreas Kjær

Early versus deferred androgen suppression therapy for patients with lymph node-positive prostate cancer after local therapy with curative intent: a systematic review

Open Access
Research article

Frank Kunath, Bastian Keck, Gerta Rücker, Edith Motschall, Bernd Wullich, Gerd Antes, Joerg J Meerpohl

Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53

Open Access
Research article

Hind Hafsi, Daniela Santos-Silva, Stéphanie Courtois-Cox, Pierre Hainaut

p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation

Open Access
Research article

Gersende Alphonse, Mira Maalouf, Priscillia Battiston-Montagne, Dominique Ardail, Michaël Beuve, Robert Rousson, Gisela Taucher-Scholz, Claudia Fournier, Claire Rodriguez-Lafrasse

A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

Open Access
Research article

Guang-Zhi Jin, Hui Dong, Wen-Long Yu, Yan Li, Xin-Yuan Lu, Hua Yu, Zhi-Hong Xian, Wei Dong, Yin-Kun Liu, Wen-Ming Cong, Meng-Chao Wu

Randomised phase 3 open-label trial of first-line treatment with gemcitabine in association with docetaxel or paclitaxel in women with metastatic breast cancer: a comparison of different schedules and treatments

Open Access
Research article

Lucia Del Mastro, Alessandra Fabi, Mauro Mansutti, Michele De Laurentiis, Antonio Durando, Domenico Franco Merlo, Paolo Bruzzi, Ignazia La Torre, Matteo Ceccarelli, Gbenga Kazeem, Paolo Marchi, Davide Boy, Marco Venturini, Sabino De Placido, Francesco Cognetti

The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer

Open Access
Research article

Yan Ni Loh, Ellen L Hedditch, Laura A Baker, Eve Jary, Robyn L Ward, Caroline E Ford

The impact of chemotherapy-associated neutrophil/ lymphocyte counts on prognosis of adjuvant chemotherapy in colorectal cancer

Open Access
Research article

Hong Chu-Yuan, Peng Jing, Wei Yi-Sheng, Peng He-Ping, Yang Hui, Zhao Chu-Xiong, Liang Guo-Jian, Wang Guo-Qiang

Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis

Open Access
Research article

Norihiko Tsuchiya, Shintaro Narita, Takamitsu Inoue, Mitsuru Saito, Kazuyuki Numakura, Mingguo Huang, Shingo Hatakeyama, Shigeru Satoh, Seiichi Saito, Chikara Ohyama, Yoichi Arai, Osamu Ogawa, Tomonori Habuchi

Outcome of patients with advanced solitary fibrous tumors: the Centre Léon Bérard experience

Open Access
Research article

Alice Levard, Olfa Derbel, Pierre Méeus, Dominique Ranchère, Isabelle Ray-Coquard, Jean-Yves Blay, Philippe A Cassier

Functional capacity, physical activity and muscle strength assessment of individuals with non-small cell lung cancer: a systematic review of instruments and their measurement properties

Open Access
Research article

Catherine L Granger, Christine F McDonald, Selina M Parry, Cristino C Oliveira, Linda Denehy

High resolution melting analysis of KRAS, BRAF and PIK3CA in KRASexon 2 wild-type metastatic colorectal cancer

Open Access
Research article

Joana G Guedes, Isabel Veiga, Patrícia Rocha, Pedro Pinto, Carla Pinto, Manuela Pinheiro, Ana Peixoto, Maria Fragoso, Ana Raimundo, Paula Ferreira, Manuela Machado, Nuno Sousa, Paula Lopes, António Araújo, Joana Macedo, Fernando Alves, Camila Coutinho, Rui Henrique, Lúcio L Santos, Manuel R Teixeira

Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro

Open Access
Research article

Thomas M Cardillo, Preeti Trisal, Roberto Arrojo, David M Goldenberg, Chien-Hsing Chang

The role of inflammation in HPV infection of the Oesophagus

Open Access
Research article

Georgia Schäfer, Siti Kabanda, Beverly van Rooyen, Martina Bergant Marušič, Lawrence Banks, M Iqbal Parker

A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies

Open Access
Research article

Jonathan W Goldman, Robert N Raju, Gregory A Gordon, Iman El-Hariry, Florentina Teofilivici, Vojo M Vukovic, Robert Bradley, Michael D Karol, Yu Chen, Wei Guo, Takayo Inoue, Lee S Rosen

Epigenetic regulation of L1CAM in endometrial carcinoma: comparison to cancer–testis (CT-X) antigens

Open Access
Research article

Uwe Schirmer, Heidi Fiegl, Marco Pfeifer, Alain G Zeimet, Elisabeth Müller-Holzner, Peter K Bode, Verena Tischler, Peter Altevogt

Characterization of in vivo chemoresistant human hepatocellular carcinoma cells with transendothelial differentiation capacities

Open Access
Research article

Christian Marfels, Miriam Hoehn, Ernst Wagner, Michael Günther

Inverse expression of hyaluronidase 2 and hyaluronan synthases 1–3 is associated with reduced hyaluronan content in malignant cutaneous melanoma

Open Access
Research article

Siiskonen Hanna, Poukka Mari, Tyynelä-Korhonen Kristiina, Sironen Reijo, Pasonen-Seppänen Sanna

Safety and efficacy of everolimus in Chinese patients with metastatic renal cell carcinoma resistant to vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapy: an open-label phase 1b study

Open Access
Research article

Jun Guo, Yiran Huang, Xu Zhang, Fangjian Zhou, Yinghao Sun, Shukui Qin, Zhangqun Ye, Hui Wang, Annette Jappe, Patrick Straub, Nicoletta Pirotta, Sven Gogov

Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors

Open Access
Research article

Nicolas Isambert, Pierre Fumoleau, Catherine Paul, Christophe Ferrand, Sylvie Zanetta, Jacques Bauer, Kevin Ragot, Gérard Lizard, Jean-François Jeannin, Marc Bardou

Genetic variations of the A13/A14 repeat located within the EGFR3′ untranslated region have no oncogenic effect in patients with colorectal cancer

Open Access
Research article

Nasrin Sarafan-Vasseur, David Sefrioui, David Tougeron, Aude Lamy, France Blanchard, Florence Le Pessot, Frédéric Di Fiore, Pierre Michel, Stéphane Bézieau, Jean-Baptiste Latouche, Thierry Frebourg, Richard Sesboüé

Expressional alterations in functional ultra-conserved non-coding rnas in response to all-transretinoic acid - induced differentiation in neuroblastoma cells

Open Access
Research article

Karen M Watters, Kenneth Bryan, Niamh H Foley, Maria Meehan, Raymond L Stallings

Patients’ perspectives on palliative chemotherapy of colorectal and non - colorectal cancer: a prospective study in a chemotherapy- experienced population

Open Access
Research article

Marika Mende, Karolin Trautmann, Anke Rentsch, Beate Hornemann, Ulrich S Schuler, Gerhard Ehninger, Gunnar Folprecht

Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells

Open Access
Research article

Eduardo C Filippi-Chiela, Marcos Paulo Thomé, Mardja Manssur Bueno e Silva, Alessandra Luíza Pelegrini, Pitia Flores Ledur, Bernardo Garicochea, Lauren L Zamin, Guido Lenz

Radiation mitigating properties of the lignan component in flaxseed

Open Access
Research article

Ralph Pietrofesa, Jason Turowski, Sonia Tyagi, Floyd Dukes, Evguenia Arguiri, Theresa M Busch, Shannon M Gallagher-Colombo, Charalambos C Solomides, Keith A Cengel, Melpo Christofidou-Solomidou

RETRACTED ARTICLE: Correlation of CD44v6 expression with ovarian cancer progression and recurrence

Open Access
Research article

Jun Shi, Zhou Zhou, Wen Di, Ningli Li

Differential outcome of concurrent radiotherapy plus epidermal growth factor receptor inhibitors versus radiotherapy plus cisplatin in patients with human papillomavirus-related head and neck cancer

Open Access
Research article

Bella Pajares, Jose M Trigo, Maria D Toledo, Martina Álvarez, Carlos González-Hermoso, Antonio Rueda, Jose A Medina, Vanessa de Luque, Jose M Jerez, Emilio Alba

Potentiation of in vitro and in vivoantitumor efficacy of doxorubicin by cyclin-dependent kinase inhibitor P276-00 in human non-small cell lung cancer cells

Open Access
Research article

Maggie J Rathos, Harshal Khanwalkar, Kavita Joshi, Sonal M Manohar, Kalpana S Joshi

First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier: a case report

Open Access
Case report

Carla B Ripamonti, Mara Colombo, Patrizia Mondini, Manoukian Siranoush, Bernard Peissel, Loris Bernard, Paolo Radice, Maria Luisa Carcangiu

Factors associated with peritoneal metastasis in non-serosa-invasive gastric cancer: a retrospective study of a prospectively-collected database

Open Access
Research article

Baojun Huang, Zhe Sun, Zhenning Wang, Chong Lu, Chengzhong Xing, Bo Zhao, Huimian Xu

‘Burden to others’ as a public concern in advanced cancer: a comparative survey in seven European countries

Open Access
Research article

Claudia Bausewein, Natalia Calanzani, Barbara A Daveson, Steffen T Simon, Pedro L Ferreira, Irene J Higginson, Dorothee Bechinger-English, Luc Deliens, Marjolein Gysels, Franco Toscani, Lucas Ceulemans, Richard Harding, Barbara Gomes

Development of a novel cell-based assay system EPISSAY for screening epigenetic drugs and liposome formulated decitabine

Open Access
Technical advance

Sue Ping Lim, Raman Kumar, Yamini Akkamsetty, Wen Wang, Kristen Ho, Paul M Neilsen, Diego J Walther, Rachel J Suetani, Clive Prestidge, David F Callen

Transcriptional effects of 1,25 dihydroxyvitamin D3physiological and supra-physiological concentrations in breast cancer organotypic culture

Open Access
Research article

Cintia Milani, Maria Lucia Hirata Katayama, Eduardo Carneiro de Lyra, JoEllen Welsh, Laura Tojeiro Campos, M Mitzi Brentani, Maria do Socorro Maciel, Rosimeire Aparecida Roela, Paulo Roberto del Valle, João Carlos Guedes Sampaio Góes, Suely Nonogaki, Rodrigo Esaki Tamura, Maria Aparecida Azevedo Koike Folgueira

Progress risk assessment of oral premalignant lesions with saliva miRNA analysis

Open Access
Research article

Ya Yang, Yue-xiu Li, Xi Yang, Long Jiang, Zuo-jun Zhou, Ya-qin Zhu

Targeting Id1 reduces proliferation and invasion in aggressive human salivary gland cancer cells

Open Access
Research article

Tomoki Sumida, Ryuichi Murase, Akiko Onishi-Ishikawa, Sean D McAllister, Hiroyuki Hamakawa, Pierre-Yves Desprez

53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19–9 in pancreatic adenocarcinoma

Open Access
Research article

Natalie L Ausborn, Tong Wang, Sabrina C Wentz, Mary Kay Washington, Nipun B Merchant, Zhiguo Zhao, Yu Shyr, Anuradha Bapsi Chakravarthy, Fen Xia

Patient self-appraisal of change and minimal clinically important difference on the European organization for the research and treatment of cancer quality of life questionnaire core 30 before and during cancer therapy

Open Access
Research article

Fanxing Hong, Jaclyn L F Bosco, Nigel Bush, Donna L Berry

Membrane Type 1 Matrix Metalloproteinase induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells

Open Access
Research article

Cong-Chong Yang, Li-Fang Zhu, Xiao-Hui Xu, Tian-Yun Ning, Jin-Hai Ye, Lai-Kui Liu

A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer - a study of the OVCAD consortium

Open Access
Research article

Dietmar Pils, Dan Tong, Gudrun Hager, Eva Obermayr, Stefanie Aust, Georg Heinze, Maria Kohl, Eva Schuster, Andrea Wolf, Jalid Sehouli, Ioana Braicu, Ignace Vergote, Toon Van Gorp, Sven Mahner, Nicole Concin, Paul Speiser, Robert Zeillinger

TP53p.R337H is a conditional cancer-predisposing mutation: further evidence from a homozygous patient

Open Access
Case report

Juliana Giacomazzi, Simone Selistre, Juliana Duarte, Jorge Pinto Ribeiro, Paulo JC Vieira, Gabriel de Souza Macedo, Cristina Rossi, Mauro Czepielewski, Cristina Brinkmann Oliveira Netto, Pierre Hainaut, Patricia Ashton-Prolla

Values and options in cancer care (VOICE): study design and rationale for a patient-centered communication and decision-making intervention for physicians, patients with advanced cancer, and their caregivers

Open Access
Study protocol

Michael Hoerger, Ronald M Epstein, Paul C Winters, Kevin Fiscella, Paul R Duberstein, Robert Gramling, Phyllis N Butow, Supriya G Mohile, Paul R Kaesberg, Wan Tang, Sandy Plumb, Adam Walczak, Anthony L Back, Daniel Tancredi, Alison Venuti, Camille Cipri, Gisela Escalera, Carol Ferro, Don Gaudion, Beth Hoh, Blair Leatherwood, Linda Lewis, Mark Robinson, Peter Sullivan, Richard L Kravitz

Indirectly estimated absolute lung cancer mortality rates by smoking status and histological type based on a systematic review

Open Access
Research article

Peter N Lee, Barbara A Forey

Preoperative chemosensitivity testing as Predictor of Treatment benefit in Adjuvant stage III colon cancer (PePiTA): Protocol of a prospective BGDO (Belgian Group for Digestive Oncology) multicentric study

Open Access
Study protocol

Alain Hendlisz, Vassilis Golfinopoulos, Amelie Deleporte, Marianne Paesmans, Hazem El Mansy, Camilo Garcia, Marc Peeters, Lieven Annemans, Caroline Vandeputte, Marion Maetens, Ivan Borbath, Damien Dresse, Ghislain Houbiers, Michael Fried, Ahmad Awada, Martine Piccart, Jean-Luc Van Laethem, Patrick Flamen

Fool’s gold, lost treasures, and the randomized clinical trial

Open Access
Debate

David J Stewart, Razelle Kurzrock

Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence

Open Access
Research article

Bilal Alaiyan, Nadia Ilyayev, Alexander Stojadinovic, Mina Izadjoo, Marina Roistacher, Vera Pavlov, Victoria Tzivin, David Halle, Honguang Pan, Barry Trink, Ali O Gure, Aviram Nissan

In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

Open Access
Research article

Drazen B Zimonjic, Lai N Chan, Veenu Tripathi, Jie Lu, Ohyun Kwon, Nicholas C Popescu, Douglas R Lowy, Fuyuhiko Tamanoi

Impact of KRAS, BRAF and PI3KCA mutations in rectal carcinomas treated with neoadjuvant radiochemotherapy and surgery

Open Access
Research article

Olfa Derbel, Qing Wang, Françoise Desseigne, Michel Rivoire, Pierre Meeus, Patrice Peyrat, Mattia Stella, Isabelle Martel-Lafay, Anne-Isabelle Lemaistre, Christelle de La Fouchardière

Cholinergic muscarinic receptor activation augments murine intestinal epithelial cell proliferation and tumorigenesis

Open Access
Research article

Zhongsheng Peng, Jonathon Heath, Cinthia Drachenberg, Jean-Pierre Raufman, Guofeng Xie

Early pneumothorax as a feature of response to crizotinib therapy in a patient with ALK rearranged lung adenocarcinoma

Open Access
Case report

Spyridon Gennatas, Susana J Stanway, Robert Thomas, Toon Min, Riyaz Shah, Mary ER O’Brien, Sanjay Popat

Can selenium levels act as a marker of colorectal cancer risk?

