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Erschienen in:
01.04.2016 | Epidemiology and Pathophysiology (B Dawson-Hughes and J Cauley, Section Editors)
Bone Quality in Paget’s Disease of Bone
Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2016
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Paget’s disease of bone is produced by a localized increase in osteoclastic and osteoblastic activity which can progress slowly to involve an entire bone if untreated. A common feature is enlarged bones which are deformed, particularly in weight-bearing regions of the skeleton such as the lower extremity. Pathologic fractures may be a consequence, and nonunion of femoral fractures is not uncommon. Analyses of bone biopsies from patients with Paget’s disease indicate that there is a lower, heterogeneous degree of bone mineralization and a younger tissue age than that found in control bone. Pagetic bone also has less resistance to plastic deformation and a straighter crack path than control bone.