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Current Rheumatology Reports
Erschienen in: Current Rheumatology Reports 12/2018

01.12.2018 | Osteoarthritis (M Goldring, Section Editor)

Bone Microdamage in Acute Knee Injury

verfasst von: Logeswaran Selvarajah, Annie M. Curtis, Oran D. Kennedy

Erschienen in: Current Rheumatology Reports | Ausgabe 12/2018

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Abstract

Purpose of Review

This review summarizes what is known about how bone tissue responds to microdamage, and how this applies to the subchondral region. This has significant relevance to acute joint injury, and is related to the occurrence of bone marrow lesions (BMLs) which are seen by MRI in 80% of acute knee joint injuries. Here, we review what is known about these phenomena (microcracks and BMLs) in the literature and discuss potential mechanisms by which they may be linked.

Recent Findings

The recent findings in this field have shown that microcracks in bone initiate targeted remodeling via RANKL expression in osteocytes. Other work has shown that subchondral microcracks co-localize with BMLs as viewed by MRI. Finally, BMLs are associated with pain and structural joint degeneration.

Summary

This paper demonstrates that subchondral microcracks likely occur during acute joint injury, and are closely linked to BML that are seem by clinical MRI and thus are potentially involved in the subsequent joint degeneration that occurs after injury.
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Metadaten
Titel
Bone Microdamage in Acute Knee Injury
verfasst von
Logeswaran Selvarajah
Annie M. Curtis
Oran D. Kennedy
Publikationsdatum
01.12.2018
Verlag
Springer US
Erschienen in
Current Rheumatology Reports / Ausgabe 12/2018
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-018-0791-8

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