Open Access
Research article

Marcin R Lener, Satish Gupta, Rodney J Scott, Martin Tootsi, Maria Kulp, Mari-Liis Tammesoo, Anu Viitak, Anders Metspalu, Pablo Serrano-Fernández, Józef Kładny, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Magdalena Muszyńska, Grzegorz Sukiennicki, Anna Jakubowska, Jan Lubiński

Mammogram image quality as a potential contributor to disparities in breastcancer stage at diagnosis: an observational study

Open Access
Research article

Garth H Rauscher, Emily F Conant, Jenna A Khan, Michael L Berbaum

Serum HMGB1 as a prognostic marker for malignant pleural mesothelioma

Open Access
Research article

Chiharu Tabata, Eisuke Shibata, Rie Tabata, Shingo Kanemura, Koji Mikami, Yoshitaka Nogi, Eriko Masachika, Tomoyuki Nishizaki, Takashi Nakano

Evidence for tankyrases as antineoplastic targets in lung cancer

Open Access
Research article

Alexander M Busch, Kevin C Johnson, Radu V Stan, Aarti Sanglikar, Yashi Ahmed, Ethan Dmitrovsky, Sarah J Freemantle

Quality of life of Bahraini women with breast cancer: a cross sectional study

Open Access
Research article

Ghufran Ahmed Jassim, David L Whitford

Human Papillomavirus-associated oropharyngeal cancer: an observational study of diagnosis, prevalence and prognosis in a UK population

Open Access
Research article

Mererid Evans, Robert Newcombe, Alison Fiander, James Powell, Martin Rolles, Selvam Thavaraj, Max Robinson, Ned Powell

Circulating tumor cells in HER2-positive metastatic breast cancer patients: a valuable prognostic and predictive biomarker

Open Access
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Yi Liu, Qian Liu, Tao Wang, Li Bian, Shaohua Zhang, Haixu Hu, Sha Li, Zhiyuan Hu, Shikai Wu, Bing Liu, Zefei Jiang

Rapid initial decline in BCR-ABL1 is associated with superior responses to second-line nilotinib in patients with chronic-phase chronic myeloid leukemia

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Research article

Andrew M Stein, Giovanni Martinelli, Timothy P Hughes, Martin C Müller, Lan Beppu, Enrico Gottardi, Susan Branford, Simona Soverini, Richard C Woodman, Andreas Hochhaus, Dong-Wook Kim, Giuseppe Saglio, Jerald P Radich

JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1

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Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer - overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression

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Berit Maria Müller, Lisa Jana, Atsuko Kasajima, Annika Lehmann, Judith Prinzler, Jan Budczies, Klaus-Jürgen Winzer, Manfred Dietel, Wilko Weichert, Carsten Denkert

Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator

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Research article

Philip Vlaicu, Philipp Mertins, Thomas Mayr, Peter Widschwendter, Beyhan Ataseven, Bernhard Högel, Wolfgang Eiermann, Pjotr Knyazev, Axel Ullrich

Older renal cell cancer patients experience increased rates of venous thromboembolic events: a retrospective cohort study of SEER-Medicare data

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Research article

Alexandra Connelly-Frost, Sumitra Shantakumar, Monica G Kobayashi, Haojie Li, Li Li

VEGF is an important mediator of tumor angiogenesis in malignant lesions in a genetically engineered mouse model of lung adenocarcinoma

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Bharat K Majeti, Joseph H Lee, Brett H Simmons, Farbod Shojaei

MicroRNA profile of paclitaxel-resistant serous ovarian carcinoma based on formalin-fixed paraffin-embedded samples

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Xiao Li, Yaer Lu, Yaxia Chen, Weiguo Lu, Xing Xie

High CRP values predict poor survival in patients with penile cancer

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Sandra Steffens, Andreas Al Ghazal, Julie Steinestel, Rieke Lehmann, Gerd Wegener, Thomas J Schnoeller, Marcus V Cronauer, Florian Jentzmik, Mark Schrader, Markus A Kuczyk, Andres J Schrader

Mortality risk of black women and white women with invasive breast cancer by hormone receptors, HER2, and p53 status

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Research article

Huiyan Ma, Yani Lu, Kathleen E Malone, Polly A Marchbanks, Dennis M Deapen, Robert Spirtas, Ronald T Burkman, Brian L Strom, Jill A McDonald, Suzanne G Folger, Michael S Simon, Jane Sullivan-Halley, Michael F Press, Leslie Bernstein

Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study

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Research article

Pablo Conesa-Zamora, Javier Ruiz-Cosano, Daniel Torres-Moreno, Ignacio Español, María D Gutiérrez-Meca, Javier Trujillo-Santos, Elena Pérez-Ceballos, Rocío González-Conejero, Javier Corral, Vicente Vicente, Miguel Pérez-Guillermo

Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study

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Research article

Alexa J Resler, Kathleen E Malone, Lisa G Johnson, Mari Malkki, Effie W Petersdorf, Barbara McKnight, Margaret M Madeleine

Odontogenic ameloblast-associated protein (ODAM) inhibits growth and migration of human melanoma cells and elicits PTEN elevation and inactivation of PI3K/AKT signaling

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Research article

James S Foster, Lindsay M Fish, Jonathan E Phipps, Charles T Bruker, James M Lewis, John L Bell, Alan Solomon, Daniel P Kestler

Is the prediction of prognosis not improved by the seventh edition of the TNM classification for colorectal cancer? Analysis of the surveilla006Ece, epidemiology, and end results (SEER) database

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Research article

Peng Gao, Yong-xi Song, Zhen-ning Wang, Ying-ying Xu, Lin-lin Tong, Jing-xu Sun, Miao Yu, Hui-mian Xu

A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy

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Research article

Tracy R Daniels-Wells, Gustavo Helguera, Richard K Leuchter, Rafaela Quintero, Maggie Kozman, José A Rodríguez, Elizabeth Ortiz-Sánchez, Otoniel Martínez-Maza, Birgit C Schultes, Christopher F Nicodemus, Manuel L Penichet

Conquer fear: protocol of a randomised controlled trial of a psychological intervention to reduce fear of cancer recurrence

Open Access
Study protocol

Phyllis N Butow, Melanie L Bell, Allan B Smith, Joanna E Fardell, Belinda Thewes, Jane Turner, Jemma Gilchrist, Jane Beith, Afaf Girgis, Louise Sharpe, Sophy Shih, Cathrine Mihalopoulos

The combination of ANT2 shRNA and hNIS radioiodine gene therapy increases CTL cytotoxic activity through the phenotypic modulation of cancer cells: combination treatment with ANT2 shRNA and I-131

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Research article

Yun Choi, Ho Won Lee, Jaetae Lee, Yong Hyun Jeon

Reduced mrna expression level of corticotropin-releasing hormone-binding protein is associated with aggressive human kidney cancer

Open Access
Research article

Hossein Tezval, Faranaz Atschekzei, Inga Peters, Sandra Waalkes, Jörg Hennenlotter, Arnulf Stenzl, Jan U Becker, Axel S Merseburger, Markus A Kuczyk, Jürgen Serth

Prognostic significance of peripheral monocyte count in patients with extranodal natural killer/T-cell lymphoma

Open Access
Research article

Jia-Jia Huang, Ya-Jun Li, Yi Xia, Yu Wang, Wen-Xiao Wei, Ying-Jie Zhu, Tong-Yu Lin, Hui-Qiang Huang, Wen-Qi Jiang, Zhi-Ming Li

Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivothrough suppression of PDGFR-β

Open Access
Research article

Jun Ohishi, Mikiko Aoki, Kazuki Nabeshima, Junji Suzumiya, Tamotsu Takeuchi, Akira Ogose, Michiyuki Hakozaki, Yuichi Yamashita, Hiroshi Iwasaki

Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility

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Research article

Peng Zhao, Peng Zou, Lin Zhao, Wei Yan, Chunsheng Kang, Tao Jiang, Yongping You

Genetic association between selected cytokine genes and glioblastoma in the Han Chinese population

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Research article

Tianbo Jin, Xiaolan Li, Jiayi Zhang, Hong Wang, Tingting Geng, Gang Li, Guodong Gao, Chao Chen

Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2V617F mutant allele detection

Open Access
Technical advance

Giada V Zapparoli, Robert N Jorissen, Chelsee A Hewitt, Michelle McBean, David A Westerman, Alexander Dobrovic

Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells

Open Access
Research article

Naoko Yamagishi, Shigetada Teshima-Kondo, Kiyoshi Masuda, Kensei Nishida, Yuki Kuwano, Duyen T Dang, Long H Dang, Takeshi Nikawa, Kazuhito Rokutan

Higher rate of skin rash in a phase II trial with weekly nanoparticle albumin-bound paclitaxel and cisplatin combination in Chinese breast cancer patients

Open Access
Research article

Li Chen Tang, Bi Yun Wang, Si Sun, Jian Zhang, Zhen Jia, Yun Hua Lu, Geng Hong Di, Zhi Ming Shao, Xi Chun Hu

Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells

Open Access
Research article

Mamoru Tanaka, Hiromi Kataoka, Shigenobu Yano, Hiromi Ohi, Keisuke Kawamoto, Takashi Shibahara, Tsutomu Mizoshita, Yoshinori Mori, Satoshi Tanida, Takeshi Kamiya, Takashi Joh

Analytic performance studies and clinical reproducibility of a real-time PCRassay for the detection of epidermal growth factor receptor gene mutations informalin-fixed paraffin-embedded tissue specimens of non-small cell lungcancer

Open Access
Technical advance

Patrick O’Donnell, Jane Ferguson, Johnny Shyu, Robert Current, Taraneh Rehage, Julie Tsai, Mari Christensen, Ha Bich Tran, Sean Shih-Chang Chien, Felice Shieh, Wen Wei, H Jeffrey Lawrence, Lin Wu, Robert Schilling, Kenneth Bloom, Warren Maltzman, Steven Anderson, Stephen Soviero

Standard or hypofractionated radiotherapy in the postoperative treatment of breast cancer: a retrospective analysis of acute skin toxicity and dose inhomogeneities

Open Access
Research article

Grazia Tortorelli, Luana Di Murro, Rosaria Barbarino, Sara Cicchetti, Daniela di Cristino, Maria Daniela Falco, Dahlia Fedele, Gianluca Ingrosso, Dania Janniello, Pasquale Morelli, Alessandra Murgia, Elisabetta Ponti, Sara Terenzi, Barbara Tolu, Riccardo Santoni

Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma

Open Access
Research article

Masao Honda, Taro Yamashita, Tatsuya Yamashita, Kuniaki Arai, Yoshio Sakai, Akito Sakai, Mikiko Nakamura, Eishiro Mizukoshi, Shuichi Kaneko

Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance

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Research article

Mohan Singh, Parvesh Chaudhry, Francois Fabi, Eric Asselin

Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells

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Research article

Emelie Karnevi, Katarzyna Said, Roland Andersson, Ann H Rosendahl

Equol enhances tamoxifen’s anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells

Open Access
Research article

Christiana Charalambous, Chara A Pitta, Andreas I Constantinou

Randomized controlled trial of toremifene 120 mg compared with exemestane 25 mg after prior treatment with a non-steroidal aromatase inhibitor in postmenopausal women with hormone receptor-positive metastatic breast cancer

Open Access
Research article

Yutaka Yamamoto, Takashi Ishikawa, Yasuo Hozumi, Masahiko Ikeda, Hiroji Iwata, Hiroko Yamashita, Tatsuya Toyama, Takashi Chishima, Shigehira Saji, Mutsuko Yamamoto-Ibusuki, Hirotaka Iwase

Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain)

Open Access
Research article

Pilar Blay, Iñigo Santamaría, Ana S Pitiot, María Luque, Marta G Alvarado, Ana Lastra, Yolanda Fernández, Ángeles Paredes, José MP Freije, Milagros Balbín

Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy

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Research article

Mamoru Takada, Toru Higuchi, Katsunori Tozuka, Hiroyuki Takei, Masayuki Haruta, Junko Watanabe, Fumio Kasai, Kenichi Inoue, Masafumi Kurosumi, Masaru Miyazaki, Aiko Sato-Otsubo, Seishi Ogawa, Yasuhiko Kaneko

Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases

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Research article

Ahsan Siraj, Virginie Desestret, Martine Antoine, Gaëlle Fromont, Michel Huerre, Marc Sanson, Philippe Camparo, Christophe Pichon, François Planeix, Julie Gonin, Aurelian Radu, Nicolae Ghinea

The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients

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Research article

Hong-Wu Xu, Yue-Jun Huang, Ze-Yu Xie, Lan Lin, Yan-Chun Guo, Ze-Rui Zhuang, Xin-Peng Lin, Wen Zhou, Mu Li, Hai-Hua Huang, Xiao-Long Wei, Kwan Man, Guo-Jun Zhang

ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas

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Research article

Sara Tomaselli, Federica Galeano, Luca Massimi, Concezio Di Rocco, Libero Lauriola, Angela Mastronuzzi, Franco Locatelli, Angela Gallo

Age dependence of tumor genetics in unfavorable neuroblastoma: arrayCGH profiles of 34 consecutive cases, using a Swedish 25-year neuroblastoma cohort for validation

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Research article

Cihan Cetinkaya, Tommy Martinsson, Johanna Sandgren, Catarina Träger, Per Kogner, Jan Dumanski, Teresita Díaz de Ståhl, Fredrik Hedborg

Neoadjuvant rh-endostatin, docetaxel and epirubicin for breast cancer: efficacy and safety in a prospective, randomized, phase II study

Open Access
Research article

Jianghao Chen, Qing Yao, Dong Li, Juliang Zhang, Ting Wang, Ming Yu, Xiaodong Zhou, Yi Huan, Jing Wang, Ling Wang

Inorganic phosphate and the risk of cancer in the Swedish AMORIS study

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Research article

Wahyu Wulaningsih, Karl Michaelsson, Hans Garmo, Niklas Hammar, Ingmar Jungner, Göran Walldius, Lars Holmberg, Mieke Van Hemelrijck

TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages

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Research article

Bao-Zhu Yuan, Joshua Chapman, Min Ding, Junzhi Wang, Binghua Jiang, Yon Rojanasakul, Steven H Reynolds

Characteristic mTOR activity in Hodgkin-lymphomas offers a potential therapeutic target in high risk disease – a combined tissue microarray, in vitro and in vivo study

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Research article

Ágnes Márk, Melinda Hajdu, Zsófia Váradi, Tamás Béla Sticz, Noémi Nagy, Judit Csomor, Lajos Berczi, Viktória Varga, Monika Csóka, László Kopper, Anna Sebestyén

Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer

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Research article

Bhupendra Singh, Anwesha Chatterjee, Amruta M Ronghe, Nimee K Bhat, Hari K Bhat

Usefulness of Serum Carcinoembryonic Antigen (CEA) in evaluating response to chemotherapy in patients with advanced non small-cell lung cancer: a prospective cohort study

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Research article

Oscar Arrieta, Cynthia Villarreal-Garza, Luis Martínez-Barrera, Marcelino Morales, Yuzmiren Dorantes-Gallareta, Omar Peña-Curiel, Susana Contreras-Reyes, Eleazar Omar Macedo-Pérez, Jorge Alatorre-Alexander

Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors

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Research article

Kirsten Ludwig, Edison S Tse, Jean YJ Wang

Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer

Open Access
Research article

Patrick C O´Leary, Sarah A Penny, Roisin T Dolan, Catherine M Kelly, Stephen F Madden, Elton Rexhepaj, Donal J Brennan, Amanda H McCann, Fredrik Pontén, Mathias Uhlén, Radoslaw Zagozdzon, Michael J Duffy, Malcolm R Kell, Karin Jirström, William M Gallagher

Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix

Open Access
Research article

Gang Chen, Cheng He, Ling Li, An Lin, Xiongwei Zheng, Ellen He, Sven Skog

Polymorphism of A133S and promoter hypermethylation in Ras association domain family 1A gene (RASSF1A) is associated with risk of esophageal and gastric cardia cancers in Chinese population from high incidence area in northern China

Open Access
Research article

Sheng Li Zhou, Juan Cui, Zong Min Fan, Xue Min Li, Ji Lin Li, Bao Chi Liu, Dong Yun Zhang, Hong Yan Liu, Xue Ke Zhao, Xin Song, Ran Wang, Ze Chen Yan, Hui Xing Yi, Li Dong Wang

Prognostic significance of maximum primary tumor diameter in nasopharyngeal carcinoma

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Research article

Shao-Bo Liang, Yan-Ming Deng, Ning Zhang, Rui-Liang Lu, Hai Zhao, Hai-Yang Chen, Shao-En Li, Dong-Sheng Liu, Yong Chen

Epigenetic regulation and role of metastasis suppressor genes in pancreatic ductal adenocarcinoma

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Research article

Wolf Arif Mardin, Joerg Haier, Soeren Torge Mees

Activity of EGFR-tyrosine kinase and ALK inhibitors for EML4–ALK-rearranged non–small–cell lung cancer harbored coexisting EGFRmutation

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Case report

Akihiko Miyanaga, Kumi Shimizu, Rintaro Noro, Masahiro Seike, Kazuhiro Kitamura, Seiji Kosaihira, Yuji Minegishi, Takehito Shukuya, Akinobu Yoshimura, Masashi Kawamoto, Shinichi Tsuchiya, Koichi Hagiwara, Manabu Soda, Kengo Takeuchi, Nobuyuki Yamamoto, Hiroyuki Mano, Yuichi Ishikawa, Akihiko Gemma

Expression of a LINE-1 endonuclease variant in gastric cancer: its association with clinicopathological parameters

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Research article

Gangshi Wang, Jie Gao, Haili Huang, Yu Tian, Liyan Xue, Weihua Wang, Weidi You, Hongwei Lian, Xiaojian Duan, Benyan Wu, Mengwei Wang

EphB4 as a therapeutic target in mesothelioma

Open Access
Research article

Ren Liu, Benjamin D Ferguson, Yue Zhou, Kranthi Naga, Ravi Salgia, Parkash S Gill, Valery Krasnoperov

Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer

Open Access
Research article

Michele T Yip-Schneider, Huangbing Wu, Keith Stantz, Narasimhan Agaram, Peter A Crooks, C Max Schmidt

IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma

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Research article

Marieke L Kuijjer, Elisabeth FP Peterse, Brendy EWM van den Akker, Inge H Briaire-de Bruijn, Massimo Serra, Leonardo A Meza-Zepeda, Ola Myklebost, A Bassim Hassan, Pancras CW Hogendoorn, Anne-Marie Cleton-Jansen

A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells

Open Access
Technical advance

Hee-Sheung Lee, Nicholas CO Lee, Brenda R Grimes, Alexander Samoshkin, Artem V Kononenko, Ruchi Bansal, Hiroshi Masumoto, William C Earnshaw, Natalay Kouprina, Vladimir Larionov

A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer

Open Access
Research article

Satoko Yamamoto, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Saori Fujiwara, Hirotaka Iwase

Evaluation of hypoxia in a feline model of head and neck cancer using 64Cu-ATSM positron emission tomography/computed tomography

Open Access
Research article

Elizabeth A Ballegeer, Nicole J Madrill, Kevin L Berger, Dalen W Agnew, Elizabeth A McNiel

Influence of gender and age on the survival of patients with nasopharyngeal carcinoma

Open Access
Research article

Guangli Xiao, Yabing Cao, Xibin Qiu, Weihua Wang, Yufeng Wang

Constructions of sex and intimacy after cancer: Q methodology study of people with cancer, their partners, and health professionals

