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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Musculoskeletal Disorders 1/2015

Body mass index at 11 years and bone mass at age 18: path analysis within the 1993 Pelotas (Brazil) birth cohort study

Zeitschrift:
BMC Musculoskeletal Disorders > Ausgabe 1/2015
Autoren:
Ludmila Correa Muniz, Ana Maria Baptista Menezes, Maria Cecília Formoso Assunção, Jeovany Martínez-Mesa, Fernando Cesar Wehrmeister, Laura D Howe, Pedro Curi Hallal, Helen Gonçalves, Fernando C Barros
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12891-015-0529-y) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

LCM, JMM and FCW participated in the data collection; LCM, JMM and LDH performed the statistical analyses; LCM carried out the first draft of manuscript. AMBM, MCFA, PCH, HG and FCB conceived the study, and participated in its design and coordination. All authors read and approved the final manuscript.

Abstract

Background

We investigated whether Body Mass Index (BMI) at 11 years old has a direct effect on bone mass at age 18 operating through alterations to bone growth and development, or whether the association is mediated by concurrent BMI, fat mass (FM), and fat free mass (FFM).

Methods

Path analysis was used to explore the association between BMI at age 11 and whole-body bone mineral content (BMC) and bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry (DXA) at age 18 in a prospective birth cohort study comprising 3,307 adolescents; we also evaluated the degree to which this association was mediated by BMI, FM (kg) and FFM (kg) assessed by plethysmography (BOD POD) at age 18.

Results

We found a positive association between BMI at age 11 and BMC (males [β = 179.7 g, 95% CI 161.4; 198.0]; females [β = 179.9 g, 95% CI 165.3; 194.6]) and BMD (males [β = 0.030 g/cm2, 95% CI 0.024; 0.035]; females [β = 0.029 g/cm2, 95% CI 0.025; 0.033]) at age 18. This association was largely mediated by BMI and FFM at age 18 in both female and male adolescents. FM at age 18 was not an important mediator.

Conclusions

Concurrent BMI and FFM were the main mediators of the association between BMC/BMD in late adolescence and BMI in early adolescence.
Zusatzmaterial
Additional file 1: Figure S1. Overall association between BMI z score at 11 and 18 years and bone mineral content at age18 among males (N = 1601). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM1_ESM.pdf
Additional file 2: Figure S2. Overall association between BMI z score at 11, fat mass and bone mineral content at age18 among males (N = 1601). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM2_ESM.pdf
Additional file 3: Figure S3. Overall association between BMI z score at 11, fat free mass and bone mineral content at age18 among males (N = 1601). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM3_ESM.pdf
Additional file 4: Figure S4. Overall association between BMI z score at 11 and 18 years and bone mineral density at age18 among males (N = 1601). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM4_ESM.pdf
Additional file 5: Figure S5. Overall association between BMI z score at 11, fat mass and bone mineral density at age18 among males (N = 1601). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM5_ESM.pdf
Additional file 6: Figure S6. Overall association between BMI z score at 11, fat free mass and bone mineral density at age18 among males (N = 1601). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM6_ESM.pdf
Additional file 7: Figure S7. Overall association between BMI z score at 11 and 18 years and bone mineral content at age18 among females (N = 1706). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM7_ESM.pdf
Additional file 8: Figure S8. Overall association between BMI z score at 11, fat mass and bone mineral content at age18 among females (N = 1706). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM8_ESM.pdf
Additional file 9: Figure S9. Overall association between BMI z score at 11, fat free mass and bone mineral content at age18 among females (N = 1706). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM9_ESM.pdf
Additional file 10: Figure S10 Overall association between BMI z score at 11 and 18 years and bone mineral density at age18 among females (N = 1706). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM10_ESM.pdf
Additional file 11: Figure S11. Overall association between BMI z score at 11, fat mass and bone mineral density at age18 among females (N = 1706). The 1993 Pelotas Birth Cohort. Brazil.
12891_2015_529_MOESM11_ESM.pdf
Additional file 12: Figure S12. Overall association between BMI z score at 11, fat free mass and bone mineral density at age18 among females (N = 1706). The 1993 Pelotas Birth Cohort Brazil.
12891_2015_529_MOESM12_ESM.pdf
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