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Research article

Janette Perz, Jane M Ussher, Emilee Gilbert

Reviewer Acknowledgements

Open Access
Reviewer acknowledgement

Christna Chap

OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2

Open Access
Research article

N Winston West, Aileen Garcia-Vargas, Charles E Chalfant, Margaret A Park

Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study

Open Access
Research article

Evangelos Briasoulis, Gerasimos Aravantinos, George Kouvatseas, Periklis Pappas, Eirini Biziota, Ioannis Sainis, Thomas Makatsoris, Ioannis Varthalitis, Ioannis Xanthakis, Antonios Vassias, George Klouvas, Ioannis Boukovinas, George Fountzilas, Kostantinos N Syrigos, Haralambos Kalofonos, Epaminontas Samantas

Claudin 1 expression in basal-like breast cancer is related to patient age

Open Access
Research article

Anne A Blanchard, Xiuli Ma, Kevin J Dueck, Carla Penner, Steven C Cooper, Drew Mulhall, Leigh C Murphy, Etienne Leygue, Yvonne Myal

NOTCH1 mutations influence survival in chronic lymphocytic leukemia patients

Open Access
Research article

Kerstin Willander, Ravi Kumar Dutta, Jonas Ungerbäck, Rebeqa Gunnarsson, Gunnar Juliusson, Mats Fredrikson, Mats Linderholm, Peter Söderkvist

Diagnostic accuracy of diffuse reflectance imaging for early detection of pre-malignant and malignant changes in the oral cavity: a feasibility study

Open Access
Research article

Manju M Stephen, Jayaraj L Jayanthi, Nisha G Unni, Philip E Kolady, Valappil T Beena, Panniyammakal Jeemon, Narayanan Subhash

Short-course radiotherapy followed by neo-adjuvant chemotherapy in locally advanced rectal cancer – the RAPIDO trial

Open Access
Study protocol

Per J Nilsson, Boudewijn van Etten, Geke AP Hospers, Lars Påhlman, Cornelis JH van de Velde, Regina GH Beets-Tan, Lennart Blomqvist, Jannet C Beukema, Ellen Kapiteijn, Corrie AM Marijnen, Iris D Nagtegaal, Theo Wiggers, Bengt Glimelius

Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells

Open Access
Research article

Alex Y Chang, Miao Wang

Infections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group

Open Access
Research article

Sonia Cellot, Donna Johnston, David Dix, Marie-Chantal Ethier, Biljana Gillmeister, David Mitchell, Rochelle Yanofsky, Victor Lewis, Carol Portwine, Victoria Price, Shayna Zelcer, Mariana Silva, Lynette Bowes, Bruno Michon, Kent Stobart, Josee Brossard, Joseph Beyene, Lillian Sung

Influence of a six month endurance exercise program on the immune function of prostate cancer patients undergoing Antiandrogen- or Chemotherapy: design and rationale of the ProImmun study

Open Access
Study protocol

Philipp Zimmer, Elke Jäger, Wilhelm Bloch, Eva Maria Zopf, Freerk T Baumann

Celecoxib alleviates tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling

Open Access
Research article

B N Prashanth Kumar, Shashi Rajput, Kaushik Kumar Dey, Aditya Parekh, Subhasis Das, Abhijit Mazumdar, Mahitosh Mandal

Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer

Open Access
Research article

Arantza Fariña Sarasqueta, Giusi Irma Forte, Wim E Corver, Noel F de Miranda, Dina Ruano, Ronald van Eijk, Jan Oosting, Rob AEM Tollenaar, Tom van Wezel, Hans Morreau

Detection of cancer before distant metastasis

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Research article

Frank AW Coumans, Sabine Siesling, Leon WMM Terstappen

The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma

Open Access
Research article

Qi Zhou, Yafeng Wang, Baogang Peng, Lijian Liang, Jiaping Li

Cancer survivors in Switzerland: a rapidly growing population to care for

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Research article

Christian Herrmann, Thomas Cerny, Anita Savidan, Penelope Vounatsou, Isabelle Konzelmann, Christine Bouchardy, Harald Frick, Silvia Ess

Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study

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Research article

Jonathan N Hofmann, Linda M Liao, Paul T Strickland, Xiao-Ou Shu, Gong Yang, Bu-Tian Ji, Hong-Lan Li, Nathaniel Rothman, Farin Kamangar, Yu-Tang Gao, Wei Zheng, Wong-Ho Chow

ID3 contributes to cerebrospinal fluid seeding and poor prognosis in medulloblastoma

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Research article

Ji Hoon Phi, Seung Ah Choi, Sang-Hee Lim, Joongyub Lee, Kyu-Chang Wang, Sung-Hye Park, Seung-Ki Kim

Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

Open Access
Research article

Gang Cheng, Jacek Zielonka, Donna M McAllister, A Craig Mackinnon Jr, Joy Joseph, Michael B Dwinell, Balaraman Kalyanaraman

The modified Glasgow prognostic score in prostate cancer: results from a retrospective clinical series of 744 patients

Open Access
Research article

Kashif Shafique, Michael J Proctor, Donald C McMillan, Hing Leung, Karen Smith, Billy Sloan, David S Morrison

The effect of different dosing regimens of motesanib on the gallbladder: a randomized phase 1b study in patients with advanced solid tumors

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Research article

Lee S Rosen, Lara Lipton, Timothy J Price, Neil D Belman, Ralph V Boccia, Herbert I Hurwitz, Joe J Stephenson Jr, Lori J Wirth, Sheryl McCoy, Yong-jiang Hei, Cheng-Pang Hsu, Niall C Tebbutt

Quantitative expression analysis and prognostic significance of the BCL2-associated Xgene in nasopharyngeal carcinoma: a retrospective cohort study

Open Access
Research article

Christos K Kontos, Ali Fendri, Abdelmajid Khabir, Raja Mokdad-Gargouri, Andreas Scorilas

CATCH: a randomised clinical trial comparing long-term tinzaparin versus warfarin for treatment of acute venous thromboembolism in cancer patients

Open Access
Study protocol

Agnes YY Lee, Rupert Bauersachs, Mette S Janas, Mikala F Jarner, Pieter W Kamphuisen, Guy Meyer, Alok A Khorana

Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivomouse colon cancer model

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Research article

Magdalena Milczarek, Mateusz Psurski, Andrzej Kutner, Joanna Wietrzyk

Association between genomic recurrence risk and well-being among breast cancer patients

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Research article

Valesca P Retèl, Catharina GM Groothuis-Oudshoorn, Neil K Aaronson, Noel T Brewer, Emiel JT Rutgers, Wim H van Harten

Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer

Open Access
Research article

Fung Lin Yong, Chee Wei Law, Chee Woon Wang

Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial

Open Access
Research article

Maria Teresa Solomón, Julio César Selva, Javier Figueredo, José Vaquer, Carolina Toledo, Nelson Quintanal, Silvia Salva, Rafael Domíngez, José Alert, Jorge Juan Marinello, Mauricio Catalá, Martha González Griego, Juan Antonio Martell, Patricia Lorenzo Luaces, Javier Ballesteros, Niurys de-Castro, Ferdinand Bach, Tania Crombet

Diagnostic markers of urothelial cancer based on DNA methylation analysis

Open Access
Technical advance

Yoshitomo Chihara, Yae Kanai, Hiroyuki Fujimoto, Kokichi Sugano, Kiyotaka Kawashima, Gangning Liang, Peter A Jones, Kiyohide Fujimoto, Hiroki Kuniyasu, Yoshihiko Hirao

The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

Open Access
Research article

Kornelius Kerl, David Ries, Rebecca Unland, Christiane Borchert, Natalia Moreno, Martin Hasselblatt, Heribert Jürgens, Marcel Kool, Dennis Görlich, Maria Eveslage, Manfred Jung, Michael Meisterernst, Michael Frühwald

Phase II/III multicentre randomised controlled trial evaluating a strategy of primary surgery and adjuvant chemotherapy versus peri-operative chemotherapy for resectable gastric signet ring cell adenocarcinomas – PRODIGE 19 – FFCD1103 – ADCI002

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Study protocol

Guillaume Piessen, Mathieu Messager, Karine Le Malicot, William B Robb, Frédéric Di Fiore, Marie Guilbert, Marie Moreau, Véronique Christophe, Antoine Adenis, Christophe Mariette

Low expression of N-myc downstream-regulated gene 2 in oesophageal squamous cell carcinoma correlates with a poor prognosis

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Research article

Wei Cao, Guozheng Yu, Qiang Lu, Juliang Zhang

Clinical outcome, proteome kinetics and angiogenic factors in serum after thermoablation of colorectal liver metastases

Open Access
Research article

Marieke WJLAE Wertenbroek, Marianne Schepers, Hannetta J Kamminga-Rasker, Jan T Bottema, Anneke C Muller Kobold, Han Roelofsen, Koert P de Jong

Co-inhibition of epidermal growth factor receptor and insulin-like growth factor receptor 1 enhances radiosensitivity in human breast cancer cells

Open Access
Research article

Ping Li, Marlon R Veldwijk, Qing Zhang, Zhao-bin Li, Wen-cai Xu, Shen Fu

Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2

Open Access
Research article

Hsien-Ming Wu, Hsin-Shih Wang, Hong-Yuan Huang, Chyong-Huey Lai, Chyi-Long Lee, Yung-Kuei Soong, Peter CK Leung

Ultrasonic spectrum analysis for in vivo characterization of tumor microstructural changes in the evaluation of tumor response to chemotherapy using diagnostic ultrasound

Open Access
Research article

Chun-yi Lin, Long-hui Cao, Jian-wei Wang, Wei Zheng, Yao Chen, Zi-zhen Feng, An-hua Li, Jian-hua Zhou

Expression and significance of HMGB1, TLR4 and NF-κB p65 in human epidermal tumors

Open Access
Research article

Hui Weng, Yunhua Deng, Yuyan Xie, Hongbo Liu, Feili Gong

Intensity-modulated radiotherapy with simultaneous modulated accelerated boost technique and chemotherapy in patients with nasopharyngeal carcinoma

Open Access
Research article

Muhammad M Fareed, Abdullah S AlAmro, Yasser Bayoumi, Mutahir A Tunio, Abdul S Ismail, Rashad Akasha, Mohamed Mubasher, Mushabbab Al Asiri

Perceived benefits and barriers to exercise for recently treated patients with multiple myeloma: a qualitative study

Open Access
Research article

Melinda J Craike, Kaye Hose, Kerry S Courneya, Simon J Harrison, Patricia M Livingston

Anti-lymphangiogenic properties of mTOR inhibitors in head and neck squamous cell carcinoma experimental models

Open Access
Research article

Oleksandr Ekshyyan, Tara N Moore-Medlin, Matthew C Raley, Kunal Sonavane, Xiaohua Rong, Michael A Brodt, Fleurette Abreo, Jonathan Steven Alexander, Cherie-Ann O Nathan

Variants at the 9p21 locus and melanoma risk

Open Access
Research article

Livia Maccioni, Panduranga Sivaramakrishna Rachakonda, Justo Lorenzo Bermejo, Dolores Planelles, Celia Requena, Kari Hemminki, Eduardo Nagore, Rajiv Kumar

Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade

Open Access
Research article

Mingo Ming Ho Yung, David Wai Chan, Vincent Wing Sun Liu, Kwok-Ming Yao, Hextan Yuen-Sheung Ngan

Genetic variants in PARP1 (rs3219090) and IRF4(rs12203592) genes associated with melanoma susceptibility in a Spanish population

Open Access
Research article

Maria Peña-Chilet, Maite Blanquer-Maceiras, Maider Ibarrola-Villava, Conrado Martinez-Cadenas, Manuel Martin-Gonzalez, Cristina Gomez-Fernandez, Matias Mayor, Juan Antonio Aviles, Ana Lluch, Gloria Ribas

N-glycosylation of ICAM-2 is required for ICAM-2-mediated complete suppression of metastatic potential of SK-N-AS neuroblastoma cells

Open Access
Research article

Joseph M Feduska, Patrick L Garcia, Stephanie B Brennan, Su Bu, Leona N Council, Karina J Yoon

Cancer testis antigens and NY-BR-1 expression in primary breast cancer: prognostic and therapeutic implications

Open Access
Research article

Dimitrios Balafoutas, Axel zur Hausen, Sebastian Mayer, Marc Hirschfeld, Markus Jaeger, Dominik Denschlag, Gerald Gitsch, Achim Jungbluth, Elmar Stickeler

Profiling of normal and malignant breast tissue show CD44high/CD24lowphenotype as a predominant stem/progenitor marker when used in combination with Ep-CAM/CD49f markers

Open Access
Research article

Hazem Ghebeh, Ghida Majed Sleiman, Pulicat S Manogaran, Amer Al-Mazrou, Eman Barhoush, Falah H Al-Mohanna, Asma Tulbah, Khalid Al-Faqeeh, Chaker N Adra

Low Annexin A1 expression predicts benefit from induction chemotherapy in oral cancer patients with moderate or poor pathologic differentiation grade

Open Access
Research article

Dong-wang Zhu, Ying Liu, Xiao Yang, Cheng-zhe Yang, Jie Ma, Xi Yang, Jin-ke Qiao, Li-zhen Wang, Jiang Li, Chen-ping Zhang, Zhi-yuan Zhang, Lai-ping Zhong

Conditional survival for longer-term survivors from 2000–2004 using population-based cancer registry data in Osaka, Japan

Open Access
Research article

Yuri Ito, Tomio Nakayama, Isao Miyashiro, Akiko Ioka, Hideaki Tsukuma

Connexin-43 can delay early recurrence and metastasis in patients with hepatitis B-related hepatocellular carcinoma and low serum alpha-fetoprotein after radical hepatectomy

Open Access
Research article

Zu-Sen Wang, Li-Qun Wu, Xin Yi, Chao Geng, Yu-Jun Li, Ru-Yong Yao

A phase I/II trial to evaluate the safety, feasibility and activity of salvage therapy consisting of the mTOR inhibitor Temsirolimus added to standard therapy of Rituximab and DHAP for the treatment of patients with relapsed or refractory diffuse large cell B-Cell lymphoma – the STORM trial

Open Access
Study protocol

Mathias Witzens-Harig, Marie Luise Memmer, Martin Dreyling, Georg Hess

Soluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors

Open Access
Research article

Rui Niimi, Akihiko Matsumine, Takahiro Iino, Shigeto Nakazora, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo

Risk of bladder cancer in patients with diabetes mellitus: an updated meta-analysis of 36 observational studies

Open Access
Research article

Zhaowei Zhu, Xianjin Wang, Zhoujun Shen, Yingli Lu, Shan Zhong, Chen Xu

Constitutional CHEK2mutations are infrequent in early-onset and familial breast/ovarian cancer patients from Pakistan

Open Access
Research article

Muhammad U Rashid, Noor Muhammad, Saima Faisal, Asim Amin, Ute Hamann

DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors

Open Access
Research article

James F Amatruda, Julie A Ross, Brock Christensen, Nicholas J Fustino, Kenneth S Chen, Anthony J Hooten, Heather Nelson, Jacquelyn K Kuriger, Dinesh Rakheja, A Lindsay Frazier, Jenny N Poynter

Measurement of tumour size with mammography, sonography and magnetic resonance imaging as compared to histological tumour size in primary breast cancer

Open Access
Research article

Ines V Gruber, Miriam Rueckert, Karl O Kagan, Annette Staebler, Katja C Siegmann, Andreas Hartkopf, Diethelm Wallwiener, Markus Hahn

Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis

Open Access
Research article

Lanhua Tang, Shushan Zhao, Wei Liu, Nicholas F Parchim, Jin Huang, Youhong Tang, Pingping Gan, Meizuo Zhong

Curcumin analogue T83 exhibits potent antitumor activity and induces radiosensitivity through inactivation of Jab1 in nasopharyngeal carcinoma

Open Access
Research article

Yunbao Pan, Mengyao Wang, Xianzhang Bu, Yinglin Zuo, Sumei Wang, Dujuan Wang, Qing Liu, Bojin Su, Tao Xu, Chunhua Wang, Francois X Claret, Huiling Yang

Cost profiles of colorectal cancer patients in Italy based on individual patterns of care

Open Access
Research article

Silvia Francisci, Stefano Guzzinati, Maura Mezzetti, Emanuele Crocetti, Francesco Giusti, Guido Miccinesi, Eugenio Paci, Catia Angiolini, Anna Gigli

Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer

Open Access
Research article

Dawn T Bravo, Yi-Lin Yang, Kristopher Kuchenbecker, Ming-Szu Hung, Zhidong Xu, David M Jablons, Liang You

Sox2 suppresses the invasiveness of breast cancer cells via a mechanism that is dependent on Twist1 and the status of Sox2 transcription activity

Open Access
Research article

Fang Wu, Xiaoxia Ye, Peng Wang, Karen Jung, Chengsheng Wu, Donna Douglas, Norman Kneteman, Gilbert Bigras, Yupo Ma, Raymond Lai

Interrogating differences in expression of targeted gene sets to predict breast cancer outcome

Open Access
Research article

Sarah A Andres, Guy N Brock, James L Wittliff

The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in Taiwanese breast cancer patients: a 10-year follow-up study

Open Access
Research article

Mei-Chi Hsu, Kuo-Ting Lee, Wei-Chiang Hsiao, Chih-Hsing Wu, Hung-Yu Sun, I-Ling Lin, Kung-Chia Young

Effects of hypoxia on human cancer cell line chemosensitivity

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Research article

Sara Strese, Mårten Fryknäs, Rolf Larsson, Joachim Gullbo

Clinical features and outcome of cryptogenic hepatocellular carcinoma compared to those of viral and alcoholic hepatocellular carcinoma

Open Access
Research article

Sang Soo Lee, Sook-Hyang Jeong, Young-Sang Byoun, Seong Min Chung, Mun Hyuk Seong, Hyung Rae Sohn, Bo-young Min, Eun Sun Jang, Jin-Wook Kim, Guan Jung Park, Yoon Jin Lee, Kyoung Ho Lee, Soyeon Ahn

MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells

Open Access
Research article

Lihua Zhang, Xueqing Wang, Pingsheng Chen

Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis

Open Access
Research article

Serges P Tsofack, Liliane Meunier, Lilia Sanchez, Jason Madore, Diane Provencher, Anne-Marie Mes-Masson, Michel Lebel

Chemokine (C-X-C) ligand 1 (CXCL1) protein expression is increased in aggressive bladder cancers

Open Access
Research article

Makito Miyake, Adrienne Lawton, Steve Goodison, Virginia Urquidi, Evan Gomes-Giacoia, Ge Zhang, Shanti Ross, Jeongsoon Kim, Charles J Rosser

The cysteinyl leukotriene 2 receptor contributes to all-transretinoic acid-induced differentiation of colon cancer cells

Open Access
Research article

Astrid M Bengtsson, Gunilla Jönsson, Cecilia Magnusson, Tavga Salim, Cecilia Axelsson, Anita Sjölander

Post-diagnosis hemoglobin change associates with overall survival of multiple malignancies – results from a 14-year hospital-based cohort of lung, breast, colorectal, and liver cancers

Open Access
Research article

Shaogui Wan, Yinzhi Lai, Ronald E Myers, Bingshan Li, Juan P Palazzo, Ashlie L Burkart, Guokai Chen, Jinliang Xing, Hushan Yang

Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen

Open Access
Research article

Lars Herfindal, Lene Myhren, Bjørn Tore Gjertsen, Stein Ove Døskeland, Gro Gausdal

Cost-effectiveness of MRI for breast cancer screening in BRCA1/2 mutation carriers

Open Access
Research article

Reka Pataky, Linlea Armstrong, Stephen Chia, Andrew J Coldman, Charmaine Kim-Sing, Barbara McGillivray, Jenna Scott, Christine M Wilson, Stuart Peacock

Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases

Open Access
Research article

Valerie Kedinger, Aline Meulle, Omar Zounib, Marie-Elise Bonnet, Jean-Baptiste Gossart, Elodie Benoit, Melanie Messmer, Pattabhiraman Shankaranarayanan, Jean-Paul Behr, Patrick Erbacher, Anne-Laure Bolcato-Bellemin

Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth

Open Access
Research article

Vita M Golubovskaya, Baotran Ho, Min Zheng, Andrew Magis, David Ostrov, Carl Morrison, William G Cance

A link between premenopausal iron deficiency and breast cancer malignancy

Open Access
Research article

Jinlong Jian, Qing Yang, Yongzhao Shao, Deborah Axelrod, Julia Smith, Baljit Singh, Stephanie Krauter, Luis Chiriboga, Zhaoxu Yang, Jinqing Li, Xi Huang

Trends of lip, oral cavity and oropharyngeal cancers in Australia 1982–2008: overall good news but with rising rates in the oropharynx

Open Access
Research article

Anura Ariyawardana, Newell W Johnson

Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case–control study in Japan

Open Access
Research article

Yingsong Lin, Junko Ueda, Kiyoko Yagyu, Hiroshi Ishii, Makoto Ueno, Naoto Egawa, Haruhisa Nakao, Mitsuru Mori, Keitaro Matsuo, Shogo Kikuchi

Defect in recruiting effector memory CD8+T-cells in malignant pleural effusions compared to normal pleural fluid

Open Access
Research article

Arnaud Scherpereel, Bogdan Dragos Grigoriu, Marc Noppen, Thomas Gey, Bachar Chahine, Simon Baldacci, Jacques Trauet, Marie-Christine Copin, Jean-Paul Dessaint, Henri Porte, Myriam Labalette

Abnormal expression of Pygopus 2 correlates with a malignant phenotype in human lung cancer

Open Access
Research article

Yang Liu, Qian-Ze Dong, Si Wang, Chang-Qing Fang, Yuan Miao, Liang Wang, Ming-Zhu Li, En-Hua Wang

Overexpression of peptide deformylase in breast, colon, and lung cancers

Open Access
Research article

Harsharan Randhawa, Shireen Chikara, Drew Gehring, Tuba Yildirim, Jyotsana Menon, Katie M Reindl

Resolving breast cancer heterogeneity by searching reliable protein cancer biomarkers in the breast fluid secretome

Open Access
Review

Ferdinando Mannello, Daniela Ligi

Destructive impact of t-lymphocytes, NK and mast cells on basal cell layers: implications for tumor invasion

Open Access
Research article

Hongyan Yuan, Yi-Hsuan Hsiao, Yiyu Zhang, Jinlian Wang, Chao Yin, Rong Shen, Yiping Su

Predictive score for estimating cancer after venous thromboembolism: a cohort study

Open Access
Research article

Bruno L Ferreyro, Federico Angriman, Diego Giunta, María Lourdes Posadas-Martínez, Fernando Vazquez, Fernán Gonzalez Bernaldo De Quirós, Andre C K B Amaral, Damon C Scales

Human papillomavirus genotypes distribution in 175 invasive cervical cancer cases from Brazil

Open Access
Research article

Cristina Mendes de Oliveira, José Humberto Tavares Guerreiro Fregnani, Jesus Paula Carvalho, Adhemar Longatto-Filho, José Eduardo Levi

Prognostic impact of serum CYFRA 21–1 in patients with advanced lung adenocarcinoma: a retrospective study

Open Access
Research article

Akira Ono, Toshiaki Takahashi, Keita Mori, Hiroaki Akamatsu, Takehito Shukuya, Tetsuhiko Taira, Hirotsugu Kenmotsu, Tateaki Naito, Haruyasu Murakami, Takashi Nakajima, Masahiro Endo, Nobuyuki Yamamoto

Genetic and epigenetic analysis of putative breast cancer stem cell models

Open Access
Research article

Marija Balic, Daniela Schwarzenbacher, Stefanie Stanzer, Ellen Heitzer, Martina Auer, Jochen B Geigl, Richard J Cote, Ram H Datar, Nadia Dandachi

Induction of chromosome instability and stomach cancer by altering the expression pattern of mitotic checkpoint genes in mice exposed to areca-nut

Open Access
Research article

Sillarine Kurkalang, Atanu Banerjee, Nitin Ghoshal, Hughbert Dkhar, Anupam Chatterjee

Design and application of a novel PNA probe for the detection at single cell level of JAK2V617Fmutation in Myeloproliferative Neoplasms

Open Access
Research article

Enrico Bracco, Valentina Rosso, Anna Serra, Francesca Carnuccio, Valentina Gaidano, Paolo Nicoli, Pellegrino Musto, Giuseppe Saglio, Francesco Frassoni, Daniela Cilloni

Clinical and experimental studies regarding the expression and diagnostic value of carcinoembryonic antigen-related cell adhesion molecule 1 in non-small-cell lung cancer

Open Access
Research article

Mu-qing Zhou, Yan Du, Yi-wen Liu, Ying-zhi Wang, Yi-qing He, Cui-xia Yang, Wen-juan Wang, Feng Gao

The life in sight application study (LISA): design of a randomized controlled trial to assess the role of an assisted structured reflection on life events and ultimate life goals to improve quality of life of cancer patients

Open Access
Study protocol

Renske Kruizinga, Michael Scherer-Rath, Johannes BAM Schilderman, Mirjam AG Sprangers, Hanneke WM Van Laarhoven

Multicentric and multifocal versusunifocal breast cancer: differences in the expression of E-cadherin suggest differences in tumor biology

Open Access
Research article

Tobias Weissenbacher, Eva Hirte, Christina Kuhn, Wolfgang Janni, Doris Mayr, Uwe Karsten, Brigitte Rack, Klaus Friese, Udo Jeschke, Sabine Heublein, Darius Dian, Nina Ditsch

Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression

Open Access
Research article

Kuo Wang, Fang Cao, Wenzheng Fang, Yongwei Hu, Ying Chen, Houzhong Ding, Guanzhen Yu

Prognostic significance of neutrophil lymphocyte ratio and platelet lymphocyte ratio in advanced gastric cancer patients treated with FOLFOX chemotherapy

Open Access
Research article

Suee Lee, Sung Yong Oh, Sung Hyun Kim, Ji Hyun Lee, Min Chan Kim, Ki Han Kim, Hyo-Jin Kim

SISH/CISH or qPCR as alternative techniques to FISH for determination of HER2 amplification status on breast tumors core needle biopsies: a multicenter experience based on 840 cases

Open Access
Technical advance

Jocelyne Jacquemier, Frédérique Spyratos, Benjamin Esterni, Marie-Joëlle Mozziconacci, Martine Antoine, Laurent Arnould, Sarab Lizard, Philippe Bertheau, Jacqueline Lehmann-Che, Cécile Blanc Fournier, Sophie Krieger, Frédéric Bibeau, Pierre-Jean Lamy, Marie Pierre Chenard, Michèle Legrain, Jean-Marc Guinebretière, Delphine Loussouarn, Gaëtan MacGrogan, Isabelle Hostein, Marie Christine Mathieu, Ludovic Lacroix, Alexander Valent, Yves Marie Robin, Françoise Revillion, Magali Lacroix Triki, Aline Seaume, Anne Vincent Salomon, Patricia de Cremoux, Geneviève Portefaix, Luc Xerri, Sophie Vacher, Ivan Bièche, Frédérique Penault-Llorca

Differences in microRNA expression during tumor development in the transition and peripheral zones of the prostate

Open Access
Research article

Jessica Carlsson, Gisela Helenius, Mats G Karlsson, Ove Andrén, Karin Klinga-Levan, Björn Olsson

Overexpression of primary microRNA 221/222 in acute myeloid leukemia

Open Access
Research article

Anna Rommer, Katarina Steinleitner, Hubert Hackl, Christine Schneckenleithner, Maria Engelmann, Marcel Scheideler, Irena Vlatkovic, Robert Kralovics, Sabine Cerny-Reiterer, Peter Valent, Heinz Sill, Rotraud Wieser

Schedule-dependent antitumor effects of 5-fluorouracil combined with sorafenib in hepatocellular carcinoma

Open Access
Research article

Lifen Deng, Zhenggang Ren, Qingan Jia, Weizhong Wu, Hujia Shen, Yanhong Wang

NK-cell-dependent killing of colon carcinoma cells is mediated by natural cytotoxicity receptors (NCRs) and stimulated by parvovirus infection of target cells

Open Access
Research article

Rauf Bhat, Jean Rommelaere

Recognizing the role of surgical oncology and cancer imaging in the multidisciplinary approach to cancer: an important area of future scholarly growth for BMC Cancer

Open Access
Editorial

Stephen P Povoski, Nathan C Hall

Secular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents

Open Access
Research article

Hiu-Ying Lau, Chit-Ming Leung, Yap-Hang Chan, Anne Wing-Mui Lee, Dora Lai-Wan Kwong, Maria Li Lung, Tai-Hing Lam

Axin gene methylation status correlates with radiosensitivity of lung cancer cells

Open Access
Research article

Lian-He Yang, Yang Han, Guang Li, Hong-Tao Xu, Gui-Yang Jiang, Yuan Miao, Xiu-Peng Zhang, Huan-Yu Zhao, Zheng-Fan Xu, Maggie Stoecker, Endi Wang, Ke Xu, En-Hua Wang

Incidence of pneumonia and risk factors among patients with head and neck cancer undergoing radiotherapy

Open Access
Research article

Chin-Nan Chu, Chih-Hsin Muo, Shang-Wen Chen, Shu-Yu Lyu, Donald E Morisky

Level of colorectal cancer awareness: a cross sectional exploratory study among multi-ethnic rural population in Malaysia

Open Access
Research article

Tin Tin Su, Jun Yan Goh, Jackson Tan, Abdul Rahim Muhaimah, Yoganathan Pigeneswaren, Nasirin Sallamun Khairun, Abdul Wahab Normazidah, Devi Kunasekaran Tharisini, Hazreen Abd Majid

MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells

Open Access
Research article

Keisuke Gotanda, Takeshi Hirota, Nozomi Matsumoto, Ichiro Ieiri

Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice

Open Access
Research article

Katrina L Watson, Roger A Moorehead

Urinary incontinence and health-related quality of life among older Americans with and without cancer: a cross-sectional study

Open Access
Research article

Alexandra J White, Bryce B Reeve, Ronald C Chen, Angela M Stover, Debra E Irwin

Differentiation of irradiation and cetuximab induced skin reactions in patients with locally advanced head and neck cancer undergoing radioimmunotherapy: the HICARE protocol (Head and neck cancer: ImmunoChemo and Radiotherapy with Erbitux) – a multicenter phase IV trial

Open Access
Study protocol

G Habl, K Potthoff, MF Haefner, A Abdollahi, JC Hassel, E Boller, M Indorf, J Debus

Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder

Open Access
Research article

Jian-Ye Liu, Yong-Hong Li, Huan-Xin Lin, Yi-Ji Liao, Shi-Juan Mai, Zhou-Wei Liu, Zhi-Ling Zhang, Li-Juan Jiang, Jia-Xing Zhang, Hsiang-Fu Kung, Yi-Xin Zeng, Fang-Jian Zhou, Dan Xie

First description of seasonality of birth and diagnosis amongst teenagers and young adults with cancer aged 15–24 years in England, 1996–2005

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Research article

Marlous van Laar, Sally E Kinsey, Susan V Picton, Richard G Feltbower

Annual Papanicolaou screening for 5 years among human papillomavirus-negative women

Open Access
Research article

Karl Ulrich Petry, Franziska Rinnau, Gerd Böhmer, Bettina Hollwitz, Alexander Luyten, Nina Buttmann, Martin Brünger, Thomas Iftner

Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors

Open Access
Research article

Mercè Juliachs, August Vidal, Xavier Garcia del Muro, Josep M Piulats, Enric Condom, Oriol Casanovas, Mariona Graupera, Jose R Germà, Alberto Villanueva, Francesc Viñals

HRG-β1-driven ErbB3 signaling induces epithelial–mesenchymal transition in breast cancer cells

Open Access
Research article

Jinkyoung Kim, Hoiseon Jeong, Youngseok Lee, Chungyeul Kim, Hankyeom Kim, Aeree Kim

Implication from thyroid function decreasing during chemotherapy in breast cancer patients: chemosensitization role of triiodothyronine

Open Access
Research article

Jianbo Huang, Liangbin Jin, Guangyan Ji, Lei Xing, Chaobo Xu, Xiong Xiong, Hongyuan Li, Kainan Wu, Guosheng Ren, Lingquan Kong

DEK over expression as an independent biomarker for poor prognosis in colorectal cancer

Open Access
Research article

Lijuan Lin, Junjie Piao, Wenbin Gao, Yingshi Piao, Guang Jin, Yue Ma, Jinzi Li, Zhenhua Lin

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Open Access
Research article

Mårten Fryknäs, Joachim Gullbo, Xin Wang, Linda Rickardson, Malin Jarvius, Malin Wickström, Saadia Hassan, Claes Andersson, Mats Gustafsson, Gunnar Westman, Peter Nygren, Stig Linder, Rolf Larsson

Nrf2 is required to maintain the self-renewal of glioma stem cells

Open Access
Research article

Jianhong Zhu, Handong Wang, Qing Sun, Xiangjun Ji, Lin Zhu, Zixiang Cong, Yuan Zhou, Huandong Liu, Mengliang Zhou

Efficacy and safety of lipegfilgrastim versus pegfilgrastim: a randomized, multicenter, active-control phase 3 trial in patients with breast cancer receiving doxorubicin/docetaxel chemotherapy

Open Access
Research article

Igor Bondarenko, Oleg A Gladkov, Reiner Elsaesser, Anton Buchner, Peter Bias

Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells

Open Access
Research article

Babu V Sajesh, Zelda Lichtensztejn, Kirk J McManus

A comparison of trends in melanoma mortality in New Zealand and Australia: the two countries with the highest melanoma incidence and mortality in the world

Open Access
Research article

Mary Jane Sneyd, Brian Cox

Radiotherapy of abdomen with precise renal assessment with SPECT/CT imaging (RAPRASI): design and methodology of a prospective trial to improve the understanding of kidney radiation dose response

Open Access
Study protocol

Juanita Lopez-Gaitan, Martin A Ebert, Peter Robins, Jan Boucek, Trevor Leong, David Willis, Sean Bydder, Peter Podias, Gemma Waters, Brenton O’Mara, Julie Chu, Jessica Faggian, Luke Williams, Michael S Hofman, Nigel A Spry

Expression of TRAIL-splice variants in gastric carcinomas: identification of TRAIL-γ as a prognostic marker

Open Access
Research article

Andreas Krieg, Sabrina Mersch, Nadine Wolf, Nikolas H Stoecklein, Pablo E Verde, Jan Schulte am Esch 2nd, Sebastian Heikaus, Helmut E Gabbert, Wolfram T Knoefel, Csaba Mahotka

IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancer

Open Access
Research article

Toshiki Hirakawa, Masakazu Yashiro, Akihiro Murata, Keiichiro Hirata, Kenjiro Kimura, Ryosuke Amano, Nobuya Yamada, Bunzo Nakata, Kosei Hirakawa

Efficacy and safety of pharmacological interventions in second- or later-line treatment of patients with advanced soft tissue sarcoma: a systematic review

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Research article

Sheetal Sharma, Shweta Takyar, Stephanie C Manson, Sarah Powell, Nicolas Penel

Prediction of metachronous multiple primary cancers following the curative resection of gastric cancer

Open Access
Research article

Chan Kim, Hong Jae Chon, Beodeul Kang, Kiyeol Kim, Hei-Cheul Jeung, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha

Plasma S-adenosylmethionine, DNMTpolymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore

Open Access
Research article

Maki Inoue-Choi, Heather H Nelson, Kim Robien, Erland Arning, Teodoro Bottiglieri, Woon-Puay Koh, Jian-Min Yuan

Design of the SHAPE-2 study: the effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk

Open Access
Study protocol

Willemijn AM van Gemert, Jolein I Iestra, Albertine J Schuit, Anne M May, Tim Takken, Wouter B Veldhuis, Job van der Palen, Harriët Wittink, Petra HM Peeters, Evelyn M Monninkhof

Three dimensional multiphoton imaging of fresh and whole mount developing mouse mammary glands

Open Access
Technical advance

Michael D Johnson, Susette C Mueller

Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model

Open Access
Research article

Tao Hu, Chunhua Zhang, Qiongling Tang, Yanan Su, Bo Li, Long Chen, Zheng Zhang, Tianchi Cai, Yuechun Zhu

Preoperative core needle biopsy is accurate in determining molecular subtypes in invasive breast cancer

Open Access
Research article

Xiaosong Chen, Long Sun, Yan Mao, Siji Zhu, Jiayi Wu, Ou Huang, Yafen Li, Weiguo Chen, Jianhua Wang, Ying Yuan, Xiaochun Fei, Xiaolong Jin, Kunwei Shen

Functional promoter -31G/C variant of Survivin gene predict prostate cancer susceptibility among Chinese: a case control study

Open Access
Research article

Jiawei Chen, Xinhai Cui, Hai Zhou, Chao Qin, Qiang Cao, Xiaobing Ju, Pu Li, Hongzhou Cai, Jian Zhu, Xiaoxin Meng, Meilin Wang, Zhengdong Zhang, Pengfei Shao, Jie Li, Changjun Yin

Molecular fingerprinting reflects different histotypes and brain region in low grade gliomas

Open Access
Research article

Samantha Mascelli, Annalisa Barla, Alessandro Raso, Sofia Mosci, Paolo Nozza, Roberto Biassoni, Giovanni Morana, Martin Huber, Cristian Mircean, Daniel Fasulo, Karin Noy, Gayle Wittemberg, Sara Pignatelli, Gianluca Piatelli, Armando Cama, Maria Luisa Garré, Valeria Capra, Alessandro Verri

The prevalence of depression and anxiety among Chinese adults with cancer: a systematic review and meta-analysis

Open Access
Research article

Yi-Long Yang, Li Liu, Yang Wang, Hui Wu, Xiao-Shi Yang, Jia-Na Wang, Lie Wang

Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island

Open Access
Research article

Reinhold Wasserkort, Alexandra Kalmar, Gabor Valcz, Sandor Spisak, Manuel Krispin, Kinga Toth, Zsolt Tulassay, Andrew Z Sledziewski, Bela Molnar

MC1Rgenotype as a predictor of early-onset melanoma, compared with self-reported and physician-measured traditional risk factors: an Australian case-control-family study

Open Access
Research article

Anne E Cust, Chris Goumas, Kylie Vuong, John R Davies, Jennifer H Barrett, Elizabeth A Holland, Helen Schmid, Chantelle Agha-Hamilton, Bruce K Armstrong, Richard F Kefford, Joanne F Aitken, Graham G Giles, D Timothy Bishop, Julia A Newton-Bishop, John L Hopper, Graham J Mann, Mark A Jenkins

Clinical variables serve as prognostic factors in a model for survival from glioblastoma multiforme: an observational study of a cohort of consecutive non-selected patients from a single institution

Open Access
Research article

Signe Regner Michaelsen, Ib Jarle Christensen, Kirsten Grunnet, Marie-Thérése Stockhausen, Helle Broholm, Michael Kosteljanetz, Hans Skovgaard Poulsen

Mammographic density in birth cohorts of Danish women: a longitudinal study

Open Access
Research article

Sophie Sell Hellmann, Elsebeth Lynge, Walter Schwartz, Ilse Vejborg, Sisse Helle Njor

Stromal matrix metalloprotease-13 knockout alters Collagen I structure at the tumor-host interface and increases lung metastasis of C57BL/6 syngeneic E0771 mammary tumor cells

Open Access
Research article

Seth W Perry, Jill M Schueckler, Kathleen Burke, Giuseppe L Arcuri, Edward B Brown

Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer

Open Access
Research article

Xing-Hua Liang, Ling-ling Li, Geng-Gang Wu, Yi-Cheng Xie, Guang-Xian Zhang, Wei Chen, Hai-Feng Yang, Qi-Long Liu, Wen-Hong Li, Wen-guang He, Yan-Nian Huang, Xian-Cheng Zeng

Influence of a patient information program on adherence and persistence with an aromatase inhibitor in breast cancer treatment - the COMPAS study

Open Access
Research article

Volker Ziller, Ioannis Kyvernitakis, Dana Knöll, Astrid Storch, Olaf Hars, Peyman Hadji

ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma

Open Access
Research article

Masaki Nagata, Arhab A Noman, Kenji Suzuki, Hiroshi Kurita, Makoto Ohnishi, Tokio Ohyama, Nobutaka Kitamura, Takanori Kobayashi, Kohya Uematsu, Katsu Takahashi, Naoki Kodama, Tomoyuki Kawase, Hideyuki Hoshina, Nobuyuki Ikeda, Susumu Shingaki, Ritsuo Takagi

BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma

Open Access
Research article

Katie A Matatall, Olga A Agapova, Michael D Onken, Lori A Worley, Anne M Bowcock, J William Harbour

Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts

Open Access
Research article

Sherrill L Macura, Jeremy L Steinbacher, Maximilian B MacPherson, Melissa J Lathrop, Mutlay Sayan, Jedd M Hillegass, Stacie L Beuschel, Timothy N Perkins, Page C Spiess, Albert van der Vliet, Kelly J Butnor, Arti Shukla, Marilyn Wadsworth, Christopher C Landry, Brooke T Mossman

Clinical complete responders to definite chemoradiation or radiation therapy for oesophageal cancer: predictors of outcome

Open Access
Research article

Antoine Adenis, Emmanuelle Tresch, Sylvain Dewas, Olivier Romano, Mathieu Messager, Eric Amela, Stéphanie Clisant, Andrew Kramar, Christophe Mariette, Xavier Mirabel

Feline mammary basal-like adenocarcinomas: a potential model for human triple-negative breast cancer (TNBC) with basal-like subtype

Open Access
Research article

David A Wiese, Tuddow Thaiwong, Vilma Yuzbasiyan-Gurkan, Matti Kiupel

Automatic registration of multi-modal microscopy images for integrative analysis of prostate tissue sections

Open Access
Technical advance

Giuseppe Lippolis, Anders Edsjö, Leszek Helczynski, Anders Bjartell, Niels Chr Overgaard

Joint pain severity predicts premature discontinuation of aromatase inhibitors in breast cancer survivors

Open Access
Research article

Kannie Chim, Sharon X Xie, Carrie T Stricker, Qing S Li, Robert Gross, John T Farrar, Angela DeMichele, Jun J Mao

Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization

Open Access
Research article

Ji-Young Jang, Jong-Kuen Lee, Yoon-Kyung Jeon, Chul-Woo Kim

Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients - a study of the OVCAD consortium

Open Access
Research article

Anna Bachmayr-Heyda, Stefanie Aust, Georg Heinze, Stephan Polterauer, Christoph Grimm, Elena Ioana Braicu, Jalid Sehouli, Sandrina Lambrechts, Ignace Vergote, Sven Mahner, Dietmar Pils, Eva Schuster, Theresia Thalhammer, Reinhard Horvat, Carsten Denkert, Robert Zeillinger, Dan Cacsire Castillo-Tong

Symptoms, CA125 and HE4 for the preoperative prediction of ovarian malignancy in Brazilian women with ovarian masses

Open Access
Research article

Denise da Rocha Pitta, Luis Otávio Sarian, Amilcar Barreta, Elisabete Aparecida Campos, Liliana Lucci de Angelo Andrade, Ana Maria Dias Fachini, Leonardo Martins Campbell, Sophie Derchain

Partial loss of Smad signaling during in vitroprogression of HPV16-immortalized human keratinocytes

Open Access
Research article

Diego Altomare, Rupa Velidandla, Lucia Pirisi, Kim E Creek

Optimizing expectations to prevent side effects and enhance quality of life in breast cancer patients undergoing endocrine therapy: study protocol of a randomized controlled trial

Open Access
Study protocol

Pia von Blanckenburg, Franziska Schuricht, Ute-Susann Albert, Winfried Rief, Yvonne Nestoriuc

Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines

Open Access
Research article

Reza Bayat Mokhtari, Sushil Kumar, Syed S Islam, Mehrdad Yazdanpanah, Khosrow Adeli, Ernest Cutz, Herman Yeger

Cancer odor in the blood of ovarian cancer patients: a retrospective study of detection by dogs during treatment, 3 and 6 months afterward

Open Access
Research article

György Horvath, Håkan Andersson, Szilárd Nemes

Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9

Open Access
Research article

Shalini Makawita, Apostolos Dimitromanolakis, Antoninus Soosaipillai, Ireena Soleas, Alison Chan, Steven Gallinger, Randy S Haun, Ivan M Blasutig, Eleftherios P Diamandis

U-CARE: Internet-based stepped care with interactive support and cognitive behavioral therapy for reduction of anxiety and depressive symptoms in cancer - a clinical trial protocol

Open Access
Study protocol

Susanne Mattsson, Sven Alfonsson, Maria Carlsson, Peter Nygren, Erik Olsson, Birgitta Johansson

Method validation of circulating tumour cell enumeration at low cell counts

Open Access
Technical advance

Jeffrey Cummings, Karen Morris, Cong Zhou, Robert Sloane, Matt Lancashire, Daniel Morris, Stephen Bramley, Matt Krebs, Leila Khoja, Caroline Dive

Metabolic system alterations in pancreatic cancer patient serum: potential for early detection

Open Access
Research article

Shawn A Ritchie, Hirofumi Akita, Ichiro Takemasa, Hidetoshi Eguchi, Elodie Pastural, Hiroaki Nagano, Morito Monden, Yuichiro Doki, Masaki Mori, Wei Jin, Tolulope T Sajobi, Dushmanthi Jayasinghe, Bassirou Chitou, Yasuyo Yamazaki, Thayer White, Dayan B Goodenowe

A multicentric randomized controlled trial on the impact of lengthening the interval between neoadjuvant radiochemotherapy and surgery on complete pathological response in rectal cancer (GRECCAR-6 trial): rationale and design

Open Access
Study protocol

Jérémie H Lefevre, Alexandra Rousseau, Magali Svrcek, Yann Parc, Tabassome Simon, Emmanuel Tiret

Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice

Open Access
Research article

Rafat A Siddiqui, Kevin A Harvey, Candace Walker, Jeffrey Altenburg, Zhidong Xu, Colin Terry, Ignacio Camarillo, Yava Jones-Hall, Cary Mariash

BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment

Open Access
Research article

Minna Ampuja, Riikka Jokimäki, Kati Juuti-Uusitalo, Alejandra Rodriguez-Martinez, Emma-Leena Alarmo, Anne Kallioniemi

Tumor necrosis factor-α attenuates starvation-induced apoptosis through upregulation of ferritin heavy chain in hepatocellular carcinoma cells

Open Access
Research article

Xingrui Kou, Yingying Jing, Weijie Deng, Kai Sun, Zhipeng Han, Fei Ye, Guofeng Yu, Qingmin Fan, Lu Gao, Qiudong Zhao, Xue Zhao, Rong Li, Lixin Wei, Mengchao Wu

Phase I study evaluating the treatment of patients with locally advanced pancreatic cancer with carbon ion radiotherapy: the PHOENIX-01 trial

Open Access
Study protocol

Stephanie E Combs, Daniel Habermehl, Meinhard Kieser, Constantin Dreher, Jens Werner, Renate Haselmann, Oliver Jäkel, Dirk Jäger, Markus W Büchler, Jürgen Debus

Intestinal-type of differentiation predicts favourable overall survival: confirmatory clinicopathological analysis of 198 periampullary adenocarcinomas of pancreatic, biliary, ampullary and duodenal origin

Open Access
Research article

Peter Bronsert, Ilona Kohler, Martin Werner, Frank Makowiec, Simon Kuesters, Jens Hoeppner, Ulrich Theodor Hopt, Tobias Keck, Dirk Bausch, Ulrich Friedrich Wellner

Suppression of thymosin β10 increases cell migration and metastasis of cholangiocarcinoma

Open Access
Research article

Sirinapa Sribenja, Kanlayanee Sawanyawisuth, Ratthaphol Kraiklang, Chaisiri Wongkham, Kulthida Vaeteewoottacharn, Sumalee Obchoei, Qizhi Yao, Sopit Wongkham, Changyi Chen

Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer

Open Access
Research article

Vlad Popovici, Eva Budinska, Fred T Bosman, Sabine Tejpar, Arnaud D Roth, Mauro Delorenzi

Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR

Open Access
Research article

Carl Sandén, Malin Ageberg, Jessica Petersson, Andreas Lennartsson, Urban Gullberg

RETRACTED ARTICLE: Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors

Open Access
Research article

Stefania Staibano, Gennaro Ilardi, Vincenza Leone, Chiara Luise, Francesco Merolla, Francesco Esposito, Francesco Morra, Maria Siano, Renato Franco, Alfredo Fusco, Paolo Chieffi, Angela Celetti

Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer

Open Access
Research article

Peter H Cashin, Haile Mahteme, Wilhelm Graf, Henning Karlsson, Rolf Larsson, Peter Nygren

The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays

Open Access
Research article

Nilanjana Tewari, Abed M Zaitoun, Arvind Arora, Srinivasan Madhusudan, Mohammad Ilyas, Dileep N Lobo

The prognostic value of Her4 receptor isoform expression in triple-negative and Her2 positive breast cancer patients

Open Access
Research article

Anna Machleidt, Stefan Buchholz, Simone Diermeier-Daucher, Florian Zeman, Olaf Ortmann, Gero Brockhoff

Prognosis of rectal cancer patients improves with downstaging by intensified neoadjuvant radiochemotherapy - a matched pair analysis

Open Access
Research article

Leif Schiffmann, Gunther Klautke, Nicole Wedermann, Michael Gock, Friedrich Prall, Rainer Fietkau, Bettina Rau, Ernst Klar

Simultaneous identification of 36 mutations in KRAS codons 61and 146, BRAF, NRAS, and PIK3CAin a single reaction by multiplex assay kit

Open Access
Technical advance

Hideaki Bando, Takayuki Yoshino, Eiji Shinozaki, Tomohiro Nishina, Kentaro Yamazaki, Kensei Yamaguchi, Satoshi Yuki, Shinya Kajiura, Satoshi Fujii, Takeharu Yamanaka, Katsuya Tsuchihara, Atsushi Ohtsu

Patient Activation through Counseling and Exercise – Acute Leukemia (PACE-AL) – a randomized controlled trial

Open Access
Study protocol

Mary Jarden, Tom Møller, Lars Kjeldsen, Henrik Birgens, Jesper Frank Christensen, Karl Bang Christensen, Finn Diderichsen, Carsten Hendriksen, Lis Adamsen

Heparan sulfate mediates trastuzumab effect in breast cancer cells

Open Access
Research article

Eloah Rabello Suarez, Edgar Julian Paredes-Gamero, Auro Del Giglio, Ivarne Luis dos Santos Tersariol, Helena Bonciani Nader, Maria Aparecida Silva Pinhal

Disparities in race/ethnicity and socioeconomic status: risk of mortality of breast cancer patients in the California Cancer Registry, 2000–2010

Open Access
Research article

Carol A Parise, Vincent Caggiano

Measuring effectiveness of the cervical cancer vaccine in an Australian setting (the VACCINE study)

Open Access
Study protocol

Elisa J Young, Sepehr N Tabrizi, Julia ML Brotherton, John D Wark, Jan Pyman, Marion Saville, C David Wrede, Yasmin Jayasinghe, Jeffrey Tan, Dorota M Gertig, Marian Pitts, Suzanne M Garland

Association of thiazolidinediones with gastric cancer in type 2 diabetes mellitus: a population-based case–control study

Open Access
Research article

Shen-Shong Chang, Hsiao-Yun Hu

Impacts of clinicopathologic and operative factors on short-term and long-term survival in renal cell carcinoma with venous tumor thrombus extension: a multi-institutional retrospective study in Japan

Open Access
Research article

Masanori Hirono, Mikio Kobayashi, Tomoyasu Tsushima, Wataru Obara, Nobuo Shinohara, Keiichi Ito, Masatoshi Eto, Tatsuya Takayama, Yasuhisa Fujii, Masaharu Nishikido, Go Kimura, Takeshi Kishida, Masayuki Takahashi, Noriomi Miyao, Yukio Naya, Takashige Abe, Tomoaki Fujioka, Kazuto Ito, Seiji Naito

RETRACTED ARTICLE: MicroRNA-302b suppresses cell proliferation by targeting EGFR in human hepatocellular carcinoma SMMC-7721 cells

Open Access
Research article

Lumin Wang, Jiayi Yao, Xin Shi, Lili Hu, Zongfang Li, Tusheng Song, Chen Huang

The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia

Open Access
Research article

Annette Künkele, Anja Grosse-Lordemann, Alexander Schramm, Angelika Eggert, Johannes H Schulte, Hagen S Bachmann

Capecitabine and bevacizumab for non-resectable metastatic colorectal cancer patients: final results from phase II AIO KRK 0105 trial

Open Access
Research article

Alexander Stein, Albrecht Kretzschmar, Dirk Behringer, Thomas Wolff, Joachim Zimber, Susanna Hegewisch-Becker, Erika Kettner, Karl-Heinz Pflüger, Andreas Kirsch, Dirk Arnold

Listening in on difficult conversations: an observational, multi-center investigation of real-time conversations in medical oncology

Open Access
Study protocol

Brittany C Kimball, Katherine M James, Kathleen J Yost, Cara A Fernandez, Ashok Kumbamu, Aaron L Leppin, Marguerite E Robinson, Gail Geller, Debra L Roter, Susan M Larson, Heinz-Josef Lenz, Agustin A Garcia, Clarence H Braddock III, Aminah Jatoi, María Luisa Zúñiga de Nuncio, Victor M Montori, Barbara A Koenig, Jon C Tilburt

Radiation-induced temporal lobe injury after intensity modulated radiotherapy in nasopharyngeal carcinoma patients: a dose-volume-outcome analysis

Open Access
Research article

Ying Sun, Guan-Qun Zhou, Zhen-Yu Qi, Li Zhang, Shao-Min Huang, Li-Zhi Liu, Li Li, Ai-Hua Lin, Jun Ma

HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis

Open Access
Research article

Thais Chile, Maria Angela Henriques Zanella Fortes, Maria Lúcia Cardillo Corrêa-Giannella, Helena Paula Brentani, Durvanei Augusto Maria, Renato David Puga, Vanessa de Jesus R de Paula, Marcia Saldanha Kubrusly, Estela Maria Novak, Telésforo Bacchella, Ricardo Rodrigues Giorgi

Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia

Open Access
Research article

Maria Mosor, Iwona Ziółkowska-Suchanek, Karina Nowicka, Agnieszka Dzikiewicz-Krawczyk, Danuta Januszkiewicz–Lewandowska, Jerzy Nowak

Cancer burden in China: a Bayesian approach

Open Access
Research article

Wanqing Chen, Bruce K Armstrong, Rongshou Zheng, Siwei Zhang, Xueqin Yu, Mark Clements

Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway

Open Access
Research article

Jiao Fu, Hongjun Lv, Haixia Guan, Xiaoying Ma, Meiju Ji, Nongyue He, Bingyin Shi, Peng Hou

RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients

Open Access
Research article

Sam Cross-Knorr, Shaolei Lu, Kimberly Perez, Sara Guevara, Kate Brilliant, Claudio Pisano, Peter J Quesenberry, Murray B Resnick, Devasis Chatterjee

The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer

Open Access
Research article

Xiang-hua Liu, Zhi-li Liu, Ming Sun, Jing Liu, Zhao-xia Wang, Wei De

Analysis of GAGE, NY-ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma

Open Access
Research article

Morten F Gjerstorff, Mette Pøhl, Karen E Olsen, Henrik J Ditzel

Expression of activator protein-1 (AP-1) family members in breast cancer

Open Access
Research article

Amirhossein Razavirad, Hui Gao, Reza Ghiasvand, Chunyan Zhao, Kazem Zendehdel, Karin Dahlman-Wright

Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression

Open Access
Research article

Kai-hua Lu, Wei Li, Xiang-hua Liu, Ming Sun, Mei-ling Zhang, Wei-qin Wu, Wei-ping Xie, Ya-yi Hou

Prognostic significance and therapeutic potential of the activation of anaplastic lymphoma kinase/protein kinase B/mammalian target of rapamycin signaling pathway in anaplastic large cell lymphoma

Open Access
Research article

Ju Gao, Minzhi Yin, Yiping Zhu, Ling Gu, Yanle Zhang, Qiang Li, Cangsong Jia, Zhigui Ma

Budget impact analysis of first-line treatment with pazopanib for advanced renal cell carcinoma in Spain

Open Access
Research article

Guillermo Villa, Luis-Javier Hernández-Pastor

Evaluating human cancer cell metastasis in zebrafish

Open Access
Research article

Yong Teng, Xiayang Xie, Steven Walker, David T White, Jeff S Mumm, John K Cowell

FOXO/TXNIP pathway is involved in the suppression of hepatocellular carcinoma growth by glutamate antagonist MK-801

Open Access
Research article

Fuminori Yamaguchi, Yuko Hirata, Hossain Akram, Kazuyo Kamitori, Youyi Dong, Li Sui, Masaaki Tokuda

MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3

Open Access
Research article

Guangxian Xu, Yilin Zhang, Jun Wei, Wei Jia, Zhaohui Ge, Zhaobo Zhang, Xiaoming Liu

Improvement of the quality of BRAF testing in melanomas with nationwide external quality assessment, for the BRAF EQA group

Open Access
Research article

Jean-François Emile, Julie Tisserand, Loic Bergougnoux, Frédérique Nowak, Gladwys Faucher, Sylvie Surel, Aude Lamy, Delphine Lecorre, Zofia Helias-Rodzewicz, Paul Hofman, Jean-Christophe Sabourin, Pierre Laurent-Puig

Clinical instability of breast cancer markers is reflected in long-term in vitro estrogen deprivation studies

Open Access
Research article

Jelena Milosevic, Johanna Klinge, Anna-Lena Borg, Theodoros Foukakis, Jonas Bergh, Nicholas P Tobin

The role of hepatocyte nuclear factor 4alpha in metastatic tumor formation of hepatocellular carcinoma and its close relationship with the mesenchymal–epithelial transition markers

Open Access
Research article

Dianbo Yao, Songlin Peng, Chaoliu Dai

Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China

Open Access
Research article

Zhengrong Sun, Zhitao Lu, Jianhua Liu, Guili Wang, Weiqiang Zhou, Lianxia Yang, Chao Liu, Bo Wang, Qiang Ruan

Synergistic growth inhibition by acyclic retinoid and phosphatidylinositol 3-kinase inhibitor in human hepatoma cells

Open Access
Research article

Atsushi Baba, Masahito Shimizu, Tomohiko Ohno, Yohei Shirakami, Masaya Kubota, Takahiro Kochi, Daishi Terakura, Hisashi Tsurumi, Hisataka Moriwaki

High-risk human papillomavirus (HPV) DNA sequences in metaplastic breast carcinomas of Mexican women

Open Access
Research article

Roberto Herrera-Goepfert, Teresa Vela-Chávez, Adela Carrillo-García, Marcela Lizano-Soberón, Alfredo Amador-Molina, Luis F Oñate-Ocaña, Rita Sotelo-Regil Hallmann

Classification tree analysis to enhance targeting for follow-up exam of colorectal cancer screening

Open Access
Research article

Yoshiki Ishikawa, Ying-Fang Zheng, Hiromu Nishiuchi, Takeo Suda, Tadahiko Hasumi, Hiroshi Saito

Overall survival and toxicities regarding thoracic three-dimensional radiotherapy with concurrent chemotherapy for stage IV non-small cell lung cancer: results of a prospective single-center study

Open Access
Research article

Sheng-Fa Su, Yin-Xiang Hu, Wei-Wei Ouyang, Bing Lu, Zhu Ma, Qing-Song Li, Hui-Qin Li, Yi-Chao Geng

Chemotherapy-induced hyaluronan production: a novel chemoresistance mechanism in ovarian cancer

Open Access
Research article

Carmela Ricciardelli, Miranda P Ween, Noor A Lokman, Izza A Tan, Carmen E Pyragius, Martin K Oehler

Antiproliferative effects of lanreotide autogel in patients with progressive, well-differentiated neuroendocrine tumours: a Spanish, multicentre, open-label, single arm phase II study

Open Access
Research article

Marta Martín-Richard, Bartomeu Massutí, Eva Pineda, Vicente Alonso, Maribel Marmol, Daniel Castellano, Emilio Fonseca, Antonio Galán, Marta Llanos, Maria Angeles Sala, Carlos Pericay, Fernando Rivera, Javier Sastre, Ángel Segura, Maria Quindós, Pascal Maisonobe

Preoperative neutrophil/lymphocyte ratio predicts overall survival but does not predict recurrence or cancer-specific survival after curative resection of node-positive colorectal cancer

Open Access
Research article

Lucy Jankova, Owen F Dent, Charles Chan, Pierre Chapuis, Stephen J Clarke

Body fatness and breast cancer risk in women of African ancestry

Open Access
Research article

Elisa V Bandera, Urmila Chandran, Gary Zirpoli, Zhihong Gong, Susan E McCann, Chi-Chen Hong, Gregory Ciupak, Karen Pawlish, Christine B Ambrosone

N-benzyladriamycin-14-valerate (AD 198) exhibits potent anti-tumor activity on TRAF3-deficient mouse B lymphoma and human multiple myeloma

Open Access
Research article

Shanique K E Edwards, Carissa R Moore, Yan Liu, Sukhdeep Grewal, Lori R Covey, Ping Xie

Survival of patients with operable breast cancer (Stages I-III) at a Brazilian public hospital - a closer look into cause-specific mortality

Open Access
Research article

Débora Balabram, Cassio M Turra, Helenice Gobbi

Phase I dose-finding study of cabazitaxel administered weekly in patients with advanced solid tumours

Open Access
Research article

Pierre Fumoleau, Jose Manuel Trigo, Nicolas Isambert, Dorothée Sémiond, Sunil Gupta, Mario Campone

Endothelial cells do not arise from tumor-initiating cells in human hepatocellular carcinoma

Open Access
Research article

Anand Ghanekar, Sharif Ahmed, Kui Chen, Oyedele Adeyi

Salinomycin increases chemosensitivity to the effects of doxorubicin in soft tissue sarcomas

Open Access
Research article

Sven-T Liffers, Daniel J Tilkorn, Ingo Stricker, Christoph Günter Junge, Sammy Al-Benna, Markus Vogt, Berlinda Verdoodt, Hans-U Steinau, Andrea Tannapfel, Iris Tischoff, Alireza Mirmohammadsadegh

Class III β-tubulin is a predictive marker for taxane-based chemotherapy in recurrent and metastatic gastric cancer

Open Access
Research article

Jun-Eul Hwang, Ji-Yun Hong, Karham Kim, Seung-Hun Kim, Won-Young Choi, Min-Jee Kim, Sung-Hoon Jung, Hyun-Jeong Shim, Woo-Kyun Bae, Eu-Chang Hwang, Kyung-Hwa Lee, Jae-Hyuk Lee, Sang-Hee Cho, Ik-Joo Chung

Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer

Open Access
Research article

Tae Woo Kim, Byungtak Kim, Ju Hee Kim, Seongeun Kang, Sung-Bin Park, Gookjoo Jeong, Han-Sung Kang, Sun Jung Kim

KRAS, BRAF genotyping reveals genetic heterogeneity of ovarian borderline tumors and associated implants

Open Access
Research article

Sabine Heublein, Katinka Grasse, Harald Hessel, Alexander Burges, Miriam Lenhard, Jutta Engel, Thomas Kirchner, Udo Jeschke, Doris Mayr

Germline mutation in the RAD51B gene confers predisposition to breast cancer

Open Access
Research article

Lisa Golmard, Virginie Caux-Moncoutier, Grégoire Davy, Essam Al Ageeli, Brigitte Poirot, Carole Tirapo, Dorothée Michaux, Catherine Barbaroux, Catherine Dubois d’Enghien, André Nicolas, Laurent Castéra, Xavier Sastre-Garau, Marc-Henri Stern, Claude Houdayer, Dominique Stoppa-Lyonnet

Malignant extra-adrenal pancreatic paraganglioma: case report and literature review

Open Access
Case report

Bilal O Al-Jiffry, Yasir AlNemary, Samah H Khayat, Moutaz Haiba, Mohammed Hatem

Upregulation of Wnt5a promotes epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cells

Open Access
Research article

Haiji Bo, Shuhui Zhang, Li Gao, Ying Chen, Jing Zhang, Xuejiao Chang, Minghua Zhu

Disentangling the body weight-bone mineral density association among breast cancer survivors: an examination of the independent roles of lean mass and fat mass

Open Access
Research article

Stephanie M George, Anne McTiernan, Adriana Villaseñor, Catherine M Alfano, Melinda L Irwin, Marian L Neuhouser, Richard N Baumgartner, Kathy B Baumgartner, Leslie Bernstein, Ashley W Smith, Rachel Ballard-Barbash

Prognostic effect of preoperative serum estradiol level in postmenopausal breast cancer

Open Access
Research article

Ju-Yeon Kim, Wonshik Han, Hyeong-Gon Moon, Soo Kyung Ahn, Jisun Kim, Jun Woo Lee, Min Kyoon Kim, Taeryung Kim, Dong-Young Noh

FELD better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases

Open Access
Case report

Filip YFL De Vos, Sasja F Mulder, Joost PH Drenth, Iris D Nagtegaal, Jurgen J Fütterer, Winette TA van der Graaf

Geographic remoteness, area-level socioeconomic disadvantage and inequalities in colorectal cancer survival in Queensland: a multilevel analysis

Open Access
Research article

Peter D Baade, Paramita Dasgupta, Joanne F Aitken, Gavin Turrell

Phase I drug-interaction study of effects of calcium and magnesium infusions on oxaliplatin pharmacokinetics and acute neurotoxicity in colorectal cancer patients

Open Access
Research article

Catherine H Han, Prashannata Khwaounjoo, Dean H Kilfoyle, Andrew Hill, Mark J McKeage

Primary Tumor Vascularity, HIF-1α and VEGF expression in vulvar squamous cell carcinomas: their relationships with clinicopathological characteristics and prognostic impact

Open Access
Research article

Hari Prasad Dhakal, Jahn M Nesland, Mette Førsund, Claes G Trope, Ruth Holm

Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors

Open Access
Research article

Jovana Klajic, Thomas Fleischer, Emelyne Dejeux, Hege Edvardsen, Fredrik Warnberg, Ida Bukholm, Per Eystein Lønning, Hiroko Solvang, Anne-Lise Børresen-Dale, Jörg Tost, Vessela N Kristensen

Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9156 patients

Open Access
Research article

Lukas Schwentner, Achim Wöckel, Jochem König, Wolfgang Janni, Florian Ebner, Maria Blettner, Rolf Kreienberg, Reyn Van Ewijk

LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells

Open Access
Research article

Susan MW Harrison, Teresa Knifley, Min Chen, Kathleen L O’Connor

Cost-effectiveness of adjuvant chemotherapy for curatively resected gastric cancer with S-1

Open Access
Research article

Akinori Hisashige, Mitsuru Sasako, Toshifusa Nakajima

“EXHALE”: exercise as a strategy for rehabilitation in advanced stage lung cancer patients: a randomized clinical trial comparing the effects of 12 weeks supervised exercise intervention versus usual care for advanced stage lung cancer patients

Open Access
Study protocol

Morten Quist, Seppo W Langer, Mikael Rørth, Karl Bang Christensen, Lis Adamsen

Increased risk of gastric adenocarcinoma after treatment of primary gastric diffuse large B-cell lymphoma

Open Access
Research article

Koji Inaba, Ryoji Kushima, Naoya Murakami, Yuuki Kuroda, Ken Harada, Mayuka Kitaguchi, Kotaro Yoshio, Shuhei Sekii, Kana Takahashi, Madoka Morota, Hiroshi Mayahara, Yoshinori Ito, Minako Sumi, Takashi Uno, Jun Itami

SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes

Open Access
Research article

Melanie Liesenfeld, Sandy Mosig, Harald Funke, Lars Jansen, Ingo B Runnebaum, Matthias Dürst, Claudia Backsch

Optical imaging of tumor vascularity associated with proliferation and glucose metabolism in early breast cancer: clinical application of total hemoglobin measurements in the breast

Open Access
Research article

Shigeto Ueda, Noriko Nakamiya, Kazuo Matsuura, Takashi Shigekawa, Hiroshi Sano, Eiko Hirokawa, Hiroko Shimada, Hiroaki Suzuki, Motoki Oda, Yutaka Yamashita, Osamu Kishino, Ichiei Kuji, Akihiko Osaki, Toshiaki Saeki

Copy number alterations in small intestinal neuroendocrine tumors determined by array comparative genomic hybridization

Open Access
Research article

Jamileh Hashemi, Omid Fotouhi, Luqman Sulaiman, Magnus Kjellman, Anders Höög, Jan Zedenius, Catharina Larsson

Expression of nerve growth factor and heme oxygenase-1 predict poor survival of breast carcinoma patients

Open Access
Research article

Sang Jae Noh, Jun Sang Bae, Urangoo Jamiyandorj, Ho Sung Park, Keun Sang Kwon, Sung Hoo Jung, Hyun Jo Youn, Ho Lee, Byung-Hyun Park, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Kyu Yun Jang

CD26 Expression on T-Anaplastic Large Cell Lymphoma (ALCL) Line Karpas 299 is associated with increased expression of Versican and MT1-MMP and enhanced adhesion

Open Access
Research article

Pamela A Havre, Long H Dang, Kei Ohnuma, Satoshi Iwata, Chikao Morimoto, Nam H Dang

Napsin A as a marker of clear cell ovarian carcinoma

Open Access
Research article

Ingiridur Skirnisdottir, Kathrine Bjersand, Helena Åkerud, Tomas Seidal

EGF receptor and COX-1/COX-2 enzyme proteins as related to corresponding mRNAs in human per-operative biopsies of colorectal cancer

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Annika Gustafsson Asting, Ava Farivar, Britt-Marie Iresjö, Helena Svensson, Bengt Gustavsson, Kent Lundholm

SmartArc-based volumetric modulated arc therapy for endometrial cancer: a dosimetric comparison with helical tomotherapy and intensity-modulated radiation therapy

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Ruijie Yang, Junjie Wang, Shouping Xu, Hua Li

Concurrent chemoradiotherapy with tomotherapy in locally advanced non-small cell lung cancer: a phase i, docetaxel dose-escalation study, with hypofractionated radiation regimen

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Alessandra Bearz, Emilio Minatel, Imad Abu Rumeileh, Eugenio Borsatti, Renato Talamini, Giovanni Franchin, Carlo Gobitti, Alessandro Del Conte, Marco Trovò, Tanja Baresic

Pleural cancer mortality in Spain: time-trends and updating of predictions up to 2020

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Gonzalo López-Abente, Montserrat García-Gómez, Alfredo Menéndez-Navarro, Pablo Fernández-Navarro, Rebeca Ramis, Javier García-Pérez, Marta Cervantes, Eva Ferreras, María Jiménez-Muñoz, Roberto Pastor-Barriuso

Phase II trial of neoadjuvant pemetrexed plus cisplatin followed by surgery and radiation in the treatment of pleural mesothelioma

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Rea Federico, Favaretto Adolfo, Marulli Giuseppe, Spaggiari Lorenzo, DePas Tommaso Martino, Ceribelli Anna, Paccagnella Adriano, Crivellari Gino, Russo Francesca, Ceccarelli Matteo, Kazeem Gbenga, Marchi Paolo, Facciolo Francesco

High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients

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Gry Irene Magnussen, Ellen Hellesylt, Jahn M Nesland, Claes G Trope, Vivi Ann Flørenes, Ruth Holm

CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1α

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Mine Esencay, Yasmeen Sarfraz, David Zagzag

Overexpression of heat shock transcription factor 1 enhances the resistance of melanoma cells to doxorubicin and paclitaxel

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Natalia Vydra, Agnieszka Toma, Magdalena Glowala-Kosinska, Agnieszka Gogler-Piglowska, Wieslawa Widlak

Small-cell lung cancer with a rare epidermal growth factor receptor gene mutation showing “wax-and-wane” transformation

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Case report

Yusuke Takagi, Yoshiro Nakahara, Yukio Hosomi, Tsunekazu Hishima

MicroRNA expression profile in head and neck cancer: HOX-cluster embedded microRNA-196a and microRNA-10b dysregulation implicated in cell proliferation

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Patricia Severino, Holger Brüggemann, Flavia Maziero Andreghetto, Carme Camps, Maria de Fatima Garrido Klingbeil, Welbert Oliveira de Pereira, Renata Machado Soares, Raquel Moyses, Victor Wünsch-Filho, Monica Beatriz Mathor, Fabio Daumas Nunes, Jiannis Ragoussis, Eloiza Helena Tajara

Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer

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Tak L Khong, Ngayu Thairu, Helene Larsen, Peter M Dawson, Serafim Kiriakidis, Ewa M Paleolog

High expression of ezrin predicts poor prognosis in uterine cervical cancer

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Jienan Kong, Yan Li, Shuangping Liu, Haidan Jin, Yongjun Shang, Chengshi Quan, Yulin Li, Zhenhua Lin

BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer

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William Jacot, Simon Thezenas, Romain Senal, Cathy Viglianti, Anne-Claire Laberenne, Evelyne Lopez-Crapez, Frédéric Bibeau, Jean-Pierre Bleuse, Gilles Romieu, Pierre-Jean Lamy

Assessment of early changes in 3H-fluorothymidine uptake after treatment with gefitinib in human tumor xenograft in comparison with Ki-67 and phospho-EGFR expression

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Songji Zhao, Yuji Kuge, Yan Zhao, Satoshi Takeuchi, Kenji Hirata, Toshiki Takei, Tohru Shiga, Hirotoshi Dosaka-Akita, Nagara Tamaki

Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer

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Agnieszka A Rawluszko, Katarzyna E Bujnicka, Karolina Horbacka, Piotr Krokowicz, Paweł P Jagodziński

RETRACTED ARTICLE: A synthetic dsRNA, as a TLR3 pathwaysynergist, combined with sorafenib suppresses HCC in vitro and in vivo

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Yu-Yin Xu, Li Chen, Gui-Lan Wang, Jia-Ming Zhou, Yi-Xin Zhang, Yin-Ze Wei, Yuan-Yuan Zhu, Jing Qin

Trends in hepatitis B virus screening at the onset of chemotherapy in a large US cancer center

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Jessica P Hwang, Michael J Fisch, Anna S-F Lok, Hong Zhang, John M Vierling, Maria E Suarez-Almazor

Activation of pro-oncogenic pathways in colorectal hyperplastic polyps

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Catherine Do, Claudine Bertrand, Julien Palasse, Marie-Bernadette Delisle, Elizabeth Cohen-Jonathan-Moyal, Catherine Seva

Altered features and increased chemosensitivity of human breast cancer cells mediated by adipose tissue-derived mesenchymal stromal cells

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Lucia Kucerova, Svetlana Skolekova, Miroslava Matuskova, Martin Bohac, Zuzana Kozovska

Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line

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Huan Gu, Xianquan Zhan, Guiying Zhang, Lu Yan, William CS Cho, Maoyu Li, Ting Liu, Zhuchu Chen

Systematic review and meta-analysis of tumor biomarkers in predicting prognosis in esophageal cancer

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Meilan Chen, Jizheng Huang, Zhenli Zhu, Jun Zhang, Ke Li

Osteopontin is a prognostic biomarker in non-small cell lung cancer

Open Access
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Ane Kongsgaard, Kjetil Boye, Miriam Øijordsbakken, Marius Lund-Iversen, Ann Rita Halvorsen, Steinar K Solberg, Gisle Berge, Åslaug Helland, Odd Terje Brustugun, Gunhild M Mælandsmo

Preoperative serum CA 72.4 as prognostic factor of recurrence and death, especially at TNM stage II, for colorectal cancer

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Daniel Ayude, Francisco Javier Rodríguez-Berrocal, José Ayude, Sonia Blanco-Prieto, Lorena Vázquez-Iglesias, Marta Vázquez-Cedeira, María Páez de la Cadena

Intensity-modulated radiotherapy versus radical prostatectomy in patients with localized prostate cancer: long-term follow-up

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Research article

Tomás Merino, Ignacio F San Francisco, Pablo A Rojas, Piero Bettoli, Álvaro Zúñiga, Pelayo Besa

Study protocol: rehabilitation including social and physical activity and education in children and teenagers with cancer (RESPECT)

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Study protocol

Troels Thorsteinsson, Anne Sofie Helms, Lis Adamsen, Lars Bo Andersen, Karen Vitting Andersen, Karl Bang Christensen, Henrik Hasle, Carsten Heilmann, Nete Hejgaard, Christoffer Johansen, Marianne Madsen, Svend Aage Madsen, Venka Simovska, Birgit Strange, Lone Friis Thing, Peder Skov Wehner, Kjeld Schmiegelow, Hanne Baekgaard Larsen

Study design: two long-term observational studies of the biosimilar filgrastim Nivestim™ (Hospira filgrastim) in the treatment and prevention of chemotherapy-induced neutropenia

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Study protocol

Didier Kamioner, Stefan Fruehauf, Fréderic Maloisel, Laurent Cals, Stéphane Lepretre, Christian Berthou

Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma

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Research article

Ronald Koschny, Sylvia Brost, Ulf Hinz, Jaromir Sykora, Emanuela M Batke, Stephan Singer, Kai Breuhahn, Wolfgang Stremmel, Henning Walczak, Peter Schemmer, Peter Schirmacher, Tom M Ganten

Fluorodeoxyglucose positron emission tomography and chemotherapy-related tumor marker expression in non-small cell lung cancer

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Research article

Xiao-Yi Duan, Wen Wang, Jian-Sheng Wang, Jin Shang, Jun-Gang Gao, You-Min Guo

Gene aberrations of RRM1 and RRM2B and outcome of advanced breast cancer after treatment with docetaxel with or without gemcitabine

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Research article

Charlotte LT Jørgensen, Bent Ejlertsen, Karsten D Bjerre, Eva Balslev, Dorte L Nielsen, Kirsten V Nielsen

Predictors for replanning in loco-regionally advanced nasopharyngeal carcinoma patients undergoing intensity-modulated radiation therapy: a prospective observational study

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Research article

DanFang Yan, SenXiang Yan, QiDong Wang, XinBiao Liao, ZhongJie Lu, YiXiang Wang

Separate episodes of capillary leak syndrome and pulmonary hypertension after adjuvant gemcitabine and three years later after nab-paclitaxel for metastatic disease

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Case report

Andrea Casadei Gardini, Michele Aquilina, Devil Oboldi, Alessandro Lucchesi, Silvia Carloni, Elena Tenti, Marco Angelo Burgio, Dino Amadori, Giovanni Luca Frassineti

Identification of the IGF1/PI3K/NF κB/ERK gene signalling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer

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Research article

Madhuri Koti, Robert J Gooding, Paulo Nuin, Alexandria Haslehurst, Colleen Crane, Johanne Weberpals, Timothy Childs, Peter Bryson, Moyez Dharsee, Kenneth Evans, Harriet E Feilotter, Paul C Park, Jeremy A Squire

Papillary thyroid carcinoma with massive metastasis in the uterine corpus: a case report

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Case report

Jian-hong Wang, Jing Yu, Chun-ping Ning, Yong-mei Sun, Shi-bao Fang

Estimate of the global burden of cervical adenocarcinoma and potential impact of prophylactic human papillomavirus vaccination

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Jeanne M Pimenta, Claudia Galindo, David Jenkins, Sylvia M Taylor

Extracellular matrix specific protein fingerprints measured in serum can separate pancreatic cancer patients from healthy controls

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Nicholas Willumsen, Cecilie L Bager, Diana J Leeming, Victoria Smith, Morten A Karsdal, David Dornan, Anne-Christine Bay-Jensen

Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study

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Research article

Adriana C Vidal, Cocoa Tucker, Joellen M Schildkraut, Ricardo M Richardson, Megan McPhail, Stephen J Freedland, Cathrine Hoyo, Delores J Grant

Time from diagnosis to surgery and prostate cancer survival: a retrospective cohort study

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Maria Theresa Redaniel, Richard M Martin, David Gillatt, Julia Wade, Mona Jeffreys

Restoration of WNT4 inhibits cell growth in leukemia-derived cell lines

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Beatriz García-Castro, Monserrat Alvarez-Zavala, Alma R Riveros-Magaña, Pablo C Ortíz-Lazareno, Sarah Ratkovich-González, Georgina Hernández-Flores, Alejandro Bravo-Cuellar, Luis F Jave-Suarez, Adriana Aguilar-Lemarroy

St Gallen molecular subtypes in primary breast cancer and matched lymph node metastases - aspects on distribution and prognosis for patients with luminal A tumours: results from a prospective randomised trial

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Anna-Karin Falck, Mårten Fernö, Pär-Ola Bendahl, Lisa Rydén

Family history of cancer, personal history of medical conditions and risk of oral cavity cancer in France: the ICARE study

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Research article

Loredana Radoï, Sophie Paget-Bailly, Florence Guida, Diane Cyr, Gwenn Menvielle, Annie Schmaus, Matthieu Carton, Sylvie Cénée, Marie Sanchez, Anne-Valérie Guizard, Brigitte Trétarre, Isabelle Stücker, Danièle Luce

Long-lasting response to electrochemotherapy in melanoma patients with cutaneous metastasis

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Research article

Corrado Caracò, Nicola Mozzillo, Ugo Marone, Ester Simeone, Lucia Benedetto, Gianluca Di Monta, Maria Luisa Di Cecilia, Gerardo Botti, Paolo Antonio Ascierto

Identification of new p53 target microRNAs by bioinformatics and functional analysis

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Alessandra Bisio, Veronica De Sanctis, Valerio Del Vescovo, Michela A Denti, Anil G Jegga, Alberto Inga, Yari Ciribilli

The novel myxofibrosarcoma cell line MUG-Myx1 expresses a tumourigenic stem-like cell population with high aldehyde dehydrogenase 1 activity

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Birgit Lohberger, Nicole Stuendl, Elisabeth Wolf, Bernadette Liegl-Atzwanger, Andreas Leithner, Beate Rinner

Severe pan-uveitis in a patient treated with vemurafenib for metastatic melanoma

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Case report

Sanne EJ Wolf, Christina Meenken, Annette C Moll, John B Haanen, Michiel S van der Heijden

Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival

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Research article

Andri Rezano, Kazuhiko Kuwahara, Mutsuko Yamamoto-Ibusuki, Masahiro Kitabatake, Penpak Moolthiya, Suchada Phimsen, Taiji Suda, Shigenobu Tone, Yutaka Yamamoto, Hirotaka Iwase, Nobuo Sakaguchi

Impact of radiotherapy in the management of locally advanced extrahepatic cholangiocarcinoma

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Research article

Laurence Moureau-Zabotto, Olivier Turrini, Michel Resbeut, Jean-Luc Raoul, Marc Giovannini, Flora Poizat, Gilles Piana, Jean-Robert Delpero, Francois Bertucci

Association of cellular and molecular responses in the rat mammary gland to 17β-estradiol with susceptibility to mammary cancer

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Lina Ding, Yang Zhao, Christopher L Warren, Ruth Sullivan, Kevin W Eliceiri, James D Shull

S-1 combined with docetaxel following doxorubicin plus cyclophosphamide as neoadjuvant therapy in breast cancer: phase II trial

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Research article

Yong Wha Moon, Soohyeon Lee, Byeong-Woo Park, Eun-Kyung Kim, Seung Il Kim, Ja Seung Koo, Seho Park, Min Jung Kim, Hyun Cheol Chung, Joo-Hang Kim, Joohyuk Sohn

Clinical implication of ZEB-1 and E-cadherin expression in hepatocellular carcinoma (HCC)

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Motoyuki Hashiguchi, Shinichi Ueno, Masahiko Sakoda, Satoshi Iino, Kiyokazu Hiwatashi, Koji Minami, Kei Ando, Yuko Mataki, Kosei Maemura, Hiroyuki Shinchi, Sumiya Ishigami, Shoji Natsugoe

Clinical significance of palliative gastrectomy on the survival of patients with incurable advanced gastric cancer: a systematic review and meta-analysis

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Jingxu Sun, Yongxi Song, Zhenning Wang, Xiaowan Chen, Peng Gao, Yingying Xu, Baosen Zhou, Huimian Xu

Estimating the lifelong health impact and financial burdens of different types of lung cancer

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Research article

Szu-Chun Yang, Wu-Wei Lai, Wu-Chou Su, Shang-Yin Wu, Helen HW Chen, Yi-Lin Wu, Mei-Chuan Hung, Jung-Der Wang

Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation

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Yunzhong Nie, Leilei Du, Yongbin Mou, Zhenjun Xu, Leihua Weng, Youwei Du, Yanan Zhu, Yayi Hou, Tingting Wang

Phosphatidylinositol 3-Kinase dependent upregulation of the epidermal growth factor receptor upon Flotillin-1 depletion in breast cancer cells

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Nina Kurrle, Wymke Ockenga, Melanie Meister, Frauke Völlner, Sina Kühne, Bincy A John, Antje Banning, Ritva Tikkanen

Measuring telomere length for the early detection of precursor lesions of esophageal squamous cell carcinoma

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Shih-Wen Lin, Christian C Abnet, Neal D Freedman, Gwen Murphy, Rosana Risques, Donna Prunkard, Peter Rabinovitch, Qin-Jing Pan, Mark J Roth, Guo-Qing Wang, Wen-Qiang Wei, Ning Lu, Philip R Taylor, You-Lin Qiao, Sanford M Dawsey

An assessment of existing models for individualized breast cancer risk estimation in a screening program in Spain

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Arantzazu Arrospide, Carles Forné, Montse Rué, Núria Torà, Javier Mar, Marisa Baré

NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells

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Meike Wagner, Michael Koslowski, Claudia Paret, Marcus Schmidt, Özlem Türeci, Ugur Sahin

The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

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Zeze Fu, Biyong Deng, Yuxin Liao, Liancheng Shan, Fei Yin, Zhuoying Wang, Hui Zeng, Dongqing Zuo, Yingqi Hua, Zhengdong Cai

Trends of risk classification and primary therapy for Japanese patients with prostate cancer in Nara Uro-Oncological Research Group (NUORG)–a comparison between 2004-2006 and 2007-2009

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Research article

Nobumichi Tanaka, Akihide Hirayama, Tatsuo Yoneda, Katsunori Yoshida, Keiji Shimada, Noboru Konishi, Kiyohide Fujimoto

The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding

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Brent W Ferguson, Xinsheng Gao, Maciej J Zelazowski, Jaeho Lee, Collene R Jeter, Martin C Abba, C Marcelo Aldaz

Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer

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Research article

Jean-Pierre Roperch, Roberto Incitti, Solène Forbin, Floriane Bard, Hicham Mansour, Farida Mesli, Isabelle Baumgaertner, Francesco Brunetti, Iradj Sobhani

A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells

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Martin Grimm, Steffen Schmitt, Peter Teriete, Thorsten Biegner, Arnulf Stenzl, Jörg Hennenlotter, Hans-Joachim Muhs, Adelheid Munz, Tatjana Nadtotschi, Klemens König, Jörg Sänger, Oliver Feyen, Heiko Hofmann, Siegmar Reinert, Johannes F Coy

Up-regulation of CLDN1 in gastric cancer is correlated with reduced survival

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Research article

Lars L Eftang, Ying Esbensen, Tone M Tannæs, Gustav P Blom, Ida RK Bukholm, Geir Bukholm

Radiographic response to neoadjuvant therapy and its impact on scope of surgery and prognosis in stage IIB/III soft tissue sarcomas

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Yong Chen, Yun Yang, ChunMeng Wang, YingQiang Shi

Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells

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Research article

Ornanong Tusskorn, Laddawan Senggunprai, Auemduan Prawan, Upa Kukongviriyapan, Veerapol Kukongviriyapan

Safety and efficacy of vemurafenib in end stage renal failure

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Case report

Mahesh Iddawela, Sarah Crook, Leah George, Amit Lakkaraju, Nihal Nanayakkara, Roland Hunt, William R Adam

The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts

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Pratiti Bandopadhayay, Anissa M Jabbour, Christopher Riffkin, Marika Salmanidis, Lavinia Gordon, Dean Popovski, Lin Rigby, David M Ashley, David N Watkins, David M Thomas, Elizabeth Algar, Paul G Ekert

Epithelial mesenchymal transition status is associated with anti-cancer responses towards receptor tyrosine-kinase inhibition by dovitinib in human bladder cancer cells

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Jörg Hänze, Marcus Henrici, Axel Hegele, Rainer Hofmann, Peter J Olbert

Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation

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Research article

Ryota Kimura, Atsushi Kasamatsu, Tomoyoshi Koyama, Chonji Fukumoto, Yukinao Kouzu, Morihiro Higo, Yosuke Endo-Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa

Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study

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Research article

Rebecca Ritte, Kaja Tikk, Annekatrin Lukanova, Anne Tjønneland, Anja Olsen, Kim Overvad, Laure Dossus, Agnès Fournier, Françoise Clavel-Chapelon, Verena Grote, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Franco Berrino, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, José Ramón Quirós, Genevieve Buckland, Esther Molina-Montes, María-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, H Bas Bueno-de-Mesquita, Carla H van Gils, Petra HM Peeters, Nick Wareham, Kay-Tee Khaw, Timothy J Key, Ruth C Travis, Elisabete Weiderpass, Vanessa Dumeaux, Eliv Lund, Malin Sund, Anne Andersson, Isabelle Romieu, Sabina Rinaldi, Paulo Vineis, Melissa A Merritt, Elio Riboli, Rudolf Kaaks

Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+T cells

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Research article

Meriem Hasmim, Cécile Badoual, Philippe Vielh, Françoise Drusch, Virginie Marty, Agnès Laplanche, Mariana de Oliveira Diniz, Hélène Roussel, Eléonore De Guillebon, Stéphane Oudard, Stéphane Hans, Eric Tartour, Salem Chouaib

Effects of recreational soccer in men with prostate cancer undergoing androgen deprivation therapy: study protocol for the ‘FC Prostate’ randomized controlled trial

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Study protocol

Jacob Uth, Jakob Friis Schmidt, Jesper Frank Christensen, Therese Hornstrup, Lars Juel Andersen, Peter Riis Hansen, Karl Bang Christensen, Lars Louis Andersen, Eva Wulff Helge, Klaus Brasso, Mikael Rørth, Peter Krustrup, Julie Midtgaard

An ongoing case-control study to evaluate the NHS breast screening programme

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Study protocol

Nathalie J Massat, Peter D Sasieni, Dharmishta Parmar, Stephen W Duffy

Brain metastasis from hepatocellular carcinoma: the role of surgery as a prognostic factor

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Research article

Moon-Soo Han, Kyung-Sub Moon, Kyung-Hwa Lee, Sung-Bum Cho, Sa-Hoe Lim, Woo-Youl Jang, Tae-Young Jung, In-Young Kim, Shin Jung

The prognostic values of EGFR expression and KRAS mutation in patients with synchronous or metachronous metastatic colorectal cancer

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Research article

Ching-Wen Huang, Hsiang-Lin Tsai, Yi-Ting Chen, Chun-Ming Huang, Cheng-Jen Ma, Chien-Yu Lu, Chao-Hung Kuo, Deng-Chyang Wu, Chee-Yin Chai, Jaw-Yuan Wang

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma

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Research article

Simion I Chiosea, Jennifer R Grandis, Vivian W Y Lui, Brenda Diergaarde, Jessica H Maxwell, Robert L Ferris, Seungwon W Kim, Alyssa Luvison, Megan Miller, Marina N Nikiforova

Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case–control study in Japanese women

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Research article

Taeko Mizoo, Naruto Taira, Keiko Nishiyama, Tomohiro Nogami, Takayuki Iwamoto, Takayuki Motoki, Tadahiko Shien, Junji Matsuoka, Hiroyoshi Doihara, Setsuko Ishihara, Hiroshi Kawai, Kensuke Kawasaki, Youichi Ishibe, Yutaka Ogasawara, Yoshifumi Komoike, Shinichiro Miyoshi

TP53 genetic polymorphisms, interactions with lifestyle factors and lung cancer risk: a case control study in a Chinese population

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Research article

Yanli Li, Shen-Chih Chang, Rungui Niu, Li Liu, Christina R Crabtree-Ide, Baoxing Zhao, Jianping Shi, Xiaoyou Han, Jiawei Li, Jia Su, Lin Cai, Shunzhang Yu, Zuo-Feng Zhang, Lina Mu

Bifractionated CPT-11 with LV5FU2 infusion (FOLFIRI-3) in combination with bevacizumab: clinical outcomes in first-line metastatic colorectal cancers according to plasma angiopoietin-2 levels

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Research article

Stefano Kim, Erion Dobi, Marine Jary, Franck Monnien, Elsa Curtit, Thierry NGuyen, Zaher Lakkis, Bruno Heyd, Serge Fratte, Denis Cléau, Najib Lamfichekh, Virginie Nerich, Boris Guiu, Martin Demarchi, Christophe Borg

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells

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Research article

Maximilian Linxweiler, Stefan Schorr, Nico Schäuble, Martin Jung, Johannes Linxweiler, Frank Langer, Hans-Joachim Schäfers, Adolfo Cavalié, Richard Zimmermann, Markus Greiner

Association between polymorphisms in ERCC2 gene and oral cancer risk: evidence from a meta-analysis

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Research article

Enjiao Zhang, Zhigang Cui, Zhongfei Xu, Weiyi Duan, Shaohui Huang, Xuexin Tan, Zhihua Yin, Changfu Sun, Li Lu

High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor

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Gregor Auf, Arnaud Jabouille, Maylis Delugin, Sylvaine Guérit, Raphael Pineau, Sophie North, Natalia Platonova, Marlène Maitre, Alexandre Favereaux, Peter Vajkoczy, Masaharu Seno, Andreas Bikfalvi, Dmitri Minchenko, Oleksandr Minchenko, Michel Moenner

Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

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Research article

Stine B Thorsen, Sarah LT Christensen, Sidse Ø Würtz, Martin Lundberg, Birgitte S Nielsen, Lena Vinther, Mick Knowles, Nick Gee, Simon Fredriksson, Susanne Møller, Nils Brünner, Anne-Sofie Schrohl, Jan Stenvang

Epigenetic silencing of glutaminase 2 in human liver and colon cancers

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Research article

Jianbin Zhang, Cheng Wang, Mingquan Chen, Jianping Cao, Ying Zhong, Liting Chen, Han-Ming Shen, Dajing Xia

Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas

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Research article

Quirinus JM Voorham, Jerry Janssen, Marianne Tijssen, Suzanne Snellenberg, Sandra Mongera, Nicole CT van Grieken, Heike Grabsch, Martin Kliment, Bjorn J Rembacken, Chris JJ Mulder, Manon van Engeland, Gerrit A Meijer, Renske DM Steenbergen, Beatriz Carvalho

Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo

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Research article

Ryan Montano, Ruth Thompson, Injae Chung, Huagang Hou, Nadeem Khan, Alan Eastman

Mechanisms of acquired resistance to EGFR-tyrosine kinase inhibitor in Korean patients with lung cancer

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Research article

Wonjun Ji, Chang-Min Choi, Jin Kyung Rho, Se Jin Jang, Young Soo Park, Sung-Min Chun, Woo Sung Kim, Jung-Shin Lee, Sang-We Kim, Dae Ho Lee, Jae Cheol Lee

Involvement of nitric oxide synthase in matrix metalloproteinase-9- and/or urokinase plasminogen activator receptor-mediated glioma cell migration

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Research article

Thompson Zhuang, Bharath Chelluboina, Shivani Ponnala, Kiran Kumar Velpula, Azeem A Rehman, Chandramu Chetty, Eleonora Zakharian, Jasti S Rao, Krishna Kumar Veeravalli

Accuracy of cause of death data routinely recorded in a population-based cancer registry: impact on cause-specific survival and validation using the Geneva cancer registry

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Research article

Robin Schaffar, Elisabetta Rapiti, Bernard Rachet, Laura Woods

Results of concurrent radio-chemotherapy for the treatment of head and neck squamous cell carcinoma in everyday clinical practice with special reference to early mortality

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Research article

Michael Schlumpf, Claude Fischer, Diana Naehrig, Christoph Rochlitz, Martin Buess

Assessment of HER2 status in breast cancer: overall positivity rate and accuracy by fluorescence in situ hybridization and immunohistochemistry in a single institution over 12 years: a quality control study

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Research article

Zsuzsanna Varga, Aurelia Noske, Constanze Ramach, Barbara Padberg, Holger Moch

Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites

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Research article

Nynke GL Jager, Rutger HT Koornstra, Andrew D Vincent, Ron HN van Schaik, Alwin DR Huitema, Tiny M Korse, Jan HM Schellens, Sabine C Linn, Jos H Beijnen

Systemic effect of catumaxomab in a patient with metastasized colorectal cancer: a case report

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Case report

Angelika Bezan, Florian Hohla, Thomas Meissnitzer, Richard Greil

Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma

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Research article

Janette Mareska Rumbajan, Toshiyuki Maeda, Ryota Souzaki, Kazumasa Mitsui, Ken Higashimoto, Kazuhiko Nakabayashi, Hitomi Yatsuki, Kenichi Nishioka, Ryoko Harada, Shigehisa Aoki, Kenichi Kohashi, Yoshinao Oda, Kenichiro Hata, Tsutomu Saji, Tomoaki Taguchi, Tatsuro Tajiri, Hidenobu Soejima, Keiichiro Joh

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Eiliv Lund, Nicolle Mode, Marit Waaseth, Jean-Christophe Thalabard

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Moritz C Oberstadt, Sandra Bien-Möller, Kerstin Weitmann, Susann Herzog, Katharina Hentschel, Christian Rimmbach, Silke Vogelgesang, Ellen Balz, Matthias Fink, Heike Michael, Jan-Philip Zeden, Henrike Bruckmüller, Anneke N Werk, Ingolf Cascorbi, Wolfgang Hoffmann, Dieter Rosskopf, Henry WS Schroeder, Heyo K Kroemer

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Improving cancer patient care: development of a generic cancer consumer quality index questionnaire for cancer patients

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Judith C Booij, Marieke Zegers, Pauline MPJ Evers, Michelle Hendriks, Diana MJ Delnoij, Jany JDJM Rademakers

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Influence of zoledronic acid on disseminated tumor cells in bone marrow and survival: results of a prospective clinical trial

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Kyoichi Kaira, Yutaka Sunose, Yasuhiro Ohshima, Noriko S Ishioka, Kazuhisa Arakawa, Tetsushi Ogawa, Noriaki Sunaga, Kimihiro Shimizu, Hideyuki Tominaga, Noboru Oriuchi, Hideaki Itoh, Shushi Nagamori, Yoshikatsu Kanai, Aiko Yamaguchi, Atsuki Segawa, Munenori Ide, Masatomo Mori, Tetsunari Oyama, Izumi Takeyoshi

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David Hersi Smith, Ib Jarle Christensen, Niels Frank Jensen, Bo Markussen, Sven Müller, Hans Jørgen Nielsen, Nils Brünner, Kirsten Vang Nielsen

Selenized milk casein in the diet of BALB/c nude mice reduces growth of intramammary MCF-7 tumors

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Jenny M Warrington, Julie JM Kim, Priska Stahel, Scott RL Cieslar, Roger A Moorehead, Brenda L Coomber, Milena Corredig, John P Cant

Evaluation of a curcumin analog as an anti-cancer agent inducing ER stress-mediated apoptosis in non-small cell lung cancer cells

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Zhiguo Liu, Yusheng Sun, Luqing Ren, Yi Huang, Yuepiao Cai, Qiaoyou Weng, Xueqian Shen, Xiaokun Li, Guang Liang, Yi Wang

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Yingying Mao, Alan Fu, Derek Leaderer, Tongzhang Zheng, Kun Chen, Yong Zhu

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Mario G Hollomon, Nancy Gordon, Janice M Santiago-O’Farrill, Eugenie S Kleinerman

Using Twitter for breast cancer prevention: an analysis of breast cancer awareness month

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Rosemary Thackeray, Scott H Burton, Christophe Giraud-Carrier, Stephen Rollins, Catherine R Draper

Increased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma

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Hironori Betsunoh, Takehiko Fukuda, Naohiko Anzai, Daisaku Nishihara, Tomoya Mizuno, Hideo Yuki, Akinori Masuda, Yoshiyuki Yamaguchi, Hideyuki Abe, Masahiro Yashi, Yoshitatsu Fukabori, Ken-Ichiro Yoshida, Takao Kamai

Common low-penetrance risk variants associated with breast cancer in Polish women

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Joanna K Ledwoń, Ewa E Hennig, Natalia Maryan, Krzysztof Goryca, Dorota Nowakowska, Anna Niwińska, Jerzy Ostrowski

Molecular subtypes in ductal carcinoma in situ of the breast and their relation to prognosis: a population-based cohort study

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Wenjing Zhou, Karin Jirström, Rose-Marie Amini, Marie-Louise Fjällskog, Thomas Sollie, Henrik Lindman, Therese Sørlie, Carl Blomqvist, Fredrik Wärnberg

Cardiopulmonary bypass has a modest association with cancer progression: a retrospective cohort study

Open Access
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Cathy Anne Pinto, Stephen Marcella, David A August, Bart Holland, John B Kostis, Kitaw Demissie

The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin

Open Access
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Quan Wang, Feng Wei, Guoyue Lv, Chunsheng Li, Tongjun Liu, Costas G Hadjipanayis, Guikai Zhang, Chunhai Hao, Anita C Bellail

PIK3R1 underexpression is an independent prognostic marker in breast cancer

Open Access
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Magdalena Cizkova, Sophie Vacher, Didier Meseure, Martine Trassard, Aurélie Susini, Dana Mlcuchova, Celine Callens, Etienne Rouleau, Frederique Spyratos, Rosette Lidereau, Ivan Bièche

Heterogeneous echogenicity of the underlying thyroid parenchyma: how does this affect the analysis of a thyroid nodule?

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Mina Park, So Hee Park, Eun-Kyung Kim, Jung Hyun Yoon, Hee Jung Moon, Hye Sun Lee, Jin Young Kwak

The influence of the treatment response on the impact of resection margin status after preoperative chemoradiotherapy in locally advanced rectal cancer

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Joo Ho Lee, Eui Kyu Chie, Kyubo Kim, Seung-Yong Jeong, Kyu Joo Park, Jae-Gahb Park, Gyeong Hoon Kang, Sae-Won Han, Do-Youn Oh, Seock-Ah Im, Tae-You Kim, Yung-Jue Bang, Sung W Ha

Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation

Open Access
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Ibtehaj Al-Sharif, Adnane Remmal, Abdelilah Aboussekhra

Annexin A7 suppresses lymph node metastasis of hepatocarcinoma cells in a mouse model

Open Access
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Yanling Jin, Shaoqing Wang, Wenjing Chen, Jun Zhang, Bo Wang, Hongwei Guan, Jianwu Tang

Wnt signaling in triple negative breast cancer is associated with metastasis

Open Access
Research article

Nandini Dey, Benjamin G Barwick, Carlos S Moreno, Maja Ordanic-Kodani, Zhengjia Chen, Gabriella Oprea-Ilies, Weining Tang, Charles Catzavelos, Kimberly F Kerstann, George W Sledge Jr., Mark Abramovitz, Mark Bouzyk, Pradip De, Brian R Leyland-Jones

The potential of hypoxia markers as target for breast molecular imaging – a systematic review and meta-analysis of human marker expression

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Arthur Adams, Aram SA van Brussel, Jeroen F Vermeulen, Willem PThM Mali, Elsken van der Wall, Paul J van Diest, Sjoerd G Elias

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Neu im Fachgebiet Onkologie

Adnexläsion zufällig im CT entdeckt? Die Befundung fällt selbst Fachleuten schwer!

06.03.2026
Gynäkologische Radiologie
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Ist eine Läsion benigne oder maligne? Und um welche Art handelt es sich genau? Ergebnisse einer kleinen US-Studie zu inzidentellen CT-Befunden sprechen dafür, dass sich auch Expertinnen und Experten bei Adnex-Auffälligkeiten häufig uneins sind – und einige maligne Läsionen verkennen.

Real-World Daten bestätigen Nivolumab bei Kopf-Hals-Tumoren

06.03.2026
DKK 2026
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In der nicht-interventionellen Real-World-Studie HANNA wurde Nivolumab bei Menschen mit rezidiviertem oder metastasiertem Plattenepithelkarzinom der Kopf-Hals-Region in verschiedenen Therapielinien geprüft. Ein Kollege präsentierte auf dem diesjährigen Krebskongress in Berlin die finalen Daten.

Wie Mikrobiom und Komedikation Immuntherapien beeinflussen

06.03.2026
DKK 2026
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Die Effektivität von Checkpoint-Inhibitoren wird unter anderem durch das Mikrobiom und Komedikationen beeinflusst. Wie Ballaststoffe wirken und welche Medikamente man nicht zusammen mit der Immuntherapie geben sollte, zeigten eine Kollegin und ein Kollege auf dem DKK in Berlin auf.

Mehr molekulare Diagnostik bei Krebs ist nicht immer besser

06.03.2026
DKK 2026
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Neue molekularpathologische Methoden erhöhen die diagnostische Sensitivität bei Tumorerkrankungen. Aber verfeinert ein stetiges Mehr an molekularer Diagnostik auch die therapeutische Präzision? Diese Frage wurde im Rahmen des Deutschen Krebskongresses (DKK) 2026 in Berlin diskutiert.

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Radiologie-Assistent bereitet Frau für CT vor/© Peakstock/stock.adobe.com (Symbolbild mit Fotomodellen), Plattenepithelkarzinom/© Springer Medizin Verlag GmbH, Frau bereitet Müsli auf Waage zu/© DragonImages / Stock.adobe.com (Symbolbild mit Fotomodell), 3D Illustration einer DNA Sequenzierung/© undefined / Getty Images / iStock